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Asian Journal of Health Research
Published by Ikatan Dokter Indonesia Wilayah Jawa Timur
ISSN : 28292979     EISSN : 28289269     DOI : https://doi.org/10.55561/ajhr
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Asian Journal of Health Research (AJHR) is an open access journal published by Ikatan Dokter Indonesia Wilayah Jawa Timur and launched in 2022. This journal is peer reviewed publishing to communicate high quality research, general articles, and all fundamental research/ clinical studies relevant to health science. The journal publishes articles Medical Sciences scope including (Obstetrics and Gynaecology, Pediatrics, Internal medicine, Ophthalmology, Surgery, Neurology, Otolaryngology, Cardiology and Vascular Medicine, Anaesthesiology and Reanimation, Dermatovenerology, Orthopaedics and Traumatology, Urology, neurosurgery, Cardiothoracic surgery, Orthopaedics and Traumatology, Plastic Reconstructive Surgery and Aesthetics, Pulmonology and Respiratory Medicine, Forensic Medicine, and Medicolegal, Psychiatry Medicine and Rehabilitation). AJHR journal is published three times per year in April, August, and December.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 67 Documents
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Effect of Administration of Red Fruit (Pandanus conoideus L.) Extract in TNF-α, Microvessels Density Expression and Endometriosis Implant Area in Endometriosis Mice Model Sutrisno Sutrisno; Hendra Brahmantyo Ratsamanda; I Wayan Arsana Wiryasa; Steven Christian Susianto; Burhan Mahendra Kusuma
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (969.757 KB) | DOI: 10.55561/ajhr.v1i2.3

Abstract

Introduction: The prevalence of endometriosis in women of reproductive age was still high. A previous study showed that the red fruit (Pandanus conoideus L.) extract consisted of alpha-tocopherol and beta carotene as antioxidants that could potentially be an alternative treatment in endometriosis. This study aimed to determine the effect of Red Fruit Extract Administration on the expression of TNF-α, microvessels density (MVD), and the area of endometriosis implant in endometriosis mice model. Methods: This was an experimental study with a randomized post-test control group design only applied to the endometriosis mice model and conducted in the Veterinary Faculty of Medicine Airlangga University, Surabaya. Twenty-eight endometriosis model mice were randomly divided into two groups. The control group (K) received CMC Na 5% for 14 days, and the treatment group (P) was given Red Fruit extract of 0,05 ml/day for 14 days. After day 28, mice were sacrificed, and immunohistochemical analysis was performed for TNF-α, microvessel density (MVD), and measured for endometriosis implant area. A T-test was used to analyze the comparison between groups. Results: Mean TNF-α, microvessel density, area of endometriosis implant in treatment group were 1,56±0,87, 1,26±0,48, 13,24±4,08, respectively. There was a statistically significant difference in TNF-α expression, MVD development, and area of endometriosis implant between the treatment and control groups (p<0.05). Conclusion: There was decreased expression of TNF-α, development of microvessel density, and area of endometriosis implant in endometriosis mice model given red fruit extract and proved to have potential effect as endometriosis therapy.
Risk Factor of Mortality Among Covid-19 Infected Doctor in East Java, Indonesia Sutrisno Sutrisno; Achmad Chusnu Romdhoni; steven christian susianto; Muhammad Shoifi; Mohammad Hud Suhargono; Muhammad Yusuf; Siti Nur Faidah; Bambang Pudjo Semedi; Rahardian Indarto Susilo; Aries Budianto; Andy Darma; Kamal Musthofa; Rachmat Agung Widodo; Burhan Mahendra Kusuma; Fahrizal Rizky Muharram; Arya Satya Rajanagara; Muhammad Tidar Abiyu; Dimas Setyanto
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.74 KB) | DOI: 10.55561/ajhr.v1i1.4

