cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
mkb.fkunpad@gmail.com
Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38 Bandung, 40161, Indonesia
Location
Kota bandung,
Jawa barat
INDONESIA
Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 541 Documents
 2   3   4   5   6 
Effect of Acute Physical Exercise with Moderate Intensities on FGF23 Gene Expression in Wistar Rat Heart Vita Murniati Tarawan; Julia Windi Gunadi; Tiodora Arimenda Br. Subekti; Wahyu Widowati; Hanna Goenawan
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.265 KB) | DOI: 10.15395/mkb.v51n4.1844

Abstract

A myokine is one of the proteins that are produced and released by myocytes in response to muscular contractions when doing physical exercise. One protein that is thought to function as myokine is FGF23.The purpose of this study was to determine the effect of acute physical exercise with moderate intensity on the expression of FGF23 gene in Wistar rat heart. This was an animal experimental study using 24 male Wistar rats that were divided into 4 groups:treatment groups that performed 30 minute acutephysical exercise with moderate intensity (20 m/min) for 3 days, 6 days, and 15 days and a control group without physical exercise. The study was conducted in the Animal Laboratory and Central Laboratory of Universitas Padjadjaran during the period of February to July 2019. Data observed were the FGF23 gene expressions in Wistar rats heart. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests. The results from the Kruskal-Wallis test showed that acute physical exercise with moderate intensity did not increase the FGF23 gene expression in Wistar rat heart (p>0.05), and the average of relative ratios of FGF23/GAPDH gene expression were as follows: control (0.970±0,03), 3 days (0.992±0.03), 6 days (1.014±0.05), and 15 days (1.056±0.02). GAPDH was used in this study as a housekeeping gene since its expression is very constant. This study proves that FGF23 is more likely to take a role in the cardiac remodeling process, especially those associated with cardiac hypertrophy after chronic exercise with no effect observed after acute physical exercise with moderate intensity in Wistar rat heart. Pengaruh Latihan Fisik Akut Intensitas Sedang terhadap Ekspresi Gen FGF23 pada Jantung Tikus Galur WistarMiokin diproduksi dan dilepaskan oleh miosit sebagai respons terhadap latihan fisik. Salah satu protein yang diduga berfungsi sebagai miokin adalah FGF23. Penelitian ini bertujuan mengetahui pengaruh latihan fisik akut intensitas sedang terhadap ekspresi gen FGF23 pada jantung tikus galur Wistar. Penelitian ini menggunakan desain eksperimental dengan tikus galur Wistar jantan yang berjumlah 24 tikus. Tikus dibagi menjadi 4 kelompok untuk diberi perlakuan latihan fisik intensitas sedang (20 meter/menit) dengan durasi 30 menit, selama 3 hari, 6 hari, dan 15 hari serta kelompok tanpa latihan fisik. Penelitian ini dilakukan di Lab Hewan dan Lab Sentral Universitas Padjadjaran pada bulan Februari hingga Juli 2019. Ekspresi gen FGF23 pada jantung tikus galur Wistar dilihat dengan PCR. Analisis data menggunakan uji Kruskal-Wallis dan Mann-Whitney. Uji statistik tidak mendapatkan peningkatan ekspresi gen FGF23 setelah dilakukan latihan fisik akut intensitas sedang selama 3 hari, 6 hari dan 15 hari (p>0,05) dan didapatkan rasio relatif ekspresi gen FGF23/GAPDH otot jantung pada : kontrol (0,970±0,03), hari 3 (0,992±0,03), hari 6 (1,014±0,05), hari 15 (1,056±0,02). GAPDH digunakan dalam studi ini sebagai gen ‘housekeping’ karena ekspresinya yang sangat konstan. Studi ini membuktikan bahwa FGF23 mungkin lebih berperan dalam proses remodeling jantung, terutama yang berhubungan dengan hipertrofi jantung setelah latihan fisik kronik. Simpulan, tidak terdapat pengaruh latihan fisik akut intensitas sedang terhadap ekspresi gen FGF23 pada jantung tikus galur Wistar.
Correlation between Serum Ferritin, Serum Cystatin C, and Renal Function in Children with β Thalassemia Major Permadi, Suci Saptyuni; Renarti, Lelani; Rachmadi, Dedi
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n3.1666

