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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 255 Documents
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Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication Khairani Ayunanda Ikhlas; Yan Edward
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25338

Abstract

Introduction: Chronic suppurative otitis media is broadly defined as chronic inflammation that involved mucose of middle ear and mastoid air cells. The most commonly encountered intracranial complication from chronic suppurative otitis media is meningitis followed by brain abscess. Antibiotics are quite effective in early and late cerebritis stage. Surgical intervention is essential once the abscess’s capsule is formed. Case Report: Reported a case of a 22-year-old male diagnosed with chronic suppurative otitis media auris dextra suspected cholesteatoma type with cerebral abscess complications. The managements are cerebral abscess drainage followed by canal wall down mastoidectomy. In patient, Recurrent cerebral abscess formed. Conclusion: Chronic suppurative otitis media with complications of cerebral abscess is treated with abscess drainage if the abscess size is >2cm and followed by canal wall down mastoidectomy. Otogenic brain abscess due to chronic suppurative otitis media can occur repeatedly if abscess antibiotic therapy was/were inadequate Keywords: otogenic brain abscess, mastoidectomy, chronic suppurative otitis media, abscess drainage
Ascariasis Detection with IgG4 Using ELISA in Adults at Pasie Nan Tigo Village Padang City Anandila Maulina; Nuzulia Irawati; Fika Tri Anggraini
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25235

Abstract

Ascariasis is still one of the most common STH infections found in school-age children, but adults may also suffer from this infection. This is due to the fact that the parasite is able to manipulate the host's immune response by increasing the IgG4 levels. The IgG4 technique is a new specific and sensitive method for detecting ascariasis. This study is aimed to determine the prevalence of ascariasis based on IgG4 levels using the ELISA method in adults at Pasie Nan Tigo Village, Padang City. This study is a descriptive study with a cross-sectional design that took place from July 2020 - May 2021 using a multistage random sampling technique where a total of 78 adult respondents in Pasie Nan Tigo Village. Blood samples were taken in order to check their IgG4 levels, using the ELISA at Prodia Laboratory. Data analysis was performed univariately with the purpose of finding the frequency distribution. The results of this study show that from the total of 78 respondents, the majority of age group found is 46-55 years old, namely 28 respondents, the majority of gender is female, namely 65 respondents, 57 respondents were positive for IgG4 where the most sufferers are 17-25 years old (88.9 %) and male (76.9%). The conclusion of this study is most of the respondents were in the age group of 46-55 years and women, there were more than half of the total respondents who detected ascariasis with the most sufferers being the age group of 17-25 years and men. Keywords: Ascaris lumbricoides, STH, T Cell Regulator
The Performance of Hematological Parameters for Diagnosis of Acute Appendicitis in Children Supangat Supangat; Akhmad Makhmudi; Azka Darajat; Elly Nurus Sakinah; Muhammad Yuda Nugraha; Achmad Ilham Tohari; Tegar Syaiful Qodar; Bagus Wahyu Mulyono
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25715

Abstract

Early diagnosis of pediatric appendicitis is still difficult to make and 30-40% of cases do not show typical classic symptoms. The negative appendectomy rate and the risk of perforation reach 20% so that new, easy, inexpensive and accurate additional examination is needed. This study aimed to compare platelet distribution width (PDW) and mean platelet volume (MPV) values of appendicitis and control patients. This study is retrospective case control study. Differences in MPV and PDW levels in patients with appendicitis and controls were analyzed with a t-test and determination of sensitivity, specificity and accuracy of the two markers in appendicitis diagnosis were performed by ROC analysis The mean MPV appendicitis was significantly lower (p <0.05) compared to controls (8.3 ± 1.9; 9.2 ± 1.5) while PDW of appendicitis patients did not differ significantly from controls (10.4 ± 1, 4, 10.7 ± 2.4; p> 0.05). AUC MPV as a diagnostic tool for appendicitis 0.619 with a normal limit of 6.6 fl has a sensitivity of 90% and specificity of 30%. MPV can be used for the diagnosis of appendicitis with a normal limit of 6.6 fl having a sensitivity of 90% and specificity of 30%. There was no significant difference between PDW of appendicitis patients with controls. There was no significant difference between MPV levels of patients with simple appendicitis and complications. Keywords: Appendicitis, MPV, PDW, Platelet
Potential of Orchids Secondary Metabolites as Anti-Cancer and Antimicrobial Based on Prediction of Phytochemical Activity with Online PASS-Software Rafida Yasmin; Wulan Usfi Mafiroh; Anggiresti Kinasih; Aulia Noor Ramadhani; Rachmi Putri; Endang Semiarti
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.26848

