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PERBANDINGAN HASIL ANALISIS SPERMA DARI PROSES COITUS INTERRUPTUS DAN MASTURBASI PADA KASUS INFERTILITAS Edy Priyanto; Fitranto Arjadi; Norina Agatri
Mandala Of Health Vol 12 No 2 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Pasangan infertil semakin banyak ditemukan di Indonesia, 40% penyebab infertilitas terkait dengan faktor suami. Analisis sperma merupakan metode untuk mengetahui penyebab infertilitas. Metode masturbasi lebih direkomendasikan dibandingkan coitus interruptus. Kekurangan pada metode masturbasi adalah adanya beban psikologis dan latar belakang agama. Tujuan penelitian adalah membandingkan hasil analisis sperma dari hasil coitus interruptus dan masturbasi pada kasus infertilitas. Jenis penelitian adalah observasional analitik. Sampel penelitian berjumlah 97 laki-laki infertil yang melakukan pemeriksaan di RSIA Bunda Arif pada bulan Januari 2017 – Juni 2018. Teknik sampling menggunakan total sampling. Analisis sperma menggunakan klasifikasi dari WHO tahun 2010. Analisis statistik yang digunakan adalah uji t tidak berpasangan. Hasil penelitian menunjukkan perbedaan bermakna konsentrasi sperma (p=0,043) pada kelompok masturbasi 46,5 ± 7,2 dan kelompok coitus interruptus 18,7 ± 5,3. Hasil yang tidak bermakna pada motilitas (p=0,632) dan morfologi (p=0,722). Kesimpulan penelitian adalah analisis sperma dengan proses masturbasi lebih baik konsentrasinya dibandingkan dengan proses coitus interruptus pada kasus infertilitas. Infertile couples are increasingly found in Indonesia and the 40% of many causes are related to husband factors consequently sperm analysis is needed to predict infertility. A method of masturbation is more recommended than coitus interruptus. The deficiency of masturbation method lies on psychological and religious burden. This research aims at comparing the sperm analysis resulted from coitus interuptus and masturbation in infertility cases. It belongs to observational analityc reserach. The subjects of the research were 97 infertile male patients who underwent examination in RSIA Bunda Arif in January 2017-June 2018 and total sampling method was applied. The sperm analysis utilized WHO classification in 2010 and independent t-test was used in statistics analysis. The results of this study showed the sperm comparison and research results (p = 0.043) in masturbation groups is 46.5 ± 7.2 and the coitus interruptus group is 18.7 ± 5.3 and the result is not suitable for motility (p = 0.632) and morphology (p = 0.722) in spite of the fact that it showed better in the masturbation group. The study concludes that the sperm concentration in sperm analysis in the masturbation process is better and more recommended than that of coitus interruptus.

