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Unit Redaksi IJPE, Gedung FOK, Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo. Jln. Jenderal Sudirman No. 06, Kota Tengah, Kota Gorontalo, 96128, Gorontalo, Indonesia. Surat Elektronik : redaksiijpe@ung.ac.id Telf/Fax : 0435-821698 / 0435-821698 Phone (Whatshaap) : +6281547458537
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INDONESIA
Indonesian Journal of Pharmaceutical Education
Published by Universitas Negeri Gorontalo
ISSN : -     EISSN : 27753670     DOI : https://dx.doi.org/10.37311/ijpe
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
ndonesian Journal of Pharmaceutical Education (IJPE) adalah junal resmi yang diterbitkan oleh Jurusan Farmasi Universitas Negeri Gorontalo yang bekerja sama dengan IAI (Ikatan Apoteker Indonesia) Provinsi Gorontalo. Artikel pada jurnal ini dapat diakses dan unduh secara online oleh publik (open access journal). Jurnal ini adalah jurnal peer-review nasional, yang terbit tiga kali dalam setahun tentang topik-topik keunggulan hasil penelitian di bidang pelayanan dan praktek kefarmasian, pengobatan masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait erat. Jurnal ini menerima naskah berbahasa Indonesia dan Inggris. Berikut merupakan area-area yang difokuskan oleh jurnal ini Farmasi Klinis Farmasi Komunitas Farmasetika Kimia Farmasi Farmakognosi Fitokimia Naskah yang terpilih untuk dipublikasikan di Indonesian Journal of Pharmaceutical Education akan dikirim ke reviewer yang pakar dibidangnya, yang tidak berafiliasi dengan lembaga yang sama dengan penulis dan dipilih berdasarkan pertimbangan tim editor. Naskah yang diterima untuk publikasi adalah salinan yang diedit untuk tata bahasa, tanda baca, gaya cetak, dan format. Seluruh proses pengajuan naskah hingga keputusan akhir untuk penerbitan dilakukan secara online.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 111 Documents
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Identifikasi Drug Related Problems (DRPs) Pasien Hipertensi di RS Multazam Kota Gorontalo Teti S. Tuloli; Mahdalena Sy. Pakaya; susi dwi pratiwi
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9945

Abstract

Hypertension is a disease that continues to increase every year, where the keys to success for its treatment are selection and use of the drugs. The treatment failure occurred if the selection and use of medication are inappropriate with the condition of patients followed by DRPs. Unresolved hypertension can cause heart attack, kidney failure and stroke. The research aimed to identify DRPs at hypertension patients with or whitout comorbidity reviewed from the drug without indication, indication without drug, high doses, low doses, and drug interaction. The research was non-experimental descriptive research which applied cross-sectional design by collecting data through a retrospective at hypertension with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods. The samples were selected by purposive sampling and obtained 79 patients who were qualified as samples. The obtained data were analyzed with univariate. The finding of research showed that the use of medication at hypertension patient with or without comorbidity at Multazam Hospital of Gorontalo City for January-Desember 2018 periods based on five categories were drug without indication was 3.08%, indication without drug was 33,84%, high doses was 27,70%, low doses was 4,62% and drug interaction was 30,76%. The identification of DRPs of use of hypertension medication with or without comorbidity at Multazam Hospital of Gorontalo City for January-December 2018 periods was categorized good.
STANDARISASI DAN KADAR FLAVONOID TOTAL EKSTRAK ETIL ASETAT KULIT BATANG NANGKA (Artocapus heterophylus L) Niluh Sri Purnama; Hamsidar Hasan; Mahdalena Sy Pakaya
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September-Desember 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11140

