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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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Quantitative structure-activity relationship of curcumin and its derivatives as μ-class of GST inhibitors Enade Perdana Istyastono; Sudibyo Martono
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The Quantitative Structure-Activity Relationship (QSAR) study has been performed on curcumin and its derivatives as μ-class glutathione Stransferase inhibitors using atomic net charges as the predictors. The charges were resulted by semiempirical AM1 quantum-chemical calculations using the computational chemistry approach. The inhibition activity was expressed as the concentration that gave 50% inhibition of μ-class GST activity (IC50). The selection of the best QSAR equation models was determined by multiple linear regression analysis. Curcumin and its derivatives were reported as selective μ-class GST inhibitors. The enzyme plays an important role in the process of inflammation and the effectivity of anti lung-cancer compounds. μ-Class GST inhibitors could enhance the effectivity of anti lung-cancer compounds.The result showed that the best QSAR equation model of curcumin and its derivatives as μ-class GST inhibitors was described by.: log (1/IC50) = (-454.686) + (314.235)qC2 + (1593.499)qC3 + (452.563)qC4 + (1057.194)qC5 + (-1.756)qBenzene’ The equation was significant at 95% level with statistical parameters : n = 10, m = 5, F/FTabel = 3.335, R2 = 0.963, SE = 0.150, and PRESS = 0.559.Key words : QSAR analysis, curcumin, μ-class glutathione S-transferase, atomic net charge.

Adverse drug reactions (ADRs) pada pasien rawat inap geriatri Rahmawati, Fita; Pramantara, I Dewa Putu; Rochmah, Wasilah; Syed Sulaiman, Syed Azhar
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Adverse drug reactions (ADRs) merupakan masalah yang sering terjadi pada pasien lanjut usia. Penelitian bertujuan mengetahui angka kejadian adverse drug reactions pada pasien rawat inap geriatri.Penelitian dilakukan dengan mengambil data secara prospektif pada 100 pasien rawat inap geriatric dengan kriteria usia pasien 60 tahun atau lebih dan menjalani rawat inap di bagian Penyakit Dalam (IRNA1) RSUP Dr. Sardjito Yogyakarta pada dua periode waktu (Januari–Februari 2006 dan Agustus–Oktober 2006). Pengambilan data dilakukan melalui catatan medic kemudian identifikasi efek samping obat dilakukan melalui diskusi farmasis dengan klinisi konsultan geriatri. Evaluasi data dilakukan secara descriptive Hasil penelitian menunjukkan bahwa ADRs diduga kuat dialami oleh 25 pasien dengan total 30 kejadian ADRs. Sebagian besar ADRs yang ditemukan berhubungan dengan gangguan pada gastrointestinal (mual, muntah, dispepsia, konstipasi, diare dan gastritis) 56,7.% dan kardiovaskular (hipertensi dan hipotensi) 16,7.%. Farmasis dapat berperan dalam identifikasi ADRs melalui kolaborasi dengan tenaga kesehatan lain di rumah sakit sehingga dapat dilakukan upaya pencegahan terhadap ADRs pada pasien geriatriKata kunci: Adverse drug reactions (ADRs), Geriatri, Rawat inap.

Inhibitory effects of daun sendok (Plantago major L.) on mast cell-mediated anaphylactic reaction Agung Endro Nugroho; Erna Prawita Setyowati; Zullies Ikawati
Indonesian Journal of Pharmacy Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Hypersensitisation reaction, which is known as an allergy, is suffered by a lot of people in the modern society. An increase of allergen uptake and the decrease of immune system are considered to be the major factors, which influence the disease. Development of medicinal plants for the allergic reaction is continuing with the extract of Plantago major as an example. This extract could inhibit histamine release from cell culture of Rat Basophilic Leukaemia (RBL-2H3) induced by DNP-BSA in vitro. This study determined the effect of Plantago major L. on systemic anaphylactic reaction induced by compound 48/80 in vivo.The research was conducted using Balb/c mice (2-3 months, 20-30 gram) which were divided into 2 main groups i.e. (1) those which were given with etanol extract on systemic anaphylactic reaction, and (2) those which were given with n-hexane extract on systemic anaphylactic reaction. Each group was divided into five sub-groups based on various dosages of Plantago major extract i.e. 0.1, 1.0, 10.0, 100.0, 1000.0 mg/kg BW. Compound 48/80, a histamine release inductor, was administered at dose of 8 mg/kg BW, an hour after Plantago major administration, and the total of death mice were observed for an hour. Pharmacological parameter, ED50 value, was determined using probit analysis.The result showed that both etanol and n-hexane extracts of Plantago major L could inhibit systemic anaphylactic reaction induced by compound 48/80 with ED50 values of 1.66 and 55.01 mg/kg BW, respectively. It can be concluded that the potency of etanol extract of Plantago major L is higher than its n-hexane extract.Key words: Plantago major L., anaphylactic, histamine and mast cells

