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INDONESIA
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Published by Universitas Airlangga
ISSN : 24069388     EISSN : 25808303     DOI : -
Core Subject : Health, Science, Education,
Chemistry Education Health Professions Medicine & Pharmacology Other
Jurnal ini adalah jurnal peer-review nasional, yang diterbitkan dua kali dalam membahas tentang topik-topik hasil penelitian di bidang pelayanan dan praktik kefarmasian, konsultasi masyarakat, teknologi kefarmasian serta disiplin ilmu kesehatan yang terkait dengan erat. Jurnal ini memfokuskan pada area-area berikut: 1. Farmasi Klinis 2. Farmasi Komunitas 3. Farmasetika 4. Kimia Farmasi 5. Farmakognosi 6. Fitokimia
Arjuna Subject : -
Articles 182 Documents
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Synthesis and Activity Test of 1-Allyl-3-(4-tertiary-Butylbenzoyl) Thioureaas a Candidate of an Analgesic Drug Rais Razak; Siswandono Siswandono; Juni Ekowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.17-23

Abstract

Background: Urea derivatives showed good analgesic activity compared to diclofenac sodium.  The addition of the allyl group to the thiourea and 4-tertiary-butylbenzoyl chlorideis expected to provide a better analgesic effect. Objective: The research aimed to synthesize 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by a modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 4-tertiary-butylbenzoyl chloride.  A writhing test was performed to observe analgesic activity in the test compound.  Confirmation of the structure of pure 1-allyl-3-(4-tertiary-Butylbenzoyl) Thiourea was obtained through UV, IR, 1H-NMR, and 13C-NMR data. Results: The compound showed better pain inhibition activity compared to diclofenac sodium, with ED5019,018 mg/kg BW. Conclusion: The compound 1-allyl-3-(4-tertiary-butylbenzoyl) thiourea showed better analgesic activity than diclofenac sodium.
Calcium Decay Ability of Extracts Chromolaena odorata L. Leaves (Asteraceae) on Kidney Stones Dimas Danang Indriatmoko; Maulani Maulani; Tarso Rudiana
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.24-31

Abstract

Background: Kidney stones are one of the causes of chronic and acute kidney failure symptoms. The flavonoid compounds in Chromolaena odorata leave extract are thought to dissolve calcium in kidney stones.  Objective: This study aims to determine the activity of Chromolaena odorata leaves extract as a laxative for calcium kidney stones and to characterize the active extract with a liquid chromatograph mass spectrometry. Methods: The leaves of Chromolaena odorata were extracted by ultrasonication method using 3 solvents in stages, namely n-hexane, ethyl acetate, and methanol. The powder for kidney stones was immersed in an extract solution of n-hexane, ethyl acetate, and methanol for 5 hours at 37° C. The reaction results were analyzed for their absorbance using a UV-Vis spectrophotometer. The fraction with the best activity was analyzed for phytochemical content with various typical reagents and LCMS. Results: Methanol extract of Chromolaena odorata has a better effect in dissolving calcium kidney stones. Methanol extract of Chromolaena odorata can reduce calcium in kidney stones with an EC50 value of 16801 µg/mL. Based on phytochemical tests and LCMS analysis, the methanol extract of Chromolaena odorata leaves contains compounds of the tannins, alkaloids, flavonoids, and steroids. Chromatogram at a retention time of 7.76; 8.96; and 10.01 in the methanol extract of Chromolaena odorata identified 3,5,7,4'-tetrahydroxy-8,3'-dimethoxyflavone; 5,7,4’-trihydroxy-3’,5’-dimethoxyflavone, and 5,6,7,8,4'-pentamethoxyflavone compounds. Conclusion: Methanol extract had the best calcium decay activity in kidney stones with an EC50 value of 16801 µg/mL. 3,5,7,4'-tetrahydroxy-8,3'-dimethoxyflavone; 5,7,4’-trihydroxy-3’,5’-dimethoxyflavone, and 5,6,7,8,4'-pentamethoxyflavone compounds are contained in methanol extract which is thought to play a role in shedding calcium in kidney stones.
Synthesis and Antiplatelet Activity of 4-Hidroxy-3-Methoxycinnamic Acid Erika Christy Marentek; Tutuk Budiati; Juni Ekowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.32-38

