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Bioscientia Medicina : Journal of Biomedicine and Translational Research

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Published by HM Publisher

ISSN : - EISSN : 25980580 DOI : https://doi.org/10.37275/bsm

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

This journal welcomes the submission of articles that offering a sensible transfer of basic research to applied clinical medicine. BioScientia Medicina covers the latest developments in various fields of biomedicine with special attention to : 1.Rhemumatology 2.Molecular aspect of Indonesia Traditional Herb 3.Cardiology and Cardiovascular diseases 4.Genetics 5.Immunology 6.Environmental health 7.Toxicology 8. Neurology 9. Pharmacology 10. Oncology 11. Other multidisciplinary studies related medicine. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 597 Documents

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Effect of Phenytoin and Vitamin C on Granulation Tissue Thickness and Total Lymphocyte Infiltration in Enterocutaneous Fistula: In Vivo Study Iwan Vanca Saragih; Trilaksana Nugroho; Ignatius Riwanto
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.587

Background: Enterocutaneous fistula (ECF) is still a problem in the surgical field because it causes high morbidity and mortality. The rate of closure of the ECF without surgical intervention in the evolving era of wound care and with parenteral nutrition has been reported to vary, with most studies showing closure rates in the 20 to 30% range. The administration of phenytoin and vitamin C is expected to be one of the modalities in the non-operative treatment of enterocutaneous fistulas. This study aims to assess the effect of phenytoin and vitamin C on granulation tissue thickness and the amount of lymphocyte infiltration in enterocutaneous fistulas. Methods: This study is an experimental study with a post-test only with a control group design. A total of 24 rats were divided into control groups, P1 (phenytoin+ vitamin c), P2 (phenytoin), and P3 (vitamin c). Histopathological assessment of granulation tissue thickness and lymphocyte infiltration was performed. Data analysis was performed using SPSS with univariate and bivariate methods. Results: The P1 group showed the thickest average thickness of granulation tissue compared to all groups. The P1 group showed a lower number of lymphocyte infiltration cells than all groups. Conclusion: The administration of phenytoin and vitamin C was effective in increasing the thickness of granulation tissue and reducing lymphocyte cells in enterocutaneous fistulas.

Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study Evan Sebastian Gunawan; Muhamad Thohar Arifin; Yuriz Bakhtiar; Yan Wisnu Pradjoko; Muhammad Nur
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.588

Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis. Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests. Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue. Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.

Psychological Stress Induced Recurrent Genital Herpes: A Case Report Jefrizal Wirman; Qaira Anum; Rina Gustia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.589

Background: Herpes simplex virus type 2 (HSV-2) infection can be caused by genital herpes with a high recurrence rate. Recurrent genital herpes affected patients’ quality of life. Precise management is needed to prevent the progression of the disease. Case presentation: This study reported a 34 years old male with recurrent genital herpes. The patient developed painful vesicles in the genital area, which turned into an ulcer. History of genital herpes and gonorrhoea urethritis were reported and had been treated. The patient had a history of having unprotected sexual intercourse with multiple partners and reported having psychological stress within 1 month. DLQI score was 12, and the DASS score was 5-85, which confirmed that the patient had anxiety. Vesicles and erosion were found in the genital area. Tzanck test showed multinucleated giant cells with borderline anti-HSV-2 IgG serologies in 2 occasional evaluations. Acyclovir 3x400 mg for 5 days was used as therapy, and no lesion was found at follow-up. Conclusion: Psychological stress was found to be a risk factor for recurrent genital herpes

The Relationship between CC Ligand 5 Plasma Levels and Modic Changes in Low Back Pain Patients’ Severity Firstisa Nuzulia Krinseani; Syarif Indra; Hendra Permana
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.590

