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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 156 Documents
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Multimodal Analgesic Effect on Proinflammatory and Anti-inflammatory Cytokines Serum Muhammad Ramli Ahmad; Tatang Bisri
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To investigate the effect of combination epidural bupivacaine and intravenous parecoxib analgesia on  immune response in patients who underwent open reduction and internal fixation of the lower limb under epidural anesthesia.  Methods: This research was conducted using the randomized, placebo-controlled double blind trial method on 52 patients who were randomly divided into 2 groups: the Parecoxib group which received 40 mg intravenous parecoxib for 30 minutes before incision and the control group which received an equal volume of 0.9% normal saline. Both groups received epidural anesthesia and postoperative epidural 0.125% bupivacaine analgesia continously. Venous blood samples were obtained before parecoxib administration, 2 and 24 hours after the surgery. The data were analyzed using Mann Whitney U and Independent t tests (p<0.05).     Results: There was a significant difference between the two groups (p<0.05) in IL-1β, IL-6, IL-10 levels and proinflammatory to anti-inflammatory ratio, 2 hours after surgery.    Conclusions: Multimodal analgesic combination of 40 mg IV parecoxib and 0.125% bupivacaine epidural analgesia have the effect to alter and stabilize the  systemic immune response.    Keywords: Cytokines, epidural analgesia, interleukins, immune response, parecoxib, tissue damage DOI: 10.15850/ijihs.v2n1.272
Relationship between Periodontal Disease Index and Low Birth Weight Babies in Pregnant Women with Periodontitis Ira Komara; Soertini E Lambri; Ina Hendiani
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To identify the relationship between periodontitis in pregnant women through the periodontal disease index (PDI) and low birth weight babies.Methods: A case-control study was conducted to determine the relationship between periodontitis in pregnant women through the periodontal disease index (PDI) and the low birth weight babies (LBW). The participants were mothers with periodontitis and non-periodontitis mothers aged 20–35 years who gave birth in the Department of Obstetrics and Gynecology-Dr. Hasan Sadikin General Hospital, Bandung in the period of December to January 2005. Results: Based on the chisquare test results a highly significant relationship between periodontitis and low birth weight (p=0.002) was found. The Odd’s ratio showed that the risk of low birth weight in pregnant women with periodontitis was 15.58 times higher compared to those who did not suffer from periodontitis. The periodontal disease index has an accuracy of 88.6% in predicting the incidence of LBW. It strongly influenced the incidence of LBW with a high Odd’s ratio of 28.0. Pregnant women who suffer from periodontitis with a PDI > 3.25, have 19.2 times higher risk for delivering babies with LBW compared to the non-periodontitis mothers. Conclusions: The loss of attachment affects the possibility of delivering LBW babies.Keywords: Periodontitis, periodontal disease index, low birth weight DOI: 10.15850/ijihs.v4n1.681 
Characteristics and Complications of Tuberculous Meningitis Patients with Hydrochepalus Undergone Fluid Diversion in Dr. Hasan Sadikin General Hospital, Bandung Adriani Lawrencia Novalia; Afiat Berbudi; Ahmad Faried; Heda Melinda Nataprawira
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.71 KB) | DOI: 10.15850/ijihs.v6n1.1048