Ability of fermented soymilk byLactobacillus plantarum 1 in bile acids binding Yusmarini .; Indrati R.; Utami T.; Marsono Y
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Some lactic acid bacteria (LAB) strains have been isolated from spontaneously fermented soymilk which showing proteolytic activity. These isolated were expected could producing bioactive peptides that could lowering cholesterol content when they used for soymilk fermentation. This research was aimed to determine the proteolytic activity of Lactobacillus plantarum 1 R.1.3.2 and L. plantarum 1 R.11.1.2 comparing with L. acidophilus FNCC 0051 as acontrol. Furthermore soymilk fermented with these isolates were monitored for their ability to bind bile acid and these results were compared with the control of soymilk with no fermentation. Proteolytic activities (U/mL) were measured spectrophotometrically using tyrosin as a standard product, while bile acid binding capacity (µM/100 mg protein) using Total bile Acid Binding Kit. The results show that all isolates use in this study had no different proteolytic activity nor bile acid binding capability to that of control strain. The fermentation process could increased their ability to bind with the bile acid.Key words :fermented soymilk, proteolytic lactic acid bacteria, bile acid binding

STUDY OF ANALGESIC AND ANTIDIARRHOEAL ACTIVITIES OF Sonneratia caseolaris (LINN.) LEAF AND STEM USING DIFFERENT SOLVENT SYSTEM. Bokshi, Bishwajit; Zilani, Md.Nazmul Hasan; Malakar, Aparajita; Roy, Debendra Nath; Shilpi, Jamil Ahmad; Sadhu, Samir Kumar
INDONESIAN JOURNAL OF PHARMACY Vol 24 No 4, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The different fractions of crude ethanol extract of leaf and stem of S. caseolaris (Linn.) (Sonneratiaceae) were screened for its analgesic and antidiarrhoeal activities. The different fraction of crude extract was obtained by using four different solvent systems. The different fractions of crude extract produced significant writhing inhibition in acetic acid induced writhing in mice at dose of 250 and 500mg/kg BW comparable to the standard drug diclofenac sodium at the dose of 25mg/kg BW. When tested for its antidiarrhoeal effects on castor oil induced diarrhea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 250 and 500mg/kg BW comparable to the standard drug loperamide at the dose of 50mg/kg BW. The overall results tend to suggest the analgesic and antidiarrhoeal activities of the different fractions of crude extract. Both ethyl acetate fraction of stem and chloroform fraction of leaf have significant analgesic activity. Again between the two fractions of crude ethanol extract ethyl acetate fraction of S.caseolaris stem have most significant antidiarrhoeal activity.Key words: analgesic, antidiarrhoeal, S.caseolaris, diclofenac sodium, loperamide.

SYNTHESIS AND ANALGESIC ACTIVITY OF 6-(MNITROPHENYL)-4-SUSTITUTED BENZYLIDENE-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE DERIVATIVES Asif, Mohammad
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

ManyÂ researchÂ groupsÂ haveÂ beenÂ interestedÂ inÂ 3(2H)-pyridazinonesÂ forÂ theÂ developmentÂ ofÂ potentialÂ analgesicÂ andÂ antiinflammatoryÂ agents.Â StimulatedÂ byÂ theseÂ findings,Â threeÂ 6-(mNitrophenyl)-4-sustitutedÂ benzylidene-4,5-dihydropyridazin-3(2H)-ones (IVa-IVc) have been synthesized and evaluated for analgesic activityÂ againstÂ hotÂ plateÂ method.Â Compounds IVa-IVc were prepared from 6-m-nitrophenyl-4,5-pyridazin-3(2H)-one by condensationÂ withÂ respectiveÂ aldehydes.Â AllÂ compoundsÂ (IVa-IVc)Â having nitroÂ phenylÂ andÂ benzylideneÂ groupsÂ atÂ positionÂ 6Â andÂ 4Â ofÂ the pyridazinoneÂ ringÂ receptively.Â AllÂ compoundsÂ (IVa-IVc)Â showed significantÂ analgesicÂ activityÂ whenÂ compareÂ toÂ controlÂ groupÂ and were found less potent than reference drug aspirin.Key words:Pyridazinones, analgesic, benzylidene, nitrophenyl.