Abstract

Renal dysfunction caused by iron overload is characterized by an increase in ferritin and cystatin C levels. The objective of this study was to determine the correlation between ferritin, cystatin C, and renal function in children with β thalassemia major. A cross-sectional observational analytic study was conducted in September 2018 on 34 children with β thalassemia major in Dr. Hasan Sadikin General Hospital. Ferritin and cystatin C levels were documented and the estimated glomerular filtration rate (eGFR) was calculated using the Schwartz formula. Statistical tests were performed using Rank Spearman and Point Biserial with p value of <0.05 considered significant. the median ferritin level, cystatin C level, and eGFR of the subjects were 2,818 ng/mL (95% CI: 2,505–3,977), 209.9±121.5 (95% CI: 167.5–252.3), and 185.5 mL/min /1.73 m2 (95% CI: 173.6–208.2), respectively. Correlations were sought between serum ferritin and eGFR (r=0.132, p=0.229), between cystatin C and eGFR: r=0.3012, p=0.041, and between ferritin and cystatin C: r=0.433, p=0.011. No correlation was found between ferritin and renal function whereas serum cystatin C presented a positive correlation with renal function. A strong correlation was found between ferritin and cystatin C. Serum ferritin and cystatin C are promising biomarkers to assist in monitoring renal function in children with β thalasemia major.Hubungan Feritin dan Cystatin C Serum dengan Fungsi Ginjal pada Anak Talasemia β Mayor Kelebihan besi pada anak talasemia β mayor mengganggu organ vital di antaranya ginjal. Gangguan fungsi ginjal karena kelebihan besi dapat ditandai dengan peningkatan kadar ferritin dan cystatin C. Penelitian ini bertujuan mengetahui hubungan kadar feritin dan cystatin C dengan fungsi ginjal pada anak talasemia β mayor. Penelitian observasional analitik dengan rancangan potong lintang, dilaksanakan bulan September 2018. Subjek penelitian adalah anak penderita talasemia β mayor di Rumah Sakit Dr. Hasan Sadikin Bandung. Dilakukan pemeriksaaan kadar feritin dan cystatin C. Penilaian fungsi ginjal menggunakan estimated glomerular filtration rate (eGFR) dengan formula Schwartz. Uji statistik menggunakan uji Rank Spearman dan Point Biserial dengan kemaknaan berdasar nilai p<0,05. Didapatkan jumlah sampel sebanyak 34 anak, dengan kadar feritin median 2818 ng/mL (IK95%:2505–3977), cystatin C 209,9±121,5 (IK95%:167,5–252,3) dan eGFR median 185,5 mL/menit per 1,73 m2(IK95%:173,6–208,2). Korelasi antara kadarferritin dengan eGFR: r=0,132, p=0,229, korelasi cystatin C dengan eGFR: r=0,3012; p=0,041 dan korelasi kadar feritin dengan cystatin C: r=0,433; p=0,011). Hasil penelitian ini tidak didapatkan korelasi antara feritin dan fungsi ginjal, sedangkan cystatin C memiliki korelasi positif dengan fungsi ginjal. Didapatkan korelasi kuat antara kadar feritin dan cystatin C serum. Pemeriksan kadar feritin dan cystatin C dapat membantu pemantauan fungsi ginjal pada anak talasemia β mayor.
Antioxidant and Antityrosinase Activities of Ethanolic Pachyrhizuserosus Peel and Tuber Extract Siregar, Irma Dolsyeria; Kusuma, Hanna Sari Widya; Widowati, Wahyu; Marpaung, Hans Hotma; Ferdinand, Sahna; Fachrial, Edy; Lister, I Nyoman Ehrich
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.515 KB) | DOI: 10.15395/mkb.v51n2.1628

