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Saleha Sungkar
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INDONESIA
eJurnal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23501426     EISSN : 23386037     DOI : 10.23886
Core Subject : Health,
Elektronik Journal Kedokteran Indonesia (eJKI) is a peer-reviewed and open access journal that prioritize the publication manuscript of students (medical education program, magister/specialist, doctoral). This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. eJKI published three times a year (April, August, December) and published by Faculty of Medicine Universitas Indonesia
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Articles 11 Documents
Search results for , issue "Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus" : 11 Documents clear
Maternal Micronutrient Deficiency during the First Trimester among Indonesian Pregnant Women Living in Jakarta Saptawati Bardosono
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Restricted fetal growth and development is supported by the adequacy of several micronutrients, andmostly by iron, zinc, calcium, folate and B12 vitamin. This study aims to evaluate the maternal micronutrientstatus from dietary intake and blood sample. A cross-sectional study as part of the micronutrient interventionstudy was carried out in 143 healthy pregnant women during their first visit to the two maternity clinics inJakarta Indonesia (August 2013 – July 2014). Twenty-four hour dietary recall and semi-quantitative foodfrequency questionnaire were used to collect micronutrient intake data, while standard laboratory procedureswere applied to analyze micronutrient status from the blood sample. The dietary assessment data showedinsufficiency of iron, zinc, calcium, vitamin D, folate and vitamin B12 intake (less than its RDA) among 88.8%,95.1%, 97.9%, 100%, 90% and 78.3%, respectively. In relation iron status, 11.2% of the subjects were anemicand 20.3% had low ferritin level. Zinc deficient was found among 35% of the subjects. Deficiency of calciumand vitamin D were found among 25.2% and 90.2% of the subjects, respectively. Furthermore, deficiency ofboth folate and vitamin B12 were found to be 2.8%. Nutrition counseling and education, and the provision ofmulti-micronutrient fortified food as well as multi-micronutrient supplement specifically designed for mothersshould be started in the earliest time, i.e. starting from the peri-conception period.
Quality of Life among Patients on Hemodialysis atRSUD Tarakan, North Kalimantan, 2014 Winson Jos
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

Patients with end-stage renal disease require renal replacement therapy. Hemodialysis is the mostcommon renal replacement therapy in Indonesia. Quality of life assessment of patient undergoing hemodialysisshould be taken since it predicts mortality of end-stage renal disease patients. This cross-sectional studywas conducted at RSUD Tarakan. Primary data, such as socio-demography, comorbidity, and laboratoryresults were taken through history taking and medical records. Quality of life was assessed using KidneyDisease Quality of Life - Short Form (KDQOL-SF)-36 which has been used to measure quality of life ofpatients undergoing hemodialysis. There were 28 samples, with mean age of 53.5&plusmn;13.8 years old, male(67.9%). high school graduates (28.6%) and main comorbidity was hypertension (83%). Hemoglobin meanscore was 8.01&plusmn;2.12, serum ureum was 144.5&plusmn;44.85 and serum creatinine score was 9.13&plusmn;4.03. Physicaland mental health components score were 38.51&plusmn;8.37 and 44.48&plusmn;8.66. Other component mean scores wasphysical function 63.39&plusmn;24.08. Limitation of role because of physical and mental reasons were 58.33&plusmn;25.71and 53.3&plusmn;16.61, pain 57.05&plusmn;28.19, health perceptions 44.82&plusmn;15.42, vitality 48.21&plusmn;20.91, mental health55.14&plusmn;21.45 and social function 53.3&plusmn;16.61. Male had significantly lower mental health components score(p<0.05) and patients with hypertension had significantly worse SF-36 mean score compared to patientswithout history of hypertension (p<0.05). In conclusion, gender and hypertension was associated with lowerquality of life of patients undergoing hemodialysis.
Pre-anesthetic Anxiety Level in Children with Congenital Heart Disease: Comparison between Maternal Presence during Anesthetic Induction and Midazolam Premedication Ratna F Soenarto; Indah Pudjiningsih; Arif H.M. Marsaban; Fransiska Kaligis
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

