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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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UJI DAYA ANTELMINTIK INFUSA BIJI WALUH (Cucurbita moschata Durch) TERHADAP CACING Ascaridia galli SECARA IN VITRO mohammad djatmiko; lusi dwi purnowati; suhardjono suhardjono
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTWormy represent one of factor which can degrade human resource quality, considering wormy will persue physical growth and also work productivity. Research which is taken is experimental research as a mean to know energy of antelmintik infusa of pumpkin seed toward worm Ascaridia galli by in vitro and also its active compound content. Substance intake by random and then sampling is made in infusa supply with a few concentration series that is hereinafter tested by its activity as antelmintik to worm Ascaridia galli with immersion method. The data observed is time of worm death and sum up the dead worm every one clock. Statistic analysis which is used is Kruskal-Wallis continued by Mann-Whithney and also Anova and continued by Tukey. Result of research indicate that mean of time of worm death of Ascaridia galli after soaked in infusa of pumpkin seed in concentration 2,5%b/v, 5,0%b/v, 7,5%b/v, 10,0%b/v and successively is 9,46; 8,63; 6,08; and 5,83 clock. While after soaked in piperazin sitrat of concentration 0,4%b/v and NaCl 0,9%b/v mean of time of worm death is 8,96 and 32,37 hours. All series of concentration of infusa of pumpkin seed in this research own difference that has a meaning negative control of Nacl 0,9%b/v, so that infusa of pumpkin seed equal to 7,43%b/v while value of LC50 after soaked in piperzin sitrat 0,73%b/v. Result of KLT inspection indicate that infusa of pumpkin seed contain compound of powered saponin of antelmimtik. Keyword : Infusa of pumpkin seed, antelmintik energy, worm of Ascaridia galli.

EVALUASI PENGGUNAAN OBAT COMMOND COLD PADA PENGOBATAN SENDIRI DI MASYARAKAT DESA KARANGGONDANG KECAMATAN MLOGO KABUPATEN JEPARA ibrahim arifin; kristian teguh prasetyo; nanang munif yasin
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCommon Cold is a resporatory disturbance symptom which well-marked by cough, sneez, clogged up nose,painful red lane, fever, and headache. Nowadays, people tend to have self medication to cope with Common Cold byconsuming free medicines and limited free medicines which sold freely in market. The aim in this research was toevaluate Common Cold medicines utilizat ion by people in Karanggondang Mlonggo Jepara.This research is a non-experimental study. Data was obtained from field survey by using quetionnaire thathave been filled by people in Karanggondang Mlonggo Jepara. The result in this research have being analized byusing descriptive non analytical method. Sample was taken proportionally with convenient sampling method.This research showed that description of self medicat ion on Karanggondang Mlonggo Jepara peple wassufferer frequency 40,25% then action that have been taken by Common Cold sufferer who tried to do selfmedication 77,75%, their reason to do self medication based on experience was 33%, basic of medicines choice ofself medication who fiitted in with certain medicines was 23,75%, informat ion source of respondents from books ormass media was 44,75%. The result of evaluation with Common Cold medicines utilization on KaranggondangMlonggo Jepara people showed that correct indication 80,06%, correct medicines 80,06%, correct patients 65,59%,correct dosage 72,67% and on guard of sleepy side effect which occur oftenly 35,69%.Key words : Medicines Utilization , Common Cold, Self-Medication, Karanggondang People