Abstract

Aging process is a physiological process in living organisms caused by, among others, free radicals. One of the free-radical-related aging problems is skin hyperpigmentation (excessive melanin) due to increasing tyrosinase enzyme activities. Natural compounds are widely used as antioxidant and antiaging agents. Bengkuang (Pachyrhizuserosus) is known as a source of various active compounds which can be used against free radicals to reduce the risk of skin aging  through  tyrosinase enzyme inhibition. This study was performed in September 2018 in Aretha Medika Utama, Biomolecular and Biomedical Research Center, Bandung, Indonesia to examine the antioxidant and antityrosinase properties of Pachyrhizuserosus peel extract (PPE) and Pachyrhizuserosus  tuber extract (PTE).The extraction of PPE and PTE was performed using 70% ethanol by maceration method, followed by  phytochemical analysis using modified Farnsworth method. Antioxidant activities were measured through 2,2-Diphenyl-1-picrylhydrazil (DPPH) scavenging activities while antiaging assay were conducted through the  tyrosinase activity inhibition. In this study, PPE contained saponin, tannin, triterpenoid, and terpenoid while the PTE showed the presence of flavonoid, saponin, phenol, tannin, and alkaloid in phytochemical analysis. In the antioxidant assay, PPE presented a higher DPPH scavenging activities (IC50= 84.09 µg/mL) when compared to PTE (IC50= 98.30 µg/mL)(p<0.05). In antiaging assay, PPE showed a higher tyrosinase inhibitory activities when compared to PTE with =97.05µg/mL and 194.51µg/mL,respectively. It can be concluded that PPE has antioxidant and antiaging activities effective for preventing skin aging. Aktivitas Antioksidan dan Antitirosinase Ekstrak Etanol Kulit dan Daging PachyrhizuserosusProses penuaan merupakan suatu proses fisiologis yang terjadi pada makhluk hidup yang dapat disebabkan oleh radikal bebas. Hiperpigmentasi kuli tmerupakan salah satu masalah penuaan yang disebabkan oleh radikal bebas melalui peningkatan aktivitas enzim tirosinase. Bengkuang (Pachyrhizus erosus) diketahui mengandung berbagai senyawa aktif yang dapat menangkal radikal bebas serta mengurangi risiko penuaan kulit. Penelitian dilaksanakan pada September 2018 di Aretha Medika Utama, Biomolecular and Biomedical Research Center, Bandung, Indonesia untuk menguji kemampuan aktivitas antioksidan dan antitirosinase pada ekstrak etanol kulit bengkuang (EEKB) dan ekstrak etanol daging bengkuang (EEDB). Pembuatan ekstrak kulit dan daging bengkuang dilakukan dengan cara mengekstraksi bahan dengan etanol 70% menggunakan metode maserasi, kemudian dilanjutkan dengan analisis fitokimia ekstrak dengan modifikasi metode Farnsworth. Aktivitas antioksidan diuji dengan mengukur pemerangkapan 2,2-Diphenyl-1-picrylhydrazil (DPPH) sedangkan antiaging diuji dengan mengukur aktivitas penghambatan tirosinase. Pada uji fitokimia menunjukkan EEKB memiliki kandungan senyawa saponin, tanin, triterpenoid dan terpenoid, sedangkan EEDB menunjukkan kandungan senyawa flavonoid, saponin, fenol, tanin, dan alkaloid. Pada uji antioksidan, EEKB memiliki aktivitas tertinggi pada pemerangkapan DPPH (IC50=84.09 µg/mL) dibanding dengan EEDB (IC50=98.30 µg/mL) (p≤0.05). Pada pengujian antiaging, EEKB memiliki nilai yang lebih tinggi pada aktivitas penghambatan tirosinase dibandingkan dengan EEDB (IC50=97.05 µg/mL; 194.51 µg/mL (p≤0.05). Simpulan, EEKB memiliki aktivitas antioksidan dan antiaging sehingga efektif dalam mencegah penuaan kulit. 
Translation and Validation of Indonesian Version of Scleroderma Health Assessment Questionnaire Irma Ruslina Defi; Jennie Jennie; Vitriana Vitriana; Farida Arisanti
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n1.2004

Abstract

Systemic sclerosis (SSc) or Scleroderma is a chronic autoimmune disease characterized by vasculopathy, fibrosis, and autoimmunity. Scleroderma Health Assessment Questionnare (SHAQ) is a measurement of SSc that is more specific than Health Assessment Questionnaire (HAQ) disability index(DI) to measure disability and function.The aim of this study was to translate SHAQ into Indonesian language and assess its validity and reability. The SHAQ was translated into Indonesian language and then back translated to ensure the meaning. The Indonesian version was then applied to the SSc outpatients. The validity of HAQ-DI and VAS scores was assessed using Pearson Product Moment Correlation and Cronbach’s alpha for the reability test of SSc HAQ score. To determine the convergent validity, comparisons were made between HAQ-DI, Scleroderma Visual Analog Scale (VAS), and Short Form 36 (SF 36). Eighteen females, ranging between 42 to 66 years old, were included in this study from Desember 2019 to February 2020. The results of the validity test in all variables of HAQ-DI and SSc-VAS were valid (r-count >0.361). Cronbach’s alpha for these variables were higher than the standardized items (r > 0.700), reflecting very good reability and acceptable. There was a statistically significant correlation between SSc HAQ score and HAQ-DI with most of SF-36 physical domains, except for general health.The Indonesian version of SHAQ demonstrates a good construct and discriminant validity as well as the reproducibility. Thus, it can be used for measuring disability in systemic sclerosis patients. Translasi  dan Validasi  Scleroderma Health Assessment Questionnaire versi  Bahasa IndonesiaSklerosis sistemik atau skleroderma merupakan penyakit autoimun kronik dengan vaskulopati, fibrosis dan autoimunitas. Scleroderma Health Assessment Questionnaire (SHAQ)menilai disabilitas dan fungsi pada pasien sklerosis sistemiklebih spesifik dibandingkan Health Assessment Questionnaire (HAQ) Disability Index (DI). Tujuan dari penelitian ini adalah menerjemahkan SHAQ ke dalam bahasa Indonesia dan menilai validitas serta relialibilitasnya. Scleroderma Health Assessment Questionnaire diterjemahkan ke dalam bahasa Indonesia dan kemudian dilakukan translasi balik lalu kuesioner diisi oleh pasien sklerosis sistemik rawat jalan. Tes validitas HAQ-DI dan Visual Analog Scale (VAS) dinilai menggunakan korelasi Pearson dan reliabilitas menggunakan Cronbach’s alpha. Perbandingan antara HAQ-DI, Scleroderma-VAS, dan Short Form 36 (SF 36) dilakukan untuk menilai validitas konvergen. Subjek terdiri dari 18 orang wanita yang berusia antara 42 sampai 66 tahun dari Desember 2019 sampai Februari 2020. Hasil validitas pada semua parameter HAQ-DI dan SSc-VAS ditemukan valid (r hitung>0,361). Terdapat reliabilitas yang baik dilihat dari nilai Cronbach’s alpha yang lebih tinggi dari nilai r tabel (r>0,700). Terdapat korelasi yang signifikan antara Skleroderma-HAQ dan HAQ-DI dengan domain SF-36 kecuali domain kesehatan umum. Simpulan, bahwa SHAQ versi Indonesia memiliki konstruk dan validitas diskriminan serta reproduktifitas yang baik sehingga dapat digunakan untuk menilai disabilitas pada pasien sklerosis sistemik.
Strong Positive Correlation between Neutrophil-to-lymphocyte Ratio and C-reactive Protein in Early Onset Sepsis Ghrahani, Reni; Yuniati, Tetty; Judistiani, Raden Tina Dewi; Setiabudiawan, Budi
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n4.1421

