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eJurnal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23501426     EISSN : 23386037     DOI : 10.23886
Core Subject : Health,
Elektronik Journal Kedokteran Indonesia (eJKI) is a peer-reviewed and open access journal that prioritize the publication manuscript of students (medical education program, magister/specialist, doctoral). This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. eJKI published three times a year (April, August, December) and published by Faculty of Medicine Universitas Indonesia
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Search results for , issue "Vol 3, No 3 (2015): December" : 13 Documents clear
Eradikasi Kusta: Apakah Memungkinkan? Widyaningsih Oentari
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

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Association between Folic Acid and Zinc Concentration with Incidence of Bacterial Vaginosis in The First Trimester of Pregnancy Noroyono Wibowo; Rima Irwinda; Jimmy S. N. Berguna; Mohammad Azmi
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Bacterial vaginosis (BV) in pregnancy is associated with the increase of adverse pregnancy outcomes such as premature rupture of membranes and preterm labor. One of the multifactorial causes of BV is thechange in vaginal immunity. Malnutrition, including micronutrient deficiency, increases the vulnerability toinfections. This study aim to investigate the association between folic acid and zinc concentration with theincidence of bacterial vaginosis in the first trimester of pregnancy. This descriptive cross sectional studyinvolved 139 mothers with first trimester pregnancy, aged between 17-39 years old. The study was conductedat dr. Cipto Mangunkusumo Hospital from September 2013 until August 2014. Vaginal secretions was sampledto diagnose BV under nugent criteria. Folic acid and zinc in the serum were measured. From 139 subject,18.7% (n=26) were found to be BV positive (nugent score =7). No deficiency of folic acid (<7 ng/mL) and40.3% (n=56) of zinc deficiency (<60 &micro;g/dL) were found. Bivariate analysis used Kruskal-Wallis test betweenfolic acid and zinc concentration with BV incidence gives p value of 0.668 and 0.478 respectively. Prevalenceof BV in this study was 18.7%. The relation between the maternal statuses of folic acid with BV in the firsttrimester of pregnancy was not found. Keywords: bacterial vaginosis, folic acid, zinc, pregnancy. Hubungan antara Kadar Asam Folat dan Seng terhadap KejadianVaginosis Bakteri pada Trimester Pertama Kehamilan Abstrak Bakterial vaginosis (BV) pada kehamilan dihubungkan dengan meningkatnya luaran maternal yang buruk seperti ketuban pecah dini dan persalinan prematur. Penyebab BV multifaktor salah satunya adalahperubahan imunitas di vagina. Malnutrisi termasuk defisiensi mikronutrien meningkatkan kerentananterhadap infeksi. Studi ini dilakukan untuk mengetahui hubungan antara kadar asam folat dan seng terhadapkejadian vaginosis bakteri pada trimester pertama kehamilan. Penelitian ini merupakan studi deskriptif potonglintang yang mengikutsertakan 139 ibu hamil trimester pertama berusia 17&ndash;39 tahun. Penelitian dilakukandi Rumah Sakit Cipto Mangunkusumo pada bulan September 2013&ndash;Agustus 2014. Sekret vagina diambiluntuk mendiagnosis BV berdasarkan kriteria nugent. Dilakukan pengukuran kadar asam folat dan seng dalamserum. Dari 139 subjek, didapatkan 18,7% (n=26) positif BV (skor nugent = 7). Tidak terdapat defisiensi asamfolat (<7ng/mL) dan 40,3% (n=56) defisiensi seng (<60 &micro;g/dL). Analisis bivariat menggunakan uji kruskalwallisantara kadar asam folat dan seng dengan BV memberikan nilai p masing-masing 0,668 dan 0,478.Disimpulkan prevalensi BV pada penelitian ini adalah 18,7%. Tidak ditemukan hubungan antara status asamfolat dan seng maternal trimester pertama dengan BV. Kata kunci: bakterial vaginosis, asam folat, seng, kehamilan
