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Sciences of Pharmacy
Published by ETFLIN
ISSN : 28307046     EISSN : 28307259     DOI : -
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health
Sciences of Pharmacy (SciPhar) is an international, peer-reviewed open-access journal of pharmacy. We offer a platform and place for researchers and intellectuals, especially the youth, to share their insights and works. Every year, we hold seminars/webinars under the ETFLIN Scientific Society to facilitate the exchange of information concerning pharmacist research progress. Publication on SciPhar is free of charge at any stage. Scope We are accepting articles related to drug development (preclinical and clinical drug development, drug delivery, and pharmaceutical formulation). Fundamental and clinical pharmacology (drug mechanisms, pharmacokinetics, pharmacodynamics, drug metabolism, and pharmacogenetics). Pharmaceuticals (gene-based, cell-based, protein-based therapy, other drug modalities, routes of administration, drug classes, drug nomenclature). Drug toxicity and safety (drug-drug interactions, adverse drug reactions, mechanisms of drug toxicity, pharmacovigilance). Pharmacoepidemiology, pharmacoeconomics, and pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 40 Documents
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Hypertriglyceridemia Induced Acute Pancreatitis: A Learn from New Cases
Sciences of Pharmacy Volume 2
Publisher : PT. ETFLIN Scientific Society

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Abstract

An increased risk of morbidity and mortality is associated with acute pancreatitis (AP) brought on by hypertriglyceridemia (HTG). It is essential to locate the root cause as soon as possible and give those affected the attention they need. The treatment plan includes efforts to lower blood triglyceride levels and supportive care. HTG-induced AP has a similar clinical course to people with other types of acute pancreatitis. However, HTG-induced AP patients have significantly higher clinical severity and associated consequences. As a result, therapy and preventing sickness recurrence depend on a correct diagnosis. At the moment, there are no acknowledged standards for the treatment of HTG-induced AP. Some therapy approaches that effectively decrease serum triglycerides include fibric acids, apheresis/plasmapheresis, insulin, heparin, and omega-3 fatty acids. Following acute phase care, lifestyle modifications, including dietary and drug therapy, are essential for long-term HTG-induced AP control and relapse prevention. To create complete and efficient HTG-induced AP treatment guidelines, more study is required.
A beginner’s guide to molecular docking
Sciences of Phytochemistry Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

In this opinion, the basics of molecular docking (MD) such as binding affinity, binding pose, and ligand interactions with common docking-related terminologies (Apo protein, positive control, native ligand, co-crystal inhibitors) are discussed. We have provided different figures to aid in the graphical interpretation of the discussed literature. Following this, a few advantages (simplicity, fast, applicability) and disadvantages of MD are highlighted. This opinion will benefit bachelor and master students (or anyone) that are interested in learning the technique of MD. We encourage the sensible use of the MD technique and strict analysis to avoid interpretation errors in the results. The binding affinity, binding pose, and ligand interactions should be collectively considered during the result analysis. For every study, we strongly recommend a strict validation of the docking protocols.
NanoPhytoformulations: what is so interesting about the nanoscale ?
Sciences of Phytochemistry Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Nanotechnology is on the threshold of providing a host of new materials and approaches in revolutionizing the medical and pharmaceutical fields. The incorporation of nanotechnology in herbal formulation investigation has a huge number of benefits for phytomedicine such as enhancement of solubility and bioavailability, reinforcement of pharmacological activity, improvement of stability, protection from toxicity, sustained delivery, and safeguarding from physical or chemical degradation. This opinion paper briefly highlights the authors perspective on herbal nanotechnology through few key points.
Bambusa vulgaris: A comprehensive review of its traditional uses, phytochemicals and pharmacological activities
Sciences of Phytochemistry Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

A versatile plant with many purposes, Bambusa vulgaris is primarily known for its industrial applications, but it is also becoming acknowledged as a possible source of bioactive substances and as a functional food. Every component of the bamboo plant, including the rhizome, culm shavings, leaves, roots, shoots, and seeds, has potential medical uses. This review aims to provide an insight into the traditional uses, and the various pharmacological activities exhibited by B. vulgaris extracts like analgesic, antihyperglycemic, antipyretic, anti-inflammatory, antioxidant, antimicrobial, antiviral, hepatoprotective, anti-amnesic, etc. It also has immense potential to be used as an important functional food as it has a high content of useful proteins, carbohydrates, high fiber content, and very low fat.
An updated review of Rubus ellipticus (an edible shrub), its bioactive constituents and functional properties
Sciences of Phytochemistry Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