The antifungal activity test of ointment and cream preparations of ”ketapang” (Terminalia cattapa L.) leaf on rabbit’s skin Elinah Yuli Sukandar; Asep Gana Suganda; Gemi Utami Pertiwi
Indonesian Journal of Pharmacy Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Ketapang (Terminalia catappa L.) leaves has been used traditionally as skin infectious disease medicine, therefore ethanolic extract of ketapang leaves was formulated in ointment and cream preparations to be tested against fungi causing dermatomycosis i.e. Trichophyton mentagrophytes. The antifungal activity of both preparations was been tested in Trichophyton mentagrophytes infected rabbit’s skin. Result showed that ointment and cream containing 10 % extract were active against the fungi compared to the control. Healing occured on day 11.0 ± 3.0 in ointment treated rabbits, and ointment on day 12.7 ± 3.5 in cream treated rabbits, whereas in control healing occured on day 16.7 ± 6.6. Skin iritation index and eye irritation scores for ointment were 0.33 (maximum score 3) and 9.95 (maximum score 110) respectively, whereas those for the cream were 0.71 and 15.69, respectively.Key words: antifungal, Trichophyton mentagrophytes, ointment, Cream.

DEVELOPMENT AND EVALUATION OF IN SITU GELS OF MOXIFLOXACIN FOR THE TREATMENT OF PERIODONTITIS Hareesh Babu Kunche; Mohammed Gulzar Ahmed; Narayana Charyulu Rompicharla
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gel dosage forms are successfully used as drug delivery systems to control drug release and protect the medicaments from a hostile environment. The main objective of the present investigation is to formulate and evaluate in situ gels of moxifloxacin for the treatment of periodontitis using gellan gum and sodium alginate based on the concept of ion activated systems. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physico-chemical parameters. Sol-to-gel transformation occurred in the presence of monovalent/divalent cations. It was found that increase in the concentration of calcium ions produced stronger gels. Formulations were evaluated for gelling capacity, drug content, clarity, viscosity, gel strength, spread ability, microbiological studies and in vitro release. The results shown by the above characterization studies were found to be satisfactory. Experimental part showed that viscosity of sols and gel strength was increased with increase in the concentration of polymers and the sustained release of drug was observed. The formulations were therapeutically efficacious, sterile and provided sustained release of the drug over a period of time. These results demonstrated that the developed system is an alternative to conventional drug delivery systems, provides patient compliance and economical.Key words: in situ gels, moxifloxacin, periodontitis, polymers, Ion activation.

Characterization of physical properties of binary system of erythromycin stearate-sodium starch glycolate by compression force effect Setyawan, Dwi; Sumirtapura, Yeyet C; Soewandh, Sundani N; Tj, Daryono Hadi
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Characterizations of the physical properties of binary system of erythromycin stearate (ERS)-sodium starch glycolate(SSG) due to compression force, had been carried out. The solid state properties were evaluated by powder X-ray diffraction (PXRD), scanning electron microscope (SEM) and differential thermal analysis (DTA) methods. The weight fraction of mixtures ERS: SSG (90:10), (80:20) and (70:30) were compressed using hydraulic press and flat plain punches with a diameter of 13 mm. The compression force was 29.5 kN. Diffraction peaks at 2θ = 5.6; 10,6 and 25.6° were used to determine the full width at half maximum (FWHM), crystallite size and preferred orientation. Peak broadening was calculated by measuring the FWHM. FWHM values, crystallite size and preferred orientation of the crystallites were calculated by WinPlotr program. The results of the study showed that the FWHM value increased at all the crystal lattice as the fraction of SSG increased. The crystallite size and peak intensity decreased gradually as fraction of SSG increased. Scanning Electron Microscope (SEM) analysis indicated that SSG was dispersed on surface and inside of the tablet of ERS at all combination. The phase diagram of binary system ERS and SSG showed a no interaction of ERS and SSG.Key words : characterization, physical properties, ERS, SSG, compression force

Jaspamide: Structure identification of cytotoxic and fungicide compound isolated from Stylissa flabelliformis sponges Setyowati, Erna Prawita; ., Sudarsono; Wahyuono, Subagus
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A research on the structure identification of cytotoxic and fungicide compound of Stylissa flabelliformis sponge has been conducted. The structure identification was analysed with spectroscopy ultraviolet, MS, 1HNMR and 13C-NMR methods.Based on the spectroscopic data and comparison with literatures, the compound was identified as jaspamide.Key words: sponge, Stylissa flabelliformis , jaspamide, structure elucidation

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