Abstract

Background: Cinnamic acid and its derivatives have been widely studied for their efficacy because of the pharmacological effect on good health and well being. Microwave irradiation is more time effective to synthesize than conventional heating method because it conducts heat faster and shortens the reaction time.  Objective: This study aimed to synthesize 4-hydroxy-3-methoxycinnamic acid using microwave irradiation and its antiplatelet activity by blood clotting time method. Methods: Synthesis of 4-hydroxy-3-methoxycinamic acid with malonic acid and 4-hydroxy-3-methoxybenzalehyde as a starting material using ammonium acetate catalyst with microwave irradiation (960 Watt, 4 minutes). The synthesis results were tested for purity by thin-layer chromatography, a melting point determination and structure identification (UV-Vis, infrared, and proton NMR spectrometry). The antiplatelet activity test consisted of a negative control group CMC-Na, a positive control acetosal, cinnamic acid, and 4-hydroxy-3-methoxycinnamic acid, each group consisted of 3 different doses, namely 0.0037 mmol/Kg (I), 0.0069 mmol/Kg (II) and 0.0139 mmol/Kg (III). Results: Synthesis of 4-hydroxy-3-methoxycinamic acid had a yield percentage of 30.55%. The test results showed that the 4-hydroxy-3-methoxycinnamic acid compound has antiplatelet activity with an ED30 value of 1.3080 mg/Kg BW and antiplatelet activity comparable to acetosal. Conclusion: 4-hydroxy-3-methoxycinamic acid can be synthesized by microwave irradiation and had antiplatelet activity 1.7 fold greater than cinnamic acid.
Acute and Subchronic Toxicity Assessment of 70% Ethanol Extract of Gendarusa Leaves In Vivo Luthfiatu Kanina; Mabluhatus Solehah; Hani Plumeriastuti; Retno Widyowati; Bambang Prajogo Eko Wardoyo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.39-47

Abstract

Background: Justicia gendarussa Burm. f., has been used traditionally in Indonesia for antifertility. Nowadays, a capsule containing 70% ethanol extract of J. gendarussa leaves has been studied for safety. Objective: This study aimed to determine the acute and sub-chronic toxicity of 70% ethanol extract of J. gendarussa leaves in vivo. Methods: In the acute toxicity study, a single dose of 2,000 mg/Kg BW was orally administered to mice (n = 10), which were monitored for 24 days. For the subchronic toxicity study, rats were randomly divided into four groups (n = 10). The control group received distilled water, while the treatment groups received a repeated dose of 40, 200, and 1,000 mg/Kg BW orally for 90 days. Blood samples were collected for hematological and biochemical evaluations. Gross pathology and histopathology of liver and kidneys were assessed. Results: No mortality and non-observed adverse effect level (NOAEL) were observed in the acute toxicity study. The hematological analysis did not show significant differences in the subchronic toxicity study. The SPGT, SGOT, and creatinine values showed no change in groups 2 and 4, but the level of SGPT increased in groups 3. The increasing level of BUN was observed in all treated groups. Abnormalities or histopathological changes were observed in the liver and kidney in groups 3 and 4. Conclusions: Using 70% ethanol extract of J. gendarussa leaves at a therapeutic dose is safer, but it needs attention at a higher dose.
Antidiabetic Activity of Ethanolic Extract of Kale (Brassica oleracea var. sabellica) Afdrian Kusumawardianingrum; Novena Yety Lindawati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.92-100

Abstract

Background: Diabetes Mellitus is a disease caused by a disruption of the pancreas in producing insulin. The International Diabetes Federation (IDF) organization identified ten countries that have the highest cases of Diabetes Mellitus. Indonesia is ranked 7th out of 10 countries and is the only Southeast Asian country included in the list. Prevention of diabetes mellitus is a solution that must be done to reduce cases of diabetes mellitus in Indonesia., one of which is by consuming vegetables that have antidiabetic activity. Objective: This study was conducted to determine the activity of kale (Brassica oleracea var. sabellica) extract in reducing glucose levels. Methods: The qualitative test results showed that the kale extract contained positive flavonoids, triterpenoids, tannins and phenols. The antidiabetic activity test was carried out using the UV-Vis spectrophotometer and the Nelson Somogyi method. This test is carried out at the 25th minute operating time and a maximum λ of 745 nm. Results: The decrease in glucose levels in kale extract concentration of 4 ppm was 2.23% ± 0.46, 6 ppm of 16.47% ± 0.27.8 ppm of 30.62% ± 0.46, 10 ppm of 41.88 ± 0.27, 12 ppm of 55.50 ± 0.20. The concentration of kale extract in reducing glucose up to 50% (EC50) was 11.13 ppm. Conclusion: Kale extract (Brassica oleracea var. sabellica) can reduce glucose levels or have antidiabetic activity.
Anti-Hepatitis C Virus Activity of Various Indonesian Plants from Balikpapan Botanical Garden, East Borneo Rina Puspitasari; Tutik Sri Wahyuni; Achmad Fuad Hafid; Adita Ayu Permanasari; Lidya Tumewu; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.48-54

