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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 207 Documents

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Perbedaan Tekanan Darah setelah Pemaparan Cold Pressure Test antara Mahasiswa Tanpa dan dengan Riwayat Hipertensi di Keluarga
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 1, No 1 (2009)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v1i1.1680

Administration of Mung Bean Extract (Phaseolus radiatus) in Increasing Hb and Ferritin Level and Decreasing Malondyaldehide (MDA) Level in Anaemic Rats Wijayanti, Heni; Nasihun, Taufiqurrachman; Hussaana, Atina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): July-December 2017
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

BACKGROUND: Mung bean, not only contains protein, carbohydrates, and fats, but also contains iron and vitamin C which are proven to overcome anemia in pregnant woman. High iron levels are potential to increase ROS production through fenton reaction.OBJECTIVE: to prove the administration of mungbean can increase Hb and ferritin levels and decreasing malondihaldehyde (MDA) in anaemic rats.METHODS: This research uses Post Test Only Control Group Design. A total of 25 anaemic rats were divided into 5 groups: normal group (Nor-G);negative control group (Neg-G), were given low Fe diet; and treatment group with low Fe and mung bean extract at dose of 0,18g/200g/days (GP-0,18), 0,36g/200g/days (GP-0.36), dan 0,72g/200g/days (GP-0.72). Low Fe diet and mung bean extract were administered for 14 days. Hb levels were measured using Sahli method, ferritine level using Immulite Ferritine Kit, and MDA were measured using TBA.RESULTS: Compare to Nor-G and Neg-G, levels of ferritin and Hb on groups with mung bean extract 0,18g (75.56), 0,36g (90.98) and 0,72g (95.87) were significantly higher (p < 0.05). While MDA levels on groups with mung bean 0,18g (4.646), 0,36g (3.396) and 0,72g (1.92) were significantly lower than on Nor-G and Neg-G groups (p < 0.05).CONCLUSION: The administration of mung bean extract can increase Hb and ferritin, also lower MDA level on anaemic rats.

The Polyphenolics and Health Effects of Pomegranate Nge, Sonya Titin; Martosupono, Martanto; Karwur, Ferry Fredy
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 6, No 1 (2015): January-June 2015
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Pomegranate (Punica granatum L.) is a useful fruit which mostly consumed as fresh fruit and can also be used as a various of processed products. Reports proved pomegranate were beneficial to health. Polyphenolic compounds in pomegranate especially ellagitannin (hydrolyzed), anthocyanins, gallotannin,and ellagic acid can maintain oral hygiene, healthy skin from the effects of free radicals caused by UV radiation, has the ability to synthesize cholesterol, destroying free radicals in the human vascular system and can prevent prostate cancer. In vitro and in vivo test has shown the fruit is acting as anti diabetic drug, and hypolipidemic, anticarcinogenic, antibacterial, anti inflamation, and antiviral. This review presenting an overview about the bioactive compound contents, physiological and health function of the fruit.

Analysis of Quality of Pharmacy Management Information System at Sultan Agung Islamic Hospital, Semarang Rosyid, Abdur; Marchaban, Marchaban; Pudjaningsih, Dwi
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): July-December 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Hospital is one of the important links in the service delivery system to the community so that the hospital is expected to provide information to support the provision of timely and accurate services. To improve the quality of hospital services, an up to date information system is needed. The user satisfaction on information system can be used to evaluate the quality of an organization's information system. Objective: to evaluate the quality of the pharmacy management information system (PMIS) at Sultan Agung Islamic Hospital (SAIH), Semarang, and determine the priority of area for improvements.Methods: In this cross-sectional qualititative study, the responses of all employees to questionnaire were obtained; these employees worked at the pharmacy of Sultan Agung Islamic Hospital in Semarang. The PIECES method was applied. The data analysis included gap and customer windowResults: The gap value on the dimension of performance, information, economic, control, efficiency, service was -1.10, -0.82, -0.28, -0.22, 0.01, -0.62, respectivelyConclusion: The user’s unfulfilled expectation on PMIS at SAIH including dimensions of performance, information, economy, control, service, and efficiency. Priority areas for quality improvement of PMIS at the Sultan Agung Islamic Hospital’s phamacy included the menu display, system responsiveness, the completeness of the system, no error occurs, the alert system of the drug stock, the responsiveness of the IT department to the problem of PIMS use.