PENGARUH EKSTRAK THYME (Thymus vulgaris) TERHADAP IL-6 DAN HITUNG KUMAN PADA HEPAR MENCIT Balb-c YANG DIINFEKSI METHICILLIN RESISTANT Staphylococcus aureus (MRSA) Galuh Yulieta Nitihapsari; Lisayani Lisayani; Helmia Farida; Muchlis Achsan Udji Sofro
Mandala Of Health Vol 12 No 2 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Meningkatnya fenomena resistensi bakteri, yaitu Metisilin-Resisten Staphylococcus aureus (MRSA), mendorong pentingnya penggalian bahan alam yang memiliki efek antibakteri atau yang memodulasi respon imun. Thymus vulgaris (TV) atau herba timi diketahui memiliki efek antimikroba dan immunomodulator, sehingga diharapkan dapat mengatasi infeksi MRSA melalui peningkatan sitokin IL-6. Efek ekstrak Thymus vulgaris terhadap IL-6 dan hitung kuman pada hepar mencit balb-c yang diinfeksi MRSA diuji pada penelitian ini. Desain penelitian adalah post test only control group design. Populasi studi menggunakan 30 ekor mencit balb-c jantan yang diinfeksi MRSA dan dibagi secara acak dalam enam kelompok. Kelompok penelitian dibagi menjadi enam, yaitu kelompok K1 (mencit diinfeksi MRSA tanpa diterapi), P1 (mencit diterapi ekstrak Thymus vulgaris, 7 hari kemudian diinfeksi MRSA), K2 (mencit diinfeksi dan diterapi vankomisin), P2 (mencit diinfeksi dan diterapi ekstrak TV + vankomisin), K3 (mencit diinfeksi dan diterapi amoksisilin), dan P3 (mencit diinfeksi dan diterapi ekstrak TV + amoksisilin). IL-6 diukur dengan ELISA, hitung kuman dinilai dengan kultur mikrobiologi. Data dianalisis dan diolah menggunakan uji hipotesis dengan uji t-test independent program SPSS 22.0. Hasilnya ditemukan kadar IL-6 yang tidak bermakna antara kelompok K1-P1 (p>0,05), K2-P2 (p>0,05), dan K3-P3 (p>0,05). Penurunan hitung kuman bermakna pada kelompok K1-P1 (p<0,05), tidak bermakna pada K2-P2 (p>0,05) dan K3-P3 (p>0,05). Kadar IL-6 dengan penurunan hitung kuman MRSA di hepar memiliki korelasi positif yang sangat lemah (r=0,086). Ekstrak Thymus vulgaris terbukti efektif dalam menurunkan hitung kuman MRSA pada kelompok yang tidak mendapatkan antibiotik tetapi tidak terbukti meningkatkan kadar IL-6. The increasing phenomenon of bacterial resistance, namely Methicillin-Resistant Staphylococcus aureus (MRSA), encourages the importance of extracting natural substances that have anti-bacterial effects or which modulate immune responses. Thymus vulgaris (TV) or herbal thyme is known to have antimicrobial and immunomodulatory effects, so it is expected to overcome MRSA infection through increased IL-6 cytokines. The effect of Thymus vulgaris extract on IL-6, and bacterial counts on the liver of balb-c mice infected by MRSA tested in this study. The study design was Post-test only control group design. The population of the study was used 30 male balb-c mice infected with MRSA and randomly divided into six groups. The study group divided into 6 groups; K1 group (mice infected by MRSA without being treated), P1 (mice treated with Thymus vulgaris extract 7 days later infected with MRSA), K2 (mice infected and treated with vancomycin), P2 (mice infected and treated with TV + vancomycin extract), K3 (mice infected and treated with amoxicillin), and P3 (mice infected and treated with TV + amoxicillin extract). IL-6 was measured by ELISA, the bacterial count was assessed by microbiological culture. Data were analyzed and processed using hypothesis testing with an independent t-test program SPSS 22.0. The results showed that IL-6 levels were not significant between groups K1- P1 (p > 0.05), K2-P2 (p >0.05), and K3-P3 (p>0.05). The decrease in bacterial count was significant in the K1-P1 group (p< 0.05), not significant in K2-P2 (p>0.05) and K3-P3 (p>0.05). The level of IL-6 with a decrease in MRSA count in the liver has a very weak positive correlation (r = 0.086). Thymus vulgaris extract was proven to be effective in reducing MRSA counts in groups that did not get antibiotics but were not proven to increase IL-6 levels