Background: Low back pain (LBP) is one of the global health problems. The most common cause of LBP is disc degeneration. Modic changes (MC) are the most common MRI features in patients with disc degeneration. As a result of cartilage and disc tissue damage, CCL 5 is released and modulates pain responses in the dorsal root ganglion. This study aims to determine the relationship between CCL5 levels and the description of Modic changes on MRI with pain levels in patients with low back pain. Methods: This study is a cross-sectional study. The research subjects were LBP patients who were treated at the Neurology Polyclinic, Dr. M. Djamil General Hospital, Padang, in the range of March 2021-December 2021, who meets the inclusion and exclusion criteria. Subjects will be taken blood to assess CCL5 plasma levels, pain assessment using the McGill Pain Questionnaire, and undergo an MRI examination. Results: A total of 52 subjects consisted of 23 men and 29 women with an age range of 34-77 years. Most of the Modic changes were found in the type 2 group. Based on the pain scale, there were two groups with mild pain and moderate pain. On examination of plasma CCL 5 levels, the median value of plasma CCL5 levels was 303,271 ng/L. There was a significant relationship between plasma CCL5 levels and pain levels in patients with low back pain (p = 0.004). There was no significant relationship between Modic changes and the severity of pain. Conclusion: Plasma CCL5 levels are associated with pain levels in patients with low back pain, while Modic changes are not associated with pain severity.

Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review Novitarini; Jason Merari P.; Dian Marlina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.591

Antibiotic resistance This causes the performance of synthetic antibiotics to decrease, so it is necessary to search for natural antibiotics. Moringa plant (Moringa oleifera Lam.) has antibacterial activity proven to inhibit and kill pathogenic bacteria and Multi-Drug Resistance (MDR)article review aims to collect data related to testing the antibacterial activity of Moringa plants as an effort to overcome antibiotic resistance. The method follows the PRISMA-2020 protocol by searching data on PubMed and ScienceDirect media using the keywords: "Antibacterial activity" and "Moringa oleifera". The data selection uses the Rayyan application by considering the inclusion and exclusion criteria that have been set. The final results obtained are 95 data which are experimental journals of the Randomized Control Trial (RCT) type published in 1981-2021. Moringa plants began to be investigated for their activity against MDR bacteria in 2012 and became a sign that research was already in the direction of finding solutions. Antibacterial testing was carried out in vitro (10 studies) and in vivo (1 study). The leaves have been thoroughly tested for their activity against Methicillin-Resistant Staphylococcus aureus (MRSA). The results of in vitro study obtained the range of zone of inhibition, minimum inhibitory concentration, and minimum kill concentration, respectively: 8.3-12 mm; 0.25-20 mg/ml; 0.50-20 mg/ml study in vivo showed that there was the healing of MRSA infection wounds in test animals.

Effects of Pancreatic Omentoplasty on Diabetes Mellitus with Obesity after Sleeve Gastrectomy: An In Vivo Study Indra Kusuma Adi Putranto; K. Heri Nugroho; Abdul Mughni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.592

Background: DM, especially type 2 diabetes mellitus (DMT2), is closely related to obesity. Insulin resistance and inflammation that occur in obese patients can be treated with SG procedures. Post-SG weight loss can reduce the lipo apoptotic process and can improve the function of pancreas β cells. The omentum is rich in potential mesenchymal stem cells and is rich in anti-inflammatory cytokines, and various growth factors, so the omentoplasty procedure is believed to be able to provide a regenerating effect on the pancreatic tissue so that the performance of the pancreas can be optimal. Methods: An experimental study with 18 rats which were divided into control and treatment groups. The treatments were sleeve gastrectomy and pancreatic omentoplasty. Furthermore, analysis of body weight and levels of IL-10 and HOMA IR was carried out with the help of SPSS software version 25 univariate and bivariate. Results: There was a difference in mean body weight, levels of IL-10, and HOMA IR before and after treatment, p<0.001. Conclusion: Omentoplasty is effective in improving the condition of diabetes mellitus with obesity after sleeve gastrectomy surgery in vivo.

Type 1 Diabetes Mellitus Comorbid with Malnutrition in Siblings Freidlander Pangestu; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.593

Background: Diabetes mellitus is a disorder of the metabolic homeostasis controlled by insulin, resulting in abnormalities of carbohydrate and lipid metabolism. Type 1 diabetes mellitus is one of the most common chronic conditions in children. This study aims to describe two cases of type 1 diabetes mellitus accompanied by malnutrition in children at Dr. M. Djamil General Hospital Padang. Case presentation: The case series describes two cases of diabetes mellitus type one with comorbid undernutrition. Both patients had a family history of diabetes mellitus. And their sibling died because of diabetes type 1. Grandmother and grandfather from the father's side had diabetes. The management of this disease consists of the management of type 1 diabetes mellitus and its complications and accompanying malnutrition. Conclusion: The management of type 1 diabetes mellitus includes the administration of insulin according to the monitoring of blood sugar levels and the management of comorbid diseases that accompany it. Education about the use of insulin and diabetes diet patterns is very important for parents and children with type 1 diabetes mellitus.