Nilai Rerata Vascular Pedicle Width, Vascular Pedicle-Cardiac Ratio Vascular Pedicle-Thoracic Ratio Orang Dewasa Normal Indonesia Studi di RS dr. Cipto Mangunkusomo Rommy Zunera; Rahmi Afifi; Amir S. Madjid; Joedo Prihartono; Vally Wulani; Marcel Prasetyo
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Vascular pedicle width (VPW) adalah jarak tepi luar vena kava superior ke tepi luar arteri subklavia kiri. Pemeriksaan VPW di foto toraks bersifat non-invasif, cepat dan mudah untuk memprediksi hipervolemia.Penelitian ini bertujuan untuk mengetahui rerata nilai VPW orang dewasa normal Indonesia. VPW diukurdengan dua metode: pertama pengukuran VPW tunggal yang akurasinya terbatas di foto toraks digital karenarelatif tidak dipengaruhi faktor magnifikasi. Metode kedua untuk foto toraks nondigital yaitu pengukuranrasio:vascular pedicle-cardiac ratio (VPCR) dan vascular pedicle-thoracic ratio (VPTR). Pengukuran serupadilakukan terhadap topogram CT scan toraks AP terlentang dan CT scan toraks lalu dibandingkan akurasipengukuran di topogram dengan CT scan toraks sebagai standar baku. Sampel terdiri atas 104 foto toraksPA subyek normal dan 103 CT scan toraks subyek terpilih. Pada pemeriksaan toraks PA didapatkan rerata VPW 48,0&plusmn;5,5mm, rerata VPCR 40,3&plusmn;4,6%, dan rerata VPTR 17,2&plusmn;1,7%. Pada pemeriksaan topogram CTscan didapatkan rerata VPW 50,3&plusmn;6,2mm, rerata VPTR 45&plusmn;5,1%, dan rerata VPTR 19,8&plusmn;2,5%. Rerata VPWpada CT scan toraks 50,4&plusmn;6,1mm. Pengukuran di foto toraks AP 10% lebih besar dibandingkan pada fototoraks PA dan pengukuranVPW di foto toraks terbukti memiliki akurasi tinggi. Kata kunci: fototoraks, vascular pedicle width, vascular pedicle-cardiac ratio, vascular pedicle-thoracic ratio, hipervolemia. The Mean Value of Vascular Pedicle Width, Vascular Pedicle-Cardiac Ratio,Vascular Pedicle-Thoracic Ratio of Normal Indonesian Adult Study In dr. Cipto Mangunkusomo Hospital Abstract Vascular pedicle width (VPW) is the distance, from a perpendicular line at the takeoff point of the left subclavian artery off the aorta to the point at which the superior vena cava. Measurement of VPW on chestx-ray is relatively non-invasive, fast and easy technique as hypervolemia predictor. The purpose of thisstudy is to know the mean VPW value of normal Indonesian adult. There are two measurement methodswas performed, the first is a measurements of single VPW, which its accuracy is limited to digital chest x-ray.The second method for non digital chest x-ray utility is a ratio measurement i.e. the ratio of cardiac vascularpedicle-(VPCR), and vascular pedicle-thoracic ratio (VPTR). Similar measurements method performed onthe thoracic CT scan topogram (AP chest x-ray) and thoracic CT scan, then compared both of measurementto evaluate the accuracy of topogram measurement as thoracic CT scan as gold standard. Data from 104 PAchest x-ray of normal subjects and 103 thoracic CT scan of selected subjects. On PA chest x-ray obtainedmean VPW 48,0&plusmn;5.5mm, mean VPCR 40.3&plusmn;4.6%, and mean VPTR 17.2&plusmn;1.7%. On CT scan topogramobtained mean VPW 50,3&plusmn;6.2mm, mean VPTR 45&plusmn;5.1%, and mean VPTR 19.8&plusmn;2.5%. On thoracic CT scanobtained mean VPW 50.4&plusmn;6.1mm. Measurements on the AP chest x-ray about 10% greater than in the PAchest x-ray, and measurement of VPW on conventional chest x-ray aproved to have high accuracy. Keyword: chest x-ray, vascular pedicle width, vascular pedicle-cardiac ratio, vascular pedicle-thoracic ratio, hypervolemia.
