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Majalah Obstetri dan Ginekologi

MOG
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Published by Universitas Airlangga

ISSN : 08540381 EISSN : 25981013 DOI : 10.20473/mog.V27I32019.90-93

Core Subject : Health,

Health Professions Medicine & Pharmacology

Majalah Obstetri & Ginekologi (MOG) or the Journal of Obstetrics & Gynecology Science is a scientific journal published by the Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, in collaboration with the Indonesian Obstetrics and Gynecology Association (POGI) of Surabaya branch.

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Articles 216 Documents

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Oxygen Hyperbaric Exposure Induces GLUT4 Expression Reduction and No Folliculogenesis Alterations in Rat PCOS with Insulin Resistance Model Varianida Veterini; Budi Santoso; Widjiati Widjiati
Majalah Obstetri dan Ginekologi Vol. 23 No. 3 (2015): September - Desember 2015
Publisher : Universitas Airlangga

Objectives: To know effect of hyperbaric oxygen therapy to GLUT4 expression and folliculogenesis in rat PCOS with insulin resistent model.Materials and Methods: this is an analytic experimental study used 30 rats induced by testosterone propionate injection 1 mg/100 g body weight daily for 28 consecutive days as a PCOS with insulin resistent model. Animal models divided into 3 groups. Negative control was not given treatment, positive control was given placebo. Treatment group was given hyperbaric oxygen 2.4 ATA 90 minutes 2x5 days. GLUT4 expression determined by immunohystochemistry to m. Gastrocnemius. Hematoxylin Eosin staining to rat ovaries were performed to know differentiation in folliculogenesis. The results were then compared.Results: There were significant decrease of GLUT4 expression in treatment group (mean0,84+0,47)compared to negative and positive control (mean3,96+3,16and3,36+2,17). There were no different folliculogenesis in these groups.Conclusion: Hyperbaric oxygen 2.4 ATA 90 minutes 2x5 days induce decrease of GLUT4 expression and no alterations in folliculogenesis in rat PCOS with insulin resistent model, therefore can not yet be used as alternative therapy in PCOS.

Pengaruh Pemberian Misoprostol 25 µg Peroral Ambulatoir pada Tenggat Waktu Persalinan Wanita Hamil > 40 Minggu Resiko Rendah Mariana Paristiwati Trihastuti; Bangun Trapsila Purwaka
Majalah Obstetri dan Ginekologi Vol. 23 No. 1 (2015): Januari - April 2015
Publisher : Universitas Airlangga

Tujuan: Mengukur pengaruh misoprostol 25 µg per oral ambulatoir terhadap interval persalinan wanita hamil risiko rendah.Bahan dan Metode: Penelitian acak, tersamar ganda, menggunakan plasebo yang membandingkan 25 µg rawat jalan secara lisan misoprostol dengan plasebo pada wanita hamil risiko rendah yang tidak melahirkan selama > 40 minggu. Setiap subjek menerima 25-mg misoprostol per oral3x/hari dan diulang setiap 36 jam jika masih belum persalinan, dengan dosis maksimum 9 dosis. Setelah pemberian obat, pasien diperbolehkan menjalani persalinan spontan kecuali terdapat indikasi untuk induksi.Hasil: Dua puluh satu wanita hamil dimasukkan secara acak dalam setiap kelompok untuk mendapatkan misoprostol dan placebo. Indikator utama hasil: interval persalinan, skor Apgar dan insidens operasi caesar. Analisis statistik dilakukan dengan uji Student t, 2, dan Mann-Whitney U, dengan P <0,05 dianggap signifikan secara statistik. Interval rata-rata dari dosis awal hingga persalinan secara signifikan lebih rendah pada kelompok misoprostol, 74,23 ± 54,42 dibandingkan dengan 200,97 ± 118,05 jam (P = 0,000). Tidak ada perbedaan dalam skor Apgar menit pertama (P = 0.713) dan menit kelima (P = 0.655). Tiga subjek dari kelompok misoprostol menjalani operasi caesar karena alasan obstetri, tapi tidak ada pasien mengalami hiperstimulasi atau memerlukan persalinan sesar untuk penilaian janin yang meragukan selama induksi. Namun, karena ukuran sampel yang kecil, efek samping seringkali terlewatkan.Simpulan: misoprostol 25-g per oral ambulatoir efektif dan aman dalam menurunkan tenggat waktu persalinan wanita usia kehamilan > 40 minggu.