ISOLASI, EFEKTIVITAS, DAN KARAKTERISASI BAKTERIOFAG LITIK Salmonella enterica SEBAGAI BIOKONTROL PENYAKIT GASTROENTERITIS Debi Arivo; Tessa Sjahriani
Mandala Of Health Vol 12 No 2 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Salmonella enterica merupakan salah satu bakteri patogen penyebab gastroenteritis yang ditransmisikan melalui air dan makanan terkontaminasi yang sering terjadi pada negara berkembang. Beberapa strain Salmonella enterica multi-resisten terhadap berbagai antibiotika. Bakteriofag litik pada famili Siphoviridae dapat menjadi solusi alternatif dalam mengurangi kejadian gastroenteritis oleh Salmonella enterica. Tujuan penelitian ini adalah untuk mengisolasi, mengetahui kemampuan bakteriofag litik Lytic Bacteriophage 1 (LB1) dalam melisis inangnya yaitu Salmonella enterica penyebab gastroenteritis, serta mengetahui karakterisasi bakteriofag litik LB 1 sebagai biokontrol penyakit gastroenteritis. Bakteriofag litik diisolasi dari pembuangan limbah domestik menggunakan teknik double layer plaque. Bakteriofag litik diidentifikasi berdasarkan morfologi plak, struktur litik, inang, aktivitas lisis sel bakteri Salmonella enterica, stabilitas dalam kondisi buffer yang berbeda dan karakterisasi protein. Bakteriofag litik LB1 hanya menginfeksi sel Salmonella enterica. Hasil pemeriksaan dengan menggunakan Transmission Electron Microscope (TEM), bakteriofag litik LB1 termasuk ke dalam famili Siphoviridae. Morfologi kepala hexagonal-icosahedral berdiameter 72.7 nm, dengan ekor non-kontraktil berdiameter 17.3 nm dan panjang 100 nm. Bakteriofag litik LB1 memiliki stabilitas terbaik dalam buffer Ringers suhu 4 oC yang ditunjukkan dengan penurunan plak sebesar 28% setelah 3 minggu penyimpanan. Hasil pengujian efektivitas menunjukkan bahwa bakteriofag litik LB1 dapat mengurangi populasi sel Salmonella sebanyak 67,12% setelah 8 jam inkubasi. Bakteriofag litik LB1 memiliki 8 protein yang berbeda dengan berat molekul yang beragam 11.4 kDa, 19.6 kDa, 23 kDa, 33 kDa, 58.3 kDa, 77 kDa, 94.5 kDa, 133 kDa. Studi ini menunjukkan bahwa bakteriofag litik LB1 yang diisolasi pembuangan limbah domestik dapat secara efektif mengurangi Salmonella enterica dengan cara melisis sel bakteri. Bakteriofag litik LB1 berpeluang dapat digunakan sebagai biokontrol penyakit gastroenteritis yang disebabkan oleh Salmonella enterica. Stabilitas terbaik bakteriofag litik LB1 pada penyimpanan dalam buffer Ringer di suhu dingin (4oC), memiliki karakterisasi famili Siphoviridae, dapat mengurangi Salmonella enterica sebanyak 67.12% setelah 8 jam inkubasi, dan memiliki berat molekul 11.4-133 kDa. Salmonella enterica is one of pathogenic bacteria causing gastroenteritis transmitted by water and food contamination which commonly occur in developing country. Some study reported that Salmonella serovar enterica strains were multi-resistant to various of antibiotics. Lytic bacteriophage in Siphoviridae family offered a good solution to reduce gastroenterytis disease caused by Salmonella enterica. This reseach aim was to isolate, effectivity test of LB 1 and to characterize lytic bacteriophage as biocontrol of gastroenterytis. Methodology and results were LB1 lytic bacteriophage was isolated from domestic waste using double layer plaque technique, was determined by the plaque morphology, the structure, the host range, the activity to lyse bacterial host cells, the stability of phage on different buffer conditions, and the protein characterization. The results showed that LB1 only infects Salmonella enterica. Based on Electron Microscope Observation showed that LB1 is grouped into Siphoviridae. It has hexagonal-icosahedral head with 72.7 nm in diameter and long-non contractile tail with 100 nm in diameter. LB1 had a good storage stability in Ringers buffer at low temperature (40C), with viability of bacteriophage decreased by 28% after 3 weeks of storage. The effectiveness showed that LB1 could reduce Salmonella enterica by 67.12% after 8 hours of incubation. LB 1 has different proteins with molecular weights: 11.4 kDa, 19.6 kDa, 23 kDa, 33 kDa, 58.3 kDa, 77 kDa, 94.5 kDa, and 133 kDa. The conclusion was LB1 was isolated from sewage water were identified to reduces Salmonella enterica effectively with concentration of 8.2x108 CFU/mL. LB 1 can be used as a biocontrol of gastroenterytis caused by Salmonella enterica, LB 1 has the best stability in buffer ringers in cold temperatures (4oC) and proven as Siphoviridae family, reduced Salmonella enterica by 67.12% after 8 hours of incubation, and has protein molecule with molecular weight 11.4 to 133 kDa.

