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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,396 Documents
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FORMULATION AND EVALUATION OF BUSPIRONE ORAL DISINTEGRATING TABLETS USING BANANA POWDER ahmed ABDUL sami
Journal of Global Pharma Technology Volume 9 Issue 11
Publisher : Journal of Global Pharma Technology

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Abstract

The present study aims to formulate and evaluate oral disintegrating tablet of buspirone. A drug that is used for the treatment of anxiety management was prepared by direct compression method using natural disintegrates. Eight formulations (F1-F8) of oral disintegrating tablets of buspirone were prepared by using natural disintegrates. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption, wetting time, and disintegration time and in-vitro dissolution study. Based on the results of FT-IR and DSC studies, majority of the excipients were found to be compatible with buspirone which were used for the preparation of buspirone oral disintegrating tablets. Among all the formulations F3 (containing 15mg of natural disintegrate banana powder) was considered to be the best formulation, which releases up to 98% drug in 8 minutes. From this study, we can conclude that, a formulated tablet of buspirone containing banana powder is better and effective to meet the patient compliance.
Polymorphism of ITS4 Gene of Candida guilliermondii Wafaa K. Al-mansour
Journal of Global Pharma Technology .
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Abstract

The aim of this study is investigate the polymorphisms of Candida guilliermondii based on ITS4 gene sequencing. To achieve this goal, samples were collected from  patients with dermal infection symptoms, were applied for microbiological analysis using SDA media DNA was isolated from Candida guilliermondii and the ITS4 gene were amplified by using specific primer, then sequencing of nucleic acid of genes was performed by machine is AB13730XL, Applied Biosystem, Macro gen company, the DNA sequencing results of flank sense of ITS4 gene from 5 strains of Candida guilliermondii was found to be compatible 99%  and score 1517 and expect 0.0 of the ITS4 gene of  Candida guilliermondii strain BO418 from the Gene Bank, The expected substitution  were found after the analysis of the sequences there were 5 Transversion  and one transition in the 5 Candida guilliermondii with  Sequence ID emb|AJ3tf10144.1| location at range of nucleotide from 5128 to 5408, compared with data obtained from Gene Bank, these finding lead to conclusion, our assay allows rapid detection of Polymorphism in Candida guilliermondii.Key words: Candida guilliermondii, ITS4 gene, Polymorphism, and Sequencing.
Photographical Assessment of Face Pleasantness using Facial Analysis for a Sample of Iraqi Adults Females (Retrospective Study) Shahbaa A. Mohammed
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Aims: The aim of this study was to assess facial attractiveness and to check if the numeric facial analysis can determine this attractiveness for a sample of Iraqi adults' females and characterize the studied sample according to subjective concepts of facial esthetics in esthetically pleasant, esthetically acceptable and esthetically unpleasant, considering frontal photographs.  Subjects and Methods: Forty frontal standardized photograph of females aged between 20 and 22 years old. The frontal photograph and lateral photograph were obtained by asking each female to look to the center of the lens and at a distant mirror respectively which is placed in front of her face. All the frontal photographs were evaluated by using our own esthetics criteria (orthodontist evaluation) as graduation in: pleasant, acceptable and not pleasant. The numeric facial analysis was then performed. Linear, proportional and angular measurements were compared among groups. Results: The sample was consisted of 25% of unpleasant, 55% of acceptable and 20% of pleasant according to subjective analysis.  In most measurements there were no differences among groups. Just in one linear measurement (sn-U1 FILS) significant statistical difference was observed. Group III has higher right and a left symmetry angel despite it has lower facial symmetry Conclusions: In the evaluation of facial measurements, it was observed that there were statistically non-significant except for the sn-U1 FILS, which is statistically significant. The photographic evaluations require more than one evaluator in different specialties to give more reliable judgment. The facial analysis influenced by, age, gender, cultural and racial factors.Keywords: Attractiveness, Facial esthetics, Facial analysis.
A Review on Novel Biochemical Mediator Triggered on Demand Drug Delivery System Mithila Sawalwade; Anup Naha; Shubham Zende
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
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Abstract

Unavailability of drug in appropriate amounts on apt time at the desired site of action can lead to further complications in the diseases which can turn into more deadly condition. Timely delivery of right amount of drug is very crucial in proper therapy, thereby avoiding the adverse effects of the drug. Feedback regulated closed loop delivery system can controllably deliver the drug on demand which means the release rates can be increased, decreased or totally stopped, as a response towards physiochemical response produced by the body. The system can be designed in such a way that the concentration of the drug released from the system is proportional to the degree of stimuli produced by the body. Various diseases and disorders progress by feedback loop mechanisms, owing to which biochemical signal triggered delivery of drug can be achieved in such conditions. The system is also advantageous in case of some drugs whose fluctuation in plasma concentrations is unenviable. In the current work, self-regulated drug delivery devices designed for various conditions like diabetes mellitus, hypercoagulation, cancer, microbial infections and opioid poisoning are reviewed. Various combinations of smart polymers are employed to design such devices that work by responding to the feedback produced by the body.
The Impact of a Training Program Using Brain-based Learning Theory in the Development of Creative Thinking and Skills of Passing and Scoring of Young Player's Handball Nabeel. Kazem Heribd
Journal of Global Pharma Technology .
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Abstract

