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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 706 Documents
 1   2   3   4   5 
Desentization therapy on allergic “galah” shrimp-induced Swiss Webster male mice Andreanus A. Soemardji; Setiadi Ihsan
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.081 KB) | DOI: 10.14499/indonesianjpharm0iss0pp26-32

Abstract

Desensitization therapy on “galah” shrimp type I-allergy have been studied on male Swiss Webster mice. Induction of type I allergy was done by intradermic injection of 30% of “galah” shrimp extracts an allergen twice within 14 days. Evaluation of allergic respons was evaluated based on active cutaneous anaphylactic reaction. Desensitization therapy was done by injecting the allergen intradermically daily in 3 weeks with gradual increased of the doses. Based on tolerance level to the cutaneos anaphylactic reaction, the result showed that allergic mice were cured, while the therapy to nonallergic mice induced the same allergic reaction.Keywords : Type I- allergic reaction, ”galah” shrimp, active cutaneous anaphylactic reaction, desentization.
Profile of sulphacetamide pharmacokinetics on uranyl nitrate-induced renal failure rats Djoko Wahyono; Arief Rahman Hakim; Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.141 KB) | DOI: 10.14499/indonesianjpharm0iss0pp117-123

Abstract

Kidney is a vital organ which has main function to maintain the body homeostasis. The role of kidney is the excretion (elimination) of waste product, and if there is pathologically a renal failure so will change the drug pharmacokinetics and in turn change it’s potency. The present study evaluated the effect of uranyl nitrate-induced renal failure on the pharmacokinetics profiles of sulphacetamide in rats.The study was conducted by employing a completely randomized design in male Wistar in bred rat (aged 2-2.5 months, 150-250 g). The animals in group I were given sulphacetamide sodium with an oral single dose 100.0 mg/kg BW (control group) and in group II were given pretreatment with uranyl nitrate at 3 days before sulphacetamide administration.After collected at some certain times, the drug concentrations on bloods were analyzed by an ultraviolet spectrophometer. The results have shown that uranyl nitrate-induced renal failure decreased the primer pharmacokinetics parameter i.e. total clearance (ClT) and volume of distribution in steady state (Vdss), significantly (P<0.05). The decreasing of these parameter could cause alteration of the secondary pharmacokinetics parameters of sulphacetamide and these derivates i.e. Cmax, tmax, AUC0-240, AUC0-inf, MRT, K and t1/2 elimination significantly (P<0.05). According from the results, it is concluded that uranyl nitrate-induced renal failure affected the pharmacokinetics of sulphacetamide or could increase the sulphacetamide concentration in blood.Key words : sulphacetamide, pharmacokinetics, renal failure, uranyl nitrate
Analgesic and anti-inflammatory activities of combrang (Nicolaia speciosaHoran) stem the extract Susilowati, Sri Sutji; Martono, Sudibyo; Riyanto, Sugeng; Nugroho, Agung Endro
Indonesian Journal of Pharmacy Vol 22 No 2, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.077 KB) | DOI: 10.14499/indonesianjpharm0iss0pp115-119

Abstract

Long-term  goal  of  this  study  is  the  use  of  combrang  (Nicolaia  speciosa Horan)  as  an  ingredient  of  traditional  medicine  after  being  evaluated  through preclinical  testing  and  clinical  trials  both  extract  and  its  bioactive  compounds. This  study  includes  analgesic-antiinflammatory  activity  test  of  n-hexane, chloroform,  ethyl  acetate  and  methanol  extract  of combrang stem.  Analgesic test against crude extract of n-hexane, chloroform,ethyl acetate and methanol, using acetate writhing method. Antiinflammatory test using inhibition method of paw oedema by carrageenan induced on Wistar rats. Analgesic-antiinflammatory activity  compared  to  Na-diclofenac.  The  result  is  four  extracts  have  analgesic and  antiinflammatory  activity,  ethyl  acetate  extract  has  the  highest  analgesic and antiinflammatory activity.Key words: analgesics, anti-inflammatory, extract of combrang stem
Antioxidant activity of aqueous extract of Sonchus arvensis L. in-vitro Sofnie M. Chairul; Ros Sumarny; Chairul .
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.576 KB) | DOI: 10.14499/indonesianjpharm0iss0pp208-215