Gambaran CT Scan Toraks Sesuai dengan Jenis Sitologi/Histologi pada Pasien Kanker Paru yang Merokok Rosa Tatun; Aziza G. Icksan; Elisna Syahruddin; Aria Kekalih
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

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Kanker paru merupakan penyebab kematian paling banyak akibat keganasan. Kanker paru memberikan gambaran CT scan yang berbeda sesuai dengan jenis sitologi/histologinya. Pemeriksaan CT scan toraksdengan teknik high resolution computed tomography (HRCT) dapat memperlihatkan kelainan kanker parusecara rinci. Penelitian dilakukan di Instalasi Radiologi RSU Persahabatan, Jakarta bekerja sama denganDepartemen Pulmonologi dan Respirasi RSU Persahabatan terhadap 100 sampel yang diperoleh pada bulanNovember 2014 hingga Maret 2015. Berdasarkan jenis sitologi/histologi kanker paru (adenokarsinoma dankarsinoma sel skuamosa/KSS) tidak ditemukan variabel yang bermakna secara statistik (bentuk, letak, tepispikulasi, tepi lobulasi, nodul satelit). Variabel yang paling banyak ditemukan pada adenokarsinoma maupunKSS adalah bentuk massa, lokasi di sentral dan paru sebelah kanan. Gambaran kanker paru adenokarsinomadan KSS pada pasien merokok paling banyak berupa massa, lokasi di sentral dan lobus kanan paru. Kata kunci: kanker paru, merokok, CT scan toraks Lung Cancer CT Scan Findings in Smoker Patients Basedon Cytology/Histology Abstract Lung cancer is the leading cause of most deaths due to malignancy. Lung cancer CT scan provides an overview according to the type of cytology / histology. Thorax CT scan with high resolution technique (HRCT) may revealdetail lung cancer abnormalities. This study was conducted between Department of Radiology and Departmentof Pulmonology Respiratory, Persahabatan Hospital Jakarta based on 100 samples, November 2014 until March2015. Based on cytological/histological type (adenocarcinoma and squamous cell carcinoma/KSS), it was not found significant meaningfull variables (shape, location, spiculate edge, lobulate edge, satellite nodules). Most commonly variables found in adenocarcinomas and KSS were mass forming, central location, right lung location.Most of adenocarcinoma and SCC in smoked patients were mass forming, central location, right lobe location. Keywords: lung cancer, smoking, thorax CT scan
Evaluasi Elektrokardiogram Interval QTc dan JTc pada Penderita Malaria Vivaks yang Diberikan Dihidroartemisinin-Piperakuin dan Primakuin Jason Sriwijaya; Rianto Setiabudy; Instiaty Instiaty; Marulam M. Panggabean
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Dihidroartemisinin-piperakuin (DHA-PPQ) telah digunakan secara global sebagai terapi malaria vivaks. Salah satu efek samping DHA-PPQ adalah pemanjangan repolarisasi ventrikel yang dapat menimbulkanaritmia ventrikuler yaitu Torsade de Pointes (TdP). Studi before-after ini bertujuan untuk mengetahuiperbedaan rerata interval QTc dan JTc penderita malaria vivaks sebelum dan sesudah pemberian DHA-PPQdan primakuin (PQ). Penelitian dilakukan di Lembaga Biologi Molekuler Eijkman, Jakarta pada bulan Mei-Juli2015. Sumber data adalah data sekunder hasil rekaman EKG pada penelitian utama &ldquo;Safety, tolerability, andefficacy of artesunat-pyonaridine or dihydroartemisinin-piperaquine in combination with primaquine as radicalcure for P.vivax in Indonesian soldiers&rdquo; tahun 2010. Subyek yang masuk kriteria seleksi pada pemberianDHA-PPQ dan PQ, masing-masing berjumlah 24 subyek dan 14 subyek. Interval QT dan JT dalam penelitianini menggunakan dua formula yang sudah dikoreksi terhadap frekuensi denyut jantung yaitu formula Bazett(QTcB, JTcB) dan Fridericia (QTcF, JTcF). Pemberian DHA-PPQ menunjukkan pemanjangan rerata intervalQTcF secara bermakna dibandingkan baseline yaitu sebesar 14,42 milidetik terjadi di D3 predose dan 20,53milidetik di D3 postdose. Rerata pemanjangan interval JTcF setelah pemberian DHA-PPQ adalah 13,43milidetik di D3 postdose. Pada pemberian PQ terdapat perbedaan nilai rerata interval QTcB dibandingkanbaseline sebesar 19,42 milidetik. Rerata pemanjangan interval