The Role of the Managerial Function of Supervisor Model 4S towards Patient Safety Culture at Sawahlunto General Hospital Annedya Handayani; Yulastri Arif; Zifriyanthi Minanda Putri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.594

Background: The culture of patient safety in hospitals is still not well implemented. Maintaining a patient safety culture is the responsibility of every healthcare professional. This study aims to explore the relationship between the supervisory function of the 4S model and the culture of patient safety at Sawahlunto General Hospital. Methods: This study is an observational study. A total of 52 respondents participated in this study. This study uses a questionnaire instrument to assess the role of supervisory and managerial functions in the 4S model with patient safety culture. Data analysis was performed by SEM-PLS. Results: There is a significant relationship between the characteristics of nurses and patient safety culture at Sawahlunto General Hospital. There is a significant relationship between the characteristics of supervisors and interpersonal supervisors with the managerial function of supervisors at Sawahlunto General Hospital. Conclusion: The managerial function of the Model 4S supervisor is related to the patient safety culture at Sawahlunto General Hospital.

Intrahepatic Cholestasis due to Cytomegalovirus Infection and Extrahepatic Cholestasis due to Sludge Bile with Confirmed COVID-19 Yusri Dianne Jurnalis; Erli Meichory Viorika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.595

Background: Human Cytomegalovirus (CMV) is a Beta-Herpes virus that leads to congenital infection in 0.4% to 2,3 % of all newborns. Diagnosis of CMV infection includes the culture of the nasopharynx, saliva, and urine. Serologic tests are also beneficial for CMV diagnosis. IgM CMV-specific antibodies can be monitored. Biliary sludge is a mixture of particulate solids that have precipitated from bile. Laparoscopic cholecystectomy offers the most definitive therapy for biliary sludge. Case presentation: A 2-month-old boy complained yellow appearance since the age of 1 week ago. Looks pale. Defecation was sometimes colored putty since the age of 2 weeks. Blood laboratory examination with hemoglobin 8,7 gr/dL, Prothrombin time, activated partial thromboplastin time, and liver function were increased. Bilirubin, alkaline phosphatase, and Gamma GT were increased. Two-phase and abdominal USG were biliary atresia. PCR CMV examination with urine and blood sample was positive. Head USG was consistent with CMV infection. Cholangiography showed sludge bile with liver cirrhosis. Therapy gansiklovir IV for 14 days then gansiklovir per oral for 6 months. Conclusion: Cholangiography is the definitive diagnosis for biliary sludge. CMV is a congenital infection that causes asymptomatic to multiple severe symptoms, so it is necessary to monitor children for adherence to treatment, improve nutritional status and reduce morbidity and mortality rates.

Expression of Estrogen Receptor and Progesterone Receptor in Meningioma Patients Teguh Iman Prakoso; Muhammad Thohar Arifin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.596

Background: Meningioma is a primary intracranial benign tumor that is affected by the balance of the estrogen and progesterone hormones. This study aimed to assess the relationship between estrogen receptor (ER) expression and progesterone receptor (PR) expression in meningioma conditions. Methods: Analytical observational research with a cross-sectional study design. The number of samples is 25 meningioma patients who performed ER and PR examinations. The research was performed at Dr. Kariadi General Hospital Semarang. Statistical test using Spearman test. Results: Relationship of ER and PR to degree of meningioma is p = 0.181 (r = -0,276) and p = 0,056 (-0,387). Conclusion: There is no correlation between estrogen receptor (ER) and progesterone (PR) receptor to the degree of meningioma

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Rachmat Hidayat

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Rachmat Hidayat

Contact Email dr.rachmat.hidayat@gmail.com

Phone +6281949581088

Journal Mail Official editor.bioscmed@gmail.com

Editorial Address Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location Kota palembang, Sumatera selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Rachmat Hidayat

Contact Email
dr.rachmat.hidayat@gmail.com

Phone
+6281949581088

Journal Mail Official
editor.bioscmed@gmail.com

Editorial Address
Jl. Sirna Raga no 99, 8 Ilir, Ilir Timur 3, Palembang

Location
Kota palembang,

Sumatera selatan

INDONESIA