The vast majority of people continue to view medicinal plants as a low-cost source of medications and treatments. Numerous trees, herbs, plants, and shrubs have been used as remedies for various ailments since the dawn of time. Rubus ellipticus Smith, a weedy wild raspberry that flourishes in damp woods at high elevations, particularly those in the Himalayas and the Nilgiris area, is one of the important ethnomedicinal plants in the genus Rubus. Traditional Tibetan medicine places a great deal of importance on the plant R. ellipticus. Because of the abundance and diversity of phenolics and flavonoids in fruits or berries, which have a high concentration of both, they are generally regarded as inherently healthful foods. The roots and leaves, as well as the fruit, have traditionally been used as therapeutic agents for several illnesses including colic pain, gastrointestinal discomfort, wound healing, diarrhea, antifertility, antibacterial, analgesic, epilepsy, and others. The objective of the current review is to concentrate on the pharmacological characteristics, nutrition profile, phytoconstituents, and folkloric therapeutic applications of R. ellipticus, therefore achieving the review's overall subject.
Antibiotic Use in Diabetes Mellitus Patients with Gangrene at Abdoel Wahab Sjahranie Samarinda Hospital
Sciences of Pharmacy Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Gangrene is one of the complications of diabetes mellitus. Along with the rising prevalence of diabetes mellitus (DM), the prevalence of gangrene and necrosis manifestations such as ulcers and infections will ascend. The selection of appropriate antibiotics is critical in infection therapy. Inappropriate use of antibiotics will result in antibiotic resistance. Therefore, this research aims to overview demographic, clinical characteristics, antibiotic use profiles, and antibiotic-related problems for DM patients with gangrene at the Abdoel Wahab Sjahranie Samarinda Hospital. The study was retrospective research and was conducted in July-December 2021. Twenty-one patients met the inclusion criteria, and demographic data showed that most patients were men 57% (n=11), and most age was 39-59 years (57%, n=12). The longest period of suffering from gangrene was 6-10 years (14%, n=3). The most common length of hospitalization was 8-14 days, as reported by 52 percent (n=11) of patients, and the most common duration of antibiotic use was ten days, as reported by 86 percent (n=18) of patients. A single-used antibiotic was ceftriaxone (19%, n=4) patients. The most used antibiotic combination was ceftriaxone and metronidazole (81%, n=17). Fourteen patients used antibiotics appropriately in dosage, route, and frequency. Four patients were unsuitable for the benefit of antibiotics in terms of antibiotic type, and three patients were unsuitable for antibiotic use in terms of duration of administration.
Knowledge Level of OTC and OTC Limited Drugs Use for Self-medication in the Community of Tondo Village, Mantikulore District, Central Sulawesi, Indonesia
Sciences of Pharmacy Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Self-medication is treatment without a doctor's prescription, based on the 2022 BPS, the percentage of self-medication for the people of Central Sulawesi in 2021 is 85.85%. The purpose of the study was to determine the characteristics of the community who did self-medication, minor illnesses that were treated with self-medication, the profile of over-the-counter (OTC) and OTC limited medicines for self-medication and the level of knowledge of these medicines use for self-medication in the community of Tondo Village. This type of research was descriptive with a sample of 386 respondents who were taken using purposive sampling. Time of data collection during August – November 2021. Based on the results, the respondents characteristics were female (52.3%) aged 26-35 (24.4%), household work (31.1%), history of high school education (46.4%). Minor illnesses that were treated using self-medication were fever (15.54%), ulcer (7.46%), cough (15.54%), flu (18.91%), diarrhea (2.85%), headache (1 .30%), and allergy (0.78%). The profiles of OTC and OTC limited drugs are limited to paracetamol for fever (33.16%), antacids for ulcers (75.70%), Komix® for coughs (28.8%), Mixagrib® for flu (36.99%), Entrostop® for diarrhea (70,00%), Ibuprofen for headaches (100%), and CTM for allergies (100%). Number of pharmacy or drug store was 61.46%. The selection of drugs were based on experience and personal/family usage history (84.46%), and the reason for self-medication was to save treatment costs (47.15%). The level of knowledge on the use of OTC and OTC limited drugs was categorized as good (75.09%). Based on the findings, we can conclude that the level of knowledge on the use of OTC and OTC limited drugs for self-medication of Tondo people is categorized as good.