THE INFORMATION ON STATUS OF ANTIBIOTIC RESISTANCE CHANGING THE PERCEPTION AND ATTITUDES OF WISELY ANTIBIOTIC USE IN BANYUMAS DISTRICT COMMUNITIES Rahmawati Wulansari; Diyah Woro Dwi Lestari; Dwi Utami Anjarwati; Eman Sutrisna
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

The wise use of antibiotics in the Banyumas community is quite alarming. Most of them still buy antibiotics without a doctor's prescription, buy half a prescription and consume antibiotics without finishing it. Good enough knowledge about the dangers of using antibiotics unwisely has not formed a correct perception and attittude of antibiotic use. This study aims to evaluate changes in people's perceptions and attitudes about antibiotic use after being given information related to their resistance status . This research was conducted qualitatively on 10 informants. Retrieval of data through focus group discussion techniques is done before and after providing resistance status information. The results showed that before giving information, perceptions and attitudes towards the use of antibiotics most (80%) of informants were not correct despite having a good level of knowledge. Changes in perceptions and attitudes about the right pattern of antibiotic use wisely occur after being given information about the status of antibiotic resistance they experience. This study can be concluded that the provision of information on the results of the examination of resistance status has a positive effect causing the changing in perception and the right attitude regarding the use of antibiotics wisely in the Banyumas community

KARAKTERISTIK INPUT DAN LUARAN NEONATUS DENGAN TERAPI SURFAKTAN METODE INTUBATION-SURFACTANT-EXTUBATION (INSURE) Nenden Nursyamsi Agustina; Agus Fitrianto
Mandala Of Health Vol 13 No 1 (2020): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRAKTerapi surfaktan diberikan pada bayi prematur dengan Hyaline Membrane Disease (HMD) yang mengalami Respiratory Distress Syndrome (RDS). Pemberian terapi surfaktan dengan metode Intubation – Surfactant – Extubation (INSURE) merupakan salah satu metode yang lebih minimal invasif dibandingkan ventilasi mekanik konvensional. Penelitian ini bertujuan mengetahui karakteristik input dan luaran neonatus yang mendapat terapi surfaktan metode INSURE di RSUD Prof. Dr. Margono Soekarjo. Desain penelitian yang digunakan adalah deskriptif dari data sekunder berupa rekam medis dan laporan pasien Neonatal Intensive Care Unit (NICU) periode Juli 2017-Juli 2019. Sampel penelitian sebanyak 11 neonatus yang mendapat terapi surfaktan metode INSURE di RSUD Prof. Dr. Margono Soekarjo. Teknik pengambilan sampel menggunakan total sampling. Karakteristik input terdiri atas jenis kelamin, berat badan lahir (BBL), status asfiksia, kehamilan dengan risiko penyulit, dan waktu pemberian surfaktan. Karakteristik luaran terdiri atas klinis selama perawatan, length of survival, dan status pulang. Asfiksia sedang terjadi pada 90,9% pasien. Sebanyak 36,4% pasien dengan berat badan lahir sangat rendah (BBLSR) dan berat badan lahir amat sangat rendah (BBLASR) dan 27,3% pasien berat badan lahir rendah (BBLR). Karakteristik input dari faktor ibu didominasi kehamilan dengan risiko penyulit. Neonatus yang mendapatkan surfaktan > 6 jam pertama setelah lahir sebesar 72,7%. Karakteristik luaran klinis neonatus selama perawatan adalah 54,5% mengalami respiratory distress dan 45,4% HMD grade III, 54,6% hanya mampu bertahan ≤7 hari, dan 45,4% bayi berhasil bertahan sampai tidak memerlukan Continuous Positive Airway Pressure (CPAP) lagi. Tiga bayi hidup sampai pulang dan 2 meninggal karena sepsis. Karakteristik input terbanyak pasien adalah laki-laki, asfiksia sedang, BBLSR atau BBLASR, dan lahir dari ibu dengan risiko penyulit. Karakteristik luaran terbanyak pasien adalah respiratory distress, HMD grade III, dan hanya mampu bertahan ≤7 hari. ABSTRACTThe surfactant replacement therapy was effective for neonates suffering from Respiratory Distress Syndrome (RDS) with Hyaline Membrane Disease (HMD). Surfactant therapy using Intubation – Surfactant – Extubation (INSURE) method is less invasive than conventional mechanical ventilation. This study was conducted to find out the input and output characteristics of neonates who got surfactant therapy with the INSURE method at Margono Soekarjo General State Hospital. It was a descriptive study by utilizing secondary data from the medical record and NICU patient reports for the period July 2017-July 2019. Total sampling technique was were used in this study. Input characteristics consisted of sexes, birth weight, asphyxia status, pregnancy with complicating risk, and time of surfactant administration. Output characteristics consisted of a clinical duration of treatment, length of survival, and discharge status. Eleven neonates got surfactant therapy using INSURE method in Margono Soekarjo General State Hospital for the period July 2017-July 2019. Moderate asphyxia occurred at 90.9%. There were 36.4% of patients with Very-Low-Birth-Weight and Extremely-Low-Birth-Weight and 27.3% patients with Low-Birth-Weight. Input characteristics of maternal factors were dominated by pregnancy with complicating risks. Neonates receiving surfactants > 6 hours first of life were 72.7%. Characteristics of neonatal clinical outcomes during treatment were 54.5% respiratory distress and 45.4% HMD grade III. There were 54,6% of patients died before 7 days of life and 45,4% of patients survived until Continuous Positive Airway Pressure (CPAP) weaning. There were three patients discharged from hospital and two patients died because of sepsis. The input characteristics of most patients were male, moderate asphyxia, BBLSR or BBLASR, and born to mothers with a risk of complications. The outcome characteristics of most patients are respiratory distress, HMD grade III, and length of survival ≤7 days.

