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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

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Articles 207 Documents

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The Effect of Tempeh on the Ability of Macrophage Phagocytosis An experimental study in male Balb/c mice Afiyata, Noven; Sarosa, Hadi; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Consuming tempeh regularly increases the levels of isoflavones in the our body influencing the IFNÃ£ and macrophage activating factor (MAF) that lead to the in increase in the ability of macrophage phagocytosis. Macrophage phagocytosis gives an illustration of the macrophages ability as the first line of phagocytic cells to digest foreign particles. This study aims at finding out the influence of tempeh on the ability of macrophage phagocytosis.Design and Methods: In an experimental study using post test only control group design, 15 mice Balb/c were divided into 3 groups of 5 mice each. Gp1: 0.5 gr of tempeh juice, Gp2: 1 mg tablet imboost in 1 cc of water (positive control), Gp3: 1 cc of 1 times (negative control). Treatment was given daily for 12 days. On day 13, Phagocytic ability of macrophages were examined using latex beads method. Data were analyzed using one Kruskal Wallis test followed by Independent T-Test.Results: The phagocytic ability for the three groups were 760,6 -----Â± 109,898 ; 244.2 Â± 70.159; 9.6 Â± 2.839 respectively. Independent t- test resulted in the significance difference (p = 0.008) between treated groups and control groups, both positive and negative ones (p<0,05).Conclusion: There is a difference in phagocytic ability between treatment and control groups (Sains Medika, 3(1):54-62).

Sterility of Gauze Packed in One and Three Layer Layer Parchment Paper Putri, Saskia Biyakto; Lestari, Endang Sri; Ciptaningtyas, Vincentia Rizke
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): January - June 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Intoduction: Sterile gauze is one of the medical devices that are often used to prevent infection. Several things, one of them is materials for packaging, can affect the sterility of gauze. Parchment paper is one of the packaging materials for sterilization. The study was done to analyze the sterility of gauze packed with parchment paper one layer and three layers on the growth of microorganism.Method: This study was an experimental study with a quasi-experimental design. Samples were 60 gauze packed with one layer parchment paper and 60 gauze packed with three layers of parchment paper. The sterility of sterile gauze tested at weeks 0, 2 and 4. Results: There was no significant difference in the sterility of gauze packed with 1 layer of parchment paper on the growth of microorganisms at 0, 2, 4 weeks (p = 0.126). No significant difference in the sterility of sterile gauze packed with 3 layers of parchment paper at 0, 2, 4 weeks (p = 0.675). There was a significant difference in the sterility of sterile gauze packed with parchment paper 1 layer and 3 layers on the growth of microorganisms (p = 0.002).Conclusion There is a significant difference of sterile gauze packed with parchment paper 1 layer and 3 layers against the growth of microorganisms. The sterility of the packaged sterile gauze with a layer of parchment paper is better than the three layers.

Sensitivitas dan Spesifisitas Pemeriksaan Imunokromatografi Tuberkulosis Dibandingkan dengan Kultur Lowenstein-Jensen
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 1, No 2 (2009)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v1i2.1677

Effect of Celery Extract Administration on 8-OHdG and Number of Foam Cell in Wistar Strain Rats With A High-Fat Diet Budiarto, Agnes; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): July-December 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

BACKGROUND: A high fat diet, accompanied by high frequency eating, results in hyperlipidemia. One prevention for hyperlipidemia is administration of celery extract.OBJECTIVE: to explore the effect of celery extract on the level of 8-OHdG (8 -Hydroxy-2’-Deoxy Guanosine) and the number of foam cell.METHODS: Experimental studies with post-test only control group design used Wistar rats, administered with adrenaline and high-fat diet forhyperlipidemic induction.Total of 35 rats were divided into 5 groups: negative controls (Neg-G); positive control treated with simvastatin (Nor-G); ES25-G,ES50-G, and ES75-G group were treated with 25 mg/200 g BW, 50 mg/200 g BW, and 75 mg/200 g BW celery extract, respectively. The treatment was given for 30 days. The 8-OHdG level was determined by ELISA, whereas the number of foam cells was determined by histopathologic preparations with HE staining. Data analysis was conducted by Kruskal-Wallis and Mann-Whitney.RESULTS: Mann-Whitney analysis showed levels of 8-OHdG in ES-25-G 12.13±0.21, ES-50-G 7.23±0.25, ES-75-G 4.41±0.45 significantly lowerthan the Nor-G 14.30±0.66, respectively p<0.001. The number of foam cells in the ES-25-G was 7.57±0.53, ES-50-G 6.57±0.79, ES-75-G 3.43±0.53,significantly lower than the Neg-G 13.57±1.27, respectively p<0.001.CONCLUSION: Celery extract capable of decreasing levels of 8-OHdG and the number of foam cells in Wistar rats induced with adrenaline and high-fatdiet.