Through field work and handball experience it was noted that there are weaknesses in the performance of basic skills (passing and scoring) and correct behavior and lack of appropriate solutions for players to perform basic skills and this negatively affects the performance of the player and thus the results of the team believes one of these reasons weakness in the creative thinking of players Therefore, the researcher sought to use the theory of learning based on the brain in the development of creative thinking and skills of passing and scoring of young players handball.This experiment is the first step in the sport in general and in the field of handball in particular, and the objectives of the research:Preparation of a training program using the theory of learning based on the brain to develop creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.To identify creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.Knowledge of the impact of the training program using the theory of learning based on the brain to develop creative thinking and skills of passing and scoring of youth handball in the club Alqasim Sports.The researcher used the experimental method and determined the research society of the players of the club Alqasim youth of handball, the number of (19) players were drawn random sample of the number (12) and were divided into two groups (control and experimental) The most important conclusions are:The training program using brain-based learning theory has a positive impact on the development of creative thinking of young players in handball.The approach adopted by the coach has a positive impact in the development of skills of passing and scoring of young player's handball.The training program using brain-based learning theory has a better effect on the development of the skills of passing and scoring of young player's in handball.Keywords: Training program, Brain, Learning theory, Creative thinking and handball.
Is There a Correlation Between Coronary Artery Ectasia and Neutrophil-Lymphocyte Ratio? Kamal Khadem Vatani
Journal of Global Pharma Technology Volume 08 Issue 04
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Abstract

Objectives: Coronary artery ectasia (CAE) has been defined as a dilated artery luminal diameter that is at least 50%greater than the diameter of the normal portion of the artery. Isolated CAE is defined as CAE without significant coronary artery stenosis and isolated CAE has more pronounced inflammatory symptoms. Neutrophil to lymphocyte ratio (NLR) is widely used as a marker of inflammation and an indicator of cardiovascular outcomes in patients with coronary artery disease. We examined a possible association between NLR and the presence of isolated CAE. Study design: The study population included 150 patients (78 male; 72 female; mean age 53.8±6.5).including 50 patients with CAE and 50 patients with coronary artery disease and 50patients with normal coronary arteries. Baseline neutrophil, lymphocyte and NLR measured at admission in all patients. Results: The NLR significantly higher in patients with CAE than dose with normal coronary arteries (2.36 ±1.16 Vs 1.44±.58 p<0.001).The isolated CAE and CAD groups were similar in terms of NLR, neutrophil counts and lymphocyte counts. Conclusion: The N/R ratio is higher in patients with CAE. This ratio is related to presence of CAE.Keywords: Coronary Artery, Neutrophil-Lymphocyte Ratio.
Molecular Detection of some Virulence Genes of Streptococcus agalactiae Isolated from Pregnant Women Lamees A. Abdul-Lateef
Journal of Global Pharma Technology Volume 11 Issue 2: 2019
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Abstract

virulence factors like surface proteins, biofilm, and exotoxins s. All these allow bacteria to adhere to tissues causing pathogenesis and invade the immune system causing serious infection. Materials and Methods: A total of 300 samples, 25 of Strep. Agalactiae were collected in this study. Strep. Agalactiae were isolated from pregnant women by standard bacteriological methods. PCR was conducted to determine the some virulence genes of the isolates by using primers cyle, scpB, and hylB. The PCR amplification products were visualized by electrophoresis on 1% agarose gels for 30min at 70v. The size of the amplicons was determined by comparison to the 100 bp allelic ladder. Results: In this study, 25 isolates of Strep. agalactiae were genotypically characterized by PCR assay. Among isolates studies it was found that cylE gene present in all isolates. Also 100% of isolates have ability to produce scpB gene while only 11(44%) was able to produce hylB.Keywords: Streptococcus agalactiae, cylE, scpB, hylB.
Association of Mannan Binding Lectin to Liver Fibrosis in Chronic HCV Patients Wafaa Ezzat
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
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Abstract