Keikutsertaan Kelas Ibu Hamil Berpengaruh terhadap Pengetahuan dan Sikap Ibu dalam Praktik Inisiasi Menyusu Dini Elsa Budi Sihsilya Rahmawati; R Kuntoro; Bambang Trijanto
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Strategi Pemerintah dalam menurunkan AKI dan AKB salah satunya kelas ibu hamil. Tujuan penelitian ini mengetahui pengaruh keikutsertaan ibu di kelas ibu hamil terhadap praktik IMD pada ibu bayi usia 6-8 bulan di wilayah kerja Puskesmas Sisir Kota Batu. Penelitian ini merupakan penelitian analitik dengan desain cohort retrospektif. Populasi terbagi menjadi dua, populasi terpapar yang mengikuti kelas ibu hamil saat hamil anak terakhir dan populasi tidak terpapar ibu yang tidak mengikuti kelas ibu hamil. Besar sampel 32 responden. Analisis data dengan uji chi square. Hasil analisis bivariat usia (p value = 0,229), pendidikan (p value = 0,1790, paritas (p value = 0,011), pengetahuan (p value = 0,047), sikap (p value = 0,893), riwayat persalinan (p value = 0,021), informasi (p value = 0,472), penolong persalinan (p value = 0,017), tempat persalinan (p value = 0,003), keikutsertaan kelas ibu hamil (p value = 0,27), pengambil keputusan (p value = 0,137), penyuluhan saat hamil (0,16) Hasil analisis menunjukkan variabel yang signifikan adalah paritas (p=0,011), pengetahuan (p=0,047), penolong persalinan (p=0,017), tempat persalinan (0,003), riwayat persalinan (p=0,021), penyuluhan saat hamil (p=0,010). Kesimpulan penelitian ini tidak ada pengaruh keikutsertaan ibu di kelas ibu hamil terhadap praktik IMD, akan tetapi kelas ibu hamil berpengaruh terhadap pengetahuan dan sikap ibu. Pengetahuan berpengaruh terhadap praktik IMD.

Genotype of human papilloma virus in invasive cervical carcinoma at Dr. Soetomo Hospital Surabaya Markus Kore; Gondo Mastutik; Sjahjenny Mustokoweni
Majalah Obstetri dan Ginekologi Vol. 25 No. 2 (2017): August
Publisher : Universitas Airlangga

Objectives: To identify the variants of genotype HPV that most often found in ICC at Dr Soetomo Hospital Surabaya.Materials and Methods: This was an explorative study with cross sectional approach. Specimens used were 30 formalin fix parrafin embedded from squamous cell carcinoma (SCC), adenocarcinoma (AD) dan adenosquamous carcinoma (AS) cervival cancer parients at Dr Soetomo Hospital Surabaya around Januari-Desember 2013, then used for DNA virus extraction and continued for PCR and HPV genotyping.Result : The result of HPV genotyping showed 10 positives from SCC, 6 positives and 4 negatives from AD, and 9 positives and 1 negative from AS. HPV infections in SCC were single infection by HPV 16, 18, 45, 56, and multiple infection by HPV 16+45, in AD were single infection by HPV 16,18, anad multiple infection by HPVhr+hr 68b+72 and HPVlr+hr 6+18+45, and in AS were single infection by HPVhr 16, 18, 45 and mutiple infection by HPV lr+hr 6+59.Conclusion : Infections HPV in ICC were single infection by HPV16, 18, 45, 56 and mutiple infection by HPV16+45, 68b+72, 6+18+45, 6+59. HPV 18 has highest prevalence in ICC patient from Dr Soetomo Hospital, followed by HPV16, 6, 45, 56, 59.

