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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,396 Documents
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NOVEL RP-HPLC METHOD FOR THE QUANTIFICATION OF ABIRATERONE ACETATE SG Vasantharaju
Journal of Global Pharma Technology Volume 08 Issue 09: (2016) September 2016
Publisher : Journal of Global Pharma Technology

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Abstract

Simple, rapid, accurate and specific RP-HPLC method has been developed for quantitative estimation ofAbiraterone acetate in bulk and tablet. Separation was attained by using Acclaim C18 column (50mm x4.6 mm, 5) at 25C and 80:20 v/v acetonitrile:ammonium acetate buffer(10mM) of pH 6.0 with flow rateof 1ml/min as mobile phase and the drug was detected at 254 nm. Analytical method was said to belinear over a range of 0.125-60 g/ml with correlation constant of 0.999. Method was appeared to beprecise, robust and rugged. LOD and LOQ were found to be 10 ng/ml and 50 ng/ml respectively and themean recovery value as 100.52%.Stability indicating capability of this method has been demonstrated byanalyzing stressed samples of drug and found labile to acidic, alkaline, oxidative, thermal and photolyticconditions. Above method was applied for the estimation in API, formulation and dissolution testing ofthe dosage form. Percentage assay of the formulation was found to be 101.66%w/w. Drug released to anextent of 85.29% at 30 minutes as per FDA published method. Thus, the analytical procedure is reliableand offers advantage in terms of speed; so could be effectively used for the routine quality controlpurpose.
Synthesis , Identification and Evaluation Antimicrobial activity of some novel N-substituted Azetidinone, Imidazolidinone and Tetrazole incorporating 2- phenyl- 3- (ethyl acetate)-quinazolin-4(3H)-one Maryam M. Sahib
Journal of Global Pharma Technology .
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Abstract

A novel series of azetidinone, imidazolidinone and tetrazole incorporating quinazolin-4(3H)-ones were synthesized and evaluated their antimicrobial activity in this research.  Anthranilic acid as a simple molecule under acylation with benzoyl chloride yielded 2-benzamidobenzoic acid [1] followed by cyclization reaction of compound [1] with acetic anhydride yielded 2-phenyl-4H-benzo[3,1]oxazin-4-one [2] that treatment with ethyl glycinate yielded 2-phenyl-3-(ethyl acetate)-quinazolin-4(3H)-one [3] as a starting compound. Compound [3] was reacted with hydrazine hydrate to gave 2-phenyl-3-acetohydrazide-quinazolin-4(3H)-one [4]. aroyl hydrazone derivatives [5-9] prepared by reacted of compound [4] with different substitution aromatic aldehydes. Then compounds [5-9] was cyclization under three pathways with chloro acetyl chloride, 2-amino acetic acid and sodium azide to gave azetidinone derivatives [10-14], imidazolidinone derivatives [15-19] and tetrazole derivatives [20-24] respectively. Moreover the chemical structure of synthesized compounds were identified via different techniques such as FTIR,1H-NMR,and13C-NMR and some of its physical properties were measured. Also we have evaluated the effect of some prepared compounds against four types of bacterial and fungal strain. The result showed significant actions for this compound as antimicrobial agents.Keywords: Quinazolin-4(3H)-one, Schiff base, Azetidine, Imidazolidine, tetrazole, Anti-microbial.
Spectrophotometric Studying for Some Organic Compounds as (Drugs) by using (FT.I.R.) Spectrum and High Performance Liquid Chromatographic Technic for Valsartan and Hydrochlorothiazide in Pharmaceutical Preparations Tablets Imad Tarek Hanoon
Journal of Global Pharma Technology Volume 11 Issue 07
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Abstract

