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Puma Arfah
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INSTITUTE FOR HALAL INDUSTRY & SYSTEM (IHIS) UNIVERSITAS GADJAH MADA Jl. Kaliurang Km.4 Sekip Utara Yogyakarta 55281
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Journal of Food and Pharmaceutical Science
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.581
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
FOCUS AND SCOPE Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research Food Chemistry Integrated Food Science Health, Nutrition, and Food Food Engineering, Materials Science, and Nanotechnology Toxicology and Chemical Food Safety Food Microbiology and Safety Drug Discovery Computational Chemistry and Molecular Modeling Pharmaceutical Biotechnology and Protein-Peptide Chemistry Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology Pharmaceutical Nanotechnology Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism Analytical and Bioanalytical Chemistry Pharmaceutical Chemistry Natural Medicine and Nutraceutical Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 152 Documents
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The Role of Chemical Analysis in the Halal Authentication of Food and Pharmaceutical Products Mursyidi, Achmad
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.851 KB) | DOI: 10.14499/jfps

Abstract

Food and pharmaceutical products (drugs and cosmetics) are one of the essential human needs since the human civilization. It is an obligation for Muslim to consume and use the halal consumer goods. Currently, there are numerous food and pharmaceutical products available in the market supplied to consumers in which the actual contents of these products are not clear; consequently, the halal verification and authentication of these are highly required. Non-halal items commonly found are pig derivatives such as pork, lard, and gelatin as well as alcohol (khamr), blood, dead meats, and the allowed animals to be consumed which are not slaughtered according to Syariah law. One of the ways to authenticate the halalness of the food and pharmaceutical products is chemical analysis which is relied to find the specific markers present or absent in the products they contain. Currently, some analytical techniques have been proposed and continuously developed for the authentication of halal products such as Fourier transform infrared (FTIR), chromatography-based methods, differential scanning calorimetry, electronic nose, and DNA-based methods. However, these methods can not verify the non-halal items which are not physical, chemical, or biological in nature like dead animal. Consequently, another method should be performed, i.e. direct and monitoring the production step (from farm to table). Besides, to succed the verification and authentication of halal products, passing the legislation of “Halal products assurance” by Indonesian parliament is urgently needed. Keyword: chemical analysis, food, pharmaceutical, halal authentication
Analysis of Canola Oil in Virgin Coconut Oil Using FTIR Spectroscopy and Chemometrics Man, Yaakob B. Che; Rohman, abdul
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.239 KB) | DOI: 10.14499/jfps

Abstract

Virgin coconut oil is a relative new oil comer in the industry of fats and oils, especially in ropical regions. In this study, we have investigated the possibility to use of Fourier transform infrared (FTIR) spectroscopy in combination with multivariate calibrations of partial least square (PLS) and principle component regression (PCR) as well as discriminant analysis (DA) for quantitative analysis and discrimination of canola oil (Ca-O) in virgin coconut oil (VCO). VCO, Ca-O, and the mixture of both oils was FTIR-spectroscopically scanned at mid infrared region (4,000 – 650 cm-1) using horizontal attenuated total reflectance. Several frequency regions as well as normal and derivative FTIR spectra were compared in order to obtain the best model for quantitative analysis. Finally, FTIR normal spectra at combined frequency regions of 1200-900 and 3027- 2985 cm-1 were selected for quantification of Ca-O due to their capabilities to provide the high correlation between actual and predicted values of CaO in VCO and low error values, either in calibration or validation models. Furthermore, DA was able to discriminate VCO and that adulterated with Ca-O. This result indicated that FTIR spectroscopy was possible to quantify and to discriminate Ca-O in VCO for authentication studies.Keywords: FTIR spectroscopy, canola oil, virgin coconut oil, multivariate calibration, discriminant analysis
Detection of nptII Gene and 35SCaMV Promoter in Tomatoes (Solanum lycopersicum L.) Suratman, A.; Ughude, J. O.; ., Sismindari
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.879 KB) | DOI: 10.14499/jfps

