cover
Contact Name
Saleha Sungkar
Contact Email
salehasungkar@yahoo.com
Phone
-
Journal Mail Official
ejki.fkui@ui.ac.id
Editorial Address
-
Location
Kota depok,
Jawa barat
INDONESIA
eJurnal Kedokteran Indonesia
Published by Universitas Indonesia
ISSN : 23501426     EISSN : 23386037     DOI : 10.23886
Core Subject : Health,
Elektronik Journal Kedokteran Indonesia (eJKI) is a peer-reviewed and open access journal that prioritize the publication manuscript of students (medical education program, magister/specialist, doctoral). This journal publishes editorial, research article, reviews, evidence-based case report, and also interesting case reports/case study. eJKI published three times a year (April, August, December) and published by Faculty of Medicine Universitas Indonesia
Arjuna Subject : -
Articles 12 Documents
Search results for , issue "Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember" : 12 Documents clear
The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats Ismawati ismawati; Ligat Pribadi Sembiring
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Various studies have studied the clinical use of alpha-lipoic acid (ALA) for treating diabetic complications. The protective effect of lipoic acid in atherosclerosis induced by diabetes mellitus type 2 (DM type 2) still needs further study. This study was aimed to investigate the protective effect of ALA in atherosclerosis induced by DM type 2. Twenty one rats were divided into 3 groups: control, DM−treated and DM+ALA-treated group. Type-2 diabetes was induced by intraperitoneal injection of streptozotocin (50 mg/kg) followed by nicotinamide (110 mg/kg). ALA was administered orally at a dose of 60 mg/kg body weight/day throughout the feeding period for three weeks. This study was an experimental study with post-test only with control method which was conducted at Biochemistry laboratory, Faculty of Medicine Universitas Riau from June-October 2016. This study showed that DM+ALA treated group achieved lower atherosclerosis scores than DM-treated group and the difference between the two groups was statistically significant. In conclusion, alpha lipoic acid can prevent atherosclerosis lesions induced by diabetes.
The Effect of Graded Doses of Oral Trihexyphenidyl on Lumen Diameter of Mus musculus Renal Kidney Devangga Kusuma; Arni K Dewi; Bambang Hermanto
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Trihexyfenidyl is a class of anticholinergic drugs used, among others, to treat the symptoms of Parkinson’s disease and to control extrapyramidal disorders due to central nervous system drugs. However, the use of high dose trihexyfenidyl may cause renal impairment. Until now, the understanding of the pathologies of renal disorders due to trihexyfenidyl is unclear. This research was conducted to look at the histologic features and changes in the renal tubules associated with the doses used. This research was an experimental study which used 36 mice (Mus musculus) and they were divided into 4 groups. Control group was given a standard feed while the treatment group consisted of three groups were given a dose of trihexyphenidyl with 0.0208mg/20grBW/day, 0.0416mg/20grBW/day and 0.0624mg/20grBW/day for 14 days. The research was done on October-November 2016 at Pharmacology, Anatomy and Histology laboratory, Faculty of Medicine Universitas Airlangga. The results showed that the average proximal tubule diameter in control goup was 24.4±2.13μm, group 1 was 21.1± 2.98μm, group 2 was 16.2± 4.1μm, and group 3 was 11.5±0.79μm. In the treatment group, the diameter of the proximal tubule decreased in proportion to the dose administered. The smallest proximal tubular lumen diameter was seen in the highest dose-treated group.
Mental Disorders in Children and Adolescents with HIV and Various Factors Related Shiely T. Hartadi; Fransiska Kaligis; R. Irawati Ismail; Charles E. Damping; Nia Kurniati
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

HIV/AIDS may affect all ages, including children and adolescent. HIV may lead to various physical and mental problems. This study aims to measure the prevalence of mental disorder in children and adolescent infected with HIV and various other factors related. This cross sectional study was done during August until November 2014, included 92 patients in Allergic-Immunology outpatient clinic in Pediatric Department of Cipto Mangunkusumo Hospital. Samples were interviewed to collect personal data, examined using SDQ and MINI KID questionnaires.The results showed 18.5% and 25% of the samples have emotional and behavioral problem. Approximately 23.9% have mental disorders, with separation anxiety (7.6%), ADHD/ attention deficit and hyperactive disorder (7.6%), adjustment disorder (1.1%), major depression (4.3%), and oppositional defiant disorder (3.3%). Analysis suggest that samples who are currently attending school, and samples that have not disclosed to their condition as being HIV+, are more protected from mental problems, though not statistically significant. The prevalence of mental disorders in children and adolescent with HIV are higher than the general population. Emotional, hyperactivity and behavioral problems are related to mental disorder.