Abstract

Sepsis is a life-threatening disease with a high number of mortality in premature infants. Premature infants have immature immune systems, with less pool neutrophils and imperfect ability to destroy pathogen. Neutrophil function is  supported by lymphocyte’s ability to form antibody or specific cell-surface receptors for particular antigens. This underlies the use of neutrophil-to-lymphocyte ratio (NLR) as an inflammation marker to detect and assess the severity of sepsis. C-reactive protein (CRP) is known as an acute phase reactant. Neutrophil-to-lymphocyte ratio is an easier, fast, and inexpensive method when compared to CRP. The aim of this study was to evaluate the correlation between NLR and CRP in detecting early-onset sepsis (EOS) in premature infants. A cross-sectional study was conducted on 53 premature infants born and hospitalized in a hospital in Indonesia who were recruited during the period of April to October 2018.  Blood was sampled from the umbilical cord at birth for laboratory examination. The NLR was determined as the ratio of neutrophil to lymphocyte count. The Tollner scoring system was used to identify sepsis. Mann Whitney-U test and Spearman Correlation test were computed for the statistical analysis. neutrophil-to-lymphocyte ratio which results showed a strong positive correlation with CRP (r= 0.702, 0=0.001) in premature infants with EOS. Leukocyte count was lower in infants with EOS than those without EOS group (median; IQR, x103: 8.9 (6.3-13.8) vs 12.5 (10.1- 16.1); p=0.016). Neutrophil-to-lymphocyte ratio and CRP tended to be lower in EOS group when compared to  that of the non-EOS group. In conclusion, NLR has a strong positive correlation with CRP in premature infants with EOS. Korelasi Positif Kuat antara Neutrophil-to-lymphocyte dan C-reactive protein pada Sepsis Awitan DiniSepsis pada bayi prematur adalah keadaan mengancam jiwa dengan mortalitas tinggi. Bayi prematur memiliki sistem imun imatur, sedikit persediaan neutrofil serta fungsi  belum sempurna untuk melawan patogen. Fungsi neutrofil didukung limfosit membuat antibodi serta reseptor permukaan spesifik untuk antigen tertentu. Neutrophil-to-lymphocyte ratio (NLR) diajukan untuk petanda inflamasi, mendeteksi dan menentukan derajat sepsis, sedangkan C-reactive protein (CRP) telah diketahui sebagai protein fase akut. Neutrophil-to-lymphocyte ratio adalah pemeriksaan yang lebih mudah, cepat, murah dibandingkan dengan CRP. Penelitian potong lintang ini bertujuan mengevaluasi korelasi NLR dengan CRP untuk mendeteksi sepsis awitan dini pada 53 bayi prematur, yang lahir dan dirawat di rumah sakit kami, selama April-Oktober 2018. Sampel darah dari tali pusat pada saat lahir. Neutrophil-to-lymphocyte ratio adalah rasio jumlah neutrofil terhadap limfosit. Skoring Tollner digunakan untuk mengidentifikasi sepsis. Analisis statistik menggunakan Uji Mann-Whitney dan korelasi Spearman. Korelasi positif antara NLR dengan CRP di antara bayi prematur dengan sepsis awitan dini adalah r=0,702, p=0,001. Bayi dengan sepsis awitan dini memiliki jumlah leukosit lebih rendah dibanding bayi non-sepsis (median; IQR, x103: 8,9 (6,3-13,8) vs 12,5 (10,1- 16,1); p=0,016). Neutrophil-to-lymphocyte ratio dan CRP lebih rendah pada kelompok sepsis dibanding non-sepsis. Simpulan, NLR memiliki korelasi positif kuat dengan CRP pada bayi prematur dengan sepsis awitan dini.
Differences in Physical Activity, Lactic Acid Concentration, and Quality of Life between Gender among First Year Medical Students Rachmawati, Maria Regina; Sidarta, Nuryani; Mediana, Dian
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n4.1636