The interaction between viral and host immune factors plays an important role in natural history of chronic HCV infection .We aimed to determine serum level of MBL and its relation to grades of liver fibrosis in chronic HCV patients.we studied the impact of serum level of MBL on early virological responsein chronic HCV patients.subjects and methods: included 70 HCV patients (40 HCV patients with liver fibrosis grades <F3 (group Ι) &30 HCV patients with liver. fibrosis ≥F3 (groupΙΙ) according to METAVIR score), who fulfilled inclusion & exclusion criteria of the National Egyptian treatment protocol of treatment of CHC, in addition to 16 control subjects. All studied cases were subjected to history taking, thorough clinical examination, routine investigation(fasting blood sugar, serum creatinine, alkaline phosphatase, ALT, AST, total bilirubin, albumin ,complete blood picture ,prothrombin activity, alpha feto-protein, TSH) ,  abdominal ultrasonography and liver biopsy in addition to ELISA for MBL. Results: mean values of MBL was significantly increased among group 2 patients more than that of group 1(P=0.001). After 12wk of combined therapy, it was found that 61 patients (87.14%) were responders to antiviral therapy, while9 patients (12.85%) were non responders.  The mean value of MBL among responders was 64.44± 26.75 while it was 90.41± 82.41 without any statistically significant differences. So it can be concluded that MBL plays an important role in the pathogenesis of liver fibrosis in HCV liver disease. MBL has no impact on early virological response among patients with chronic HCV infection.
Instruction Ability of Wild F. Solani Related by Mutant Straining for Production Au NPs Intesar Ali Mezeal
Journal of Global Pharma Technology Volume 10 Issue 06: (2018) June 2018
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Abstract

Present determination studies creation of Au NPs by gentle F.solani besides influenced modified straining toward divider by everyone .Cell filtrate of F.solani castoff on behalf of reduction gold nitrate to Au NPs.  Values obtainable attainment uninhabited and the modified straining tilted (Fusarium solani B1), (Fusarium solani B2),( Fusarium solani B3), ( Fusarium solani B4) , That stayed intellectual toward manufacture   Au NPs. Values obtainable consultation stayed absorption afterward four hrs. by modified    ( Fusarium solani B3)  make sure extreme absorption band  (0.739) observed via  ( Fusarium solani B1) (0.723) afterward four hrs., followed via ( Fusarium solani B2)   (0.701)  afterward five hrs., followed via ( Fusarium solani B4)   (0.663 ) afterward five hrs., however trendy  in uninhabited  straining  stayed (0.578) afterward six hrs. numbers obtained by micrograph pictures via   (TEM) pledge dispersed figure , size of Au NPs below observation of images, conferences stayed create to stay assortments of Au NPs in size diversity (50–60) nm shaped   (Fusarium solani B3)  , nevertheless  in   ( Fusarium solani B1) size variety (40-50), while they were between   (30-40) in ( Fusarium solani B2) and  between (20-30) by  (Fusarium solani B4)  , whereas in uninhabited straining were between (15-20). Occupied data discuss that noticeably unprotected the information to AuNPs consumed unimportant effect on seed growth as connected to controller management. Typical produced atoms not behavior several toxicological properties in seeds concluded growth therefore development percentage stayed not pretentious.                                                                                          Keywords: Modified, Bio control, TEM, Au NPs, Fusarium solani, growth. 
Estimation of Some Immunological and Physiological Parameters for Obese Human Amera Kamal Mohammed
Journal of Global Pharma Technology Volume 9 Issue 10
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Abstract

Adipose tissue expansion during obesity is associated with inducing Proinflammatory and inflammatory cytokine responses, decreasing insulin sensitivity, type 2 diabetes mellitus and dyslipidemia. The objective of this study was to determine some humeral immune levels including, serum IL-1βand C-reactive protein (CRP) as well as blood glucose and lipid profile as physiological criteria. Blood samples were collected after  an overnight fast from a group of obese (n = 48)and none- obese (41) as a control group depending on BMI withwaist circumference with age ranged between (20-40 year).The results  revealed that significant increase (P≤ 0.05) in mean of BMI(Kg/M2) ,WC (cm), CRP (ng/mL), FBG (mmol/L), total cholesterol(mmol/L)and , low density lipoprotein (mmol/L), while there is no significant difference  in the levels of IL-1β (pg/mL), triglyceride(mmol/L), high-density lipoprotein (mmol/L) and very low density lipoprotein (mmol/L) among obese individuals  compared with control group , and depending  on the sex of the study groups the results showed that significant increase (P≤ 0.05) in means of BMI(Kg/M2) , WC (cm), IL-1β (pg/mL), FBG (mmol/L) ,while there is no significant difference  in means of CRP (ng/mL), TC(mmol/L) , LDL(mmol/L), TG(mmol/L), HDL(mmol/L) and VLDL(mmol/L). The data demonstrated that the three classes of obesity had higher significant differences (P≤ 0.05) in means of BMI (Kg/M2), WC (cm), and CRP (ng/mL), FBG (mmol/L), TC (mmol/L) and, LDL (mmol/L).Keywords: Obesity, Type 2 diabetes, Insulin resistance, Immunity, Inflammation.

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