The Correlation Cervical Radiograph in ThreeImages Position With Clinical Symptoms of Cervical Syndrome Ana Majdawati
Mandala Of Health Vol 13 No 1 (2020): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Cervical Syndrome is a complaint of pain in the cervical vertebrae area, which has the most number 2 after complaints of low back pain (LBP). 3-position cervical radiographic examination is a diagnostic investigation which is still frequently proposed in cervical syndrome cases. The formulation of the problem in this study is there a relationship between cervical 3 position radiography and clinical symptoms of Cervical Syndrome? This research method is cross sectional to obtain cervical radiolographic relationship which includes osteophytes, DIV/FIV narrowing, subchondral sclerotic, fracture/compression, listhesis, calcification of anterior/posterior cervical ligament with clinical symptoms of Cervical Syndrome patients ie neck stiffness, neck/neck pain, fractures/compressions, listhesis, calcification of anterior / posterior cervicalis ligaments with clinical symptoms of Cervical Syndrome patients ie neck stiffness, neck / neck pain, fractures/compressions, listhesis, calcification of anterior/posterior cervicalis ligaments with clinical symptoms of Cervical Syndrome patients ie neck stiffness, neck/neck pain, propagation, compression pain to the shoulder, back of the head and arms, movement disorders and paresthese. The data obtained were tested by chi square analysis with p = 0.036. The results of this study show a significant relationship between clinical symptoms of cervical syndrome with cervical 3 position radiographic results.

