cover
Contact Name
Yayuk Andayani
Contact Email
sjp@unram.ac.id
Phone
+6281936732708
Journal Mail Official
sjp@unram.ac.id
Editorial Address
Jl. Majapahit No. 62 Mataram
Location
Kota mataram,
Nusa tenggara barat
INDONESIA
Sasambo Journal of Pharmacy
Published by Universitas Mataram
ISSN : 27232824     EISSN : 27232832     DOI : -
Core Subject : Health,
Sasambo Journal of Pharmacy (p-ISSN: 2723-2824; e-ISSN: 2723-2832) is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by the Pharmacy Study Program, Mataram University. Sasambo Journal of Pharmacy receives manuscripts in both English and Indonesian Language (Bahasa Indonesia) with abstracts in bilingual, both Indonesian and English. We’re open for various fields such as: Pharmaceutical Technology, Pharmacology and Toxicology, Pharmaceutical Chemistry, Drug Discovery, Pharmacokinetics, Pharmaceutical Biology, Herbal Medicines, Pharmaceutical Microbiology and Biotechnology, Community Pharmacy, Clinical Pharmacy, and Pharmaceutical Education
Articles 26 Documents
Formulasi dan Evaluasi Sifat Fisik Lotion Ekstrak Etanol Daun Kemuning (Murraya paniculata (L) Jack) dan Daun Lidah Buaya (Aloe vera Linn) Subaidah, Windah Anugrah; Juliantoni, Yohanes; Hajrin, Wahida
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.65 KB) | DOI: 10.29303/sjp.v1i1.6

Abstract

The ultraviolet radiation and skin water loss could damage the skin. Kemuning leaves (Murraya paniculata (L) Jack) as a source of anti-oxidants and Aloe vera leaves (Aloe vera Linn) can prevent this action. This study aims to formulate and evaluate lotion containing the Kemuning leaves and Aloe vera extract. The extract of Kemuning leaves was obtained by sonication using 70% ethanol solvent. Aloe vera juice was obtained by smoothing the aloe vera gel then filtered using clean gauze.  The kemuning leaves extract and aloe vera extract had formulated into lotion preparation. The physical properties of the lotion (homogeneity, type of emulsion, pH, spreadability, and adhesion) were determined. The organoleptic test showed that the color of the lotion was pale yellow with a smooth texture and had extract scent. The lotion was showed good homogeneity, spreadability 7.31 cm, pH 7, type oil in water and adhesion 45 seconds. The physical properties parameters of lotion preparations showed that the lotion preparations had fulfilled the requirements of good preparations.
Antibacterial Activities from Gel Hand Sanitizer of Jatropha curcas Leaves Ethanolic Extract Against Staphylococcus aures ATCC 25923 Margaretha, Erviana Vernanda; Juliantoni, Yohanes; Wirasisya, Dyke Gita
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.453 KB) | DOI: 10.29303/sjp.v1i1.8

Abstract

Food borne disease is a disease with symptoms such as nausea, diarrhea and vomiting. The main cause of FBD was food contamination of Staphylococcus aureus. Jarak pagar (Jatropha curcas Linn) leave is a plant that have antibacterial activity against S. aureus because it contains saponin, flavonoid, and tannin. This research aimed to determine the antibacterial activity of the ethanolic extract of Jatropha curcas Linn. leaves, formulated them as gel hand sanitizer, and evaluated the antibacterial activity of the formula. The sample was collected, determined, and extracted with ethanol 70% using maceration, and the phytochemical screening conducted to the concentrate extract. The antibacterial activity test conducted by well diffusion method with concetration 50, 100, dan 150 mg/mL. Then the effective extract group has formulated to gel hand sanitizer. The gel hand sanitizer formula tested the antibacterial activity and physical properties by organoleptic, pH, stability, and spreadablility. The result showed that the extract with concentration 50, 100, dan 150 mg/mL has inhibition zone diameter was 9.9, 15.7, and 16.4 mm, respectively. The gel hand sanitizer of Jatropha curcas Linn extract was formulated by using 100 mg/mL concentration of extract. The gel was physically stable and had inhibition zone diameter was 15.6 mm
Analisis Tingkat Kepuasan Pasien Terhadap Kualitas Pelayanan Di Instalasi Farmasi Rawat Jalan RSUDProvinsi NTBPeriode Maret-April 2019 Harpiani, Suvia; Puspitasari, Candra Eka; Erwinayati, G.A.P Sri; Annisa, Baiq Sofianti
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (211.024 KB) | DOI: 10.29303/sjp.v1i1.9