JTcF dibandingkan baseline 16,50 milidetik diD42 postdose dan secara statistik bermakna. Kata kunci: dihidroartemisinin-piperakuin, primakuin, malaria vivaks, Torsade de Pointes, interval QTc, interval JTc. Electrocardiogram Evaluation of QTc and JTc Interval of DihydroartemisininPiperaquine and Primaquine Therapies Given to The Vivax Malaria Patients Abstract Dihydroartemisinin-piperaquin (DHA-PPQ) has been used globally as standard combination therapies for vivax malaria treatment. One of the side effects that must be put into caution is the prolongation ofventricular repolarization, which can lead to the development of ventricular arrhythmia known as Torsadede Pointes (TdP). This study used &lsquo;before and after&rsquo; design and was aimed to find out whether there was asignificant difference of QTc and JTc interval of vivax malaria patients pre and post DHA-PPQ and Primaquin(PQ) dose. The ECG record of DHA-PPQ and PQ, respectively, 24 and 14 subjects. QT and JT intervalsare affected by heart rate, thus, both of them have to be corrected according to the heart rate using twoformulas, i.e.: Bazett (QTcB, JTcB) and Fridericia (QTcF, JTcF) formulas. The results showed significant QTcFprolongations of 14.42 ms predose and 20.53 ms postdose on D3 DHA-PPQ treatment compared to thebaseline value, whereas prolongations of JT interval were 13.43 ms found on D3 postdose. The results aftergiven PQ showed mean difference of QTcB compared to the baseline value was 19.42 ms. The result for JTcFinterval after given PQ, showed mean difference of prolongations compared to the baseline value was 16.50ms, which was statistically significant. Key words: dihydroartemisinin-piperaquine, primaquine vivax malaria, Torsade de Pointes, QTcinterval,JTc interval
The Effect of Mangosteen Rind Glucose Transport in Small Intestine Cell Membrane of Wistar Rats Vejaya Vejaya; Diah D. Djunaedi; M. Nurhalim Shahib
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Seven percent of the people in the United States have hyperglycemia, which a third of them are unaware with the condition. To prevent this from occurring, mangosteen rind can be taken as daily supplements. Itsfruit hull has been used as traditional medicine in Southeast Asia countries. The objective of this researchis to study the effect of mangosteen rind (Garcinia mangostana) on glucose transport across small intestinecell membrane of wistar rats. Perfusion method of mangosteen rind was used to carry out this experiment.Nine rats were used after overnight fasting. They were divided into three groups where each group received20%, 40% and 60% of mangosteen rind. Each rat received simple glucose solution as the control and glucosewith mangosteen rind infusion as the treatment. The sample was taken every 15 minutes for 1 hour from thesmall intestine and was measured using a spectrophotometer. The results were not statistically significant forall three different concentration of mangosteen rind. The mangosteen rind has inhibitory effect but it is notstatistically significant on glucose absorption across small intestine cell membrane. Further investigation isneeded to be done by using higher concentration of mangosteenrind infusion. Keywords: Mangosteen rind, Garcinia mangostana), antihyperglycemic, glucose transport, small intestine Efek Kulit Manggis terhadap Transpor Glukosa MelaluiMembran Sel Epitel Usus Halus Tikus Wistar Abstrak Banyak orang tidak sadar bahwa mereka menderita hiperglikemia. 