Abstract

Nangka (Artocarpus heterophylla L) adalah tumbuhan yang banyak terdapat di Indonesia. Hampir seluruh bagian pohon nangka dapat dimanfaatkan sebagai obat herbal dimana senyawa flavonoid terprenilasi merupakan metabolit sekunder utama yang terdapat dalam genus Artocarpus. Di Indonesia penggunaan obat herbal masih bersifat tidak terukur baik dari segi takaran, maupun proses penyiapannya. Sehingga perlu dilakukan standarisasi hal ini dilakukan untuk menjaga konsistensi serta keseragaman dari bahan obat herbal. Penelitian ini bertujuan untuk menentukan parameter standarisasi spesifik dan non spesifik serta menentukan kadar flavonoid total ekstrak etil asetat kulit batang nangka. Metode ekstraksi yang digunakan adalah maserasi bertingkat menggunakan pelarut n-heksan, etil asetat dan metanol. Hasil penelitian mengenai parameter organoleptik dari ekstrak etil asetat kulit batang nangka yaitu berwarna merah kehitaman, bau khas, rasa pahit sepat dengan tekstur kental. Simplisia kulit batang nangka memiliki tiga lapisan warna yaitu abu-abu kehijauan dengan bercak putih, lapisan orange dan lapisan coklat muda dengan permukaan tidak rata dan tebal kulit batang kurang lebih 1 cm, serbuk simplisia kulit batang nangka memiliki fragmen kristal oksalat bentuk prisma, serabut, jaringan gabus hablur, dan  parenkim dengan amilum. Ekstrak etil asetat mengandung senyawa flavonoid, dan alkaloid. Dan parameter non spesifik ekstrak etil asetat kulit batang nangka yaitu kadar air 16,97%, susut pengeringan 10,48%, kadar abu 9,78%, kadar abu tidak larut asam 1,58% dan bobot jenis 0,912. Dengan kadar flavonoid ekstrak etil asetat adalah 28,1025 µg/mL.
SKRINING FITOKIMIA DAN UJI DAYA HAMBAT EKTRAK DAUN JAHE MERAH (Zingiber officinale var rubrum) TERHADAP BAKTERI Staphylococcus Epidermidis DAN Escherichia Coli Annisa Humairah Ibrahim; Hamsidar Hasan; Mahdalena Sy. Pakaya
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.10547

Abstract

Infectious disease is one of the diseases caused by microbes, including bacteria. Staphylococcus epidermidis and Escherichia coli are gram-positive and gram-negative bacteria that cause infectious diseases. The selection of medicinal plants as an alternative solution is an effective way of reducing the resistance of bacteria. Based on the empirical data, herbal plants with antimicrobial potential are red ginger (Zingiber officinale var rubrum). This research aimed to determine the inhibition test on Staphylococcus Epidermidis and Escherichia coli due to phytochemical compounds contained in the leaves of red ginger which serve as an antibacterial. Through this experimental laboratory research, a crude drug was extracted using n-hexane, chloroform, ethyl acetate, and methanol solvent. The phytochemical screening results of n-hexane extract showed that red ginger leaves contain alkaloids and terpenoids; chloroform extract contains alkaloids, steroids, and tannins; ethyl acetate extract contains alkaloids, steroids, flavonoids, and tannins; and the methanol extract contains alkaloids, terpenoids, flavonoids, and tannins. Chloramphenicol and Dimethyl sulfoxide (DMSO) were used as the positive control and negative control respectively. Inhibition test results were obtained from the four n-hexane extracts, chloroform extracts, ethyl acetate extracts, and methanol extracts with three different concentrations.The results obtained the greatest inhibition against Staphylococcus Epidermidis bacteria, namely at a concentration of 20% chlorform extract of red ginger leaves as large as 18,90 mm. Meanwhile, the inhibition of Escherichia Coli is at a concentration of 20% n-hexane extract with an inhibitory power of 17,84 mm inhibition zone that is classified as a strong category to inhibit the growth of bacteria .The results of the One Way ANOVA data analysis (p less than 0.01) with a confidence level of 99%.
Tingkat Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Di Puskesmas Tombulilato Kabupaten Bone Bolango Rosmala Amran; Widysusanti Abdulkadir; Madania Madania
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.10123

Abstract

Tuberculosis is an infectious disease caused by the Mycobacterium tuberculosis bacterium. Compliance wiyh long-term medication is the key  to tuberculosis control. It also has become a complex and dynamic phenomenon with various factors that are impactful on the patients’ behavior of taking drugs. This non experimental observation research aims to measure the patients’ compliance level of using anti-tuberculosis drugs in puskesmas (Community Health Center) Tombulilato. Relying on the cross-sectional design, this study collected the data from qualitative approach and employing the purposive sampling technique in selecting 38 respondents suffering from tuberculosis aged 15-75 years. Further, the collected data were processed using the SPSS program and were  analyzed  utilizing the univariate analysis. The results reveal that the respondents in the site area are categorized as “being compliant” in using anti-tuberculosis drugs, with the percentage 86,8%.
BIOSINTESIS NANOPARTIKEL PERAK EKSTRAK ETANOL 96% DAUN KELOR (Moringa oleifera) DAN UJI AKTIVITASNYA SEBAGAI ANTIOKSIDAN Fujiana Abd Karim; Robert Tungadi; Nur Ain Thomas
Indonesian Journal of Pharmaceutical Education Vol 2, No 1 (2022): Januari-April 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i1.11725