The level of Anxiety in Cervical Cancer Patients of Lower Socioeconomic Status Receiving Chemoteraphy in RSUD Dr. Moewardi Yolanda, Albina Eva; Karwur, Ferry Fredy
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Chemotheraphy for cervical cancer can result in physical and psychological side effects. One of the physical effects is anxiety. This study aimed at identifyingthe level of anxiety in cervical cancer patients of lower socioeconomic status receiving chemotherapy. The anxiety assessment was based on the physicaland psychological quetionnaire (HRS-A) with a guided interview with 40 patients of RSUD Dr. Moewardi. The data from the respondents were tabulatedand analyzed using pivot table of Microsoft Ecxel. The result showed that 40% of the respondents had anxiety symtoms, 30% had a mid anxiety and20% had a medium anxiety and 10% had a severe anxiety. Patients with a personal budget tend to have a higher anxiety compared with those who had agovernment health insurance (JAMKESMAS/Public Health Coverage Insurance). There had been several concerns among the patients including 1) thefear of side effect of chemotheraphy, 2) pessimism of the treatment outcome and the thought of death, 3) inconvenience of regular check for chemoteraphyto hospital and concern about the children and family. The level of anxiety varied among respondents. A lower socioeconic status, lower level of educationand the local wisdom of â€˜nrimoâ€™ were responsible for the abcence or lower level of anxiety symptoms in some patients.

The effect of Gandarusa Leaf extract (Justicia gendarussa Burm F.) Administration on Estradiol Hormone Level and the Amount of Antral Ovarium Follicle on Female Mice Laili, Ni'mah Hidayatul; Nasihun, Taufiqurrachman; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): July-December 2018
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Physiologically, woman experiencing aging characterized by menopause. Gandar usa leaf contains isof lavon, a phytoesterogen expected to be used as esterogen replacement therapy.Objective: the aim of this research is to investigate the administrative ef fect of gandar usa leaf extract on the increase of estradiol hor mone level and the number of antral ovarium follicle of female mice.Methods: This is experimental study with posttest only control group research design. Samples are 24 balb-c female mice, aged 16-17 months, weighed 19-35 grams, divided into 4 groups. Control group (Ctrl-G) were given 0.48 ml aquadest; group JB10-G, JB20-G, and JB30-G, each were given gandar usa leaf extract with concentration 10%, 20%, dan 30% in volume 0.48 ml orally twice a day. Af ter treatment, dissection were conducted to make ovarium histology preparation with Hematoxylin Ehrlich-Eosin staining, obser vation were conducted using microscope.Results: Post hoc analysis indicated that the estradiol level and the number of antral ovarium follicle on administration of gandar usa leaf extract with concentration 10%, 20%, dan 30% are signif icantly higher, p < 0.05. The increase of estradiol level with extract concentration of 10% are signif icantly negatively cor related with the number of antral ovarium follicles p<0.05. negatively cor related with the number of antral ovarium follicles p<0.05.Conclusion: The administration of gandar usa leaf extract increase the estradiol hor mone level and the number of antral ovarium follicle in female mice.

The Effect of Dates Juice on The Bleeding Time An Experimental Study of Male Wistar Strain Rats that Induced by Aspirin. Sari, Rachma Purnama; Sampurna, Sampurna; Pertiwi, Danis
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2013): January-June 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Juice of dates (Phoenix dactylifera) is widely used to reduce the risk of spontaneous bleeding by shorting the bleeding time, for example on hemorrhargic fever and the consequence of consuming drugs (e.g. aspirin, anti coagulant, anti cancer, diuretic, etc). This study aimed to investigate the effect of dates juice on the bleeding time of male Wistar strain rats that induced by aspirin. This study was experimental research with post test only control group design. In this study, 10 male Wistar strain rats were randomly divided into 2 groups. The first group (positive control) were only treated by aspirin and the second group (treatment group) were treated by aspirin and palm dates juice. Mean of the bleeding time in first group was 42,6 + 11,5 seconds and in second group was 28,0 + 3,0 seconds. Distribution of data was normal but not homogenous, so that data was analyzed by non parametric statistic test Mann-Whitney. The result showed that there was significant difference between the first and the second group. This study concluded that juice of dates affects the bleeding time of male Wistar strain rats that induced by aspirin.