General anesthesia was needed by children with congenital heart disease (CHD) who underwent cardiaccatheterization procedure and surgery. Pre-anesthetic anxiety in children with CHD can cause significantproblems during induction of anesthesia which leads to negative postoperative outcomes. This studycompared the role of maternal presence during anesthesia induction with midazolam premedication onpre-anesthetic anxiety level in children with CHD. Dr. Cipto Mangunkusumo National Hospital on April toSeptember 2014. Forty-five CHD patients aged 2-5 years old who underwent cardiac invasive procedurewere divided into P group (received midazolam premedication) and M group (had maternal presence duringanesthesia induction). Modified Yale Pre-anxiety Scale (MYPAS) was used for measuring anxiety level ineach patient during preoperative visit, on the time patient entered the procedure room and during induction ofanesthesia. There was no significant difference of MYPAS scores between the two groups in all measurementtimes. The MYPAS score results were non-anxious (median score 23.4) and the highest was at induction ofanesthesia. Inter-rater agreement test between 2 observers was good (k>0.5). In conclusion, there was nosignificant difference between the effect of maternal presence during induction of anesthesia and midazolampremedication on pre-anesthetic anxiety level in children with CHD.
The Effectiveness of Clomiphene Citrate and Letrozole for Ovulation Induction Related to Endometrial Thickness and Number of Dominant Follicle Budi Wiweko; Endy M. Moegni; Veinardi Madjid; Mushlihani Mushlihani
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

The aim of the study is to know the effectiveness of clomiphene citrate and letrozole for ovulationrelated to endometrial thickness and number of dominant follicle. Study design was cross sectional basedon medical records of women who underwent ovulation induction from January 2011-May 2015. A numberof 143 anovulation women were divided into clomiphene citrate 50mg, clomiphene citrate 100 mg, letrozole2.5mg and letrozole 5mg. Each group received the agent daily on 3rd-7th day of menstrual cycle. On 12thday of menstrual cycle, the transvaginal ultrasound was performed to measure endometrial thickness anddominant follicle number. From all subjects, 45 subjects (31.5%) were in 50mg clomiphene citrate groups, 29subjects (20.3%) in 100mg clomiphene citrate group, 23 subjects (16.1%) in 2,5mg letrozole group, and 46subjects (32.2%) in 5mg letrozole group. Subjects who received letrozole had thicker endometrium comparedto clomiphene citrate (p<0.05). Different doses were not associated with endometrial thickness betweensubjects who received either letrozole or clomiphene citrate. In addition, subjects receiving letrozole hadhigher proportion of having trilaminar endometrium morphology. We did not observe the difference in totalnumber of dominant follicle between groups. It is concluded that letrozole is more effective than clomiphenecitrate in terms of endometrial thickness but not for number of dominant follicles.
Mangiferin Effects against Doxorubicin Toxicity in Rat Testis Supraja Dwiyono; Wawaimuli Arozal; Radiana Dhewayani
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Abstract