PENGARUH VARIASI KONSENTRASI EKSTRAK ETANOLIK DAUN TEH HIJAU (Camelia sinensis L.) DALAM SEDIAAN KRIM TERHADAP SIFAT FISIK DAN AKTIVITAS ANTIBAKTERI nanik widyaningrum; mimik murrukmihadi; syarifatun karuniaekawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTGreen tea is one of a herbal nature which has been proved its special virtue anti acne. Green tea leafcontains of 30-40% polifenol which is known as katekin has a characteristic as antimicroba.To make it easierto use, the extrac etanolic of green tea leaf is made in cream formulation. The purpose of this experiment is toknow variation concentration effect of green tea etanolic extract in cream formulation to the physic andantibacteria activity especially for the acne bacteria, also in spesific concentration will be find the best ofextrac etanolic green tea leaf toward physic characteristic and anti bacterial activity.In this experiment, the thick extrac of green tea leaf is obtained by maseration way of the using 50%etanol liquid. The cream is made in five formulas that is using the extrac etanolic of green tea leaf for 1%, 3%,5%, 7% and 9% concentration with the modification formula of anti acne cream. Cream is tested the physicalcharacteristic including the homogenity , isolation percent, spreading, and adhesing and also for antibacterialactivity. The data is analysed by non parametric statistical using Kruskal Wallis test continued by doing MannWhitney test with 95% of trust capacity.The result in this experiment showes that the cream of extrac etanolic form of green tea leaf in anycream concentration have good homogenity and did not isolation. As biger concentration of cream extracetanolik of green tea leaf as a smaller spreading test and adhesing test but as a biger antibacterial activitytoward Staphylococcus aureus bacterial. Cream extrac etanolik of green tea leaf as a control positive in physiccharacteristic and antibacterial activity is 7% concentration.Key words : Green tea of extract etanolic, Cream, Physic characteristic test, Bacterial activity test.

ANALISIS KANDUNGAN BORAKS SEBAGAI BORON PADA GENDAR YANG DIPRODUKSI OLEH INDUSTRI RUMAH TANGGA DI DAERAH AMBARAWA sugiyono sugiyono; siti musinah; rukhanah rukhanah
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTGendar is a type of food produced by adding bleng, which is a chemical compound containing borax asboros. This research was intended to find out (1) the borax contents in the gendar taken from Ambarawa areas and(2) whether there were significant differences in borax levels contained in fresh gendar, dry gendar, gendar fried infresh vegetable oil and gendar fried in used vegetable oil.This was a non-experimental research with the data analyzed descriptively and analytically. The variablesmeasured were borax levels, acting is boros, contained in fresh gendar, dry gendar, gendar fried in fresh vegetableoil and gendar fried in used vegetable oil. The samples for this research were taken randomly from three householdindustried of gendar in Ambarawa areas. The contents of borax were measured using spectrophotometri UV-Vis.The analyses on the borax content in the four types of gendars (fresh gendar, dry gendar, gendar fried in freshvegetable oil and gendar fried in used vegetable oil) used Kruskall-Wallis non-parametric statistical tests followedby Mann-Whitney tests.The analyses showed that all of the four types of gendars really contained borax, as boros, but in diffirentlevels among the diffirent gendars borax contents in the four different gendars taken from Bandungan andSumowono had significant values 0,182 and 0,643 respectively (P > 0,05), contents in the four different gendarstaken from Ambarawa areas also had a significant value of 0,004 (P < 0,05), meaning also that there werestatistically significant differences in the borax contents.Keywords : Borax, Gendar, Spectrophotometri UV-Vis.

PENGARUH PERBEDAAN KONSENTRASI EKSTRAK ETER REBUSAN DAUN SIRIH (Piper betle Linn) DALAM SEDIAAN SALEP TERHADAP SIFAT FISIK DAN DAYA ANTIBAKTERINYA yulias ninik windriyati; esti oktaria
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBetle leaves has been used as antibacteria or antiseptic and was formulated in gargle. Betel leaves extractformulated in ointment in order to practical and effective to the skin. The aim of this research is to know the influenceof difference concentration of betle leaves extract in ointment to its physical properties and antibacteria effet againtsStaphylococcus aureus.Extract was obtained from leaves of the plant by decoction and continued by extraction with ether. Ointmentwere made in fine formulas with extract concentration 0.2, 0.4, 0.6, 0.8 and 1% w/w. The ointment was tested for itsphysical properties such as consisted of homogenity, viscosity, stickness and spreadibility. Antibacterial activityagaints Staphylococcus aureus was tested by diffusion method.The result of this research shown that the ointment homogenous. The difference of extract concentration had notinfluence on their viscosity and dispersive power, however had influence on their fixed time. The ointment of betleleaves extract had antibacterial activity againts Staphylococcus aureus.Keywords: Betle leaves extract, Ointment, Physical Test, antibacteri

