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Dinia R Dwijayanti,
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Biotropika
Published by Universitas Brawijaya
ISSN : 23027282     EISSN : 25498703     DOI : 10.21776/ub.biotropika.
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology
Biotropika: Journal of Tropical Biology invites research articles, short communication, and reviews describing new findings/phenomena of biological sciences in tropical regions, specifically in the following subjects, but not limited to biotechnology, biodiversity, microbiology, botany, zoology, biosystematics, ecology, and environmental sciences.
Arjuna Subject : -
Articles 505 Documents
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Identification of Mudskipper Species in Mangrove Area of Luwu Timur, Luwu Utara, and Wajo South Sulawesi Indonesia Annisa Zakiyah Darojat; Agung Pramana Warih Marhendra; Nia Kurniawan
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.02

Abstract

Mudskipper is amphibious fish that inhabited sandy beaches, mudflat, and mangrove areas. This fish is euryhaline because of its tolerance to varying salinity as well as pH, temperature, conductivity, and dissolved oxygen. This study aimed to identify the taxonomy status of mudskipper in Banua Pangka Mangrove Ecotourism, Seta-Seta Beach, and Masiae River, it was expected to be additional information used as a basis for management and benefaction in taxonomic and ecological aspects. The sampling method of this study was purposive sampling. Morphological identification was carried out by observing morphometric and meristic character. The result found two mudskipper species from three sampling sites, namely Periophthalmus argentilineatus and Periophthalmodon freycineti. Water quality parameter values at three sampling locations were within the optimal range for mudskipper species according to the previous study. The temperatures ranged from 28-33 Celsius, the dissolved oxygen ranged from 2.04-6.74 mg/L, the pH ranged from 6.57-7.1, conductivity ranged from 3.47-41.2 mS/cm, and the salinity ranged from 1.7-2.58 per-mille.
In silico Exploration of Bioactive Compounds from Withania somnifera as Inhibitor for Alpha Delta Bungarotoxin of Bungarus candidus Venom Kartika Prabasari; Nia Kurnianingsih; Nia Kurniawan
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.01

Abstract

The antivenom for Malayan krait (Bungarus candidus) venom has not yet been available in Indonesia, leading to many fatal snakebite cases. Alternative treatment approaches using medicinal plants are needed to be explored. This study investigated the potential of medicinal plants’ natural bioactive compounds as toxic alpha-delta bungarotoxin protein inhibitors in B. candidus venom. The approach taken is using the 3D structure of the alpha-delta protein of bungarotoxin B. candidus predicted by SWISS-MODEL. Knapsack Family Database and PubChem were used for bioactive compounds datamining. ADME analysis and drug-likeness of the compounds were carried out with SWISS-ADME. Docking between alpha-delta-Bungarotoxin protein and bioactive compounds was carried out with Pyrx 0.9.5. Visualization of docking results was performed with PyMOL and Discovery Studio 2016 was used to evaluate docking interactions. The docking results showed that a compound with the potential inhibitor of alpha-delta bungarotoxin came from Ashwagandha (Withania somnifera) with a binding energy ranging from -6.6 to -6.9. The compound with the best inhibitor potential, namely withanolide D, was seen from the stability of the interaction based on hydrogen bonding at three amino acid residues: THR59, SER62, and THR63. The evaluation is supported by the results of molecular dynamics simulations which show stability in almost all aspects. Our results suggest the potential for exploratory research in the field of bioinformatics related to bioactive compounds from herbal plants as an alternative to antivenom.
Microplastic Contamination in Waters and Sediments in the Selorejo Reservoir, Malang Regency, East Java Bayu Agung Prahardika; Iqbal Fatkhul Akbar; Muhammad Imam Muzammil
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.06