Abstract

Introduction: The report of doctors who died with COVID-19 in Indonesia was high and influenced by several factors. This study examined COVID-19 infected doctors and mortality risk factors in East Java. Material and Methods: This observational cohort study was conducted among doctors infected with COVID-19 in East Java during March 2020-September 2021 and collected the COVID-19 infected doctors’ deaths report. Doctors received a questionnaire on the status of COVID-19, history of covid-19 infection, age, sex, type of doctor, type of specialization and resident, pregnancy, underlying disease and nutritional status. All data were described and potential risk factors’ association was analyzed. Results: We reported 2041 doctors infected with COVID-19. Majority of them (52,5%) was male, 162 doctors were more than 59 years old, 162 doctors (7,9%) were died and 41,4% was general practitioner. The odds ratio in each risk factor for mortality was older age doctors 15,468 (95% CI 10,587-22,601), male 6,128 (95% CI 3,906-9,614), general practitioner 2,461 (95% CI 1,769-3,423), doctors with underlying disease 39,842 (95% CI 23,077-68,798), Type II diabetes mellitus 82,504 (95% CI 42,767-159,162), cardiovascular disease 50,152 (95% CI 16,672-150,866), hypertension 19,425 (95% CI 10,528-35,840), Chronic Obstructive Pulmonary Disease 5,52 (95% CI 0,610-49,992), Asthma 2,091 (95% CI 0,626-6,986), Obesity 30.750 (95% CI 15,293-61,828) and Pregnant doctors 43.013 (95% CI 10.986-168.414) (p<0,05). Conclusion: Older age, male, general practitioner, doctors with underlying disease, cardiovascular disease, Type II diabetes mellitus, hypertension, chronic obstructive pulmonary disease, asthma, obesity, pregnant doctors had been mortality risk factors among COVID-19 infected doctors.
The Genistein Daidzein in Kudzu Root (Pueraria lobata) Extract Decreased Malondialdehyde Plasma Levels in Hypoestrogenic Rats Nany Nita Noviana; Nina Rini Suprobo; I Wayan Arsana Wiyasa
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.269 KB) | DOI: 10.55561/ajhr.v1i1.6

Abstract

Introduction: Menopause can reduce women's quality of life and cause health issues. The decline in estrogen during menopause is thought to trigger oxidative stress. When the creation of antioxidants does not match the synthesis of reactive oxygen species (ROS) as an antidote, oxidative stress ensues, characterized by malondialdehyde. The aim of the research is to evaluate the effect of the dose of isoflavone genistein daidzein powder in Kudzu root (Pueraria lobata) extract on the decrease in plasma malondialdehyde (MDA) plasma levels in hypoestrogenic rats. Methods: 30 rats Wistar rats were separated into five groups, namely: the control group, the ovariectomy (OVX) group, waited two weeks to produce hypoestrogenic rats. Of the four groups, the positive group was not given a Pueraria lobata powder containing the isoflavones genistein and daidzein (IGD), and the other group was given 15 mg, 30 mg, 60 mg per kg body weight per day, respectively. Twenty-one days later, the mice were killed, and plasma was taken to be checked for MDA levels using spectrophotometry. Results: Genistein Daidzein in kudzu root extract was effective in reducing the oxidative stress. All IGD doses significantly reduced plasma MDA levels. At a dose of 60mg/kg BW, the plasma MDA levels were comparable to those in the control group, it could prevent a significant increase in plasma MDA levels in hypoestrogenic rats. Conclusion: Isoflavone Genistein and Daidzein of kudzu root (Pueraria lobata) extract reduced MDA plasma levels in hypoestrogenic rats.
Local Non Soy Isoflavone Attenuates Bone Loss In The Menopausal Women I Wayang Agung Indrawan; I Wayan Arsana Wiyasa; Achmad Hidayat; Qonita Prasta Agustia
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (915.952 KB) | DOI: 10.55561/ajhr.v1i2.8

Abstract

Background: Identification and isolation of local non-soy isoflavone based on cow pea (Vigna unguiculata) by The Indonesian Menopause Society (PERMI) in Malang District, Indonesia No published studies have directly examined the effect of that non-soy isoflavone on bone mineral density in menopausal women. Objective: To determine the effect of 24 weeks' consumption of non-soy isoflavone (67,5 mg) to reduce osteoporotic bone loss in menopausal women. Design and Methods: Menopausal subjects were randomly assigned, double-blind to treatment: non-soy isoflavone (n-30), or placebo (n-30). At baseline and posttreatment, bone mineral density (BMD) was measured by using quantitative ultrasonography. Collected data were analyzed by Analysis of Covariance (ANCOVA). Results: There were no differences in BMD changes between the treatment and placebo group for 24 weeks intervention. The mean of BMD changes in treatment group were 0,952 (p-value 0,006, SE-0,221) from baseline, and the placebo group had mean at -0,768 (p-value -0,006, SE-0,212). Despite this, coffee as the concomitant variable had a significant effect on BMD changes (p value=0,43) at 3rd-month evaluation, but not in 6 months. Participant compliance is good. Conclusion: Non-soy Isoflavone attenuates bone loss in menopausal women. Keywords: non-soy, phytoestrogen, osteoporosis, postmenopausal women
Effect of Isoflavon Genestein Daidzein from Pueraria Lobata Extract on Vascular Endothelial Growth Factor Expression in The Aorta of Hypoestrogenic Rat Akhmad Suaidi; Achmad Hidayat; Wening Hapsari
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (833.36 KB) | DOI: 10.55561/ajhr.v1i2.9