Left Ventricular Myocardial Intrinsic Function in Mitral Stenosis: Evaluation of Pre and Post Balloon Mitral Valvotomy Nisa Ike Rini Asnil; Amiliana M. Soesanto; Ario S. Koencoro; Mira Fauziah
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of the treatment options in mitral stenosis (MS) is balloon mitral valvulotomy (BMV) which may improve myocardial intrinsic function. This study was aimed to observe myocardial systolic function with intrinsic parameter by using STDS- focusing on global longitudinal strain (GLS) - in MS pre and post BMV. This descriptive analytic study which included MS patients who underwent BMV from 2009-2011, were examined by routine echocardiography examination, one day pre BMV and maximal 5 days post BMV. STDS of 4 Left ventricle chambers were taken. Exclusion criteria were: post BMV gradient more than 10 mmHg and post BMV significant mitral regurgitation. Paired t-test analysis was used to compare variables pre and post BMV procedure. There were 45 MS patients with mean age of 39 years old (&plusmn; 10.7), pre BMV: mean MVA 0.68 cm2 (SD 0.57), mean MVG 14.02 mmHg (SD 5.06), mean EF 58.26% (SD 8.82) and mean GLS -11.81 (SD 3.50). Post BMV: mean MVA 1.4 cm2 (p : 0.000), mean MVG 5.82 (p<0.001), mean EF 61.28% (p=0.001) and GLS also significantly improved to 13.18 (p=0.02). Improvement of LVMIF after BMV procedure, may explain beneficial effect of BMV in regional myocardial deformation and systolic function in MS patients.
Effectiveness of Influenza Vaccination in Preventing Acute Asthma Exacerbations in Adult Patient Nabella Qisthina Laksita Dewi; Erni Juwita Nelwan
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acute respiratory tract infection is a major cause of acute exacerbations in asthma. One example of viral respiratory tract infection is influenza caused by influenza virus. Administering influenza vaccine to asthmatic patients is expected to protect them from acute asthma exacerbations caused by influenza virus.The purpose of this case study is to determine the effectiveness of influenza vaccines in protecting the patients from acute exacerbations of asthma in adults. Literature search was conducted in the Pubmed database, EBSCO, Clinical Key, Google Scholar, and Science Direct to identify relevant articles. Literature search was done on March 30th, 2015. There were two selected articles that met the criterias and fully accessible for further review. Both articles had good validity and showed that there was no significant effect of influenza vaccination against acute asthma exacerbations. Number Needed to Treat (NNT) value from one of the articles showed no significancy. Influenza vaccination does not have significant protective effect against acute asthma exacerbations in adults.
Association of FSH Level with Spermatogenic Histology Based on Johnson Criteria in Azoospermic Patients Ponco Birowo; Namira Kesuma Jelita; Pudji Sari; Nur Rasyid
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aims of this study is to know the association FSH level with spermatogenic histology on testical biopsy and to evaluate the use of FSH level as predictor of the succes of testical biopsy on azoospermic patient using Johnson criteria. This is a cross-sectional study, comparing two groups, i.e. spermatogenic histology pattern using Johnson criteria and FSH level (IU/L). Age, FSH level, spermatogenic histology pattern are collected from medical record. Population of this study were azoospermic patients in the Deparment of Urology Cipto Mangunkusumo hospital and Morula Clinic Bunda Hospital between 2011 &ndash; 2015. Descriptive study was calculate, followed by one way ANOVA comparative test with post-hoc test Duncan and ROC curve analysis to determined the AUC and cut-off value. The age of the patients were 21-51 years old and the most frequent were 31-40 years old (67%). The most frequent histology pattern and Johnson criteraia were maturation arrest (41%) and 5 (27.8%) respectively. Mean level of FSH was 15.83 IU/L with minimum level was 2.35 IU/L and maximaum 41.3 IU/L. There was association between FSH level and spermatogensis histology pattern using Johnsosn criteria, however the validity to predict the outcome of sperm in biopsy in azoospermic patients using FSH level was still low.