Abstract

Microplastic waste particles are a new contamination material in aquatic and terrestrial ecosystems. Heaps of garbage and fishing activities around residential areas are examples of anthropogenic activities around the Selorejo Reservoir and can potentially become sources of microplastic contamination. This research aims to observe the presence of microplastic contamination type and its abundance in water and sediment samples taken from the Selorejo Reservoir. The purposive sampling method was applied at five different stations, including the Konto River inlet, Kwayangan River inlet, residential area (kauman hamlet), tourism area, and reservoir outlets. Each station has three transects (as replicates), and about 100 liters of water and 1000 grams of sediment were taken. Water and sediment samples were then destruction using 30% H2O2 acid and 30% H2SO4 to remove organic components that were still attached and later facilitated observation under a stereo microscope with a magnification of 400X to make it clearer. All types of microplastics found were then counted based on their respective numbers. The analysis results showed that there was microplastic contamination in the reservoir water samples at each station. The highest abundance of microplastics was successively found in the Konto River inlet with a total abundance value of 39.27x101 particles/liter, then in the residential area (kauman hamlet) a number of 35.34x101 particles/liter, tourist areas 33.67x101 particles/liter, outlet 30.36x101 particles/liter and Kwayangan river inlet 29.67x101 particles/liter. Meanwhile, the presence of microplastics was also found in reservoir sediment samples. The highest abundance of microplastics was also found in sediments in the Selorejo Reservoir originating from the Konto River inlet with a total abundance value of 3.68 particles/gram, then in the tourist area 2.08 particles/gram, in the Kwayangan River inlet 1.56 particles/gram, in the residential area a number of 1.2 particles/gram and outlets 1.12 particles/gram. The types of microplastic found in the waters of the Selorejo Reservoir include fibers, fragments, and filaments. While the types of microplastics found in Selorejo Reservoir sediments include fibers, fragments, filaments, and films. This result is related to the existence of various community activities which are sources of microplastic contamination.
Ethnobotany of Medicinal Plants of the Sumba Trible in Central Sumba Regency, East Nusa Tenggara Timur Ariski Vevi Liswandari; Sulisetijono; Frida Kunti Setiowati
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.03

Abstract

The Sumba tribe is a local community that inhabits Sumba Island, one of which is in Central Sumba Regency. The majority of the people of the Sumba Tribe still have close interactions with nature, one of which is still using plants used for traditional medicine. This traditional medicine has been carried out for a long time and has become a tradition passed down from generation to generation in the customs of the Sumba people. This study aims to determine the diversity of plant species used for medicine by the Sumba people, the Use Value Index per species (UVs), and the Index of Cultural Significance (ICS) of medicinal plants in Central Sumba Regency. This study used the snowball sampling method by conducting open-ended interviews. The results of this study have found a diversity of plants that have potential as medicine. It is known that there are 116 species of medicinal plants used by the people of the Sumba tribe for medication. Medicinal plants can be found in the yard of the house. Based on the analysis of UVs, it was found that the species with the highest use value (Andrographis paniculata Ness), had the highest UVs (5.60), while for the ICS analysis, papaya (Carica papaya L.) had the highest ICS value (850).
Study of Flavonoid in Apium graveolens L. as a Kirsten Rat Sarcoma Protein Inhibitor in Colorectal Cancer Based on In Silico Study Abdullah Abdullah; Nenis Try Melani Putri; Nuraini Rosyadah; Putri Ramadhani; Siti Aqila Kharisma Putri; Muhammad Hermawan Widyananda; Nia Kurniawan; Fatchiyah Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 11 No. 2 (2023)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2023.011.02.07

Abstract

Colorectal cancer (CRC) is considered the second deadliest cancer, mainly caused by the mutation of Kirsten Rat Sarcoma (KRAS) type G12D; it’s still undruggable. Flavonoids are secondary metabolites in celery, consisting of apigenin, luteolin, quercetin, and kaempferol. This study aims to analyse the most potential flavonoid compounds in Apium graveolens L. as KRAS inhibitors in CRC with in-silico. This study starts by collecting the 3D structure, Compound ID, formula, and canonical SMILES of compounds from PubChem and the 3D structure of KRAS G12D from the RCSB-PDB. Ligand and protein preparations using OpenBabel PyRx and Biovia Discovery Studio 2019. The SwissADME web server is used to analyse drug-likeness, the PassOnline web server is used to analyse biological activity, docked using PyRx VinaWizard, and visualisation by Biovia Discovery Studio 2019. RMSD and RMSF values were obtained by analysing binding stability with the YASARA application. The molecular docking test showed that chrysoeriol, luteolin, and apigenin have the highest binding affinity and advance to molecular dynamic test. Results of the molecular dynamic showed that chrysoeriol could potentially inhibit the KRAS protein drug in CRC since it also had the lowest toxicity and the strongest binding affinity to the KRAS.

Page 51 of 51 | Total Record : 505

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