Abstract

The detection of nptII (kanamycin resistance) as a transgenic marker gene and 35SCaMV as promoter in tomatoes has been carried out. DNA from tomatoes samples was isolated using PureLinkTM plant total DNA purification kit. The purity of DNA samples was estimated using UV-Vis spectrophotometry at 260 nm and 280 nm. They gave an absorbance ratio (A260/A280) of 1.74-1.79 which indicated its purities. The quality of the DNA was confirmed by a clear and thick band, as analyzed in 0.8% agarose gel electrophoresis. In order to identify the transgenic tomatoes, a 786-bp fragment of the nptII gene and a 86-bp fragment of 35SCaMV promoter were amplified using polymerase chain reaction (PCR). PCR reaction was prepared at optimum condition, namely annealing temperature at 56°C and 55°C for nptII gene and 35SCaMV promoter, respectively and 300 ng of DNA template. The PCR results were visualized on 2% agarose gel electrophoresis. The results showed that one of three tomatoes (code ST2) contains 35SCaMV promoter and no tomatoes contain nptII gene, indicating that ST2 is transgenic tomato.Key words: tomatoes, PCR, nptII, 35SCaMV
Effect of Taurine on The Respiratory System of Rats E.M, Ammer; A.A., Shaaban; H.A., Ghonem; H.A., Elkashef
Journal of Food and Pharmaceutical Sciences Vol 1, No 2 (2013): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.479 KB) | DOI: 10.14499/jfps

Abstract

The present study was designed to investigate the effect of taurine on isolated trachea and pulmonary artery of rats and the possible  mechanism(s) of action. The possible antioxidant effect  of  taurine  was  also  studied  by  measuring  its  protective  effect  against cyclophosphamide  induced  lung  injuiry.  Taurine  produced  a  concentration  dependent relaxation  in  the  isolated  tracheal  strips  and  pulmonary  arterial  rings  precontracted  by serotonin  (2x10-4 mM). The  relaxing effect of  taurine was not  influenced by pretreatment with  nitric  oxide  synthase  inhibitor  (L-NAME)  ,  cysteinyl  leukotreines  receptor  1  blocker (montelukast)  ,  H1  receptor  blocker  (chlorpheniramine)  ,  β-adrenoceptor  blocker (propranolol),  potassium  channel  blocker  (amiodarone)  ,  cyclo-oxygenase  inhibitor (indomethacin) or   muscarinic  receptor blocker  (atropine). Preincubation with  adenosine receptor blocker  (aminophylline) significantly potentiated  the  relaxing effect of  taurine  in the  tracheal  strips  and  pulmonary  arterial  rings.  Cyclophosphamide  (CYP,  150  mg/kg) administerated  i.p.  in  a  single  dose was  used  to  produce  lung  injuiry  in  rats.  CYP  caused marked  increase  in  lung  lipid peroxides  (MDA)  and  decrease  in  lung  reduced  glutathione (GSH).  Administration  of  taurine    (1%  in  drinking  water)  starting  7  days  before  CYP  and continuing  throughout  the  duration  of  the  experiment  (24  hours)  improved  significantly the lung GSH and MDA. It can be concluded that taurine relaxes precontracted rat tracheal strips and pulmonary arterial rings probably by direct effect on the smooth muscles. Also, the observed  antioxidant    activity of  taurine   which may  contribute  to  its  relaxant  effect suggesting the usefulness of turine in pulmonary hypertension.
The Effect of Size Reduction and Preparation Duration on The Antioxidant Activity of White Saffron (Curcuma mangga Val.) Pujimulyani, Dwiyati; Raharjo, Sri; Marsono, Y; Santoso, Umar
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.451 KB) | DOI: 10.14499/jfps