Abstract

Abstrak: Pelayanan kesehatan dapat dinilai berdasarkan kualitas pelayanan kefarmasian yang baik dan berorientasi langsung kepada pasien. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pasien terhadap kualitas pelayanan kefarmasian di Instalasi Farmasi Rawat Jalan RSUD Provinsi NTB. Metode yang digunakan adalah metode servQual dengan cara membandingkan nilai kinerja dan harapan pasien. Tingkat kepuasan diukur berdasarkan lima dimensi, meliputi reliability (kehandalan), responsiveness (daya tanggap), assurance (jaminan), empathy (empati) dan tangibles (bukti langsung). Analisis data menggunakan rumus kepuasan untuk melihat tingkat kepuasan pasien dan rumus kualitas pelayanan untuk melihat tingkat kualitas pelayanan. Hasil menunjukkan bahwa rata-rata tingkat kepuasan pasien umum dan BPJS sangat puas (lebih besar dari 0,80). Kualitas pelayanan menunjukkan harapan pasien lebih besar daripada kenyataan dengan rata-rata bernilai negative (-).  Selain itu juga dilakukan analisis perbandingan tingkat kepuasan pasien umum dan BPJS dengan hasil tidak ada perbedaan pada tiap dimensi (p lebih besar dari 0,05) kecuali pada dimensi bukti langsung (p lebih kecil dari 0,05). Berdasarkan hasil penelitian dapat disimpulkan bahwa pasien umum dan BPJS sangat puas terhadap pelayanan yang diberikan.
Interaksi Obat Antara Klopidogrel dan Proton Pump Inhibitor (PPI) Dewi, Ni Made Amelia Ratnata
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.948 KB) | DOI: 10.29303/sjp.v1i1.12

Abstract

Abstrak: Pemberian Proton Pump Inhibitor (PPI) dapat menurunkan terjadinya kejadian perdarahan gastrointestinal berulang pada pasien yang mendapatkan dual therapy antiplatelet yaitu klopidogrel dan aspirin. Klopidogrel diaktivasi melalui proses metabolisme oleh enzim CYP2C19 sedangkan obat golongan PPI dimetabolisme dan menghambat enzim CYP2C19. Studi farmakodinamik menunjukkan adanya efek PPI terutama omeprazole terhadap metabolisme klopidogrel yang dapat mengakibatkan penurunan efek dari inhibisi platelet. Beberapa studi klinik mendapatkan bahwa tidak terdapat kejadian yang dapat menyebabkan permasalahan pada jantung (cardiovascular event) jika kedua obat diberikan secara bersamaan. Kemaknaan klinis dari interaksi obat dari klopidogrel dan PPI belum diketahui secara jelas sehingga untuk keamanan direkomendasikan untuk membatasi penggunaan PPI terutama omeprazole. Pilihan lain adalah dengan mengganti PPI dengan H2 blocker ataupun menggunakan golongan PPI yang tidak banyak dimetabolisme oleh enzim CYP2C19 seperti pantoprazole.
Studi In Silico Bioaktivitas Antikanker Senyawa Aktif Dalam Minyak Biji Buah Wali [Brucea javanica (L.) Merr] Ananto, Agus Dwi; Muliasari, Handa; Hamdin, Candra Dwipayana
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.127 KB) | DOI: 10.29303/sjp.v1i2.13