The Influence of Administering Propolis CMCE Extract on FSH, LH, and Testosterone Levels in MSG-Induced Male Wistar Rat Sofyanita, Eko Naning; Nasihun, Taufiqurrachman; Zulaikhah, Siti Thomas
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 10, No 2 (2019): July-December 2019
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Monosodium Glutamate (MSG) increase free radicals and effecting on male reproductive hormone balance. CMCE propolis extract can be used as supplement to protect cells from free radical.Objective : To prove the effect of CMCE propolis extract to increase FSH, LH and Testosterone levels in male Wistar rats induced by MSG.Methods : This research was an experimental with post test only control group design used 18 male Wistar rats and divided into 3 groups. Each group on Control (K), P1 and P2 were induced by MSG of 140mg, then on P1 added 8,3mg CMCE propolis extract and P2 10,8mg for 21 days. Then on 22th day of blood was taken through the orbitalis sinus and serum was used for the analysis FSH, LH and Testosteron levels with ELISA method.Results : ANOVA analysis test showed significant differences each group p=0,000(p˂0,05). Post hoc LSD test showed FSH, LH and Testosterone levels in the 8,3mg dose CMCE propolis extract and 10,8mg were significant different compared with control group p=0,000(p˂0,05). CMCE propolis extract 10,8mg dose had the significantly highest effect of FSH, LH and Testosterone levels than CMCE propolis extract 8,3 mg.Conclusion : CMCE propolis extract 10,8mg/day for 21 days is proven to increase FSH, LH and testosterone levels in male Wistar rats induced by MSG.

Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus) Purnasari, Perez Wahyu; Fatmawati, Dina; Yusuf, Iwang
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Wound healing is very important to return skin as soon as possible and the integration is a complex and dynamic process. Proliferation phase involving fibroblasts is one of important step-on wound healing. Use of drugs such as povidone iodine on cuts aims to accelerate wound healing is still being debated. Healing by land snailsâ€™ mucus can be an alternative because it has many benefits. This study wants to know about the influence of land snailsâ€™ mucus on the number of fibroblasts in healing cuts.Design and methods: The study is an experimental research with post test only randomized control group design. The subjects were 18 Mus musculus strain mice that were divided into 3 groups. 1st group as a control group of untreated, 2nd group was given povidone iodine 10%, and 3rd group was given land snailsâ€™ mucus during 5th days. On the 6th day the mices were killed for histological study.Results: The data showed that average number of fibroblast in 1st group is 93,85; 2nd group is 126,37; and 3rd is group 217,5. The results of one way anova statistical test showed significant difference among the three groups p = 0,000. The results of post hoc test showed significant difference in all groups (p < 0,05).Conclusion: The mucus of land snail is influence the number of fibroblast in healing cuts (Sains Medika, 4(2):195-203).

CMCE Propolis Extract Improve Caspase 3 Expressions of The Hepatocytes and IL-6 Levels in Rats Exposed with CCl4 Firdaus, Chalid; Chodidjah, Chodidjah; Nasihun, Taufiqurrachman
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2020): July-December 2020
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Liver plays an important role in the metabolic processes possibly exposed to the toxic materials. One of those hepatotoxic substances is carbon tetrachloride. The propolis extract contains the balsamic active substances, CAPE compounds and flavonoids. Flavonoids can prevent from the apoptosis and reduce the inflammation.Objective: To validate propolis extract’s (CMCE method) ability in improving caspase 3 expressions of hepatocytes and IL-6 levels in Wistar male rats induced with carbon tetrachloride.Methods: An experimental study with a post-test only control group design applied to the study. The research subjects were 28 male Wistar rats, divided into four groups. The negative control group (CN-G) was only injected with CCl4, while the experimental groups were administered with the CMCE propolis at the dosages of 3.6 mg/200g (CM3-G), 7.2 mg/200g (CM7-G), and 14.4 mg/200g (CM14-G). The CMCE propolis extract was administered for 14 days and on day 14, the CCl4 was then given. The caspase 3 expression of hepatocytes was measured using HE liver cell preparations, while the IL-6 levels were measured using ELISA method.Results: The results of Mann-Whitney U statistical analysis showed that the hepatocytes’ caspase 3 expressions in CM14-G (2.77 ± 0.531), CM7-G (3.14 ± 0.378), and CM3-G (4.22 ± 0.690) were lower than those in CN-G (5.43 ± 0.535), p<0.05. Meanwhile, the Post Hoc LSD analysis Results showed that IL-6 levels in CM14-G (55.032 ± 9.336), CM7-G (78.362 ± 8.313), and CM3-G (114.975 ± 10.359) were lower those in CN-G (180.301 ± 5.428), p<0.05.Conclusion: the administration of propolis extract (CMCE method) improve the caspase 3 expressions of hepatocytes and Il-6 levels in Wistar male rats induced with carbon tetrachloride.

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