Abstract

Objective: To describe the clinical characteristics and complications observed in tuberculous meningitis (TBM) patients with hydrocephalus who had undergone fluid diversion management.Methods: This was a cross-sectional descriptive observational study involving 28 TBM patients with hydrocephalus aged 0–5 years who had undergone ventriculoperitoneal shunt or extraventricular drainage in the period of July 2011 to July 2016 in Dr. Hasan Sadikin General Hospital, Bandung. Age, gender, head circumferences, nutritional status, and classical characteristics such as sunset eye, frontal bossing, cracked pot sign, venectation as well as complications such as infection, phlebitis, and exposed shunt documented in the hospital medical records were analyzed.Result: The study discovered that infant group was predominant (21/28). Some of the patients had macrocephalus (7/28) and 18 had good nutrition status (18/28). There were 4 patients with frontal bossing characteristics (4/28) and almost none was found with others classic hydrocephalus characteristics. This study found no complication such as infection, phlebitis, and exposed shunt in TBM patients with hydrocephalus who had undergone fluid diversion therapy in Dr. Hasan Sadikin General Hospital, Bandung.Conclusion: One of the most dominan characteristics of TBM patients with hydrocephalus is frontal bossing. Tuberculous meningitis patients with hydrocephalus in our center did not show any fluid diversion-related complications such as infection, phlebitis, or exposed shunt.Keywords: Tuberculous meningitis, hydrocephalus, fluid diversion DOI: 10.15850/ijihs.v6n1.1048
Strategy for the Use of Erythropoetin Alpha to Maintain Hemoglobin Level in Breast Cancer Patient Treated with Anthracycline-base of Adjuvant Chemotherapy Dimyati Achmad; Yusuf Hariady Hariady; Benny Isakh; Maman Abdurrahman; Ahmad Faried
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate the value of erythropoietin alpha (epoetin) administration, as an alternative treatment of anemia in the operable breast cancer patients.Methods: This is a multicenter phase III randomized clinical trial to evaluate the value of epoetin administration among anemic breast cancer patients who are undergoing anthracyclin-based adjuvant chemotherapy. Sixty four patients were incuded in this trial with initial hemoglobin (Hb) level of 10–12 g/dL. The patients were randomly distributed into two groups: one group received aministration of 40,000 IU epoetin/week for six times a week after operation and the other did not.  In the third week after the operation, both groups were started on a 6 cycles of adjuvant chemotherapy with three weeks intervals. Hb levels were evaluated during every chemotherapy cycle. Results: The Hb levels in the epoetin group were always above 10 g/dL up until the end of the sixth chemotherapy cycle or until the twenty first week post operation without blood transfusion. Conclusions: The administration of epoetin 3 weeks prior and 3 weeks after the first cycles of chemotherapy, maintains a sufficient/normal Hb level in breast cancer patients receiving anthracycline-based chemotherapy.Keywords: Anthracyclin-based chemotherapy, breast cancer, erythropoietin alpha DOI: 10.15850/ijihs.v1n1.102
NR2B Gene Expression Change in Wistar Rat Practicing Aerobic Exercise Comparing to Soybean (Glycine max) or Phyllanthus niruri Intakes and Soybean and Phyllanthus niruri Composition Intake Vita Muniarti Tarawan; Diah Dhianawaty; Tetty Yuniati; Muhamad Nurhalim Shahib
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3012.63 KB) | DOI: 10.15850/ijihs.v3n2.582