Abstract

Food processing is usually conducted through preparation stages such as peeling, slicing, or cutting. The purpose of this research was to determine the correlation between the antioxidant activity and the total phenolic compounds of white saffron as affected by different level of size reduction and the duration of rhizome preparation at room temperature. White saffron rhizomes were peeled, washed, and cut into 1x1x1 cm3. The whole white saffron was sliced diagonally at thickness of 4 x 2 mm, and grated. The antioxidant activity of the white saffron was determined by radical scavenging activity using 2-2-diphenyl-1-picrylhydrazyl (DPPH) radical and by ferric reducing antioxidant power FRAP) method. The total phenol and total flavonoid contents were also determined at 2, 4, and 6 hours, respectively. The result showed that the antioxidant activities, total phenolic and flavonoid contents due to the preparation of whole white saffron for 6 hour are not statistically different compared to those of fresh white saffron. The preparation of white saffron sliced at 2 mm and grated for 2 hour showed a significant decrease in the antioxidant activities, compared to those of fresh white saffron.Keywords: white saffron, preparation duration, antioxidant activity, total phenol
Some Physico-chemical Properties of Red Fruit Oil (Pandanus Conoideus Lam) from Hexane and Chloroform Fractions Arumsari, Novita Inar; Riyanto, Sugeng; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Vol 1, No 2 (2013): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.005 KB) | DOI: 10.14499/jfps

Abstract

As  functional  food  oil,  red  fruit  (Pandanus  conoideus  Lam)  oil  has  been  believed  by  local community  to  threat  several  degenerative  diseases  like  cancer.  Red  fruit  oil  (RFO)  has commanded high price value in Indonesian market. Therefore, the objective of the present study was to  investigate several physico-chemical properties of RFO. Some parameters of RFO  obtained  from  hexane  and  chloroform  fractions  have  been  evaluated.  Such parameters include acid value, saponification value, anisidine value, conjugated dienes and trienes as well as p-anisidine value. Besides, absorptivity coefficient, fatty acid composition, and volatile compounds were also determined. Acid value and saponification value of RFO from chloroform fraction were higher than those in RFO from hexane fraction. In addition, RFO  in hexane  fraction has  the higher  iodine and anisidine values  than  that  in chloroform fraction. Hexane  is  the  best  solvent  to  be  used  for  analysis  of  RFO,  as  indicated  by  the highest  absorptivity  coefficient  of RFO  in hexane.  The main  fatty  acid  composed  of RFO was oleic acid  followed with palmitic acid. The main volatile compound present  in RFO of hexane and chloroform fractions was 9-octadecenoic acid accounting of 41.57 % and 65.06 %, respectively.
Changes in Gibberellic Acid (GA3) Content in Oryza sativa Due to Paclobutrazol Treatment Syahputra, Bambang S.A.; Sinniah, Uma Rani; SR, Syed Omar; Ismail, Mohd. Razi
Journal of Food and Pharmaceutical Sciences Vol 1, No 1 (2013): J.Food Pharm.Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.451 KB) | DOI: 10.14499/jfps

Abstract

The objective of this study was to determine the level of plant hormone gibberellic acid (GA3) in paddy due to the treatment of Paclobutrazol (PBZ) treatment using high performance liquid chromatography (HPLC) with UV-vis detection at 208 nm. The separation was achieved using reversed column Crestpak C18 (150 mm x 4.6 mm i.d; 5 µm) at 30 ± 1° C using mobile phase of acetonitrile-water (30:70%; v/v), pH 6.80. The treatment of PBZ with different concentration of 100, 200, 400, and 600 mg/L reduced the concentration of GA3 in paddy. The level of GA3 in paddy treated with 100 mg/L of PBZ did not show significant difference from untreated one. However, the level of GA3 in paddy treated with other concentrations (200, 400, and 600 mg/L) of PBZ was significantly different (P < 0.05) from untreated paddy.Keywords: analysis, gibberellic acid, paclobutrazol, HPLC
Myocardial Depression and Inhibition of Positive Inotropic Effect of Digoxin by Rosiglitazone Said, Shehta A.; Nader, Manar A.
Journal of Food and Pharmaceutical Sciences Vol 1, No 2 (2013): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.011 KB) | DOI: 10.14499/jfps