Sudden Blindness as Post-Hemodialysis Complication Experienced by Patients at The End-Stage of Kidney Disease: a Case Report Perdhana, Langgeng; Chasani, Shofa; Martiningsih, Wahju Ratna; Yekti, Murwani; Arinawati, Arinawati
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): July-December 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Hemodialysis is the most preferred Renal Replacement Therapy (RRT) options for End-Stage Kidney Disease (ESKD) patients. Although it is safe and beneficial for patients, several complications may occur during hemodialysis process. One complication that is rarely found in the hemodialysis process is visual impairment. Visual impairment or even sudden blindness occured during or within 24 hours post hemodialysis. Objective: To describe the occurring sudden blindness as a rare complication in patients undergoing hemodialysis and its etiology.Brief Case: 19 years old man with ESKD undergoing hemodialysis for 1 month with a complaint of sudden blindness in both eyes occurring <24 hours post hemodialysis.Discussion: Fast and precise efforts are needed to diagnose the etiology of blindness, so that prevention and appropriate treatment can be immediately taken. Multidisciplinary teamwork is needed to diagnose the etiology of visual impairment.Conclusion: Sudden blindness in this case may be caused by the 3rd degree hypertensive retinopathy caused by malignant hypertension and Posterior Reversible Encephalopathy Syndrome (PRES)

No Structural Change in Mice Intestinal Gut-Associated Lymphoid Tissue After Trichuris muris Egg Infestation Illiandri, Oski
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): July-December 2021
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: It has been known that the infestation of Trichuris muris egg in the intestinal mice may induce a host immune ‎response to eliminate the worms. Worms antigen will stimulate host immune response in the intestinal ‎secondary lymphoid organs. One of the secondary lymphoid organs in the intestinum is GALT (gut-‎associated lymphoid tissue). Worm antigen activate naive T cells and naive B cells in GALT and ‎trigger differentiation of T cells into Th2 and stimulate B cell to produce gut IgE. However a structural change of GALT structure is still poorly understood.‎ Objective: This study aims to find influence of embrionic Trichuris muris egg infestation to the structural ‎changes of mice intestinum GALT.Methods: This research uses true experimental method with post-test only with control group design. Mice are grouped into 3 groups. The first group was given 40 Trichuris muris embryonic egg peroral, second group was given 200 eggs, and third was control group. On the 30th day after treatment, the mice were sacrificed and intestinal GALT structural change has been analyzed (p<0.05). Results: There was no effect of Trichuris muris embryonic egg infestation on the structure of mice intestinum GALT. However, there is a unique finding of GALT in the form of a Peyer’s patch in the basal plica transversalis colon proximalis of 1 mice given egg T. peroral murmus, at low doses or high doses. Conclusion: There was no effect of Trichuris muris embryonic egg infestation on the structure of mice intestinum GALT

Aluminum chloride impaired spatial memory, but not senile plaques formation in the rat model of Alzheimer’s disease Narwanto, Muhammad Ihwan; Rahayu, Masruroh; Soeharto, Setyawati; Nurdiana, Nurdiana
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Aluminum compounds can be easily found in the environment. Aluminum contamination is the environmental factor as one of the risk factors for Alzheimer's disease (AD). In the animal model, aluminum chloride (AlCl3) induces inflammation and oxidative stress. Inflammation and oxidative stress are important pathogenesis pathways in the AD. This study was conducted to determine whether AlCl3 can impair spatial memory and induce senile plaques formation. A total of 24 young adult Wistar rats were used in this study. The rats were divided into four groups; one control group and three AlCl3 treated groups with doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg, respectively for 8 weeks. The spatial memory test was measured using Morris water maze and the histopathology was done by identification of senile plaques formation in the hippocampal tissue. Statistical analysis was performed using one-way analysis of variance (ANOVA) followed by Tukey's test for multiple comparisons. The level of statistical significance was set at a p value < 0.05. This study showed that there are significant differences (p<0,05) between the control group and all the AlCl3 treatment groups in the memory test, however, there is no change in the senile plaque’s expression in all groups. Administration of AlCl3 for 8 weeks can cause the impaired of spatial memory without senile plaques formation.