Profile of Intravenous Preparation Mixing in Patients at the Regional General Hospital's Intensive Care Unit Abdoel Wahab Sjahranie Samarinda
Sciences of Pharmacy Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Compatibility is one of the quality characteristics of intravenous (IV) preparations that influences the effectiveness of patient therapy in the Intensive Care Unit (ICU). The purpose of this study was to determine the compatibility profile of IV medication formulations given to ICU patients. This prospective observational research was undertaken on patients in the ICU of a private hospital in Samarinda. The data on intravenous combination of drugs were compared in this study utilizing the ASHP Injectable Drug Information literature 21st edition, Injectable drug guide, and Manual Book. Injectable Drug Mixing was published in 2009 as a resource for determining the compatibility of intravenous formulations. Using certain criteria, combinations of intravenous medicines and their solvents are classed as compatible (C), incompatible (I), and unknown (U). The ICU had 25 patients, 15 of whom were male and 10 of them were female. There is no mixing of drug compounds containing incompatible solvents. All drugs were carried out with 100% compatible solvents. The limited information related to the compatibility and stability of these intravenous preparations encourages continuous monitoring of the patient's condition and drug levels.
In-silico design and screening of cephalosporin derivatives for their inhibitory potential against Haemophilus influenza
Sciences of Phytochemistry Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Antibiotics kill bacteria by blocking essential metabolic processes which prevent them from reproducing thereby allowing the immune system to fight bacterial infections. However, the emergence and the quick spread of bacterial resistance against clinically approved antibiotics have become alarming. This necessitates the development of novel treatment options and alternative antimicrobial therapies in the fight against bacterial infections. In this study, we aim to virtually design and carry out in-silico studies to identify a cephalosporin derivative with inhibitory potential against Haemophilus influenza. Data Warrior software, Discovery studio software, PyRx tool, Swiss ADME web tool, and ProTox-II web tool were used to screen the cephalosporin derivatives. Initially, 17 cephalosporin derivatives were preliminarily screened for their toxicity followed by in-silico ADME studies. Among the cephalosporin derivatives, C1, C6, and C12 were found to be the potential drug-like molecules with binding energies of -7.4 kcal/mol, -7.1 kcal/mol, and -7.1 kcal/mol, respectively. In particular, C1 was predicted to have a moderate biological activity with a high bioavailability score. Based on the ADME profile, toxicity, binding energy, drug-likeness, and drug score, we conclude C1 (‘F’ at the 3rd position) as the potential lead molecule to inhibit H. influenza.
Evaluation of Mixed Intravenous Preparation in Patients at the Hospital "X" Samarinda's Intensive Care Unit (ICU)
Sciences of Pharmacy Volume 1
Publisher : PT. ETFLIN Scientific Society

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Abstract

Mixing intravenous preparation especially in patients intensive care unit (ICU) at the hospital requiring special attention relating to their higher had medication errors, as nosocomial infection and incompatibility drugs. Things that need to be considered in mixing sterile preparations, namely compounding personnel, facilities and infrastructure and the process of mixing sterile preparations. This study aims to calculate the percentage of suitability for the mixing process for intravenous preparations based on the Basic Guidelines for Dispensing Sterile Preparations, Guidelines for Injectable and Cytostatic Drugs in 2009 and the Handbook of Injectable Drugs Edition 16th for Intensive Care Unit (ICU) patients at the hospital “X” Samarinda. The research is descriptive research using sheets observational data collection. The subject of research is do mixing, facilities, and infrastructure as well as mixing procedure. The results of observations as many 215 processes of mixing intravenous preparations observed in the ICU showed that 100% of compounding personnel were carried out by nurses, and 100% of infrastructure did not have a clean room, LAF, and pass box, 53% carried out the mixing process according to procedures, and physical quality tests. drug preparations are 100% in accordance with the Handbook of Injectable Drugs Edition 16th, namely the preparations produced are clear and free of foreign particles.

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