PERBANDINGAN INDEKS ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) PADA PASIEN SIROSIS HEPATIS DAN KARSINOMA HEPATOSELULER Muhammad Rifqi Fauzan Nurkamal; Vitasari Indriani; Ika Murti Harini
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRAK Sirosis hepatis dianggap sebagai kondisi sebelum terjadinya karsinoma hepatoseluler. Sirosis hepatis dan karsinoma hepatoseluler perlu dideteksi lebih awal dengan menggunakan indeks sederhana karena prognosisnya yang buruk. APRI merupakan indeks yang dapat membantu diagnosis fibrosis dan sirosis secara signifikan. Hasil penelitian sebelumnya melaporkan adanya perbedaan signifikan pada rerata indeks APRI yang diambil dari data rekam medis pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian ini mengkaji rerata indeks APRI dari hasil pemeriksaan laboratorium pasien yang baru terdiagnosis sirosis hepatis dan karsinoma hepatoseluler. Untuk mengetahui perbandingan indeks APRI pada pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian analitik observasional dengan pendekatan cross sectional dilakukan pada 11 pasien sirosis hepatis dan 11 pasien karsinoma hepatoseluler yang baru terdiagnosis di RSUD Prof. Dr. Margono Soekarjo. Pengambilan data dilakukan dengan teknik consecutive sampling pada sampel darah pasien yang kemudian dikirim ke laboratorium Patologi Klinik. Analisis hipotesis menggunakan uji T tidak berpasangan. Rerata indeks APRI pada pasien sirosis hepatis adalah 0,79 ± 0,60. Rerata indeks APRI pada pasien karsinoma hepatoseluler adalah 7,27 ± 7,11. Terdapat perbedaan bermakna pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler dengan nilai p = 0,00 (p < 0,05). Terdapat perbedaan rerata pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler. Kata Kunci: APRI, karsinoma hepatoseluler, sirosis hepatis ABSTRACT Hepatic cirrhosis was considered as a condition before the occurrence of hepatocellular carcinoma. Hepatic cirrhosis and hepatocellular carcinoma needed to be detected earlier using a simple index because of their poor prognosis. APRI was an index that could helped diagnosing fibrosis and cirrhosis significantly. The results of previous studies reported a significant difference in the mean of APRI taken from the medical record data of hepatic cirrhosis and hepatocellular carcinoma patients. This study investigated the mean of APRI from laboratory results of newly diagnosed patients with hepatic cirrhosis and hepatocellular carcinoma. To determine the comparison of the APRI in patients with hepatic cirrhosis and hepatocellular carcinoma. An analytic observational study with cross sectional model was conducted among 11 hepatic cirrhosis and 11 hepatocellular carcinoma patients which newly diagnosed in Prof. Dr. Margono Soekarjo General Hospital. Data collection was performed by consecutive sampling method on the patient's blood sample which was then sent to the laboratory of Clinical Pathology. Hypothesis was analysed using independent t-test. The mean of APRI in hepatic cirrhosis patients is 0.79 ± 0.60. The mean of APRI in hepatocellular carcinoma patients is 7.27 ± 7.11. There is a significant difference of the APRI between the hepatic cirrhosis and hepatocellular carcinoma patients with a value of p = 0.00 (p <0.05). There is a mean difference of the APRI between the hepatic cirrhosis and hepatocellular carcinoma patients. Keywords: APRI, hepatic cirrhosis, hepatocellular carcinoma

CORRELATION OF ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) WITH THE DEGREE OF SEVERITY LIVER ORGAN IN CIRRHOSIS HEPATIC PATIENTS mahendra aulia rakhman; Vitasari Indriani; Dwi Arini E
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Background: Cirrhosis hepatic is a chronic liver disease characterized by the replacement of liver tissue into scar tissue resulting in decreased liver function. The patient's diagnosis is gold standard for cirrhosis hepatic by invasive assessment cause tissue damage. The development of the way of diagnosis with secondary markers is APRI score was considered quite good in determining cirrhosis hepatic. On the other to, there is a method for assessing the severity of the liver organ in patients with cirrhosis hepatic using the Child-Pugh score. APRI scores and Child-Pugh scores are based on the calculation of secondary markers caused by hepatocyte cell fungtional damage. This is very useful in the early diagnosis of cirrhosis hepatic patients using simple markers and predicting the severity of the liver organ to assess further prognosis and management. Objective: To knowing the correlation of APRI index with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. Specifically, it aims to determine the APRI score and Child-Pugh score in patients with cirrhosis hepatic. Methods: This study used a cross sectional design with a sample of 31 patients with a diagnosis of cirrhosis hepatic which was selected using a consecutive sampling technique. Primary data were obtained from a one-time blood sampling calculation and secondary data were obtained from medical records from patients with a diagnosis of liver cirrhosis from the physician in charge. Hypothesis analysis using Pearson correlation test. Resuls: Pearson test results showed a significant difference p = 0.024 (p <0.05) with the strength of the relationship r = 0.404 and the direction of a positive relationship on the correlation of APRI scores and Child-Pugh scores. Conclusions: There is a significant correlation between APRI scores with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. The average APRI score in patients cirrhosis hepatic is 3, 107. The Child-Pugh score for the degree of severity liver organ is 8 or in the category of Child-Pugh B or moderate category.