Abstract

Moringa leaf potentially has a high antioxidant becouse it contains secondary metabolite, one of which is quercetin. Therefore, to avoid harmful chemicals in the synthesis of silver nanoparticles, it is made by using a bio reductant of Moringa leaf extract. This study aims to know the optimal temperature in the formation of silver nanoparticles, to characterize the nanoparticle, and to rest the antioxidant AgNPs of Moringa leaf by using the DPPH method. This is a laboratory experimental study. The synthesis of nanoparticles uses a concentration of 0,4% Moringa leaf extract, which is reacted to AgNO3 with a concentration of 1 mM in a ratio of 1:9 at various temperatures of 60oC, 70oC, and 80oC for 30 minutes. The formed nanoparticles are characterized by using UV-VIS spectrophotometry and showing the optimum temperature for nanoparticles formation, which is 80oC. It is then continued to characterize using PSA and showing the average size of nanoparticles at a temperature of 80oC, which is 82,9 nm with a PDI value of 0,225. The result of the calculation of IC50 AgNPs shows that Moringa leaf obtains a value of 61.78 ppm, which is included in the strong category, meanwhile the thick extract of Moringa leaf without the addition of silver nanoparticles obtain a value of 124.41 ppm, which is included in the weak category.
Formulasi Sediaan Emulgel Ekstrak Daun Kelor (Moringa oleifera Lam) Dan Uji Aktivitas Antioksidan Menggunakan Metode DPPh Endah Nurrohwinta Djuwarno; Faramita Hiola; Ishak Isa
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9947

Abstract

Moringa (Moringa oleifera Lam) is one of the plants that has high antioxidant activity, especially in the leaves. Emulgel is one of the topical dosage which dermatologically has several beneficial properties, namely thixotropic, not oily, easy to spread, easy to clean, soft, easy to wash, long lasting, transparent and comfortable when used. The purpose of this research was to formulate moringa (Moringa oleifera Lam) leaves extract into emulgel dosage forms and determine the antioxidant activity of the dosage using DPPH method.The research began with extraction of moringa leaves and optimization of the base by varying the concentration of carbopol 940 as gelling consisting of F1 0.5%, F2 1%, F3 1.5% and F4 2%. The base that met the requirements of good physical stability was F2.  The F2 base was then made into emulgel dosage with 3 concentration variations of the extract, namely F2a 4%, F2b 5% and F2c 6%. The physical stability test result of each formula met the organoleptic test,the pH test, the dispersion test, the adhesion test, the viscosity test, and the freeze-thaw test. The One way ANOVA statistical test result showed that the p value was greater than 0.05, which meant that the emulgel dosage had good physical stability. The IC50values of each antioxidant activity result were F2a (t0 = 120.464 g/mL; t28 = 144.887 g/mL), F2b (t0 = 113.642 g/mL; t28 = 128.407g/mL), F2c (t0 = 74.745 g/mL; t28 = 90.618 g/mL). The statistical results of the t-test showed thep value = 0,027, (less than 0.05), This indicated that there were significant difference results of the antioxidant activity test between the three formulas on the first day (t0) and on the 28th day (t28).
ANALISIS EFEKTIVITAS BIAYA TERAPI ANTIHIPERTENSI AMLODIPIN DIBANDINGKAN DENGAN CANDESARTAN PADA PASIEN HIPERTENSI RAWAT JALAN DI RSUD TOTO KABILA Madania, Madania; Tuloli, Teti Sutriyati; bangol, asnia asnia
Indonesian Journal of Pharmaceutical Education Vol 1, No 3 (2021): September 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i3.11368

Abstract

Hipertensi merupakan penyakit tidak menular yang ditandai dengan terjadinya peningkatan tekanan darah sistolik dan diastolik yang lebih dari 140 mmHg dan 90 mmHg. Penelitian farmakoekonomi merupakan proses identifikasi, pengukuran dan perbandingan biaya, akibat dan keuntungan suatu program pelayanan dan terapi, serta menentukan pilihan mana yang memberikan outcomes kesehatan terbaik untuk sumber yang diinvestasikan. Analisis yang digunakan adalah Analisis Efektivitas Biaya untuk menentukan rekomendasi terapi terbaik. Penelitian ini bertujuan untuk mengetahui penggunaan antihipertensi Amlodipin dibandingkan Candesartan, biaya terapi yang dikeluarkan pasien, dan antihipertensi yang paling efektiv biaya. Penelitian ini bersifat deskriptif analitik secara retrospektif, subyek penelitian adalah pasien hipertensi yang menggunakan terapi Amlodipin dan Candesartan sebanyak 46 pasien yang memenuhi kriteria inklusi. Data diolah menggunakan ACER dan ICER. Hasil Penelitian menunjukkan jumlah pasien hipertensi lebih banyak diderita oleh perempuan yaitu 27 orang dengan persentase 58,7%, berdasarkan usia pada kelompok 51-60 tahun pada perempuan yaitu 14 orang dengan persentase 51,9%. Efektivitas pengobatan Amlodipin 86,36%, dan Candesartan 75%. Berdasarkan nilai ACER yang paling cost effective adalah Candesartan dengan nilai ACER sebesar Rp 2.113,58 per % efektivitas.
Analisis Kadar Rhodamin B Pada Blush-On Menggunakan Metode Spektrofotometri Uv-Vis Muhammad Taupik; Moh Adam Mustapa; Sintia Sitti Gonibala
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.10666