Abstract

Background: Hepatitis C Virus infection is a serious health problem that leads to chronic liver disease, liver cirrhosis, hepatocellular carcinoma, which causes high morbidity. Direct-Acting Antiviral Agents have been used as anti-hepatitis C Virus therapy. However, it was covered only in limited patients due to the high cost. Moreover, serious side effects and resistance cases were also reported in some HCV genotypes. Objective: This research aimed to find new anti-HCV from some Indonesia plants collected from Balikpapan Botanical Garden, East Borneo. Methods: Twenty-one leaf and stem barks extracts were successively extracted in n-hexane, dichloromethane, and methanol. Extracts were screened for their anti-HCV activity under in vitro culture cells in the concentration of 30 µg/mL. Plant extracts were inoculated in the Human Hepatocellular 7it and infected with HCV Japanese Fulminant Hepatitis strain 1a. Determination of 50% Inhibitory Concentration (IC50) value was further conducted at concentration of 100; 30; 10; 1; 0.1; 0.01 µg/ml of extracts. Results: In vitro anti-HCV activity revealed that among 21 plants extract, 11 extracts, namely, n-hexane extract from Luvunga scandens leaves, DCM extract from the leaf of L. scandens, Artocarpus sericicarpus, Artocarpus dadah, Eusideroxylon zwageri, Neolitsea cassiaefolia, methanol extract from A. sericicarpus and A. anisophyllus leaves, DCM extract from A. anisophyllus and A. elmeri stem bark, methanol extract from A. dadah stem bark, having potential inhibition with IC50 range 0.08 ± 0.05 to 12.01 ± 0.95 µg/mL. Conclusions: These results indicate that the eleven extracts could be good candidates as sources of anti-HCV agents.
Ethnomedicine Study on Justicia gendarussa for Male Contraception at the Nimboran Ethnic, Jayapura Niluh Indrawati; Retno Widyowati; Pilipus Kopeuw; Bambang Prajogo Eko Wardoyo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.55-61

Abstract

Background: Justicia gendarussa from Papua has traditionally been used for the treatment of several diseases, and phytochemical studies have been carried out since 1987. Objective: This study aimed to determine the use of this plant as a male contraceptive that the Nimboran Ethnic and their perspectives have long used. Method: A qualitative method with an ethnographic approach was used, while data were collected through interviews, observations, and documentation. The informants were selected using purposive and snowball sampling. Result: The results showed that 44% of people use it to delay pregnancy, 24% due to young marriage with poor economic conditions, 14% after moving to another place 12% because of tribal wars over fertile land to multiply offspring. The preparation and usage of this plant through the collection, mixing, and manufacturing method and in terms of dosage, time, and duration of use were explored more deeply by conducting interviews with 50 informants. The effectiveness and success as a method of contraception are presented in the way the community has known the plant over different generations, and this method is still used as an alternative option considering the very wide area profile from one place to another. Conclusion: Justicia gendarussa is used by the Nimboran Ethnic group as an ingredient in traditional medicines, especially for male contraception.
HPLC Method Optimization for Simultaneous Determination of Quercetin, Luteolin, Sinensetin, and Stigmasterol in Herbal Medicines Asih Imulda Hari Purwani; Riesta Primaharinastiti; Mochammad Yuwono
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.62-68