7% dari orang-orang di Amerika Serikat, hampir sepertiga dari mereka saat ini tidak menyadari bahwa mereka memiliki hiperglikemia. Untuk mencegahhal ini, kulit buah manggis dapat dijadikan sebagai suplemen harian karena memiliki banyak manfaat. Kulitbuahnya telah digunakan sebagai obat tradisional di negara Asia Tenggara karena anti-inflamasi, antiulkusdan antiseptik. Tujuan dari penelitian ini adalah untuk mempelajari pengaruh dari kulit buah manggis (Garciniamangostana) pada transportasi glukosa yang melintasi membran sel usus kecil pada model tikus wistar. Metode perfusi dari kulit buah manggis digunakan dalam percobaan ini. Sembilan tikus digunakan dipuasakan selama 8-10 jam. Tikus tersebut dikelompokkan menjadi tiga kelompok dan masing-masing kelompok menerima 20%,40% dan 60% dari kulit buah manggis. Setiap tikus menerima larutan glukosa sederhana sebagai kontrol danglukosa dengan kulit buah manggis sebagai eksperimen. Sampel diambil dari usus kecil lalu diukur denganspektrofotometer. Ditemukan hasil yang tidak signifikan secara statistik pada semua kelompok dengan tigakonsentrasi berbeda kulit manggis. Kulit buah manggis memiliki efek penghambatan tetapi tidak signifikansecara statistik pada penyerapan glukosa melalui membran sel usus kecil. Kata Kunci: Kulit manggis, Garcinia mangostana, antihiperglikemik, transpor glukosa, usus kecil
Cakupan Pemberian Obat Pencegahan Massal Filariasis di Kabupaten Sumba Barat Daya Tahun 2012-2013 Zahrotul Habibah; Saleha Sungkar
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Filariasis merupakan masalah kesehatan masyarakat terutama di Indonesia Timur antara lain di Kabupaten Sumba Barat Daya (SBD). Untuk mengeliminasi filariasis, WHO membuat program PemberianObat Pencegahan Masal (POPM) dengan dietilkarbamazin sitrat dan albendazol setiap tahun selama 5tahun berturut-turut. Untuk mengetahui keberhasilan POPM, perlu dilakukan evaluasi cakupan POPM setiaptahun. Tujuan penelitian ini adalah mengetahui cakupan POPM di SBD pada tahun 2012-2013. Penelitanini menggunakan data POPM Dinas Kesehatan SBD pada tahun 2012 dan 2013. Cakupan POPM filariasisdihitung berdasarkan jumlah penduduk minum obat dibagi penduduk total dan jumlah penduduk sasaran.Target cakupan pengobatan penduduk sasaran adalah >85% dan dari penduduk total adalah > 65%. Hasilpenelitian menunjukkan cakupan POPM filariasis berdasarkan penduduk total pada tahun 2012 adalah 1,96%dan tahun 2013 sebesar 1,13%. Cakupan POPM filariasis berdasarkan penduduk sasaran pada tahun 2012adalah 2,51% dan tahun 2013 adalah 1,35%. Disimpulkan bahwa cakupan POPM filariasis berdasarkanpenduduk sasaran dan penduduk total di SBD sangat rendah dan cakupan tahun 2013 lebih rendahdibandingkan tahun 2012. Kata kunci: W. bancrofti, B.malayi, B.timori, pemberian obat masal pencegahan, Sumba Barat Daya Coverage of Mass Drugs Administration (MDA) for Filariasis inSouth West Sumba on 2012-2013 AbstractFilariasis is a disease caused by Wuchereria bancrofti, Brugia malayi and Brugia timori. It is transmitted by mosquitos. It cause defect in patient&rsquo;s physical condition, decrease social life, and increase health spending.WHO concepts a program to eliminate filariasis by Massal Drugs Administration (MDA) of filariasis. It hasto be evaluated each year in five years by counting the coverage of MDA of filariasis in total population andtargeted population. This research used secondary data from Dinas Kesehatan in SBD to know the coverageof MDA of filariasis in SBD on 2012-2013. The coverage of MDA of filariasis based on total population in SBDon 2012 was 1.96% and on 2013 was 1.13%. The coverage of MDA of filariasis based on targeted populationin SBD on 2012 was 2.51% and on 2013 was 1.35%. Consequently, the coverage of MDA of filariasis basedon total and targeted population in SBD on 2013 lower than on 2012. Keywords: W. bancrofti, B.malayi, B. timori, massal drugs administration, Sumba Barat Daya
Gambaran Hasil Terapi TB Paru pada Pasien TB-HIV di RSUP dr.Hasan Sadikin Bandung Tahun 2012-2014 Dinka Anni Zamy; Bony Wiem Lestari; Yovita Hartantri