Abstract

Cosmetic are mixture of materials that are ready to be used on the outside of the body. One type cosmetics makeup that is often used is Blush-On. This Blush-On cosmetics has a distinictive red color, so it issu red color, so it is suspected that there is still a misuse in the addition of Rhodamine B to Blush—n cosmetics, especially cosmetics that are not registered to BPOM (The Nationalof Drug and Food Control). Based on the PERMENKES RI No. 445/Menkes/Per/V1998 concerning certain dyes declared dangerous it is a synthetic dye Rhodamine B which is one of the dyes that is prohibited for use in-cosmetics products because the fidings of BPOM from 2014 to 2015, Rhodamine B is still used as one of the dyes. This study aims to knowthe misuse of the addition of synthetic dye Rhodamine B to Blush-On cosmetics and to know how much Rhodamine B is contained in the Blush-On cosmetic samples. The results of the qualitative test with the staining method on the Blush-On cosmetics samples A,B,C,D, and E, it is sample E that produces a clear reddish color that has he potential to contain Rhodamine B . Furthemore, it is continued with a quantitative test by using Uv-Vis Spectrofotometry, and it obtains levels of Rhodamine B in sample E is 9,98mquantitative test by using Uv-Vis Spectrofotometry, and it obtains levels of Rhodamine B in sample E is 9,98mg/g.
EFFECT OF VARIATION OF LUBRICANT CONCENTRATION (MAGNESIUM STEARATE) ON THE PHYSICAL QUALITY OF METOCLOPRAMID HCl TABLETS WITH DIRECT PRINTING METHOD Valiandri Puspadina; Deny Budi Legowo; Erna Fitriany; Andri Priyoherianto; Winda Damayanti
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.10567

Abstract

Metoclopramide HCl is used to relieve nausea and vomiting. Market availability in the form of tablets, syrup and injection. The most preferred drug use by patients is oral medication because of its ease of use. Chewable tablets are a new product as an alternative for treatment in pediatric and adult patients who have difficulty swallowing drugs. This study aims to formulate the chewable tablet preparations of metoclopramide HCl using variations in lubricant concentrations. The variations of magnesium stearate with concentrations of 1%, 2%, and 3% using the direct printing method made to obtain a better physical quality test including organoleptics, weight uniformity, uniformity of size, tablet hardness, tablet brittleness, tablet crush time, uniformity of content. The results of the physical quality test were statistically analyzed using one way ANOVA to determine the effect of variations in the concentration of lubricants on the characteristics of chewable tablets. The results showed that variations in the concentration of magnesium stearate lubricant in the manufacture of metoclopramide HCl chewable tablets had an effect on the physical quality of metoclopramide HCl chewable tablets. The concentration of magnesium stearate which produces metoclopramide HCl chewable tablets with good physical properties is 2%.
Hubungan Pengetahuan dan Sikap terhadap Tindakan Pemilihan Obat Untuk Swamedikasi Madania Madania; Mahdalena Sy. Pakaya; Pirdawati Papeo
Indonesian Journal of Pharmaceutical Education Vol 1, No 1 (2021): Januari-April 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i1.9948

Abstract

One of the curative efforts often carried out by the community is self-medication. Self-medication is one of the efforts in treating symptoms of illness or illness that is being suffered by someone without consulting a doctor in advance. Self-medication in its implementation cannot be separated from the use of traditional medicine and modern medicine. This study aimed to measured the correlation between the knowledge and attitude of the people of Tontulow village, North Sulawesi, regarding the tradisional medicine and modern medicine towards their act of selecting the type of medicine for self-medication. This study was an observational study with a cross sectional design. The sampling technique was performed by cluster sampling method. The instrument of  the study was using questionnaire. For normality tes used Klomogrov-Smirnov test while for the correlation test used Pearson test. The number of participants were 83 respondents. Most of the people of Tontulow village have a sufficient level of knowledge regarding the traditional medicine and modern medicine, as many as 67 respondents (80.7%) with their attitude tended to be positive towards both medicine type. There was a correlation between knowledge and attitude regarding the tradisional medicine and modern medicine towards the act of selecting medicine type (the result of Pearson test: significance value less than 0,05)

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