Abstract

Antioxidants are the compounds which have ability to inhibit reactive oxygen species (ROS) and free radicals in human body. Based on this activitiy the antioxidants prevent cell damage and various pathological processess e.q. cardiovascular, diabetes mellitus, atherosclerosis, respiratorydiseases, carcinogenesis, inflammation, cell degenerative. One of the famous Indonesian traditional medicine is tempuyung or S. arvensis L.(Asteraceae). The antioxidant test has been conducted on the dried water extract by measuring the peroxide value (POV) and in-vitro antioxidant activity test was carried out by spectrophotometry applying thiocyanate method at the wave length of 500 nm.The results showed that peroxide value of dried water extract of tempuyung (S. arvensis L. ) by titration iodometric method has a lower value (865.60) compared to positive control -tocoferol (1142.77). In-vitro antioxidant activity test has remarkable results at the various extract concentrations (1, 5 dan 10 %) and had significant differential absorbance(A) with positive control (K+) as well as negative control (K-), and among the extract concentrations (P  0,5). Absorbance value increased along with increasing storage time, in which negative control reached higher value of A (0,987) in the seven days and maximal value after eight days (A  1), while the absorbance value of positive control (K+) was 0.648, and dried water extract of tempuyung 1, 5 & 10 % was 0.576, 0.488 & 0.314 after 14 days, respecticly. The absorbance value of absorbance (A) was inversely compared to extract concentrations. Increasing of extract concentrations resulted in decreasing A value, in other words increasing extract concentration resulted in the increas of antioxidant activity.Key words : Sonchus arvensis L, Asteraceae, POV, antioxidant, thiocyanate method.
Increasing of the bacteriostatic effects of HCl tetracycline–polyethylene glycol 6000 – tween 80 (PT) Riswaka Sudjaswadi
Indonesian Journal of Pharmacy Vol 17 No 2, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.35 KB) | DOI: 10.14499/indonesianjpharm0iss0pp98-103

Abstract

The antibacterial effect of HCl tetracycline – polyethylene glycol-tween 80 (PT) solid dispersion in the mole fraction of 0,1; 0,5; 0,7; 0,9; and 1,0 on Saphylo coccus aureus and on Escherichia coli had been studied by using the diffusion methods, in order to obtain the roles of PT on the drug penetration through the membrane and on the bacteriostatic effects.The results shown that the effects on Staphylococcus aureus in the mole fraction of 0,1; 0,5; 0,9 seemed to be the same when using the diffusion method (hole systems), whilst using the diffusion method (paper disc), all agents performed the increased effects in the mole fraction of 0,5; 0,7; and 0,9; in comparison with the mol fraction of 1,0, respectively.It had been concluded that PT expressed the increased effects of HCL tetracycline from 100,00 % up to 124,54 % on Staphylococcus aureus, and 108,90 % to 127,27 % on Escherichia coli.Key words : solid dispersion, bacteriostatic, HCl tetracycline, PEG-tween 80.
The effect of variation of dose, time toward cauli flower (Brassica oleracea var BotrytisL.) On hepatic cytochrome P-450 level rats given theophylline Sunarsih, Endang Sri; hakim, Lukman; ., Sugiyanto; ., Sumantri
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.974 KB) | DOI: 10.14499/indonesianjpharm0iss0pp323-329

Abstract

Cytochrome  P-450  as  a  major  component  enzyme  system  in  drug metabolism. Activity  enzyme  of  cytochrome  P-450  was  influenced  by  internal and external factors. Vegetables of Brassicaceae such as cauli flower were often consumed  in  the  long  term,  its   has  inductor  activity  of  oxidation  enzyme systems and conjugation reactions. Theophylline as a bronchodilator drugs have the unknown effects on hepatic microsomal enzyme, such as cytochrome P-450 and   have  not  been  many  studies  that  tried  to  prove  it.  The  purpose  of  this study  was  to  prove  the  effects  of Cauliflower  and  indol  on  level  cytochrome  P-450  enzyme.  90  rats  were  divided  into  3  groups.  Group   I,  were  given Theophylline  20  mg/kg  BW.  In  group  II  30  rats  were  treated  with  indole  1,2; 2,4; 3,6 mg/kg BW, and group III 30 rats were treated with cauliflower extract respectively  doses  100,  200,  300  g/kg  BW.  Each  dose  was  given  on  10  rats, each group were divided 2 sub-groups were treated for 5, 10 days. On the last day  of  treatment  were  given  Theophylline  20  mg/kg  BW.   Cytochrome  P-450 enzyme  levels  were  determined  by  the  method  of  Omura  and  Sato(Snell,  and Mullock,1987). An induction cauliflower and indole did not increased levels of hepatic  cytochrome  P-450.  The  long  treatment  and  the   increased  of administered  dose  did  not  enhanced  the  levels  of  hepatic  cytochrome  P-450 enzyme. cauliflower and indole contained in vegetables when consumed together with theophylline drug, would not affect the metabolism of theophyllineKey words: Cauli flower, cytochrome P-450, theophylline, indole, spectrofotometric.
OPTIMIZATION OF EXTRACTION CONDITIONS FOR ANDROGRAPHOLIDE USING FRACTIONAL FACTORIAL DESIGN Mohamad Rafi
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.243 KB) | DOI: 10.14499/indonesianjpharm25iss3pp145