Abstract

Objective: The objective of this study is to examine the relation between nutrition and brain memory. Qualified human resource is the most valuable national asset. Adequate nutrition and regular exercise provide higher achievement to create healthy and smart generations.Methods: The method applied in this study was experimental laboratory. This study was conducted on Juni 2011–Juli 2012 at the Biomedical and Biochemistry laboratory, Faculty of Medicine, Universitas Padjadjaran. The subjects were 8 weeks approximately 200–250 grams, male Wistar rats. The examination involved 56 male Wistar rats divided into 8 groups with different treatments. The groups which received exercise treatment were also given Glycine max and Phyllanthus niruri intakes. Results: NR2B gene expression changes can be described as the following results: (1) without practicing exercise (3,8) and after exercises (4,6); (2) Glycine max intake minus exercise (2,86) and Glycine max intake and exercises (3,17); (3) Phyllanthus niruri intake minus exercises (4,7) and Phyllanthus niruri intake and exercises (4,9); and (4) Glycine max and Phyllanthus niruri composition intake minus exercises (3,14) and Glycine max and Phyllanthus niruri composition intake and exercises (4,83).Conclusions: This study determines that exercises and Phyllanthus niruri intake enhance NR2B gene expressions. Glycine max inhibits the NR2B gene expressions. Glycine max and Phyllanthus niruri composition intake and either with or without practicing exercises enhance NR2B gene expressions. Therefore, practicing exercises and Phyllanthus niruri intake might cause brain cell apoptosis while Glycine max intake inhibits brain cell apoptosis. Keywords: Exercise, gene expressions, Glycin max, NR2B, Phyllanthus niruri DOI: 10.15850/ijihs.v3n2.582
Effect of Quadriceps Muscle Strengthening Exercise on Quadriceps and Hamstring Muscle Strength Ratio in Patients with Osteoarthritis Grade 2 and 3 Thomas Sintong Pratama Purba; Marina Annette Moeliono; Sunaryo Barki Sastradimadja
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate the effect of quadriceps muscle strengthening exercise on quadriceps and hamstring strength ratio in knee osteoarthritis (OA). Methods: This was a quantitative study with quasi-experimental design. The subjects in the study were 16 female patients with knee OA grade 2 and 3. Quadriceps muscle strengthening exercise was given to the subjects 3 times a week during 8 weeks. The study was conducted at the Department of Physical Medicine and Rehabilitation of the Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital in August–September 2015. Results: It was revealed that the quadriceps muscles improved significantly. However, the hamstring muscles did not show significant improvement based on the comparison between before and after performing the exercise. The average right quadriceps muscle strength before exercise was 12.46 and after exercise was 18. The average left quadriceps muscle strength before and after exercise were 11.59 and 17.7, respectively. The average right hamstring muscle strength before and after exercise were 7.29 and 7.94, respectively. Conclusions: There are quadriceps muscle strength improvements after practicing quadriceps muscle strengthening exercise. However, no significant hamstring muscle strength improvement is seen after practicing quadriceps muscle strengthening exercise. An improvement in quadriceps and hamstring muscle ratio is observed. Keywords: Osteoarthritis, quadriceps and hamstring muscle strength ratio, quadriceps muscle strengthening exercise DOI: 10.15850/ijihs.v5n2.1041 
Comparison of VO2 Max Prediction Value, Physiological Response, and Borg Scale between 12-Minute and 3200-Meter Run Fitness Tests among Indonesian Army Soldiers Maulidi Abdillah; Tertianto Prabowo; Marietta Shanti Prananta
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To compare the VO2 max and physiological responses between 12-minute and 3200-meter run fitness tests.Methods: The subjects were 40 soldiers aged 18–21 years old of the Infantry Battalion 303/SSM of Cikajang, Garut, West Java, Indonesia. The 12-minute and 3200-meter run fitness tests were conducted with one week resting period. The measurement of the VO2 max prediction was based on each of the formulations and the measurement of physiological response included blood pressure, heart rate, respiratory rate, Borg scale and oxygen saturation before and after the tests. This study used a cross-sectional method while the data were analyzed statistically using t-test (p=0.05). Results: The results showed that the VO2 max prediction in 12-minute run fitness test was 52.046±2.980 mL/KgBB/min and the 3200-meter run test was 55.323±3.238 mL/KgBB/min. The value was statistically significant (p=0.008). There was no significant difference in the physiological response in both tests, except the SpO2 parameter after the tests (p=0.021). Conclusions: There is a significant difference in VO2 max prediction between 12 minutes and 3200 meter run test. No significant difference was found in the physiological response in both tests, except the SpO2 parameter. Keywords: 12-minute run fitness test, 3200-meter run fitness test, physiological response, soldiers, VO2 max DOI: 10.15850/ijihs.v4n2.836
Infused Oyster Mushroom (Pleurotus ostreatus) Inhibits Glucose Absorption through Intestinal Mucosal Membrane in Wistar Rats Eko Fuji Ariyanto; Muhammad Nurhalim Shahib; Abdullah Firmansah Wargahadibrata
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (146.482 KB) | DOI: 10.15850/1354