Abstract

Introduction: Currently, there is no research about the effect of isoflavone-based phytoestrogens on the expression of VEGF in arteries which play a role in preventing vascular diseases in menopause women (hypoestrogenic state). We want to know the effect of Isoflavone Genistein Daidzein in Pueraria lobata extract on VEGF expression in the arterial endothelium of hypoestrogenic rats. Methods: This is an analytical, experimental study with a post-test-only control group design. Subjects were Wistar strain rats (Rattus novergicus) randomized into five groups of different treatments by simple random sampling. The aorta was then examined for VEGF expression. Statistical analysis used were ANOVA, followed by multiple comparison tests by the Tukey Honestly Significant Difference and regression test with SPSS series 11.0. The analysis is significant if p < 0.05. Results: Isoflavone Genistein Daidzein (IGD) in Pueraria lobata extract will increase the expression of hypoestrogenic rat endothelial VEGF. IGD dose of 15 mg/kg BW/day resulted in VEGF expression with an average of 6.67 ± 2.94,30 mg/kg BW/day with an average of 9.83 ± 2.71, and 60 mg/kg BW/day with an average of 9.83 ± 2.71 (p<0.05). Conclusion: VEGF in arteries of hypoestrogenic rats without IGD supplementation was not significantly different from VEGF in the average rats. There was a significant positive effect on VEGF expression in hypoestrogenic rat arteries due to the administration of IGD in Pueraria lobata extract.
The Effect of Isoflavone in Cowpea (Vigna unguiculata) Powder Supplement on Post-Menopausal Vaginal Maturation Index at Malang, Indonesia Tatik Sujiati; Budi Siswanto; A Hidayat; Ayu Rizky Widowati
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (779.983 KB) | DOI: 10.55561/ajhr.v1i1.10

Abstract

Background: Only a few published studies have directly demonstrated the effects of local soy isoflavone on the post-menopausal vaginal maturation index. This study focused on the effect of 24 weeks of local soy isoflavone (67,5 mg) consumption to improve the post-menopausal vaginal maturation index. Material and Methods: 50 post-menopausal women were randomly assigned to a double-blind clinical trial to receive cowpea (Vigna unguiculata) powder treatment (n=25) and placebo (n=23). Vaginal cytology (maturation index, maturation value) was evaluated at pre and post-treatment in Anatomy Pathology Laboratories. Collected data were analyzed by using the analysis of covariant (ANOVA) method. Result: There is no difference in maturation vaginal index between the treatment and the placebo group. The treatment was not significantly improved the vaginal maturation index (p<0,05). The concomitant variable, age, post-menopausal interval, BMI, marital status, and initial cell condition have no significant effect on the maturation vagina index. Conclusion: Cowpea powder supplement with 67,5 mg isoflavone cannot improve the vaginal maturation index on post-menopausal patients.
Early Breastfeeding Initiation Effect in Stunting: A Systematic Review Steven Christian Susianto; Nina Rini Suprobo; Maharani Maharani
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (816.006 KB) | DOI: 10.55561/ajhr.v1i1.11

Abstract

Introduction: Stunting has been a global burden worldwide, resulting in severe outcomes, including inadequate brain development until mortality. Early breastfeeding initiation as a global strategy affects the success of continuous breastfeeding that influences the children’s growth and development. This study aimed to provide a literature review on how early breastfeeding initiation might help children avoid stunting. Methods: We searched articles published from 2017 to 2022 in PubMed, Science Direct, Cochrane, and the Indonesia Database with keywords “Early breastfeeding initiation” OR “Early breastfeeding” OR” Early Initiation Breastfeeding” AND “stunting.” All data were gathered and analyzed. Results: A total of 12 articles from 6690 articles met the inclusion, exclusion, and eligibility criteria. The mean of early breastfeeding initiation was 61,82%, with the lowest study in Chimborazo and Tungurahua, Ecuador, and stunting was 33,07% as the highest prevalence was in Chimborazo and Tungurahua, Ecuador, while the lowest in Saharawi refugee camps, Algeria. The mean prevalence of children who did not get early breastfeeding initiation and stunting occurred at 40,85%, and eight studies reported that early breastfeeding initiation was associated with stunting. Conclusion: Early breastfeeding initiation can lower stunting risk in children. Early breastfeeding initiation ensures children obtain enough colostrum that enhances the children’s immunity and probability of exclusive breastfeeding, ensuring children obtain adequate nutritional intake and prevent stunting.
Black-Eyed Pea Diet Alleviates High-Density Lipoprotein Cholesterol In Menopausal Women; Randomized Clinical Trial Study Handi Wiradharma; Pande Made Dwijasa; Maharani Maharani
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (998.583 KB) | DOI: 10.55561/ajhr.v1i1.12