KARAKTERISTIK HISTOPATOLOGI TUMO KARAKTERISTIK HISTOPATOLOGI TUMOR ORBITA DI RS MATA CICENDO BANDUNG TAHUN 2017-2018 Tirta Wardana; Raudatul Janah
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Tumor orbita adalah tumor dalam rongga orbita yang terdiri atas primer, sekunder penyebaran dari struktur sekitar/metastasis Pemeriksaan histopatologi merupakan pemeriksaan goldstandar pada tumor orbita. Penelitian ini bertujuan untuk mengetahuai karakteristik histopatologi tumor orbita di RS mata Cicendo bandung tahun 2017-2018. Penelitian ini merupakan penelitian deskriptif dengan jumlah sampel 760 Data dikumpulkan berdasarkan catatan medis berupa umur, jenis kelamin, mata yang terlibat, lokasi tumor, tindakan, diagnosis klinis, hasil pemeriksaan patologi tumor. Penelitian ini didapatkan hasil umur pasien >45 tahun (43,4%), Mayoritas Laki-laki sebesar 55,4%, mata yang terlibat di mata kiri 51,1%, dengan lokasi terbanyak pada palpebral 36%. Dilakukan tindakan operasi sebanyak (24%). Hasil diagnosis klinis lesi tumor jinak sebesar 68,3% dan lesi tumor ganas sebesar 31,7% dimana limfoma maligna yang paling sering ditemukan. Hasil histopatologis berupa lesi tumor jinak sebesar 71,4% dan lesi tumor ganas sebesar 28,6% dimana squamous cell carcinoma menduduki angka tertinggi sebanyak 50%. Karakteristik histopatologi tumor orbita di RS mata cicendo Bandung didominasi oleh laki-laki, usia >45 tahun pada mata kiri dan terletak di palpebral dengan hasil diagnosis klinis dan histopatologis tersering adalah lesi /tumor jinak.

PENGARUH BERKUMUR DENGAN LARUTAN PROBIOTIK TERHADAP KADAR IgA DALAM SALIVA Recita Indraswary; Hilma Yunita Nurenda; Helmi Faturrahman
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRACT Saliva contains IgA which acted as the first line of defense against a pathogen in the oral cavity. IgA salivary in the elderly have decreased which caused prone to oral infection. The alternative way to increased salivary IgA levels was by gargling a probiotic solution. Gargling was a mechanical stimulation to increase the flow rate of saliva. Probiotic contains bacteria which can give advantage for the human body. Probiotics can stimulate the immune system to increased IgA levels. The purpose of this study was to determine the effect of gargling probiotic solutions on salivary IgA levels in the elderly. This study used a quasi-experimental pre and post-test design group. The number of samples was 11 people. Each sample was instructed to gargling probiotic solution 10 ml every morning and evening along with their saliva was taken before and after gargle the probiotic solution. Data analysis was done using a paired t-test. The result showed the mean of salivary IgA levels before gargling probiotic solution were 206.6818±25.17419 and salivary IgA levels after gargling probiotic solution were 223.4091±12.52042. Based on the paired t-test got a value of p=0.059 (>0.05) means there is no significant difference. The conclusion of this study was gargling probiotic solution can increase salivary IgA but is not statistically significant. Keywords: Salivary IgA, probiotic solution, elderly

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INDONESIA

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Home Page

OAI Link

Editorial Team

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Contact Name Wahyudin

Contact Email mandalaofhealth.journal@gmail.com

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Journal Mail Official mandalaofhealth.journal@gmail.com

Editorial Address Jl. Dr. Gumbreg, Medical Street, Mersi, Purwokerto Central Java 53122 Telp. (0281) 622022, Fax. (0281) 624990

Location Kab. banyumas, Jawa tengah INDONESIA

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Wahyudin

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+6281343880797

Journal Mail Official
mandalaofhealth.journal@gmail.com

Editorial Address
Jl. Dr. Gumbreg, Medical Street, Mersi, Purwokerto Central Java 53122 Telp. (0281) 622022, Fax. (0281) 624990

Location
Kab. banyumas,

Jawa tengah

INDONESIA