Used and complete organic analytical spectrum by using (FT.I.R.) spectrum to prove the chemical structures for some organic compounds as (drugs) of Valsartan and Hydrochlorothiazide (1) and supported by reverse phase high performance liquid chromatography (HPLC) method has been developed for the determination of valsartan and hydrochlorothiazide in pharmaceutical preparations tablets .Chromatography was carried out on supelco L7 column (25cm×4.6m.m), 5µm. Using Buffer solution , methanol and acetonitrile at ratio 35 :25 :40 accurately  as mobile phase. The flow rate was 1.0 ml.min-1 with Uv-detection at 270 nm at 50C°. Separation was completed within 1.42 min and 5.74 min. Calibration curve was linear coefficient correlation 0.9948 and 0.9980 over a concentration range of (30-50µg.ml-1) and (5-15µg.ml-1). The relative standard deviation (RSD) was found <1%.The proposed method was successfully applied to the determination of valsartan and hydrochlorothiazide in pharmaceutical preparations.Keywords: Valsartan, Hydrochlorothiazide, Linearity, FT.I.R., HPLC, Tablet form
Association between obesity and depression among women in Indonesia: A questionnaire based study Susi Ari Kristina; Nur Aini Mardea; Suci Hanifah
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Obesity is a global public health issue and the prevalence of obesity is growing worldwide every year. Studies have been performed since the early 1970s on the association between obesity and depression or other psychological disorders. In Indonesia, however, only a small number of studies have been carried out. The aim of this study was to examine whether obesity was associated with depression in a sample of women with overweight and obesity based on their BMI, anti-obesity treatment experience, and age among women in one province in Indonesia. Women aged 18 years and older who were selected from fitness centers in urban area of Yogyakarta province and self-reported BMI categorized as overweight and obese were eligible to participate. Voluntary participation in study survey was consented. A set of questionnaire consisting demographic characteristics and depression symptoms was developed and validated. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9), with a score of ≥10 used to indicate severe depression. Respondents who classified as overweight mostly had minimal depression level (33.58%) and none had severe depression level, whereas respondents who classified as obese mostly had moderate depression level (44.74%) and 3.95% had severe depression level. This study found that BMI, experience of using anti-obesity drugs, and age of respondents were significantly affected PHQ-9 score. Thus, these factors determined the level of depression among women surveyed. The study reported significant association between obesity and depression among women. This association depends on BMI, anti-obesity treatment experience, and age variables. Approaches to public health to reduce the burden of obesity or depression have to consider the strong link between these two common conditions.
Synergistic Effects of Bleomycin and Hypericum Triquetrifolium Extract on Bone Marrow and Germ Cells of Albino Mice Bushra Mohammed Amin Mohammed
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
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Abstract

The aim of this study was to explore the cytogenetic effects of Bleomycin (BLM) and the aqueous extract of Hypericum triqutrifolium  each alone and their interaction (pre-treatment, post-treatment, co-treatment) on bone marrow and germ cells of Swiss albino mice depending on  Chromosome aberration assay, Micronuclei test , Mitotic index assay in addition to sperm abnormal morphology assay .The result showed  that the administration of a single dose of Bleomycin (80mg/kg) and of H. triqutrifolium (17mg/kg) each alone, for three consecutive days  have the ability to increase the total abnormal chromosomes, total micro nucleated cells and reduce the percentage of mitotic index value in bone marrow cells, in addition to enhancing the total number of abnormal spermatozoa .While their interaction revealed that the co-treatment (the mixture of Bleomycin and H. triqutrifolium ) amplify  significantly the total aberrant chromosomes  ,the most frequent types were ;chromatid break with fragment, ring chromosome, dysenteric chromosome , and  chromatid gap. Similar reduction in the percentage of cell proliferation but with a non-significant value was observed in pre, post and co-treatment.  Moreover the co-administration had increased the total number of micro nucleated cells and enhances significantly the frequency of abnormal sperm cells such as bent mid piece, irregular head, coiled tail and corkscrew types compared with the treated and untreated animals. Overall, those results herein found suggest an herb-drug interaction between H. triqutrifolium extract and Bleomycin, which clearly increase the drug bioavailability, with the lowest acute cytotoxicity .To reliably assess the clinical impact of these findings appropriate human studies should be conducted.Keywords: Bleomycin, Chromosome aberration, H.triqutrifolium, Micronuclei test, Mitotic index sperm abnormalities.
The Study of Electrical Activity of the Triceps Brachia Muscle according to the Chemical Changes of Water Loss during Spike in Volleyball Haythem Ali Alsayigh
Journal of Global Pharma Technology .
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Abstract

