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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 706 Documents
 1   2   3   4   5 
Influence of administration of gadung corm ((Dioscorea hispida Dennst) infusion to decrease of blood glucose level at aloksan inducted male diabetic rats. Endang Sri Sunarsih; Djatmika .; Retno Sri Utomo
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.566 KB) | DOI: 10.14499/indonesianjpharm0iss0pp29-33

Abstract

Traditional herba medicine, Gadung (Dioscorea hispida Dennst) has already known can be used for oral anti diabetic drug. But it have not be proved experimentally. The purpose of experiment want to know the influence of Gadung (Dioscorea hispida Dennst) corm infuse, can decrease blood glucose consentration diabetic aloxan inducted rats.This experiment use 20 rats by randomized design at 2-3 months, 140-280 gram BW, Aloxan inducted diabetic male albino Wistar strain. The dose of aloxan 150 mg/BW given by intraperitonial. The rats divided in 4 groups, each group consist of 5 rats. First group : positif controle which is given insulin 12,6 UI/BW subcutanly; Second group : negative controle which is given aqua dest 5 mL/BW orally; Third group is given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW orally and Forth group is given Gadung (Dioscorea hispida Dennst ) corm infuse 1260 mg/BW dose orally. The experiment results of blood glucose level, was analyzed by 2 way ANOVA (p<0,05).The conclusion of the experiment is the rats has given Gadung (Dioscorea hispida Dennst) corm infuse 630 mg/BW and 1260 mg/BW can decrease blood glucose consentration proporsionally with insulin effect (p<0,05).Key words : Gadung (Dioscorea hispida Dennst), Aloksan, antidiabetic drug.
ARTEMISININ PRODUCTION BY SHOOT CULTURE OF ARTEMISIA CINA BERG. EX POLJAKOV Maria Marina; Aziz Purwantoro; C. J. Soegihardjo
Indonesian Journal of Pharmacy Vol 14 No 2, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.881 KB) | DOI: 10.14499/indonesianjpharm0iss0pp322-325

Abstract

Artemisinin is a secondary metabolite has a potential effect as an antimalaria. Research in artemisinin content in A. cina from shoot culture have not been reported. The aim of this research were:(i) to know the ability of A. cina shoot culture to produce artemisinin, (ii) to asses the effect of concentration of yeast extract, sucrose and their combination in promoting the production of artemisinin, (iii) to determine the highest artemisinin concentration produced by shoot culture in the medium containing different concentration of yeast extract, sucrose and their combination. The factorial of randomised complex block design (RCBD) was used in this experimental design. The first factor was concentration of sucrose ( 1%, 3%, 5%, 7%) and the second factor was concentration of yeast extract (0 mg/l, 100 mg/l, 200 mg/l, 300 mg/l). HPLC was used. To analyse quantitatively the artemisinin production, analysis of variance (ANOVA) and DMRT were used to analyse the data. The results showed that the addition of yeast extract and sucrose increased the concentration of artemisinin from the A. cina shoot culture. The highest artemisinin content produced was 14.035 mg/g dry weights which was produced by combination of 3 % sucrose concentration and 200 mg/l yeast extract. This result suggest that A. cina shoot culture could be used as a method to producing artemisinin.Key words : Artemisinin, shoot culture, Artemia cina Berg. Ex Poljakov
Relationship between blood level chloroquine, metabolite desethylchloroquine and paracytaemia of Plasmodium falciparum infection in malaria endemic area Purworejo Handayani, Rina; Prahasto, Iwan Dwi; Tjokrosonto, Soesanto
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.001 KB) | DOI: 10.14499/indonesianjpharm0iss0pp38-44