Abstract

This study was taken to investigate the effect of rosiglitazone (RGN) on the contractility of the isolated rat atrium as well as its possible inhibitory effect on positive inotropic effect of digoxin. RGN significantly increased the dose of digoxin required to produce cardiac arrest in anesthetized rats. RGN (10, 20, 40, 60, 80 & 100 µM) produced concentration dependant depressant effect on atrial contractility  in both diabetic and non-diabetic animals with  the depressant  effect was more  pronounced  in  diabetic  rats  than  in  non-diabetic  ones.  RGN also  inhibited  the positive  inotropic effect of digoxin  (0.1, 0.3 &  1µM)  in  isolated  rat  right atrium  treated  with  4  mg/kg  orally  daily  for  21  days.  Moreover,  RGN  also  produced significant increase in serum K+ and decrease in Na+ levels in rats. These results indicate that RGN has a negative  inotropic effect on  the heart especially  in diabetics and  it  inhibits  the positive inotropic effect of digoxin.
Analysis of Melamine Using Electronic Nose, Gas Chromatography-Time of Flight - Mass Spectrometry and High Performance Liquid Chromatography Rohman., Abdul; Che Man, Yaakob B.; Hafidz, R. M.
Journal of Food and Pharmaceutical Sciences Vol 1, No 2 (2013): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.106 KB) | DOI: 10.14499/jfps

Abstract

An  electronic  nose  (E-Nose)  has  been  used  as  rapid  analytical  technique  for  melamine detection  in  food  samples.  The  parameter  used  is melamine  retention  index  (MRI)  in  E-Nose  chromatogram.  The  value  of MRI  was  also  confirmed  using  two  dimensional  gas chromatography-time of flight-mass spectrometry (GCxGC-TOF-MS). The value of MRI using E-Nose and GCxGC-TOF-MS was nearly close  i.e 1486 and 1540 respectively. HPLC has been used  for  quantitative  analysis  of melamine  in  some milk  products  suspected  to  contain melamine using column Nova-Pak® C18;(150 x 3.9 mm  i.d; 4 µm) at 30°C. The mobile phase was  5 mmol  L−1  NaH2PO4  delivered  isocratically  at  flow  rate  of  1 mLmin-1 . Melamine was linear at concentration range of 0.0625 – 50.0 µg/ml with coefficient of determination (R2 ) of 0.999.
Extraction and Stability Test of Anthocyanin from Buni Fruits (Antidesma Bunius L) as an Alternative Natural and Safe Food Colorants Amalia, Fera; Afnani, Galih Nur
Journal of Food and Pharmaceutical Sciences Vol 1, No 2 (2013): J. Food Pharm. Sci (May-August)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (527.93 KB) | DOI: 10.14499/jfps

Abstract

Synthetic  dyes  have  widely  been  usedin  food  products.  However,  the  safety  issues regarding  the  use  of  synthetic  dyes  arise.  Buni  (Antidesma  bunius)  which  contains anthocyanins can be an alternative of synthetic dyes. Anthocyanins are red, blue, or violet natural  colorants  from many  types of plants. The aim of  the  study was  to determine  the best  extraction process  and  to  evaluate  the  stability of  anthocyanins  extracted  from  the Buni fruits. Different combinations of the solvents namely aquadest, ethanol, hydrocloride acid,  and  citric  acid  were  used  to  extract  the  anthocyanins.  The  most  appropriate combination of solvent was determined by the analysis of total anthocyanins content and color  intensity  using  UV-Visible  spectrophotometer.  The  stability  of  anthocyanins  was evaluated using different pH values and  temperature. Ethanol at 70% and citric acid at 3% was  the  most  appropriate  combination  for  the  extraction  with  the  highest  total concentration  of  anthocyanin  (0.58%)  and  color  intensity  (0.324).  The  stability  of  the anthocyanins from Buni was affected by the value of pH, which the most stable condition was set at pH values of 4-5.

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