Abstract

Andrographolide is a major bioctive compound found in king of bitter (Andrographis paniculata). In this study, the extraction method and its condition were investigated in order to get an extract with maximum amount of andrographolide by comparing three other extraction methods, i.e. maceration, soxhletation and ultrasonication and also determination for the optimum condition of the selected extraction method. The highest andrographolide amount was found by maceration, so this method was choosen for further optimization of extraction condition. The optimum condition based on the prediction amount from 27 factor combinations was obtained in 360 times of extraction time, 2g/100mL of sample to solvent ratio, and 3fold of extraction frequency with prediction of andrographolide amount was 3.50%. While by using prediction profile, the optimum condition was obtained in 360min of extraction time, 2 g/100mL of sample and solvent ratio, and 4 times of extraction frequency with the amount was 3.47-3.74%.
IDENTIFICATION OF BAWANG SABRANG (Eleutherine americana Merr. ex K. Heyne) IN INDONESIA BASED ON CHROMOSOME CHARACTERS Daryono, Budi Setiadi; Rahmadani, Wenny Deisshinta; ., Sudarsono
Indonesian Journal of Pharmacy Vol 24 No 1, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.932 KB) | DOI: 10.14499/indonesianjpharm24iss1pp22-29

Abstract

Bawang Sabrang (Eleutherine americana Merr. ex K. Heyne) is a plant belongs to Iris family (Iridaceae). Genetic study of the Eleutherine species should be investigated to yield valuable information for breeding program. The aim of this research was to determine chromosome characters as a preliminary research on the genetic characterization of Bawang Sabrang. Squash method on the root tips was used for chromosome preparation of this plant. The results showed that the time of cell division and prometaphase stages of Bawang Sabrang were occurred at about 08.00-08.30 a.m. and 08.20 a.m., respectively. Chromosome number of Bawang Sabrang was 2n=12 and the karyotype consisted of 8 (4 pairs) of metacentric chromosomes, 2 (1 pair) submetacentric chromosomes and 2 (1 pair) subtelocentric chromosomes which have the longest of total length chromosomes. Therefore, the karyotype formula of Bawang Sabrang was 2n=12=8m+2sm+2stSAT. Besides that, on the pair of subtelocentric chromosomes there was a satellite at each of the chromosome. Analysis of chromosome characters exhibited that the long of total length chromosomes was about 1.687 ± 0.111 µm to 5.320 ± 0.716 µm. Based on the R value ( 3,65 ± 0,41), it revealed that there was variation of chromosome size on this Eleutherine species in Indonesia. Moreover, data of the chromosome characters is important to complete the database of Bawang Sabrang as a potential medicinal herb in Indonesia Keywords: Bawang Sabrang, Eleutherine americana, chromosome, karyotype
The impact of hot melt granulation method on propranolol hydrochloride physicochemical properties Ilma Nugrahani; Hasan Rahmat; Joshita Djajadisastra
Indonesian Journal of Pharmacy Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.272 KB) | DOI: 10.14499/indonesianjpharm0iss0pp167-172

Abstract

Hot melt granulation is based on agglomeration by use of thermoplastic binder material that is solid at room temperature and softens and melts at higher temperature. By selecting a binder that is insoluble in water, melt granulation is a way of producing modified release granules, i.e. lipids/waxes to exhange the release of soluble drugs. The critical problem of this method is drugs instability because of heating. It has been studied the impact of hot melt granulation method on propranolol hydrochloride physicochemical properties. Physicochemical properties were evaluated including : water content titration – Karl Fischer, chemical structure analysis by Fourier Transforms Infrared Spectrophotometry (FTIR), and thermodynamic analysis by Differential Scanning Calorimetry (DSC). The results showed that hot melt granulation did not change the propranolol hydrochloride physicochemical structure but it changed anhydrate ß lactose to anhydrate a lactose. Key words : carnauba wax ; hot melt granulation; propranolol hydrochloride; physicochemical properties.
In Vitro CYTOTOXIC ASSAY OF CHLOROFORM EXTRACT OF Brucea javanica L .(Meer), Ipomoea batatas Poir., Mussaenda pubescens Ait.F., AND Portulaca oleracea L. TO HeLa CELLS M, Sonlimar; ., Sismindari; ., Mustofa
Indonesian Journal of Pharmacy Vol 13 No 4, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp215-222

Abstract

Some plants, such as Ipomoea batatas Poir., Mussaenda pubescens Ait. F., Portulaca oleracea L., Brucea javanica L. (Meer), have been used traditionally to treat cancer, even though the scientific base of this activity has yet been completely investigated. The study was conducted to evaluate the cytotoxic activity of these plants on HeLa cell lines.The cytotoxicity of chloroform extract from these plants were determined using micro radioactive method by measuring an incorporation (3H)-hipoxanthine on the cells after 24 and 48 hours incubation with each extract, using doxorubicine as a positive control. Extract free cell culture was refered to as 100% growth. IC50 value, showing 50% inhibition of the cell growth, was determined based on the concentration versus percentage inhibition curves.The result showed the extract B. javanica was the most active to hela cells with the IC50 value of 13.69 1.07 and 55.78.4 g/ml after 24 and 48 hours incubation respectively.Key words: Ipomoea batatas Poir., Mussaenda pubescens Ait. F., Portulaca oleracea L., Brucea javanica L. (Meer), Cytotoxic, HeLa cell lines.

Page 3 of 71 | Total Record : 706

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