Abstract

Chloroquine is the drug of choice for Plasmodium falciparum and has long been used as the first line treatment in malaria in Indonesia. However, recent studies show that chloroquine resistance has been found in several endemic area. This study was aimed at investigating the correlation between whole blood chloroquine and desethylchloroquine levels and paracytaemia in the endemic areas.The study was carried out in Pituruh sub-district of Purworejo district. Thirty two subjects were enrolled using active case detection and passive case detection methods. Inclusion criteria: age 10-50 years old, asexual P falciparum > 1000/μl blood, not pregnant women, not having complication of malaria, willing to be observed for 28 days and agree to take part in study by signing an informed concent.The 32 samples were collected at day 2, and 10 samples were collected at 0, 2, 7, 14, 21, 28 days to detect the precence of paracytaemia and chloroquine and desetylchloroquine levels. A high Performance Liquid Chromatograph (HPLC) was used to analyze blood chloroquine and desethylchloroquine levels.The result show that chloroquine has been regurarly used (in 78.12% of subject) the day before the treatment was started. Mean blood redundant chloroquine and desethylchloroquine (combined) redundant in day 2 were 397.7 (SEM: 38.1) and prosentage of paracytaemia inhibitory effect was 93.7% (SEM: 2.07). This study observed no significant correlations between blood chloroquine and desethylchloroquine levels and paracytaemia.The result showed that increasing and decreasing of blood level chloroquine and desethylchloroquine has no correlation to the increasing or decreasing of paracytaemia inhibition in patients with Plasmodium falciparum infection in the endemic areas, which might be due to many factors including resistance to chloroquine.Key words : chloroquine, desethylchloroquine – P falciparum
Chemical investigation on Pseudoceratina purpurea collected from Banyuwangi Indonesia Triana Hertiani; RuAngelie Edrada; Rob W.M. Van Soest; Werner E.G. Muller; Sudarsono .; Peter Proksch
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.691 KB) | DOI: 10.14499/indonesianjpharm0iss0pp17-26

Abstract

Chemical investigation on marine sponge Pseudoceratina purpurea collected from Banyuwangi, Indonesia has been performed. This study was aimed to isolate and to identify structures of the sponge secondary metabolites as well as to test their cytotoxicity activity on mouse lymphoma cell line L5178Y.Isolation procedure was performed by using different chromatography techniques. NMR spectroscopy and mass spectrometry methods were used to identify the compounds chemical structures. Cytotoxicity of the isolates was tested on mouse lymphoma cell line L5178Y by using the microculture tetrazolium (MTT) assay.This study yielded five known tyrosine-derived alkaloids, two of which, aplysamine-2 (1) and aeroplysinin-1 (2) showed growth inhibition of mouse lymphoma cell line L5178Y with IC50 value of 1.7 mg/mL and 0.57 mg/mL, respectively.Key words: Pseudoceratina purpurea, sponge, alkaloids.
Influence of learning and growth toward internal business processes: case studies on Departement of Hospital Pharmacy in DIY ., Satibi; Fudholi, Achmad; Kusnanto, Hari; ., Jogiyanto
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.147 KB) | DOI: 10.14499/indonesianjpharm0iss0pp238-250