Abstract

Insilico study of anticancer bioactivity in oil of “buah wali” [Brucea javanica (L.) Merr] has been successfully carried out. “Buah Wali” (Brucea javanica (L.) Merr) is known to treat various diseases such as diabetes, diarrhea, and malaria. In addition, “buah wali” seeds are supported to have antidiabetic, antioxidant, and anticancer activities. The stages of the study began by taking a sample of “buah wali”seeds, then extracted to get oil of “buah wali”. While GC-MS analysis resulted Octadec-9-enoic acid (56.25%), palmitic acid (13.82%), stearic acid (10.57%), and acids -9-octadecanoate (5.91%) were found as the major components of the seed oil. Based on these compounds, docking molecular was carried out to find anticancer bioactivity. The results obtained are compounds that have lower binding energy than the native ligands [Octadec-9-enoic acid (-72.4518), hexadecanoic acid (-70.2136), octadecanoic (-72.2362).
Formulasi Sediaan Gel Sari Buah Duwet (Syzygium cumini) dengan Basis Karbopol 940 Sebagai Gelling Agent Juliantoni, Yohanes; Hajrin, Wahida; Subaidah, Windah Anugrah
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (185.863 KB) | DOI: 10.29303/sjp.v1i2.14

Abstract

Duwet fruit (Syzygium cumini) is a local Indonesian fruit that has many benefits. Duwet juice contains antioxidants that have DPPH free radical activity. But the use of duwet fruit is not practical for modern society. This research was conducted to formulate duwet juice into a gel-based carbopol 940 with the physical quality test of the gel. Duwet fruit extraction was tested for phytochemical screening qualitatively. The gel is made in 5 formulas namely I (100% aquadest: 0% ethanol 70%); II (75% aquadest: 25% ethanol 70%); III (50% aquadest: 50% ethanol 70%); IV (25% aquadest: 75% ethanol 70%); and V (0% aquadest: 100% ethanol 70%). The results showed that Duwet juice contained of flavonoid, polyphenols, and anthocyanins based on phytochemical screening tests. The formula of gel I, II, and III has fulfilled the pH requirements of 4.5-6.5, homogeneity, and spread capacity of 5-7 cm. Increasing the concentration of 70% ethanol in the gel formula will increase the pH value and spread capacity.
Pola Penggunaan Obat Antihipertensi Pada Pasten Geriatri Rawat Jalan di Rumah Sakit TK. II Pelamonia Makassar Pada Bulan Januari-Maret talun 2019 Fajar, Desi Reski; Fardin, Fardin; Dyka, Nur Fadliyah
Sasambo Journal of Pharmacy Vol. 1 No. 1 (2020): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.243 KB) | DOI: 10.29303/sjp.v1i1.20

Abstract

Hypertension in the elderly can increase the workload of the heart and arteries which, if continued, can cause damage to the heart and blood vessels. So that requires routine medication adherence to reduce blood pressure. While the elderly with hypertension must take medication regularly because adherence and a good understanding in carrying out therapy can affect blood pressure and prevent complications. This study aims to determine the pattern of the use of hypertension drugs in outpatient geriatric patients in kindergarten hospitals. II Pelamonia Makassar in January-March 2019. This type of research is a non-experimental quantitative study using descriptive design. Descriptive research that aims to make a systematic, factual, and accurate description of the facts and the nature of a particular population or area. This study obtained 23 medical records of geriatric patients who met the inclusion criteria. The inclusion criteria in this study were geriatric patients diagnosed with hypertension with age usia 60 years and receiving hypertension treatment. The results showed that the most commonly used classes of hypertension were amlodipine by 23%, single candesartan by 17%, and micardis by a single 13%, and the most used drug combination therapy was a combination of amlodipine and candesartan by 17%, amlodipine and valsartan by 13%), while candesartan and bisoprolol by 17%.
Formulasi Sediaan Gel Basis HPMC Ekstrak Etanol Daun Jarak Cina (Jatropha multifida) Sebagai Penembuhan Luka Sayat pada Tikus Putih (Rattus norvegicus) Farid, Nurfiddin; Kalsum, Ummu; Yustisi, Juaella; Wahyuli, Resky
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.369 KB) | DOI: 10.29303/sjp.v1i2.25