Abstract

Abstract Orchidology is part of the branch of botany, it deals with a large family of monocotyledonous plants, Orchidaceae. Orchids have been used as traditional herbal medicines in Indonesia which are believed to be antimicrobial and anti-cancer. Orchids are able to produce secondary metabolites as their protective agent due to the extreme environment. Orchids have great diversity and potential to be the object of research, not only in experimental studies but also in a computational studies like in silico. Nowadays, molecular or metabolite data are available on the official-standard website as an international database. This study was conducted by analyzing web-based data to provide information about the potential of orchids that have been trusted as herbal medicines. In this study, secondary metabolite from Vanilla spp., Dendrobium spp., and Vanda spp., were selected in the existing literature as antimicrobial and anti-cancer drugs. Secondary metabolites obtained from the KNApSAck-3D core system and Phytochemical and Prediction of Substance Activity Spectrum (PASS) were performed to determine the potential anti-cancer and antimicrobial activity. Based on in silico analysis through PASS online, the secondary metabolites of orchids that have potential as antimicrobials in this study were Dendroside E and Dendromonilised D from Dendrobium also Parviflorin, Licoisoflavone and Luteine ​​extracted from Vanda spp. The secondary metabolite of Vanilla planifolia which has potential as anti-cancer for further research is 4-Hydroxybenzoic acid as a Chlordecone reductase inhibitor extracted from shoots. Keywords: orchid, antimicrobial, anticancer, secondary metabolite, PASS online
Analysis of the Relationship between Laboratory Biomarkers and the Severity of COVID-19 at Kaliwates General Hospital Jember Nadzir Ansharullah Akbar; Angga Mardro Rahardjo; Dita Diana Parti; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.29062

Abstract

Coronavirus Disease 2019 (COVID-19) has become a global health problem since the WHO declared the disease a pandemic. In July 2021, Indonesia experienced a very sharp spike in cases and an increase in mortality due to COVID-19, including at the Kaliwates General Hospital in Jember. Laboratory biomarkers in the form of Neutrophile Lymphpocyte Ratio (NLR), D-dimer, and SpO2 can be a clue to assess the severity of COVID-19 patients. This research is an observational analytical study using a Cross Sectional Study with the aim of knowing the relationship between laboratory biomarkers and the severity of COVID 19 at RSU Kaliwates Jember. This study uses secondary data in the form of medical records of COVID-19 patients during July 2021 with a total of 50 samples. The results of this study were carried out by the Spearman correlation test and it was found that there was a correlation between NLR values ​​and oxygen saturation with the severity of COVID-19, but there was no relationship between D-dimer levels and the severity of COVID-19. The conclusion of this study is that NLR biomarkers and oxygen saturation can be used as predictors of the severity of COVID-19.
In silico Test Proteolytic Potential of Papain and Zingibain Enzymes Against Protein Forming Congenital and Senilis Cataracts Gangsar Lintas Damai; Nugraha Wahyu Cahyana; Ayu Munawaroh Aziz
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.23324

Abstract

Abstract Phacoemulsification is cataract therapy’s gold standard with lowest complication rate and best visual outcome. However, phacoemulsification is expensive and difficult to use widely. Pathogenesis of cataract related to Crystalline P23T γD protein in congenital cataracts and β-amyloid protein in senile cataract. Papain enzymes and zingibain enzymes are cataract’s alternatives therapy with proteolytic effects that potentially lyse these proteins. Proteolytic injection with 30-gauge needle results in small, safe incision. Papain enzyme from Carica Papaya plant and zingibain enzyme from Zingiber Officinale plant which grows plentifully in Indonesia that becomes cheap source of proteolytic. This study’s purpose is to compare probability of binding energy based on Binding Interaction Model (BIM) between papain and zingibain enzymes against Crystalline P23T γD protein and β-amyloid protein with molecular docking. This research uses https://cluspro.bu.edu./login.php. BIM with lowest binding energy has most stable bond. Docking results show interaction probability between papain enzyme and Crystalline P23T γD protein has lowest binding energy of -730.4 kJ/mol at BIM 1. Probability of interaction between papain enzyme and β-amyloid protein has lowest binding energy of -697.2 kJ/mol at BIM 1. Probability of interaction between the enzyme zingibain and the crystalline P23T protein γD has lowest binding energy of -890.5 kJ/mol at BIM 2. Probability of interaction between the enzyme zingibain and the β-amyloid protein has lowest binding energy of -873.5 kJ/mol at BIM 0. It was concluded that the zingibain enzyme has the most stable probability of forming a stable bond to Crystalline P23T γD protein and β-amyloid protein. Keyword:In silico, papain, zingibain, cataract
Case Report: Ranula and Sublingual Glands Extirpation as Intraoral Ranula Procedures Rizki Saputra; Sukri Rahman; Pamelia Mayorita
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.27612