Reverse-Transcriptase Characteristics of Hepatitis B Virus Polymerase Gene in Treatment-Naïve Asymptomatic Chronic Hepatitis B Individuals Turyadi Turyadi; Meta Dewi Thedja; Susan Irawati Ie; Vanny Narita; Neni Nurainy; David Handojo Muljono
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Nucleos(t)ide analogues (NUCs) remain the main treatment for chronic hepatitis B (CHB). Long-term use of NUCs significantly reduces disease progression; however, it might lead to resistance-associated mutations. We studied characteristics of polymerase gene related to NUCs resistance in na&iuml;ve hepatitis B surface antigen (HBsAg)-positive individuals. The research was done at Laboratory of Hepatitis, Eijkman Institute, Jakarta Thirty eight samples were obtained and submitted for HBV DNA detection. Identification of mutations was performed by PCR-sequencing, and analyzed to obtain NUCs resistance motifs. Genotype and subtype were determined based on HBsAg sequence. Mutation of rtQ238H/N was found in 37 (97.4%) samples. Of those, 23 (62.2%) showed rtQ238H mutation, 10 (27.0%) had rtQ238N mutation, and four (10.8%) with double mutations of rtA194T and rtQ238H. Genotype B was found in 26 (68.4%), C in 11 (28.9%), and D in one (2.6%) samples. Statistically, the mutation variant of rtQ238H was associated with genotype B (p<0.001), while rtQ238N with C (p<0.001). The ayw subtype was found in 25 (65.8%), adr in 11 (28.9%), and adw in two (5.3%) samples. No mutation associated with NUCs resistance was found in most samples. This emphasizes that NUCs are still a prospective treatment in na&iuml;ve CHB patients. Mutation of rtQ238H was a variant found to be significantly associated with HBV genotype B and rtQ238N with genotype C.
Trauma and Injury Severity Score in Predicting Mortality of Polytrauma Patients Bambang Gunawan; Risa Dumastoro; Achmad Fauzi Kamal
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

TRISS (Trauma and Injury Severity Score) is one of the most commonly used trauma score. Currently, there is no data about using TRISS in the care of polytrauma patients at emergency department of dr. Cipto Mangunkusumo Hospital (CMH). This research was intended to evaluate whether TRISS can predict the mortality of polytrauma patients at CMH. This was an analytic descriptive study with retrospective cohort design. Data was collected from medical records of polytrauma patients who were admitted to emergency department of CMH from 2011-201 4 then we analyzed the relationship between TRISS and patient's prognosis. Furthermore, we conducted bivariate and multivariate analysis by SPSS 20 software. Seventy medical records were included in this study. The majority of patients were male (65%) in young age. There were 69 patients who experienced blunt trauma, with the majority (94.3%) were caused by motor vehicle accident. After receiving trauma care, there were 26 deaths, while other 44 patients survived. From bivariate and multivariate analysis, we found a significant difference between TRISS and patient's prognosis. TRISS strongly predicts polytrauma patient's mortality (AUC 0,899; IK95% 0,824-0,975). TRISS has 84,6% sensitivity and 81.8% specificity with optimal intersection point &le; 90,5. TRISS is able to predict the mortality of polytrauma patients at CMH.
Mengatasi Aritmia, Mencegah Kematian Mendadak Yoga Yuniadi
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tidak ada abstrak
The Comparison of Survival, and Cost Effectiveness of Geriatric Patients Admitted in Dr. Cipto Mangunkusumo Hospital Before and During National Health Insurance Program Implementation Czeresna Heriawan Soejono; Paskalis Gunawan
eJournal Kedokteran Indonesia Vol 5, No 3 (2017): Vol 5, No. 3 (2017): Desember
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Comprehensive Geriatrics Assessment (CGA) has been proven to improve the overall outcome of geriatric patients care, and has been implemented in RSCM as the standard geriatric medical care. National Health Insurance Program (NHIP) was implemented in Indonesia in January 2014. It is unclear how NHI program will affect survival and cost effectiveness of geriatric patients receiving CGA. The aim of this study was to compare the survival and cost effectiveness between geriatric patients hospitalized during NHIP and before NHIP era in RSCM. This was a retrospective cohort study with historical control. The subjectswere geriatric inpatients aged &ge;60 years old with one or more geriatric giants between July to December 2013 (non NHIP) and January to June 2014 (NHIP). A survival analysis and determination of incremental costeffectiveness ratio (ICER) was used to compare the survival and cost-effectiveness between the two groups. The clinical and demographic characteristics were relatively similar between the NHIP and non NHIP group. No difference in mortaliy rate during hospital care and 30 days survival rate between NHIP and non NHIP group (31.2% vs 28%, p=0.602; 65.2% vs 66.4%, p = 0.086, respectively). No significant difference was found in the survival curve between the two groups. Calculation of ICER showed that NHIP was associated with an increased cost of 1.4 million rupiah and 1.2 % higher mortality rate. Further research is needed to evaluate this result when NHI Program has been implemented for a longer duration.

Page 1 of 2 | Total Record : 12