Abstract

Medical students have fewer opportunities to do physical activities (PA) that may increase the risk for chronic diseases. The aim of this study was to assess the correlation between PA, as assessed using the International Physical Activity Questionnaire (IPAQ), and Lactic acid (LA) concentration, as well as the differences in IPAQ, LA, and quality of life (QoL) between genders. This was a cross-sectional study conducted in April - November 2017 by a private university in West Jakarta. Subjects of the study were selected using simple random sampling approach with female subjects as the more dominant gender ( n=76, 60%) from the 126 subjects recruited. The median of IPAQ, La- 1, and La-2 in male and female were 707 (474–944) vs 423 (392–501) Mets (p=0.7), 4.6 (3.8–5.4) vs 2.8 (2–3) mmol/L (p=0.001), and 8.4 (7.7–8.9) vs 10 (9.3-10.5) mmol/L (p<0.001) respectively. The higher the IPAQ, the lower of the La- 2 concentration (p=0.012) was when analyzed using Kruskal-Wallis test. Total score of QoL in males and females were 2628.6 (2,496-2757) and 2,765 (2,687–2,859) (p=0.067), respectively, while the concepts of Role Limitation due to Physical Health was higher in female (p=0.006), as shown by Mann-Whitney test. In conclusion, subjects arephysically inactive with females are less active and have a higher La-2 concentration than males. However, the QoL concept of the RLPH is better in female students.Perbedaan Aktivitas Fisik, Asam Laktat, dan Kualitas Hidup antara Jenis Kelamin pada Mahasiswa Kedokteran Tahun PertamaMahasiswa Fakultas Kedokteran memiliki sedikit kesempatan untuk melakukan aktivitas fisik yang dapat meningkatkan terjadi penyakit kronis. Tujuan penelitian menemukan korelasi aktivitas fisik (PA) yang dinilai menggunakan the International Physical Activity Questionnaire (IPAQ) dengan kadar asam laktat (LA), serta perbedaan IPAQ, LA dan kualitas hidup (QoL) antar jenis kelamin. Desain penelitian adalah potong lintang, seleksi subjek secara acak sederhana, pada April–November 2017, pada universitas swasta di Jakarta Barat. Hasil penelitian diperoleh 126 subjek, 76 (60%) perempuan. Rerata IPAQ, LA -1, dan LA -2 pada laki-laki dan perempuan secara berurutan adalah; 707(474–944) vs 423 (392–501) Mets (p=0,7), 4,6 (3,8–5,4) vs 2,8 (2–3) mmol/L (p=0,001), dan 8,4 (7,7–8,9) vs 10 (9,3-10.5) mmol/L (p<0,001). Semakin tinggi IPAQ, semakin rendah LA (p=0,012), dengan Uji Kruskal-Wallis. Skor total QoL pada pria dan wanita adalah 2.628.6 (2496–2.757) vs 2.765 (2.687–2.859) (p=0,067), sementara nilai konsep Role Limitation due to Physical Health (RLPH) pada perempuan lebih tinggi (p=0,006) dengan Uji Mann-Whitney. Kesimpulan, subjek memiliki PA tidak aktif, sementara perempuan lebih tidak aktif dan memiliki LA-2 lebih tinggi. Namun, QoL pada konsep RLPH lebih baik pada mahasiswa perempuan.
Histopathological Effects of Ageratum Leaf Extract (Ageratum Conyzoides) on Wound Healing Acceleration After Acute Excisional Wound on Epidermis in Type 2 Diabetes Mellitus Model of Sprague Dawley Rats (Rattus norvegicus) Yudhantoro, Liliek; Hidajat, Nucki Nursjamsi; Ismiarto, Yoyos Dias; Ismono, Darmadji
Majalah Kedokteran Bandung Vol 51, No 3 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n3.1652