Effect of pregnant women’s knowledge and therapy regimentation towards compliance in consuming iron (Fe) tablets and anemia degree in South Kediri Public Health Center year 2016 Dina Dewi Anggraini; Windhu Purnomo; Bambang Trijanto
Majalah Obstetri dan Ginekologi Vol. 24 No. 2 (2016): May - August
Publisher : Universitas Airlangga

Objectives: This study aimed to analyze the influence of knowledge and regimentation of pregnant women consume tablets therapy adherence iron (Fe) and anemia in pregnant women in the South Regional Health Center Kediri.Materials and Methods: This study used observational analytic with cross sectional design. The population consisted of 63 third trimester pregnant women and samples taken were 34 third trimester pregnant women who have received 90 tablets of iron (Fe), with a simple random sampling technique. Data obtained from questionnaires, books Maternal and Child Health, and in-depth interviews. Data analysis was performed using ordinal regression and logistic regression.Results: There was an effect of knowledge of pregnant women on adherence to consume tablets of iron (Fe), there is no influence regimentation of therapy on adherence to consume tablets of iron (Fe), and no effect of compliance sufficient to consume tablets of iron (Fe) against anemia in pregnant women (p=0.012). Conclusion: The higher the level of knowledge possessed by pregnant women, pregnant women, the more it tends to stick to consume tablets of iron (Fe) during pregnancy. And no regimentation of therapeutic effect on adherence to consume tablets of iron (Fe) in pregnant women.

Overview of relation between coverage of health services and maternal mortality in East Java Province in 2015 Wahyul Anis; Kuntoro Kuntoro; Soenarnatalina Melaniani
Majalah Obstetri dan Ginekologi Vol. 24 No. 2 (2016): May - August
Publisher : Universitas Airlangga

Objectives: to analyze the efforts of maternal health services that may affect maternal mortality rate.Materials and Methods: The study was conducted at the Health Office of East Java using secondary data from 38 districts/cities in East Java in 2015 that includes performance antenatal care K1 and K4, postnatal care, early detection of complications in pregnant women, natal in health workers and health facilities, management of complications by health workers and MMR. Data were analyzed with statistical method with spatial regression and illustrated with thematic maps by application ArcView statistics.Results: the highest MMR was in Bojonegoro district, Lumajang, Probolinggo, Bondowoso, Situbondo and Probolinggo city. Some districts/cities that have the highest maternal mortality has proximity of areas, namely the district Lumajang, Probolinggo, Bondowoso, Situbondo and Probolinggo city. Their proximity concluded an association condition and the causes of MMR between districts so they can be studied more in depth about the causes of MMR kind of social, cultural and geographical characteristics. The coverage maternal health services to all districts/cities in East Java province is not much difference.Conclusion: the maternal mortality rate in the district/city of East Java province in 2015 was not much affected by maternal health services so we need more research on other causes of MMR in districts/city of East Java Province.

Characteristics of uterine leiomyoma patients at the Department of Obstetrics and Gynecology, Dr. Soetomo Hospital, Surabaya, from January to December 2014 Listiana Rizka Pranandari; Hari Nugroho; Dwi Aprilawati
Majalah Obstetri dan Ginekologi Vol. 25 No. 3 (2017): December
Publisher : Universitas Airlangga

Objectives: To study the characteristics of patient with uterine leiomyoma to be used as reference and evaluation.Materials and Methods: The data of this study taken by assess-ing patients’ medical record to be analyzed descriptively.Results: Of 145 patients, 69,7% were female who are older than forty years of age. Uterine leiomyoma often occur in patients of reproductive age (31%). Only 2.8% patient used oral contra-ceptive and 15.2% had menarche at the age of 12-13 years. The number of uterine leiomyoma was higher in female who had history of pregnancy less than or equal to two times (35.2%) and dominated by patients who had history of birth less than or equal to two times (37.2%). 63.4% patient never consume cigarette. Moreover, 29.7% of patients were overweight female. Unfortun-ately, there is no data about family history, exercise habit and history of tissue injury in the medical record.Conclusion: In this study, patients with uterine leiomyoma are dominantly female at age more than forty and at reproductive or perimenopause period with history of pregnancy and birth less than or equal to 2 times, never consume cigarette and overweight.