Abstract

Saat ini banyak penelitian yang mengembangkan tanaman berkhasiat untuk pengobatan tradisional. Salah satu tanaman yang dapat digunakan sebagai obat tradisional adalah tanaman Jarak cina (Jatropha multifida L). Berdasarkan pengalaman empiris secara turun temurun banyak digunakan oleh masyarakat khususnya Jeneponto, Desa Bulusibatang untuk menyembuhkan luka baru. Di Desa Bulusibatang lebih dikenal dengan tanaman ampicillin (Daun Jarak cina). Pemanfaatan tanaman obat masih perlu terus digali dan dikembangkan berdasarkan penelitian dan pengkajian secara mendalam seiring dengan kemajuan teknologi. Oleh karena itu, peneliti ingin melanjutkan penelitian dengan membuat sediaan farmasi untuk mempermudah penggunaannya secara topikal yaitu sediaan Gel ekstrak etanol Daun Jarak cina (Jatropha multifida L) untuk mengobati luka sayat pada tikus putih (Rattus novergecus). Penelitian ini merupakan penelitian Eksperimental Laboratorium yaitu Uji Efektivitas sediaan Gel ekstrak daun Jarak cina (Jatropha  multifida L) terhadap penyembuhan luka sayat pada Tikus putih (Rattus norvegicus). Data hasil pengamatan dianalisis dengan menggunakan metode analisis statistic yaitu analysis of variance (ANOVA) untuk mengetahui rata-rata kelompok perlakuan dan kelompok kontrol. Berdasarkan hasil penelitian, kontrol positif Bioplacenton lebih efektif dibandingkan kontrol negatif. Dan konsentrasi sediaan gel Ekstrak daun Jarak cina (Jatropha multifida) pada konsetrasi 15% yg paling efektif dalam penyembuhan luka sayat dibandingkan dengan konsetrasi 5% dan 10%.
Pola peresepan antibiotik pada pasien infeksi saluran kemih di instalasi rawat jalan RSUD Provinsi NTB tahun 2017 Herlina, Dwi; Hasina, Raisya; Dewi, Ni Made Amelia Ratnata
Sasambo Journal of Pharmacy Vol. 2 No. 1 (2021): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.408 KB) | DOI: 10.29303/sjp.v2i1.26

Abstract

Urinary tract infection (UTI) is an infection due to the proliferation of microorganisms in the urinary tract. UTI is usually occur in the community at various ages. In 2014, Indonesian Ministry of Health showed that the number of people with UTIs reached 90-100 cases per 100,000 population per year. Antibiotics are the main therapy used in treating urinary tract infections. The purpose of this study was to determine the pattern of antibiotic prescribing in UTI patients and determine the suitability of therapy with guidelines for UTI at the Installation of NTB Provincial Hospital in 2017. The design of this study was descriptive by collecting data retrospectively. The study was conducted on 105 UTI patients at the Installation Hospital of NTB Province in 2017, then the data obtained from the medical record and prescription sections were processed using Microsoft Excel software. The results showed that therapy for UTI patients was antibiotics with the most use of ciprofloxacin (45.71%), then cefixime (40%), urinter (pipemidic acid) (11.43%), levofloxacin (1.90%), cefadroxil (0.95 %). Based on these results, the suitability of prescription was seen from the type of drug and the dosage in the main therapy (antibiotics) was 100% according to the treatment guidelines, but the frequency and duration of administration only reached 99.05% and 88.6%.
Pola Pengobatan Insulin dan Ace - Inhibitor pada Pasien Diabetes Melitus Tipe 2 dengan Hipertensi Terhadap Kontrol Glikemik dan Tekanan Darah astari, chitra
Sasambo Journal of Pharmacy Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (217.287 KB) | DOI: 10.29303/sjp.v1i2.32

Abstract

This research aimed to analyze the insulin and ACE Inhibitor therapy to patients with DM type 2 with hypertension, and giving a picture about the influence on the blood sugar control and blood pressure using the parameter of  fasting blood glucose, HbA1C, and blood pressure. The research was conducted in the  endocrine clinic  of DR. Wahidin Sudirohusodo General Hospital, Makassar,  from 2 May through 12 July, 2016. The research was a Cross-Sectional study with the samples chosen using the evhaustive sampling technique. The types of insulin and antihypertension class ACE inhibitor as revealed by the interviews with the patients. The therapy effects of pre and post interventions were analyzed using the parameter of glycemia, and HbA1C using  the pair sample T-test and blood pressure using Wilcoxon test. The research results indicated that the level of blood sugar after fasting was reduced to 64.08 and the level of HbA1C was reduced to 1.51 with the value of P = 0.000. The parameter of systolic and diastolic blood pressures had equal degradation of 12.56 and 12.32 respectively with value of P = 0.000, meaning P<0.05 in statistics.

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