Abstract

Diabetic wound healing problem often occurs if proper care is not given which will lead to the development of a chronic wound. Ageratum (Ageratum conyzoides L.) leaves is one of the most common plants in tropical areas, including Indonesia, which are frequently used in traditional treatment due to its anti-bacterial properties. This experimental study aimed to identify the effects of topical application of Ageratum leaf extract on wound healing based on histopathological examination of the reepithelization, ulceration, neovascularization, and the presence of inflammatory cells. This study was performed in the period of September to December 2017 at the Pharmacology and Pathology Anatomy laboratories of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. Excisions were made on the back of the 36 rats that were divided into control and test groups. The test group then received a topical application of Ageratum leaf extract. The resulting histopathologic appearance of the wound was then examined. The test group showed better wound healing in all parameters inspected when compared to the control group. Mann-Whitney Test with 95% confidence interval (p<0.05) showed that the re-epithelialization, ulceration, neovascularization, and presence of inflammatory cells reflected a statistically significant improvement in the test group (p=0.319, p=0.290, p=0.251, and p=0.245, respectively). This study concludes that the topical application of Ageratum leaf extract has a statistically significant benefit on diabetic wound healing.Pengaruh Histopatologis Ekstrak Daun Ageratum (Ageratum Conyzoides) terhadap Akselerasi Penyembuhan Luka Setelah Luka Eksisi Akut pada Epidermis pada Model 2 Diabetes Mellitus Tikus Sprague Dawley (Rattus norvegicus) Luka diabetes sering menyebabkan luka kronik jika tidak mendapat penanganan yang tepat. Ageratum (Ageratum conyzoides) merupakan tanaman khas daerah tropis termasuk Indonesia, yang daunnya digunakan untuk pengobatan tradisional karena mengandung zat anti bakteri. Penelitian eksperimental ini menggunakan desain kelompok kontrol post-test untuk mengidentifikasi efek aplikasi topical dari ekstrak daun Ageratum pada penyembuhan luka dengan pemeriksaan histopatologis dari reepitelialisasi, ulserasi, neovaskularisasi, dan sel radang. Penelitian ini dilakukan antara September hingga Desember 2017 di laboratorium Farmakologi dan Patologi Anatomi Rumah Sakit Umum Dr. Hasan Sadikin Bandung. Eksisi dilakukan pada tiap-tiap tikus dari 36 tikus yang dibagi menjadi kelompok kontrol dan kelompok uji di mana kelompok uji dilakukan perawatan dengan ekstrak etanol daun ageratum secara topikal. Setelah diaplikasikan ekstrak daun Ageratum, luka diperiksa secara histopatologi. Observasi pada kelompok uji menunjukkan penyembuhan luka eksisional tikus diabetes yang lebih baik daripada kelompok control untuk semua parameter. Uji Mann-Whitney dengan interval kepercayaan 95% (p <0,05) menunjukkan bahwa nilai p untuk reepitelisasi, ulserasi, neovaskularisasi, dan sel radang adalah p=0,319, p=0,290, p=0,251, dan p=0,245. Aplikasi topikal dari ekstrak daun Ageratum memiliki manfaat pada penyembuhan luka diabetes dan hasilnya signifikan secara statistik. 
Role of Physical and Cognitive Factors in Passing Abilities of Futsal Athletes in Universitas Padjadjaran Lubis, Leonardo; Muhammad, Afan Maulana; Nandina, Oktavia
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n2.1578

Abstract

Futsal is a variation of soccer, to be played on a smaller field, with the fastest development among other indoor sports. Futsal players need to master several basic playing techniques to be able to play good futsal, one of them is passing. There are 2 factors that affect futsal athlete skills; physical and mental factors, including cognitive factors. This study aimed to determine the contribution of physical and cognitive factors on the ability to execute passing techniques. A cross-sectional analytic study was conducted in October 2018 on 33 participants who were listed as futsal players in the Faculty of Medicine Futsal Unit, Universitas Padjadjaran, and in the amateur futsal club, La Coruna FC. Physical factor data consisting of body muscle mass percentage, leg muscle percentage, total body fat percentage, and legs subcutaneous fat percentage were measured using Body Impedance Analysis tool while the cognitive factors consisting of; attention, short term memory, and spatial ability, were measured using grid concentration test, digit span test, and spatial ability test, respectively. Athlete’s passing ability was measured using 30 second pass and stop test. Data were then analyzed using regression analysis. The results showed that the percentage of leg muscles has the highest significance value for the athlete’s passing ability. (β=0.6, p<0.05) while the leg muscles percentage and attention level are shown to be the physical and cognitive factors which play greater roles in the passing ability of futsal athletes.Peran Faktor Fisik dan Kognitif  terhadap Performa Teknik Dasar Passing Atlet Futsal Universitas Padjadjaran Futsal adalah variasi sepakbola yang dimainkan di lapangan yang lebih kecil. Atlet futsal perlu menguasai beberapa teknik bermain dasar untuk bermain futsal dan salah satunya adalah passing. Ada 2 faktor yang memengaruhi keterampilan atlet futsal, yaitu fisik dan mental yang salah satunya adalah kognitif. Penelitian ini bertujuan mengetahui kontribusi faktor fisik dan kognitif terhadap kemampuan teknik passing. Studi analitik cross-sectional dilakukan terhadap 33 peserta yang terdiri dari atlet futsal Fakultas Kedokteran dan atlet futsal klub amatir, La Coruna FC selama Oktober 2018 di Jatinangor. Data komponen fisik terdiri atas persentase massa otot tubuh, persentase otot tungkai, persentase lemak tubuh total, dan persentase lemak subkutan kaki yang diukur dengan alat analisis impedansi tubuh, sedangkan kognitif terdiri atas konsentrasi, memori jangka pendek, dan kemampuan spasial yang masing-masing diukur dengan uji konsentrasi grid, uji rentang digit, dan uji kemampuan spasial. Kemampuan passing diukur menggunakan tes pass and stop selama 30 detik. Data kemudian diproses dengan analisis regresi. Hasil Analisis regresi menunjukkan persentase otot kaki memiliki nilai signifikansi tertinggi untuk kemampuan passing atlet. (β=0,6, p<0,05). Persentase otot tungkai dan tingkat konsentrasi adalah faktor fisik dan kognitif yang memiliki peran lebih besar dalam kemampuan passing atlet futsal Jatinangor. 
Role of Cystatin-C as Serum Biomarkers in Predicting Glomerular Function-Associated with Copper-Induced Acute Kidney Injury Fiska Maya Wardhani; Linda Chiuman; Chrismis Novalinda Ginting; Sahna Ferdinand Ginting
Majalah Kedokteran Bandung Vol 52, No 1 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.919 KB) | DOI: 10.15395/mkb.v52n1.1793