Comparison of serum soluble edoglin (sEng) level in eary onset preeclampsia, late onset preeclampsia and normal pregnant woman Aldika Akbar; Mita Herdiyantini; Aditiawarman Aditiawarman
Majalah Obstetri dan Ginekologi Vol. 25 No. 1 (2017): April
Publisher : Universitas Airlangga

Objectives: This study aimed to compare the serum levels of soluble Endoglin (s-Eng) between early onset preeclampsia, late onset preeclampsia and normal pregnant women.Materials and Methods: This was an analytic observational study (Cross-Sectional) performed on 39 pregnant women with early-onset preeclampsia (EO-PE), late-onset preeclampsia (LO-PE), and normal pregnancy. The patients were consecutively chosen in Dr. Soetomo Hospital, Airlangga University Hospital and Dr. M. Soewandhi Hospital Surabaya in May-July 2016. The serum concentration of soluble Endoglin were collected by venous puncture taken from maternal circulation and measured by ELISA.Results: From this study, serum concentrations of soluble Endoglin was higher significantly on the early onset preeclampsia compared with late onset preeclampsia and normal pregnancy (47,65 ± 40,17 vs 13,46 ± 9,48 vs 6,11 ± 1,45 ng/mL; p=0.000). Conclusion: This study shows angiogenic imbalance was more prominent compared in early-onset than late-onset preeclampsia. This may be because the placental dysfunction, placental ischemia, which produce excessive anti angiogenic factors, whic later causing endothelial dysfunction was more related to early onset preeclampsia.

Parity as failure determinants of labor induction in Bangka Belitung Dina Delvin Anggriani; Lilik Herawati; Ernawati Ernawati
Majalah Obstetri dan Ginekologi Vol. 24 No. 3 (2016): September - December
Publisher : Universitas Airlangga

Objectives: to identify factors affecting labor induction failure in Sungailiat General Hospital, District Bangka, Bangka Belitung.Materials and Methods: This is a case control retrospective analytic study. Population of this study was postterm delivering mother at delivery room Sungailiat General Hospital during July 1st, 2012 to July 1st, 2015. Sampling method conducted for case group was total sampling method with labor induction failure as a inclusion criteria, and no data for first trimester ultrasound, didn’t have a routine antenatal care history, and maternal complication as exclusion criterias as many as 78 samples. Whereas, control group was women whose underwent a success labor induction used random sampling method with 1:1 ratio. Data source was from medical records. Data analysis was chi square with 95% confidence interval.Results: From the 78 samples with labor induction, 19,2 % was ≥ 35 years old, 48,7% was primiparas, 62,8% with infant birth weight ≥ 3500 gram, and from 96 samples, 47,5% with ≥ 5 years pregnancy interval. Statistical analysis result showed factors that affecting induction failure were parity (P Value 0,014, odds ratio 2,970), baby’s weight (P Value 0,016, odds ratio 2,631), pregnancy interval (P Value 0,023, odds ratio 2,993), whereas mother’s age did not show significant effect (P Value 0,383, odds ratio 2,278).Conclusion: Parity has a 2,9 times risk to develop induction failure.

Three years survival rate of epithelial ovarian cancer patients in Dr. Kariadi Hospital, Semarang, Central Java Indah Nur Damayanti; Indra Yulianti; Etty Hary Kusumastuti
Majalah Obstetri dan Ginekologi Vol. 24 No. 3 (2016): September - December
Publisher : Universitas Airlangga

Objectives: to determine the association between prognostic factors of ovarian cancer with a 3-years survival rate of epithelial ovarian cancer patients.Material and Method: Retrospective cohort study was conducted in 90 patients (during 2012) at Dr.Kariadi General Hospital. Kaplan meier, Log rank and Cox regression were used to analyse survival rate and prognostic factors that influence the disease.Result: Overall 3-years survival rate of epithelial ovarian cancer patients were 58.5% (Kaplan meier). Three-years survival rates were 89.3%, 44,4%, and 35.1% for patients in stage I, stage II, and stage III, respectively, and no patient survive up to 3 years in stage IV. Prognostic factors that associated with 3-years survival rate were stage of the disease, ascites, residual tumor, and type of histopathology {p<0,001; p=0,001; p=0,004; p=0,041, respectively (Log rank test)}, whereas age and size of tumor were not associated. After using multivariate analysis (Cox regression) only stage of the disease was associated with 3-years survival rate of epithelial ovarian cancer patients.Conclusion: There were an association between stage of the disease, ascites, residual tumor, type of histopathology, and 3-years survival rate of epithelial ovarian cancer patients. Stage of the disease was a prognostic factor that most influence 3-years survival rate of epithelial ovarian cancer patiens in this study.

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