EVALUASI KEPATUHAN PENULISAN OBAT DALAM KARTU OBAT PENDERITA RAWAT INAP RUANG KUTILANG TERHADAP FORMULARIUM RUMAH SAKIT DI RSUP Dr. KARIADI SEMARANG PERIODE 2007 sri susilowati; winarni winarni; saroja saroja
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDrug formularium is a method used by hospital medical staff to evaluate and choose a drug for patient treatments from various available drug trade name preparations within hospital. Objective of this study was to evaluate prescription compliance on drug cards of Kutilang in-patients ward towards Dr Kariadi Hospital Formularium during 2007. Non experimental, retrospective and non analytical observational study design was done. Sample collected by a proportional stratified random sampling from Kutilang in-patient drug card during 2007. Data were compared to Dr Kariadi Hospital Formularium. When prescription of drugs trade name different with formularium but generic name available, it was considered as non-formularium A and non-formularium B if either trade name or generic name drugs were not present. The results showed there were 56.1% female patients and 43.9% male patient hospitalized in Kutilang ward during 2007, in which 30.4% was belong to Internal medicine patients. Total number of drugs used were 613 items consist of 46.8% generic drugs and 53.2% trade name (patent) drugs. Overall agreement of drug used to the formularium was 77.7%. The rank of drug prescription agreement were as follows, anesthesiologist and psychiatry both were 100% agree to formularium, cardiologist was 14.8% agree to non-formularium A and dermato-venerologist was 40.9% belong to non-formularium B. The higest rank of prescription based on treatment classes were immunosuppressant (92.9%) among formularium, anti diabetics (32.2%) among non-formularium A and ENT drugs (83.3%) among non-formularium B. Key words : formularium, compliance, in-patient, dr Kariadi Hospital

DAYA ANTELMINTIK EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP CACING Ascaridia galli SECARA In Vitro DAN PROFIL KLTNYA riyanta aribawa; anis wihdayanti; mustofa mustofa
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeople used noni leaf (Morinda citrifolia L.)for medication many kinds disease, one of as anthelmintic. Worm infection most generally in the world, especially in growing countries including indonesia. To prove the truth were efficacious noni leaf as anthelmintic has been research anthelmintic capability ethanol extract of noni leaf on the worm Ascaridia galli on in vitro. This research has done by using Lamson and Brown method submerges that has been modified. Research using 270 of worms A. galli female, that devided into 9 groups, that’s 4 groups treatment with ethanol extract of noni leaf in consentration of 20 mg/mL, 30 mg/mL, 40 mg/mL and 50 mg/mL, 4 groups positive control (citrate piperazin) consentration 2 mg/mL, 4 mg/mL, 6 mg/mL dan 8mg/mL and I group negative control (NaCl 9 mg/mL) each group consist of 6 petri disc (each petri disc contain 5 of worms and 25 ml solution). Anthelmintic capability showed with worm mortality time that’s observed every 2 hours and LC50 that needed consentration to wipe out 50% of worm. The result of this research shown rates worm mortality time after submerges with ethanol extract of noni leaf consentration 20 mg/mL, 30 mg/mL, 40 mg/mL and 50 mg/mL as hight as 48,00 ± 1,79 ; 44,33 ± 1,51; 40,33 ± 1,51; 36,00 ± 2,53 (hours). But after submerges with citrate piperazin 4 mg/mL is 34,33 ± 1,51 (hours). LC50 after submerges ethanol axtract of noni leaf is 50,21 mg/mL and after submerges 2,27 mg/mL. The result of the observed Thin Layer Chromatography (TLC) shown ethanol extract of noni leaf containes compounds from flavonoid and fenol. Based on result of the reseach would be concluded that ethanol extract of noni leaf contain compounds that calculate have anthelmintic activity, possibilty that’s compounds is flavonoid and fenol. Keyword : Morinda citifolia L. , anthelmintic, submerges of Lamson and Brown.