Abstract

Cystatin C is a 13 kD molecular-weight protein synthesized by all nucleated cells which functions as a cysteine protease inhibitor. Cystatin C is detectable when kidney function decreases due to the excessive accumulation of nephrotoxic substances such as copper. Previous studies have proven that white turmeric rhizome can act as a nephroprotector agent at a dose of 500mg/BW. The purpose of this study was to compare Cystatin-C marker and serum creatinine as biomarkers in the examination of acute kidney injuries induced by nephrotoxic substance. This was a post-test only controlled experimental study on wistar strain male rats that were divided randomly using simple random sampling approach into three groups: normal control group, treatment control group (Curcumin for 2 weeks followed by CuSO4 for 3 days at each weekend), and CuSO4 pentahydrate control group. This study was conducted in Faculty of Pharmacy and Faculty of Medicine of the University of North Sumatera in May to August 2019. Results were normally distributed with significant differences in levels of Cystatin-C, creatinine, and protein serum due to differences in the treatment of each group  (p<0.05). Serum Cystatin-C is proven to be a more sensitive biomarker for detecting acute kidney damage compared to serum creatinine. Peran Cystatin-C sebagai Biomarker Serum dalam Memprediksi Fungsi Glomerulus-Terkait dengan Cedera Ginjal Akut yang Dipicu TembagaCystatin C adalah  protein dengan berat molekul 13 kD disintesis oleh setiap sel yang memiliki inti berfungsi sebagai inhibitor protease sistein. Cystatin C terdeteksi ketika fungsi ginjal menurun oleh zat nefrotoksik seperti tembaga. Tembaga merupakan salah satu logam yang dapat menjadi zat nefrotoksik bila terakumulasi berlebihan. Ekstrak rimpang kunyit putih memiliki manfaat sebagai nefroprotektor dengan dosis  mg/kgBB. Penelitian ini dilakukan untuk mengetahui perbandingan Cystatin-C dan kreatinin serum sebagai biomarker dalam pemeriksaan kerusakan ginjal akut akibat zat nefrotoksik. Penelitian eksperimental ini menggunakan the post test only control group design dengan teknik simple random sampling. Penelitian ini dilakukan di Fakultas Farmasi dan Fakultas Kedokteran Universitas Sumatera Utara pada bulan Mei hingga Agustus 2019. Tikus jantan dengan galur wistar dibagi tiga kelompok; kontrol normal, kontrol kunyit putih (500 mg/kgBB) sebagai pre-treatment (curcumin selama 2 minggu diikuti CuSO4selama 3 hari di setiap akhir pekan), dan kontrol  CuSO4 pentahidrat. Hasil analisis data terdistribusi normal dan terdapat perbedaan yang signifikan kadar Cystatin-C, kreatinin dan protein serum pada setiap kelompok dimana nilai p<0.05. Cystatin-C serum sebagai biomarker lebih sensitif dalam mendeteksi kerusakan ginjal akut dibanding dengan kreatinin serum.
Elderly’s Expectations of Services in Integrated Health Post (Posbindu): A Qualitative Study Destyana Wulandari Azana; Sharon Gondodiputro; Didah Didah
Majalah Kedokteran Bandung Vol 51, No 4 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n4.1786