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Tuberkulosis (TB) merupakan penyakit infeksi oportunistik yang sering dijumpai pada pasien Human Immunodeficiency Virus (HIV). Berkaitan dengan tingginya kejadian TB pada penderita HIV World HealthOrganization (WHO) mencanangkan program penanggulangan TB-HIV. Penelitian ini bertujuan untukmengetahui hasil terapi TB Paru pada pasien TB-HIV yang dirawat inap dan rawat jalan di RSUP dr.HasanSadikin. Penelitian deskriptif kuantitatif ini menggunakan sumber data dari rekam medis pasien TB-HIV diinstalasi rawat inap dan rawat jalan RSUP dr.Hasan Sadikin Bandung Tahun 2012-2014. Karakteristik sosiodemografi meliputi usia, jenis kelamin, pendidikan, pekerjaan, status pernikahan, dan tempat tinggal. Terdapat60 (84,5%) subjek yang berusia 20-40 tahun, laki-laki 50 (70,4%) subjek, lebih banyak dari perempuan.Subjek dengan pendidikan SMA sebanyak 33 (46,4%) orang dan subjek yang tidak bekerja 20 (71,8%) orang,47 (66,2%) subjek sudah menikah dan subjek yang berdomisili di Bandung 56 (78,9%) orang. Luaran terapipada pasien ko-infeksi TB-HIV yang sembuh berjumlah 17 (23,9%) subjek, sembuh lengkap 14 (19,7%)subjek, putus pengobatan 24 (33,8%) subjek, pindah sebanyak 8 (11,3%) subjek, dan meninggal 8 (11,3%)subjek dan tidak terdapat luaran terapi gagal. Hasil luaran terapi TB paru pada pasien ko-infeksi TB-HIVdi instalasi rawat inap dan rawat jalan di RSUP dr.Hasan Sadikin yang banyak adalah putus pengobatandibandingkan dengan luaran terapi sembuh. Kata kunci: Koinfeksi, TB-HIV, luaran terapi TB. Overview Treatment Results of Pulmonary TB in TB-HIV Patients atdr. Hasan Sadikin Hospital Bandung In 2012-2014 Abstract Tuberculosis (TB) is commonly found as an opportunistic infection in patients with Human Immunodeficiency Virus (HIV). Due to the high incidence of TB in people with HIV, World Health Organization (WHO) declared TB-HIV program. This study aims to determine the results of pulmonary TB therapy inhospitalized and ambulatory TB-HIV patients at dr. Hasan Sadikin Hospital. This quantitative descriptivestudy was done by using the medical records of inpatient and outpatient TB-HIV data in 2012-2014. Sociodemographiccharacteristicsinclude age,gender,education,occupation, marital status, andresidence. Therewere60 (84.5%) subjects aged 20-40 years old, comprised of 50 male (70.4%) subjects, which more thanwomen. Subjects with a high school education were 33 (46.4%), unemployed were 20 subjects (71.8%), 47(66.2%) of subjects were married and lived in Bandung were 56 (78.9%) people. The outcomes therapy inpatients co-infected with TB-HIV were as followed 17 (23.9%) of subjects were cured, 14 (19.7%) of subjectsfully recovered, 24 (33.8%) of the subjects were dropped out from treatment, 8 (11.3%) of the subjects movedaway, 8 (11.3%) of the subjects passed away, and there was no failure therapy. More patients were found outto be dropping out of treatment compared with to the cured patients in Pulmonary TB treatment outcomes inpatients co-infected with TB-HIV at the inpatient and outpatient care of dr. Hasan Sadikin. Keywords: co-infection, TB-HIV, TB treatment outcomes.
Peran Beras Angkak dalam Mempercepat Penyembuhan Fraktur dengan Gangguan Vaskularisasi pada Rattus novergicus Phedy Phedy; Aryadi Kurniawan; Nuryati C. Siregar
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
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Abstract

Beras angkak dapat meningkatkan proliferasi osteoblas dan efek anabolik massa tulang. Penelitian ini bertujuan mengetahui efek beras angkak terhadap penyembuhan fraktur dengan gangguan vaskularisasi.Penelitian dibagi tiga tahap: pertama mengembangkan model fraktur pada diafisis tulang femur dengangangguan vaskularisasi. Tahap ke-2 menentukan inter dan intra-observer agreement skor Allen dan skorSalkeld modifikasi. Tahap ke-3 studi eksperimental dengan desain randomized post test only control group.Sebanyak 45 tikus jantan R.novergicus dibagi 3 kelompok lalu diberikan ekstrak angkak 25x10mg/gBB dan50x10mg/gBB. Kelompok kontrol berupa akuades. Pemeriksaan histopatologis minggu ke-8 tidak tampakpembentukan tulang rawan atau tulang. Skor Allen menunjukkan inter-observer dan intra-observer agreementyang baik (kappa 0,759 dan 0,746). Skor Salkeld modifikasi menunjukkan inter-observer dan intra-observeragreement yang buruk (kappa 0,493 dan 0,461). Uji regesi linier skor Salkeld modifikasi menunjukkankoefisien konstanta 0,643 (p<0,001) dan koefisien skor Allen 0,929 (p<0,001). Uji regresi linier skor Allendiperoleh koefisien konstanta -0,508 (p<0,001) dan koefisien skor Salkeld modifikasi 0,953 (p<0,001). Tidakada neovaskularisasi atau proliferasi jaringan fibrous pada RYR 25 dan RYR 50. Pada RYR 25 penyembuhanlebih baik dan pada RYR 50 terdapat pembentukan tulang rawan. Pemberian beras angkak mempercepatpenyembuhan fraktur dan dosis 50 mg/kgBB memberikan hasil lebih baik dibandingkan 25 mg/kgBB. Kata kunci: Beras angkak, BMP-2 dan VEGF, RYR 25, dan RYR 50-3 The Role of Angkak Rice in Accelerating Fracture Healing and ImpairedVascularization in Rattus novergicus Abstract Angkak rice increase stimulation of osteoblast proliferation and provides an anabolic effect on bone mass. This study aims to know the effect of angkak rice on fracture healing with impaired vascularization.The study was divided into three stages: the first was to develop a model in the diaphysis femur fractureswith impaired vascularization. Phase two was to determine inter and intra-observer agreement with Allen and Salkeld modification scores. Phase three was to conduct experimental study with post test only control group. Forty five males R.novergicus were divided into 3 groups, then given angkak extract of 25x10mg/gBW and50x10-3mg/gBW. The control group given distilled water. Histopathologic examination of the 8 week showedno cartilage or bone formation. Allen scores indicated a proficient inter-observer and intra-observer agreement(kappa 0.759 and 0.746). Salkeld modification scores showed poorly in the inter-observer and intra-observeragreement (kappa 0.493 and 0.461). Based on the linear regression for Salkeld modification the constantcoefficient was 0.643 (p<0.001) and Allen score was 0.929 (p<0.001). The linear regression for Allen scorethe constant coefficient was -0.508 (p<0.001) and the Salkeld modification was 0.953 (p<0.001). There wasno neovascularization or fibrous tissue proliferation in the RYR 25 and 50. The 25 RYR had better healing andthe RYR 50 formed cartilage formation. Angkak rice administration accelerates fracture healing and the doseof 50 mg/kg gave better results than 25 mg/kg. Keywords: Angkak rice, BMP-2, VEGF, RYR 25, RYR 50th-3-3
AplikasiTelemedicine dalam Merujuk Pasien dari Daerah Rural Lidwina Anissa; Sri Linuwih Menaldi
eJournal Kedokteran Indonesia Vol 3, No 3 (2015): December
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Kusta adalah penyakit menular yang disebabkan oleh basil lepra. Penderita kusta tersebar di seluruh Indonesia. Dalam Standar Kompetensi Dokter Indonesia, penanganan kusta tanpa komplikasi merupakankompetensi tingkat 4A, sedangkan penanganan reaksi kusta merupakan kompetensi tingkat 3A. Penanganankasus reaksi kusta dengan proses rujukan konvensional ke layanan kesehatan yang memilliki tenaga ahliterkendala oleh berbagai macam penyulit. Pemanfaatan teknologi smartphone berupa aplikasi Whatsapp,dengan menerapkan konsep telemedicine, diharapkan dapat menjadi solusi untuk meretas hambatanjarak, waktu dan finansial dalam proses rujukan pasien secara konvensional. Demi memberikan pelayanan kesehatan yang bersifat paripurna, sebaiknya konsep telemedicine dipelajari lebih lanjut dan diterapkan dalam pelayanan kesehatan. Kata Kunci: kusta, reaksi kusta, rujukan, smartphone, telemedicine, Whatsapp Telemedicine Application for Rural Patients&rsquo; Referral Abstract Leprosy is a communicable disease caused by leprosy bacillus. People with leprosy are distributed in all areas of Indonesia. In Indonesian Doctor Competence Standards, leprosy management is at level 4Acompetence; meanwhile leprosy reaction management is at level 3A competence. Management of leprosyreaction that needs a conventional referral to higher level of health centre has faced many obstacles.Smartphone instant messaging application (eg. Whatsapp) utilizes the concept of telemedicine, which will bea solution in solving distance, time and financial problems in conventional referral process. In order to provideholistic health service, telemedicine should be learnt further and applied. Keywords: leprosy, leprosy reaction, referral, smartphone, telemedicine, Whatsapp

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