Abstract

Hospital Pharmacy have revenue contribution to the Hospital reached 40-60%,  thus  becoming  one  of  the  hospital  revenue  center.  However  hospital pharmacy  services  in  Indonesia  are  still  many  shortcomings,  is  considering several  constraints  such  as  the  ability  of  pharmaceutical  workers,  the  limited ability  of  hospital  management,  hospital  management policies,  and  limited knowledge of the relevant parties of hospital pharmacy services. Such conditions must be efforts to change with the development of learning and growth factors, because  these  factors  (human  capital,  organizational  capital  and  information capital)  and  that  effective  management  is  a  source  of  sustainable  competitive advantage. The research objective is to determine the relationship and influence of learning and growth to the internal business processes in Hospital Pharmacy. Kind  of  research  is  non-experimental  research  is  associative.  Research  tool includes a questionnaire indicators of learning andgrowth, and internal business processes.  The  subjects  was  the  head  of  hospital  pharmacy  in  the  hospital region  of  Daerah  Istimewa  Yogyakarta  (DIY).  Sample  size  was  35  hospital.  In addition  to  sending  questionnaires,  random  interviews  will  be  conducted  on several  hospital  pharmacies  to  enrich  the  results  of  the  survey  questionnaire. The  data  was  analyzed  by  correlation  and  linear  regression  to  determine  the relationship  and  influence  the  learning  and  growth  factors  to  the  internal business  processes  in  hospital  pharmacy.  Results  obtained  from  statistical calculations  with  95%  confidence  show  that  there  is a  strong  relationship between  the  organizational  culture  against  internal business  processes  with  r value of 0.981 with a contribution of 96.20% of theorganizational capital of the sustainability  of  the  internal  business  processes  in  Hospital  pharmacy  in Yogyakarta  Special  Region.  There  is  not  significant relationship  between  the human  capital  against  internal  business  processes.   There  is  not  significant relationship between the information capital against internal business processesKey words:learning and growth, internal business processes, the hospital pharmacy 
Evaluation of drug release from fatty based suppository: the difference between intrinsic and non-intrinsic dissolution methods ., Marchaban
INDONESIAN JOURNAL OF PHARMACY Vol 15 No 4, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.416 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-168

Abstract

Study on the difference of evaluation methods, namely intrinsic and non-intrinsic dissolution methods, on the drug release from fatty-based suppository has been performed. The study was done by producing the suppositories consisting of 50, 100, 150, 200 and 250 mg of sodium salicylate respectively. The drug release from the suppositories was then evaluated using intrinsic dissolution apparatus that limited the contact area of the suppository with the medium, and non-intrinsic that not limited its contact area. The aim of the study was to know the difference of the drug release profiles if they are evaluated using intrinsic and non-intrinsic dissolution methods.The results showed that the drug release using non-intrinsic dissolution method was always higher than that of the intrinsic method at any drug concentration, the drug concentration has not showed proportional relationship with their release although the drug release tend to be higher as the concentration was higher.Key words: suppository, dissolution
The antiviral activity of srikaya seed (Annona squamosa L.) ethanolic extract against newcastle disease virus in chicken embryo Nanik Sulistyani; Ibnatul Azizah; M. Kuswandi
Indonesian Journal of Pharmacy Vol 20 No 2, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.358 KB) | DOI: 10.14499/indonesianjpharm0iss0pp62-67

Abstract

Srikaya (A. squamosa L.) is a plant containing polyphenol, flavonoid, tannin, alkaloid and saponin compounds. These compounds could be extracted by ethanol solvent. Previous study shown that infuse of Srikaya seed had antiviral activity with value of IC50 3,236 'g/mL against Newcastle Disease Virus (NDV). Therefore, the aim of research is to know the potency of ethanolic extract of Srikaya seed as antiviral against Newcastle Disease Virus.The 28 chicken embryos at age of 9-11 days were classified into 7 groups, i.e. : control of virus, control of solvent ethanol : aquadest (1:10) and treatment groups were given ethanolic extract of Srikaya seed with concentration 0.1 'g/mL; 0.15 'g/mL; 0.2 'g/mL; 0.25 'g/mL; dan 0.3 'g/mL. NDV was inoculated into allantoic cavity intermediate after inoculated of extract and then incubated for 2 days. Antiviral activity were observed by hemaglutination method. The value of IC50 was calculated by probit analysis.The result showed that ethanol extract of srikaya seed (A. squamosa L.) had antiviral activity because of increasing concentration caused the higher inhibition percentage of hemaglutination. The value of IC50 is 0.152 'g/mL.Key words: Antiviral, Annona squamosa, Newcastle Disease Virus (NDV).
REDUCTION ABILITY OF CURCUMIN AND DERIVATIVES ON FERRI : A MOLECULAR DYNAMIC STUDY Ari Sudarmanto, Bambang Sulistyo; Margono, Supardjan Amir
INDONESIAN JOURNAL OF PHARMACY Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (144.157 KB) | DOI: 10.14499/indonesianjpharm0iss0pp77-85