Age Krisniawati, Nia; Ciptaningtyas, Vincentia Rizke; Reki, Winarto
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Most blood culture contaminants are coagulase-negative staphylococci (CoNS), which are also the leading cause of nosocomial bloodstream infections. To date, no research in Indonesia has analyzed the potential causes of a CoNS infection in the bloodstream. The goal of this research was to better understand who is at risk for developing a CONS-related bloodstream infection while in a hospital setting. Secondary data from the CONS blood culture results at Dr. Kariadi Hospital Semarang were used in this retrospective cross-sectional study conducted between January 1 and December 31, 2016. The Vitek-2 Compact System (Biomerieux, USA) and the Kirby Bauer method (Clinical & Laboratory Standards Institute (CLSI) of the USA) were used for the antibiotic identification and sensitivity testing, respectively. Multivariate with multiple logistic regressions and the Chi-Square test for categorical variables were used in the analysis. Among the study's 272 participants, 158 (58.1%) developed CONS-related bloodstream infections. Risk factors for central nervous system (CNS) bloodstream infection in 18-year-olds include preterm birth, low birth weight (LBW), compromised immunity, malnutrition, immunosuppressive therapy, and peripheral intravenous use. Age >=18, malnutrition, and immunosuppression therapy all ranked high as risk factors in a multivariate analysis. Risk factors for CONS-causing bloodstream infections in people aged 18 include malnutrition and immunosuppressant therapy.

Effect of Phylantus ninuri leaf extract on kidney and liver histopathological features in formaldehyde-exposed rats Milla, Meidona Nurul; Istadi, Yani; Rizaldy, Rheza
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Formaldehyde (FA) metabolism in the body reduces glutathione levels, resulting in liver and kidney damage. Phylantus ninuri (meniran) has been demontrated to have hepatoprotective properties. However, the effect of meniran administration on the histological features of the liver and kidney in in formaldehyde-exposed rats has not been adequately studied. The study was aimed to determine the effect of meniran on the histopathological feature of liver and kidney cell. This was a posttest randomized control group design. A total of 24 male Wistar rats were divided into 4 groups of 6 rats each. Group 1 was a control group that received only oral formaldehyde. Group 2, Group 3, Group 4 was administered oral formaldehyde together with meniran extract at dose of 100 mg/kg BW, 200 mg/kg BW, and 300 mg /kg BW respectively for 14 days. The histopathological changes of the kidneys and liver were assesed using hematoxylin and eosin (HE) staining. The mean of kidney and liver damage in the meniran group at various doses was lower than that of control group. There was a significant difference in the mean of kidney damage between the control group and the meniran group at various doses (p<0.05). The mean histopathological score of liver damage showed a significant difference between the control group and various treatments (p<0.05). Ethanolic extract of meniran leaves ameliorates liver and kidney damage in formaldehyde-exposed rats.

The use of herbal medicines in patients with type-2 diabetes mellitus in Indonesia Utomo, Astika Widy; Annisaa, Eva; Antari, Arlita Leniseptaria; Armalina, Desy
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

In Indonesia, the use of herbal medicine as an alternative medicine is increasing. Herbal remedies are used as complementary medicine and self-medication. Diabetes mellitus requires treatment over the long term. This may contribute to the medication adherence problem. Consequently, many patients seek alternative treatments, such as herbal medications. The purpose of this study was to determine the use and type of herbal medicines among diabetic patients in Indonesia. A cross-sectional study with 190 respondents selected at random from multiple cities in Indonesia. A questionnaire was used to determine the most frequently used herbal medicine, the demographic profile of the patients, the health services, and the level of patient satisfaction with the use of herbal medicines. The participants were predominantly female (62.7%), housewives (39.5%), aged between 40 and 65 (84.5%), high school graduates (74.7%), and had low to moderate incomes (74.7%). The use of herbal medicine was 22%, and the combination of herbal medicine and prescription medication was 6%. Bitter leaves (10%), mangosteen peel (8.9%), insulin leaves (7.9%), mahkota dewa herbs (6.3%), and bitter melon are used as herbal or traditional medicines (4.7%). In terms of satisfaction, 28.7%, 40.9%, and 14.4% of respondents were quite satisfied, satisfied, and very satisfied with the use of herbal medicines, respectively. Herbal remedies are commonly used in alternative diabetes treatments. Bitter leaves are the most frequently used herb, with over half of respondents expressing satisfaction with the benefits of herbal medicine.

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