Abstract

Ranula is a cystic lesion that develops from saliva extravasation caused by trauma to the sublingual gland or the occurrence of duct blockages. The ranula is divided into intraoral (simple ranula) and plunging ranula. There are several options of methods in the management of ranulas such as sclerotherapy, marsupialization, and extirpation with or without gland removal involved, incision and drainage with intraoral approach, excision lesions with the extra-oral approach. A case of ranula was reported in a girl aged 12 years diagnosed with intraoral ranula (simple ranula). Treatment is done by performing ranula extirpation accompanied by the removal of the sublingual gland and its ducts. The extirpation of the ranula followed by removal of the involved sublingual salivary gland gave satisfactory results with no recurrence until 1 year of follow-up on the management of intra-oral ranula. Keywords: ranula, simple ranula, intraoral ranula
Predictors Factors of Mortality Hepatocelullar Carcinoma Patients RSD dr. Soebandi Jember 2018-2020 Roan Pratama Putra; Irawan Fajar Kusuma; Adelia Handoko
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.25275

Abstract

Liver cancer, predominantly Hepatocellular Carcinoma (HCC), is a tumor that originates from hepatocytes and is clinically progressive. In Indonesia, according to the Ministry of Health in 2019, liver cancer is the second most common cancer in men, amounting to 12.4 per 100,000 population with an average death rate of 7.6 per 100,000 population. There are very few studies on HCC in RSD dr. Soebandi Jember. This study aims to determine the characteristics and factors that can be predictors of death in HCC patients. This study uses an observational analytic research type with a case-control research design. The data of this study used secondary data from the medical records of HCC patients at RSD dr. Soebandi Jember, as well as primary data in the form of telephone interviews. The results of this study with a total of 72 samples showed that there was a significant difference between liver cirrhosis and HCC patient mortality within 90 days (p = 0.005), and could be used as a predictor of HCC mortality (OR = 17.15; 95% CI = 1.532-192.017). Keywords: HCC, predictors of death, HCC mortality
Cardiology Services During The Second Year Of The Covid-19 Pandemic Sidhi Laksono; Hillary Kusharsamita
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.26975

Abstract

Cardiology services have been affected by the COVID-19 pandemic. The consequences of the disease on cardiology services have not been studied in Indonesia, especially in the second year of this pandemic, as the surge in infections is currently declining. It is necessary to quantify the impact of the COVID-19 pandemic on cardiology services to evaluate whether or not cardiac services have returned to normal during this second year of the pandemic. The basis of research used in this study is a survey using a Google Form application. The technique to determine the research subjects carried out in this study is non-random sampling with the Purposive Sampling technique.One hundred and fifty-seven subjects were included in this study, with the majority gender of men (61.1%) as a clinical cardiologist (50.3%). Data were collected from several provinces in Indonesia from Jakarta to West Nusa Tenggara, with National Cardiovascular Center Harapan Kita as a majority hospital (n=15, 9.55%). There were generally sustained reductions in all aspects of cardiology service. However, the number of outpatients who underwent cardiac device implantation procedures did not increase. Telemedicine has been applied to 52.9% in the hospital where the subject works, yet the proportion of patients receiving telemedicine are less than 25%. During the second year of the COVID-19 pandemic, cardiology services need to establish new strategies to aid people with cardiovascular disease. More research is also needed in order to improve the efficacy of telemedicine in the future. Keywords: Hospital Cardiology Service, Telemedicine, COVID-19 Pandemic
Wound Healing Activity of Galam Flower (Melaleuca Cajuputi Subsp. Cumingiana (Turcz.) Barlow) Methanol Extract Wistar Rats Kartika veranisa putri; Ika Novitasari; Hilma Wardatina; Lilis Tangkeallo; Muhammad Dawud Ashari; Isnaini - Isnaini
Journal of Agromedicine and Medical Sciences Vol 8 No 1 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i1.27451

Abstract

Wound is an incontinence condition of skin or mucosal epithelial tissue due to physical or thermal damage. One of the plants that has the potential as a wound healer is gelam (Melaleuca sp). Gelam flower methanol extract has antibacterial activity with a minimum inhibitory level of 1.7 mg/mL. This study aimed to analyze the wound healing activity of gelam flower methanol extract (Melaleuca sp.) in Wistar strain rats that were initiated by the wound seen from the histology of the rat skin. This research uses posttest only method with control group design. Thirty male wistar rats were divided into five groups consisting of a positive control group, a negative control group, 1% gelam flower extract gel, 2% gelam flower extract gel, and 4% gelam flower extract gel. Based on histological data, the positive control treatment group and 4% gel treatment group gave the same results. Both indicate that the skin tissue has begun to connect. The conclusions the three gelam flower methanol extract gel formulas showed wound healing activity and the 4% gelam flower methanol extract gel (Melaleuca Sp.) gave the greatest wound healing activity. Keyword: Melaleuca sp, antibacterial activity, wound initiated healing

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