The aim of this study is to study muscle activity of triceps according to what happens from chemical changes due to loss of water in a volleyball game, especially in spike skill, since this skill requires the performance of high accuracy and speed of a big reaction. Was selected sample of players who suffer from potassium deficiency (Hypokalemia) as a result of incorrect nutrition and not to drink fluids regularly as well as the performance of the game in hot weather, which led to an imbalance in the ionic balance of the cell as a result lost a little amount of potassium ion is essential for the occurrence of muscle contraction. The results showed that continued positive performance without compensation potassium element led to an imbalance in muscular activity of the triceps muscle.Keywords: Electrical activity, Muscle triceps brachial, Chemical changes, Water loss, Spike and volleyball.
The Role of Rooting Cofactors in Improvement of Rooting Response in Difficult-to-Root Cuttings of Nerium Oleander Var. White (Vs .Pink var.) Abdullah I. Shaheed
Journal of Global Pharma Technology Volume 11 Issue 09: (2019) September 2019
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Abstract

In the current study, it has been identified that white oleander is impossible or difficult-to-root (0.00%) while, pink oleander is slightly difficult -to-root cuttings (6.67 %) in absence of supplied auxin (treated with distilled water). However, to improve the capability of rooting response of white oleander cuttings (difficult-to-root variety), six treatments have been employed including identified (e.g. o-coumaric acid) and un-identified co-factors (e.g. whitetope seeds extract), individually and in combination with IBA and the results revealed the followings:-Some of these treatments were at high level of significance (P0.05), verifying an original  successful and economical acceptance by vegetative propagation of difficult-to-root cuttings (white oleander) that  caused (induced) to root and increased vegetative traits, when supplied individually or in combination with  IBA, the highest values are represented in the following treatments:-O-Coumaric acid  in combination with  IBA  was induced  rooting  percentage (33.33%), average roots no.(23.67), chlorophyll content (28.03 SPAD unit) and length of branches (15.00 cm)  Whitetope seeds extract in combination with IBA, induced rooting response (20%), roots no. (28.60)/cutting, leaves no. (39.30) and leaf surface area (15.80) cm2  IBA, Whitetope seeds extract, were induced rooting percentage (6.67%).   As a comparison with pink oleander, all treatments that have been tested were stimulated rooting  when supplied in combination  with   IBA , at a rate higher than white  oleander except d/H2O, o- Coumaric acid  and whitetope extract treatments, where the response is zero. However, the maximum response in rooting % was found with combination between IBA and o- Coumaric acid followed by IBA+whitetope extract (33.33%). However, the discussion was focused on a)phenolic compounds as auxin protectors from destruction by IAA-O enzyme  b) o-coumaric acid as anti-oxidant by activation of electronic conjugation c) plant extracts containing substances considered as precursor for its conversion into non enzymetic anti-oxidant such as GSH, proline. etc and its role in AsA-GSH cycle, or substances that enhances CAT, SOD enzymes that activates the anti-oxidant defense mechanisms and consequently enhances rooting response.Keywords:- Anti-oxidants, Co-factor, Difficult-to-root cuttings, IAA-O, IBA, Improvement of rooting response, Inhibitors, Nerium Oleandr, o-Coumaric acid and whitetope  seeds extract.
Detection of Lgc1 Gene Low Glutelin Content in Rice Cultivars Iraq using Indel Markers Zeina Thamer Abdul Hussein Al-Rufaye
Journal of Global Pharma Technology Volume 10 Issue 08: (2018) August 2018
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Abstract