Abstract

Introduction: Menopause is defined as the last menstruation cycle in women. Estrogen concentration in menopausal women was decreased and altered the lipid metabolism profiles. Menopausal women reportedly have a high risk of cardiovascular disease, arthritis, diabetes mellitus, and stroke. This study focused on the effect of the black-eyed pea diet on the lipid profiles in menopausal women. Material and Methods: A randomized clinical study was performed to analyzedd the effect of the black-eyed pea diet on lipid profiles. Fifty-four menopausal women were selected as respondents and classified into two groups, black-eyed pea diet and placebo. Black-eyed pea diet treatment was performed by consuming black-eyed powder containing 67.5 mg of isoflavones and were monitored in week – 0 and week – 12 after treatment. Lipid profile of black-eyed pea diet and placebo in 12 weeks monitoring showed no significant value. After 12 weeks of treatment, total cholesterol and triglyceride were higher than before treatment. Results: Interestingly, the black-eyed pea diet increased the HDL and lowered the LDL after 12 weeks of treatment. Conclusion: This study concluded that black-eyed pea improved lipid profile, especially in elevating HDL level and decreasing LDL level in 12 weeks consumption.
Case Report: Massive Hematocel with An Intrauterine Pregnancy Qonita Prasta Agustia; Halida Nelasari; Sutrisno
Asian Journal of Health Research Vol. 1 No. 1 (2022): Volume 1 No 1 (April) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (769.27 KB) | DOI: 10.55561/ajhr.v1i1.15

Abstract

Introduction: Incidence of ectopic pregnancy can be an acute or chronic condition. The condition of chronic ectopic pregnancy itself is unique, arises from a minor rupture, and then develops into a hematocele. Chronic ectopic pregnancy is quite complicated to diagnose because it usually has a prolonged clinical course and can disappear spontaneously. Case Presentation: A woman aged 31-32 weeks, aged 24 years, complained of right abdominal pain accompanied by nausea and vomiting. Examination of vital signs was 120/80 mmHg, pulse 84 x/min, RR 20x/min, temperature 36.70C, and SpO2 of 98% with pale conjunctiva and abdominal tenderness in the right upper quadrant. On laboratory examination, the patient found severe microcytic normochromic anemia (Hb 4.5 mg/dl; MCV 96.6 Fl; MCH 30.2 pg), thrombocytopenia (platelets 133,000 L) and hypoalbumin (albumin 2.82 L). Ultrasound examination showed a mass in the right adnexa accompanied by intrauterine pregnancy. The patient underwent a laparotomy and found a mass in the form of a blood clot (hematocele) of 30x20x20 cm. Conclusion: Chronic ectopic pregnancy is a rare condition, especially in developed countries. A clinician should be more detailed in diagnosing and considering the ultrasound, an amorphous mass with avascularity to amass with complex vascular formation. This is very necessary considering that this hematocele mass can develop progressively to cause fetal growth disorders.
Case Report: Secondary Amenorrhea with Hyperprolactinemia due to Pituitary Macroadenoma Annissa Febriani; Donny Wisnu Wardhana; Nugrahanti Prasetyorini; Pande Made Dwijayasa
Asian Journal of Health Research Vol. 1 No. 2 (2022): Volume 1 No 2 (August) 2022
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (731.489 KB) | DOI: 10.55561/ajhr.v1i2.19

Abstract

Introduction: Secondary amenorrhea has a broad etiology, so each case must be studied in depth. One of the causes of secondary amenorrhea is a state of hyperprolactinemia caused by a mass in the anterior pituitary. Pituitary macroadenoma patients may be asymptomatic or have a hormone imbalance or mass impact symptoms. Tumors in asymptomatic patients might be identified during a routine head imaging examination for unrelated medical issues. Case Presentation: A 24-year-old unmarried woman with complaints of headache, blurred vision, and worsening for one year ago. The patient complained of not having menstruation in the past five years ago, with a history of previous normal menstruation. On physical examination, found breast and pubic Tanner stage 5. On laboratory examination, it was found FSH (2.21), Oestradiol (20.23), and Prolactin (1365.47). On an MRI of the head examination on April 14, 2021, a solid intrasellar mass of suspected pituitary macroadenoma was found with a size of ± 1.3 cm x 1.4 cm x 1.6 cm. Conclusion: Secondary amenorrhea caused by hyperprolactinemia due to pituitary macroadenoma is a rare case (40%). First-line therapy for prolactinomas is dopamine agonist administration because most pituitary macroadenomas respond to dopamine agonists.

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