KAJIAN INTERAKSI OBAT PADA PASIEN KANKER LEHER RAHIM (Serviks Uteri) RAWAT INAP DI RSUP Dr. KARYADI SEMARANG TAHUN 2007 ibrahim arifin; nurul latifah; mustofa mustofa
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCervical uterine cancer is a deadly tumor attacking the cervix uteri. In Indonesia, cervix uteri cancer constitutes the most aggresive and deadly cancer. Frequently, combinations of several different drugs are used for treating this disease. The purpose of this study was to find out the stastisticts and kind of drug interactions hospitalized in Dr. Kariadi Hospital Semarang for cervix uteri cancer in 2007. This study was a non-experimental research conducted retrospectively. The research was implemented to the medical records for cervix uteri cancer patients hospitalized in Dr. Kariadi Hospital Semarang. Data obtained were analysed with descriptive non-analytic method. The result of this study showed that 96 in-patients of cervix uteri cancer, 55 patients (57,29 %) had drug interactions, while 41 patients (42,7 %) had not drug interactions. From a total number of 149 cases, 134 cases (89,93 %) had drug interaction, while 15 cases (10,07 %) had not drug interaction. Based on the types of interactions, 6 patients (4,48%) had pharmakokinetic interactions and the other 128 patients (95,52 %) had unknown mechanism drug interactions. The most drugs producing interactions were midazolam and propofol. Key words : Drug Interactions, Cervix Uteri Cancer, Cer, Dr. Kariadi Hospital.

ANALISIS BIAYA DAN GAMBARAN PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID RAWAT INAP DI PUSKESMAS TLOGOSARI KULON TAHUN 2007 mohammad djatmiko; sugiyanti sugiyanti; yance anas
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThyfoid fever is a suddenly fever causing by Salmonella Typhii infection. Pharma coeconomi research can help pharmacologist and nursing for deciding exact and efficient antibiotic medicine using. Direction of this research showing description of antibiotic using which consist of choosing group and type of antibiotic, single or combination using, oral on injection antibiotic supply, identification of component and therapy cost, calculating medicine using cost comparison against therapy cost on typhoid fever room caring patient in Puskesmas Tlogosari Kulon on 2007. This research is retrospective with descriptive data analysis. Data taken from 183 medical report of room caring typhoid fever patient on Puskesmas Tlogoari Kulon on 2007. Information from medical record is patient identity, medicine therapy, laboratory and caring time. Therapy cost counted from healthy tariff service book of Puskesmas Tlogosari Kulon. The result of research showing description of antibiotic using in typhoid fever room caring on Puskesmas Tlogosari Kulon on 2007 consist of : the most antibiotic used penisilin 40,45%, kuinolon 23,16%, kloramfenikol 22,64% the most antibiotic used ampisilin 34,35%, siprofloksasin 23,16%, kloramfenikol 17,81%, the most single giving antibiotic is kloranfenikol 5,15%, siprofloksasin 4,46%, combination antibiotic is ampisilin and siprofloksasin 26,80%, ampisilin and kloramfenikol 15,98%, the most givig way is oral combination and injection 82,52%,. Component and therapy cost of typhoid fever patient consist of : antibiotic cost Rp. 87.404,- non antibiotic cost Rp. 104.168,- accommodation and administration Rp.85.131,- visit cost or medician visit consultation Rp. 31.902,- act cost Rp. 25.306 and supporting checking cost Rp. 37.279. Medicine using cost comparison is 51,61% against total therapy cost Rp. 371.189,- Key word : cost analysis, tifoid fever, Puskesmas Tlogosari Kulon

EVALUASI SISTEM PENGELOLAAN OBAT DI INSTALASI FARMASI RSUP Dr. KARIADI SEMARANG TAHUN 2007 mohammad djatmiko; eni rahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTDrug management in hospital sonstitutes an important aspect of hospital management. This research was inteded to find out the methods and effectiveness of drug management at Pharmaceutical Installation of Dr. Kariadi Hospital Semarang. This was non experimental research with a descriptive non analytic design. The samples were taken retrospectively from the exdisting drug supply forms, using a technique of simple random sampling, as well as from the drug prescriptions. The drug prescripsions used as the samples of data were collected by means of document reading and an interview to the head of the Drug Management Departement. The data were then translated into tables, percentages and rupiah values. The evaluations on the drug management during the period of 2007 showed that the percentage of fund availability was 95,53 %, percentage of deviation from the plans was 8,75 %, the frequency of supplying each drug type ranged 1 to 16 times per year, the congruence between the records and the drug supply forms was 100 %, the percentage of broken and expired drugs was 0,32 %, the percentage of drug dead supply was 8,57 %, the percentage of drug unavailability was 2,1 %, the percentage of served drugs was 98,97 %, the percentage of reporting timeliness was 16,67 % and the congruence between drug hospitalization forms and the drug supply forms was 100 %. Keywords : Evaluation, Drug Management, Pharmaceutical Installation of Dr. Kariadi Hospital Semarang

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