The use of doxorubicin (DOX) as an anti-cancer agent might cause side effects to other organs suchas testicle due to increased oxidative stress. This study was aimed to investigate the antioxidant effect ofmangiferin inside Mangifera indica for lowering testicle toxicity. A total of 24 sprague dawley male rats wasdivided into 4 groups. The normal group was injected with 0.9% of NaCl, the negative control group receivedDOX with dosage of 15 mg/BW while DOX treated group received mangiferin with dosage of 30 mg/BW and60 mg/BW. After 7 weeks, all rats were killed and testicles from every rats were subsequently collected foroxidative stress parameter analysis which were measuring the rate of malonedyaldehide (MDA), superoxidedysmutase activity, histological changes, and apoptosis of caspase-9 and caspase-12. Administration ofmangiferin with dosage of 30 mg/BW and 60 mg/BW for 7 weeks decreased the destruction of spermatogeniccells and sertoli cells of seminiferous tubule, decreased the rate of MDA, and lowered the expression ofcaspase-9 in the group which received DOX and mangiferin. Improvement in those parameters indicated thatmangiferin had a protective effect towards spermatogenic and sertoli cells of seminiferous tubule destructionin rats which were given DOX.
Systemic Hypoxia Effect on Rat Brain Malondialdehyde, Glial FibrillaryAcidic Protein, and Acetylcholine Esterase Activity Andriani Andriani; Ani Retno Prijanti; Ninik Mudjihartini; Sri Widia A. Jusman
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Sistemic hypoxia causes lack of oxygen and energy in brain that trigger the release of acetylcholine,free radical and Glial fibrillary acidic protein (GFAP), a specific protein in astrocyte cells that act to strenghtenastrocite membrane. The aim of the research was to evaluate the damages of brain in systemic hypoxiathrough activity of acetylcholine esterase, neuron and astrocyte membran damages. The research conductedat the Chemistry and Molecular Biology Laboratory, FM Universitas Indonesia, in 2013. Twenty-five malespraque dawley rats were subjected to systemic hypoxia devided into 5 group of by placing them in thehypoxic chamber supplied 8-10% of O2 for 0, 1, 3, 5, and 7 days. Malondialdehyde (MDA), acetylcholineesterase specific activity and glial fibrillary acidic protein concentration were measured in plasma and braintissues. The result show that 7 day systemic hypoxia did not increase MDA concentration in plasma and braintissues, but increase significantly the spesific activity of acetylcholine esterase and GFAP concentration inbrain tissues. Systemic hypoxia as long as 7 day did not cause oxidative stress, but show increasing of AChEactivity and astrocyte adaptation through increasing of GFAP in brain tissues.
The Prevalence of Skin Diseases and its Association with Hygiene Behavior and Level of Education in a Pesantren, Jakarta Selatan 2013 Mohamad A. Sahala; Soefiannagoya Soedarman; Luddwi A. Rizky; Ahmad P. Natanegara; Muhamad S. Advani; Saleha Sungkar
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Skin diseases are very common in places where the society lives in a crowded area. Pesantren is anIslamic school with a dormitory for its students, thus making the spread of skin infection easier to occur. Theobjective of this research was to identify the association between the prevalence of skin diseases with the hygienebehavior and level of education of santris (students of pesantren). This cross-sectional study was conducted in apesantren in South Jakarta. Data collection was carried out through a questionnaire consisting of ten questionsabout hygienic behaviors and history of previous dermatological examinations from July until September 2013.Results showed that out of 98 santris, 88 of them had skin diseases (89.7%). The most frequent skin infectionwas scabies with 67 cases (49.3%). Furthermore, 78 (88.6%) out of all santris who had skin diseases, werecategorized to have poor hygienic behaviors. There were only 10 santris that did not have any skin disease, 3of them had good hygienic behaviors. There was no significant difference between hygienic behaviors of santrisand the prevalence of skin disease (p=0.350). Associated with the level of education, ibtidaiyah had the highestnumber of santris (51.2%) affected by skin diseases. There was a significant difference between the level ofeducation and the prevalence of skin diseases (p<0.001). In coclusion, the prevalence of skin diseases in thepesantren was 89.7%; there was no association between skin diseases and hygienic behaviors. However, therewas an association between skin diseases and level of education.
The Relationship between Participation of Health Insurance with BloodPressure Control in Adult with Hypertension Della P. Sari; Mirtha T. Listya
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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This evidence based case report aimed to investigate the relationship between participation of healthinsurance with blood pressure control in adult with hypertension. Literature review was conducted on May19th, 2016 using Pubmed&rsquo;s Clinical Queries, Proquest, and EBSCO, which resulted in 6 useful articles to becritically appraised. The result of critical appraisal was uninsured patients with hypertension increased the riskof failure in blood pressure control by 1,23-2,89 times compared with insured patients. It can be concludedthat participation in national health insurance is very important to make sure every hypertensive patientsreceive regular anti-hypertensive drugs and hence target blood pressure can be achieve.
The Role of Imaging in Uveitis Diagnosis Ratna Sitompul
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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Uveitis is an inflammatory disease affecting iris, ciliary body, pars plana, vitreous, choroid and retina.Inflammation process can be either limited in uveal tract or as part of systemic inflammation caused byautoimune, infection or cancer. Uveitis can cause phophobia, pain, reduced visual accuity and blindness if notproperly treated. Therefore, right diagnosis and prompt treatment should be given immediately to reduce themorbidity. Diagnosis of uveitis is made based on anamnesis, ophtalmic and physical examination, followedby imaging to confirm the patologic changes in the eyes. Slit lamp and simple photography can be usedto evaluate sign of inflammation in anterior chamber and outer part of the eye. Inflammation marker canbe counted using laser flare photometry (LFP) and fundus fotography can visualize pathologic changes inposterior part of the eyes. Fundus fluorescein angiography (FFA), indocyanine green angiography (ICG), andfundus autofluorescence (FAF) can be used to evaluate the integrity of vascular part in retina and choroid.Ultrasound (USG), optical coherence tomography (OCT), and multimodal imaging visualize retina, choroid,optic nerve and nerve fiber layer of retina using non-contact and non-invasif technique. MRI also used toevaluate inflammatory process in the eye. These imaging modalities are usefull to confirm the diagnosis ofuveitis, monitor the disease progression and evalute the treatment.
Mikrobioma: Pemahaman Baru tentang Peran Mikroorganisme dalam Kehidupan Manusia Pratiwi P. Sudarmono
eJournal Kedokteran Indonesia Vol 4, No 2 (2016): Vol 4, No. 2 (2016): Agustus
Publisher : Faculty of Medicine Universitas Indonesia

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