Abstract

Objective: To observe the effects of infused oyster mushroom (latin name: Pleurotus ostreatus) on glucose absorption through the intestinal mucosal membrane in Wistar rats.Methods: This study used experimental design. Subjects of this study were six Wistar rats which were randomly divided into two groups; three rats were used for the analysis of the most effective time for glucose absorption and the other three were used to evaluate the effect of infused oyster mushroom on glucose absorption. The intestine of subjects was connected to in situ perfusion machine. Control glucose solution (Ctr) or glucose solution containing 5% (Oys 5%), 10% (Oys 10%), and 20% (Oys 20%) infused oyster mushroom was added into the perfusion machine and flowed back and forth in the lumen of intestine subsequently, accompanied by washing procedures using 0.9% NaCl between treatments. The glucose concentration was determined using deproteinization method followed by absorbance measurement. Student’s t test was performed to analyze the difference between groups.Results: The level of glucose absorbed through intestinal mucosal membrane in control glucose solution and glucose solution with different concentrations of infused oyster mushroom, i.e. 5%, 10% or 20%, was 25.19+3.4 mg/dL, 16.27+0.86 mg/dL, 13.22+1.58 mg/dL and 10.03+1.25 mg/dL, respectively. Student’s t test showed significant differences between groups; Ctr and Oys 5% (p=0.03), Ctr and Oys 10% (p=0.02), and Ctr and Oys 20% (p=0.007).Conclusion: Infused oyster mushroom inhibits glucose absorption through intestinal mucosal membrane in Wistar rats.Keywords: Oyster mushroom (Pleurotus ostreatus), glucose absorption, intestine DOI: 10.15850/ijihs.v6n2.1354
Cardiovascular Disorders in Adolescents with Chest Pain Sri Endah Rahayuningsih; Rahmat Budi; Herry Garna
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To detect cardiovascular abnormalities in adolescents with chest pain.     Methods: In this cross sectional study, the subjects were 25 adolescents with chest pain who came to the Cardiac Center of Dr. Hasan Sadikin General Hospital, Bandung during the period of January 2008 to January 2011. The presence of established cardiovascular disorders were based on history, physical examination, electrocardiography and echocardiography    Results: It was found that 13/25 adolescents with chest pain had cardiovascular abnormalities. Of the 25 teens that came with chest pain, most of which showed normal electrocardiographic results, only 9/25 of those with dysrhythmias experienced sinus tachycardia and 8 had a first degree AV block. Echocardiography examination showed only four patients with abnormal cardiac anatomy.  No correlation between nutritional status and chest pain, and cardiovascular abnormalities and chest pain (p = 0.206 and p = 0.632, respectively). There was a positive correlation between sex and cardiovascular abnormalities in adolescents with chest pain (p = 0.007).Chest pain is a prevalent problem that is usually benign and that it frequently signals underlying cardiac disease.Conclusions: Cardiovascular abnormalities in adolescents with symptoms of chest pain are found in some cases. There is no correlation between female and male adolescents with chest pain  and  cardiovascular abnormalities.Keywords: Adolescents, cardiovascular, chest painDOI: 10.15850/ijihs.v2n1.287
Fetus inside Brain - Mature Cystic Teratoma in Posterior Fossa Farid Yudoyono; Mirna Sobarna; Agung Budi Sutiono; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To describe a rare case of posterior fossa cystic teratoma in central nervous system. Methods: A 2-year old boy was admitted with a chief complaint of decreased consciousness with tonic clonic seizure. Non-Contrast Head Computed Tomography (NCCT) scan showed acute hydrocephalus and a well-defined extra-axial cystic lesion mass, 3.4x3.9x4.2 cm in size, in the posterior fossa.Results: Patient underwent a total resection of the tumor. No systemic complication was found in ten days following the surgery. There was no evidence of tumor recurrence one year after the surgery. The histopathologycal diagnosis of the tumor was cystic teratoma.Conclusions: Mature cyst teratoma located in the posterior fossa is a rare case. Total resection and long-term follow up is the treatment of choice for mature teratoma.Keywords: Hydrocephalus, posterior fossa, teratoma DOI: 10.15850/ijihs.v4n1.687

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