Abstract

Many factors influence the compliance of the elderly to visit the Integrated Health Post (Posbindu). One factor that needs to be explored is the expectation of the elderly on the services in this post. Expectations that are met with performance will create satisfaction, leading to a regular visit to the Posbindu. This study aimed to explore the expectations of the elderly towards services provided in the Posbindu. A qualitative phenomenology study using a in-depth interview was conducted to 8 elderly informants from 7 Posbindu from 7 public health centers (Pusat Kesehatan Masyarakat, Puskesmas) who were selected by purposive sampling in Bandung City. Posbindu and Puskesmas was selected in a simple random manner. The study was conducted from July to October 2018. Explored concepts were structure, process, and output of expectations. The collected data was processed by coding and categorization.This study discovered that the structural expectation covered three subthemes, namely accessibility, human resources, and facilities. The process expectation was formed by three subthemes: behavior and communication skills of the cadres; behavior and communication skills of the health providers; consultation and treatment. The output expectation was formed by three categories, including information about their illness, controlled disease, and the desire to stay healthy. This study discovered 3 new categories from several subthemes of the health care provided in the Posbindu, i.e. free services, attendance of a doctor, and medicine prescription. In conclusion, the expectation of the elderly towards the health services at the Posbindu has been identified. Ekspektasi Lansia terhadap Pelayanan di PosbinduBanyak faktor yang mempengaruhi kepatuhan lansia untuk datang ke Pos Pembinaan Terpadu (Posbindu). Salah satu faktor yang perlu digali adalah harapan para lansia. Harapan sesuai dengan kenyataan akan menciptakan kepuasan, yang mengarah ke kunjungan rutin ke Posbindu. Tujuan dari penelitian ini adalah mengeksplorasi harapan para lansia terhadap layanan di Posbindu. Penelitian fenomenologis kualitatif dilakukan dengan menggunakan wawancara mendalam kepada 8 informan lansia dari 7 Posbindu (dari 7 Puskesmas) yang dipilih secara purposive sampling di Kota Bandung. Pemilihan Posbindu dan Puskesmas dilakukan secara acak sederhana. Studi ini dilakukan dari Juli hingga Oktober 2018. Konsep yang dieksplorasi adalah struktur, proses, dan output dari harapan. Data yang dikumpulkan, diproses dengan pengkodean dan kategorisasi. Penelitian ini menemukan harapan struktural dicakup oleh tiga sub-tema, yaitu aksesibilitas, sumber daya manusia, dan fasilitas. Harapan proses dibentuk oleh tiga sub-tema, yaitu perilaku dan komunikasi kader; perilaku dan komunikasi tenaga kesehatan; konsultasi dan perawatan. Harapan masukan dibentuk oleh tiga kategori, termasuk informasi tentang penyakit mereka, penyakit terkendali, dan keinginan untuk tetap sehat. Studi ini menemukan 3 kategori baru dari beberapa subtema yaitu tidak perlu membayar , kehadiran dokter, dan pemberian obat. Simpulan, harapan lansia terhadap layanan kesehatan di Posbindu telah diidentifikasi.

Page 4 of 55 | Total Record : 541

 2   3   4   5   6 

Filter by Year

2012 2023


Reset
Filter By Issues
All Issue Vol 55, No 3 (2023) Vol 55, No 2 (2023) Vol 55, No 1 (2023) Vol 54, No 4 (2022) Vol 54, No 3 (2022) Vol 54, No 2 (2022) Vol 54, No 1 (2022) Vol 53, No 4 (2021) Vol 53, No 3 (2021) Vol 53, No 2 (2021) Vol 53, No 1 (2021) Vol 52, No 4 (2020) Vol 52, No 3 (2020) Vol 52, No 2 (2020) Vol 52, No 1 (2020) Vol 51, No 4 (2019) Vol 51, No 3 (2019) Vol 51, No 2 (2019) Vol 51, No 1 (2019) Vol 50, No 4 (2018) Vol 50, No 3 (2018) Vol 50, No 2 (2018) Vol 50, No 1 (2018) Vol 49, No 4 (2017) Vol 49, No 3 (2017) Vol 49, No 2 (2017) Vol 49, No 1 (2017) Vol 48, No 4 (2016) Vol 48, No 3 (2016) Vol 48, No 2 (2016) Vol 48, No 1 (2016) Vol 47, No 4 (2015) Vol 47, No 3 (2015) Vol 47, No 2 (2015) Vol 47, No 1 (2015) Vol 46, No 4 (2014) Vol 46, No 3 (2014) Vol 46, No 2 (2014) Vol 46, No 1 (2014) Vol 45, No 4 (2013) Vol 45, No 3 (2013) Vol 45, No 2 (2013) Vol 45, No 1 (2013) Vol 42, No 3 Vol 44, No 4 (2012) Vol 44, No 3 (2012) Vol 44, No 2 (2012) Vol 44, No 1 (2012) Vol 43, No 4 Vol 43, No 3 Vol 43, No 2 Vol 43, No 1 Vol 42, No 4 Vol 42, No 2 Vol 42, No 1 Vol 41, No 4 Vol 41, No 3 Vol 41, No 2 Vol 41, No 1 More Issue