Low glutelin content rice is a good diet for patients with renal failure. Delete about a 3.5kb of a Low glutelin content Lgc1 gene sequence located in the second chromosome on the short arm between highly similar glutelin genes GluB5 andGluB4. To increase the significant, we proposed to select the adequacy in Lgc1 rice breeding, 2 molecular markers we developed to reveal the gene Lgc1, which were specified as InDel-Lgc1-2 & InDel-Lgc1-1, respectively. Our results such as The PCR results showed that band 509bp in all varieties of rice, we conclude varieties of rice in Iraq have high glutelin content. Therefore, we cannot use it for the patients with kidney failure and diabetes.Keywords:  Oryza sativa L, Lgc1 Gene, Indel Markers.
Cytotoxicity of Fumaria Officinalis on Leishmania Tropica, L20B Cell Lines and Bacteria In Vitro Ahmed Younus Abed
Journal of Global Pharma Technology Volume 11 Issue 03
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Abstract

Fumaria officinal is (Shahatraja in Arabic), one of the popular herbal medicines used in Iraq. There are more than 60 species of Fumaria around the world, and many useful properties recognized for this herb. The aim of this study is to investigate the effects of the extracted alkaloids, and crude alcoholic extract on Leishmania tropica (L tropica), and L20B cancer cell lines, in additional to study the toxic effect of these two extracts on many types of bacteria and comparing the results in both cases. Viability rate of treating L tropica cells by the alkaloids and crude extracts were increased significantly in all concentrations. All concentrations of alkaloids extract showed toxic effect on L20B cell lines, except (0.015 mg/ml). While for crude extracts, there was no effect on Viability rates of L20B cell lines at all concentration, except (0.125 mg/ml), shown some decrease in Viability rate. The antibacterial activities of the alkaloids increased comparing with crude extracts in four strains of bacteria, Staphylococcus aureus, Bacillus spp., Klebsiella spp., and Proteus spp. While for Salmonella spp., the inhibition zone was increased in crude extracts more than alkaloids. The results for three remaining bacteria (Streptococcus pyogenes, E. coli, and Enterobacter spp.) were equal in their inhibition activity. From results of present study, the alkaloids that extract from Fumaria officinalis, made the best effect as anticancer and antibacterial agent.Keywords: Cytotoxicity, Anticancer activity, alkaloids, Fumaria officinalis, L20B cell line, antibacterial agent.
Molecular Detection of Multi-drug Resistant Acinetobacter baumannii from Patients Wounds Amina N. Al-Thwani
Journal of Global Pharma Technology Volume 12 Issue 02 (2020) Feb. 2020
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Abstract

150 swabs were collected from patient's wounds and hospital units, population of this study included both genders with different ages in AL-Imamein AL-Kadhimein Medical City in Baghdad. The collected swabs were cultured using appropriate media and tested biochemically in order to find out the profile of bacteria that colonize patient's wounds and hospital units. The results of culture revealed that, the most common isolated bacteria were, Staphylococcus aureus followed by Pseudomonas aeruginosa and A.baumannii. The isolates of A. baumannii was tested for antibiotic susceptibility, the results showed that, clinical and environmental isolates were (100%) resist to Ceftriaxone, Ceftazidime Ampicillin–Sulbactam, and Cefepime. Metallo Beta Lactamase (MBL) genes as bla IMP gene and bla VIM were detected by Molecular method (PCR) in 12 clinical and environmental isolates of A.baumannii. The result revealed that among all isolates (12) only bla IMP gene was detected in 4 isolates while the reminder isolates (8) of A.baumannii have no amplified bands for neither bla VIM nor bla IMP. It was concluded that, A.baumannii responsible for many nosocomial infections, and these bacteria were high resistant to different types of antibiotics.

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