Abstract

Background: Quercetin, luteolin, sinensetin and stigmasterol each is the main marker compound in extracts of Sonchus arvensis, Plantago major, Orthosiphon stamineus, and Strobilanthes crispus, respectively. These extracts show nephrolithiasis activity. For quality control of herbal medicines, a high performance liquid chromatography (HPLC) method has been developed in this study using quercetin, luteolin, sinensetin and stigmasterol as phytochemical markers. Objective: to show optimal conditions of analysis and evaluate the stability of quercetin, luteolin, sinensetin and stigmasterol. Methods: The optimal conditions for analysis were carried out by determining the composition of the mobile phase, the flow rate, and the detector's wavelength. Zorbax Eclipse Plus C18 150 x 4.6 mm, 5 μm was used as the column. The stability test was done by analyzing the standard and samples stored at 4oC for 0, 3, 6 and 24 hours. Results: The best separation of the extract was achieved under isocratic conditions using a mixture of water: methanol: phosphoric acid: acetic acid : acetonitrile (50: 30: 0.05: 0.05: 20 v/v/v/ v/v) as mobile phase with detector wavelength of 352 nm, a mobile phase flow rate of 1 mL/min, and a sample injection volume of 10 μL. Conclusion: In this study, the optimal condition for analysis of quercetin, luteolin, sinensetin and stigmasterol. Quercetin, luteolin, sinensetin and stigmasterol were not stable during 6 hours storage, therefore, standard solutions and samples should be made fresh to maintain the stability.
Potential Drug–Drug Interactions in Ambulatory Patients with Hypertension: a Retrospective Study Marcha Debby Saraswati; Shafira Muti Ardiana; Budi Suprapti; M. Yusuf Assegaf; Suharjono Suharjono; Khusnul Fitri Hamidah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.69-74

Abstract

Background: Patients with cardiovascular diseases (CVD) are vulnerable to experiencing drug-drug interactions (DDIs). DDIs are a concern among patients receiving multiple drug regimens but they are also an avoidable cause of adverse drug reactions. The study of potential DDIs (pDDIs) would make it easier for the healthcare provider to deliver better patient care and mitigate pDDIs incidence. Objective: This study aimed to assess the frequency, severity level and risk factors associated with pDDIs among medications used to treat hypertensive ambulatory patients in Universitas Airlangga hospital. Methods: A retrospective observational study was carried out from electronic prescriptions received by hypertensive patients in March 2021. Data collection includes demographic data, the profile of antihypertensive drug use, and pDDIs. pDDIs were identified by severity using Lexicomp Drug Interaction Checker (Application). Univariate logistic regression analysis was used to find associated factors of major pDDIs. A p-value less than 0.05 (≤ 0.05) was considered statistically significant. Results: From 704 patients, 53.98% women and 46.02% men, 89.06% (n = 627) patients had minor to major pDDIs; 1354 pDDIs were identified, 89.4% (n = 1,210) were moderate and 9.8% (n = 133) were major class. Multiple antihypertensive drug regimens had significance associated with the major pDDIs occurrence. Conclusion: We found a high prevalence of pDDIs among hypertensive patients. The majority of pDDIs were of moderate severity. Multiple antihypertensive drug regimens were associated factors in the presence of major pDDIs.
Molecular Docking of Active Compound of Lavandula angustifolia Mill Essential Oil against N-methyl-D-aspartate (NMDA) Receptor Baiq Risky Wahyu Lisnasari; Aniek Setiya Budiatin; Chrismawan Ardianto; Junaidi Khotib
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.75-81

Abstract

Background: Lavender oil is widely known to possess a relaxant effect to relieve stress, anxiety, and depression. Linalyl acetate, linalool, geranyl acetate, and β-caryophyllene were the major constituents of lavender oil that potentially act on NMDAR (N-methyl-d-aspartate receptors), and emerging targets in the treatment of depression. Objective: This study aims to predict the binding of lavender compounds to NMDA receptors using an in silico model. Methods: The ligands of the docking study were four major chemical compounds of lavender oil, i.e., linalyl acetate, linalool, geranyl acetate, and β-caryophyllene. 5YE was defined as a native ligand, while memantine, an NMDAR antagonist, was used as a reference ligand. The NMDAR structure was taken from Protein Data Bank (ID 5H8Q), while the lavender compound was sketched in Chem3D. Autodock 4.2 was used to perform the docking analysis. Results: The result showed that beta-caryophyllene had the most potent interaction with NMDAR (free binding energy was -8.02 kcal/mol and inhibitory constant was 1.32 µM). Conclusion: The docking results suggest that beta-caryophyllene could be an NMDAR antagonist and be developed as a treatment for depression.

Page 13 of 19 | Total Record : 182

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