Abstract

Molecular dynamics (MD) simulation has been applied to curcumin, 4-methyl curcumin and 4-isopropil curcumin. They have reducting activities on Ferri to Ferro. A computation method used is AM1 (Austin Model 1) semiempiric method. Studying of computation is arranged to theoretical studying of structure and reactivity relationship on these molecules without solvent interaction (in vacuo). The time of simulation is taken from 0 – 10 ps (pico secon) with interval 0,0005 ps on 300oK. The result of experiment that has been proposed from the MD simulation is the structure of conformation trajectory of each molecules. By considering total energy and potential energy changes to time of simulation, along with the change of bonding length, bonding angle, and the atomic charges of -diketon active site to time of simulation. Reactivity of these molecules are analyzed from the geometric shape of the active site indicated that 4-isopropyl curcumin was the most reactive than the other to produce complex with Ferri, while 4-methyl curcumin within the complex was easiest in the reduction of Ferri to Ferro.Key words : molecular dynamic, curcumin, reduction
THE SULPHAMETHOXAZOLE BIOAVAILABILITY OF POLYMORPH IIA IN RABBITS Siti Nurasiyah; Tedjo Yuwono
Indonesian Journal of Pharmacy Vol 12 No 4, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (96.784 KB) | DOI: 10.14499/indonesianjpharm0iss0pp205-210

Abstract

Sulphamethoxazole, a sulphonamide antibacteria, is usually combined with trimetoprime, namely cotrimoxazole, to obtain higher potency. Because of the solubility of sulphamethoxazole in water is minute, its dissolution rate would be slow. Consequently, dissolution rate become the limiting step in the absorption process. In order to overcome this problem, therefore, some polymorph forms of sulphamethoxazole were created. The previous study found a polymorph IIA crystal form, a new modified internal crystal structure of sulphamethoxazole. This study was a continuing investigation of the bioavailability of the polymorph IIA, in capsule dosage forms, in rabbits. It was evident that the bioavailability of polymorph IIA was twice of that polymorph I. The bioavailability parameter changes of polymorph I to polymorph IIA were: the AUC increased from 872 to 1,530 mg hr L-1, the peak time (tmax) increased from 2 hours to 0.9 hours, the blood plasma level peak (Cpmax) increased from 104 to 136 mg/ L-1. Key words: bioavailability, sulphamethoxazole polymorph
PGV-1 is a potent antimitotic agent Barinta Widaryanti; Edy Meiyanto; Muhammad Da&#039;i; Masashi Kawaichi
Indonesian Journal of Pharmacy Vol 19 No 3, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.103 KB) | DOI: 10.14499/indonesianjpharm0iss0pp145-150

Abstract

Carcinogenesis can be involved in the malfunctioning of programmed cell death Most of the anticancer drug in current use induce apoptosis in susceptible cells. The fact that disparate agent interacting with different targets seem to induce cell death through some common mechanism suggest that anticancer activity is determined by the ability of inhibiting cell growth.Pentagamavunon-1 (PGV-1) is one of the curcumin analogue which showed to have potency in inhibiting proliferation of human breast carcinoma cell T47D. The effect on T47D growth is associated with cell cycle arrest in G2/M phase at the concentration of 2.5 mM, followed by hyperploidy. Our data on polymerization assay, indicate PGV-1 interact with tubulin in different manner from taxol. PGV-1 inhibit tubulin polymerization on cell culture while taxol stabilized tubulin polymerization. Immunostainning data on cell treated with PGV-1 showed slightly tubulin condensation, while cell treated with taxol showed tubulin condensation distinctly at 12 minutes after releasing from depolymerization agent.In conclusion, PGV-1 represent a new microtubule inhibitor and has the potential to be developed for anticancer drugKey words: Pentagamavunon-1, T47D, tubulin, antimitotik

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