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<![CDATA[ADMINISTRATION OF RED ROSELLAâS PETALS EXTRACT (Hibiscus sabdariffa) INCREASE LEVEL OF SUPEROXIDE DISMUTASE (SOD) WISTAR RATS WHICH INDUCED BY REPETEADLY HEATED COOKING OIL ]]>
<![CDATA[Herdiani, Novera]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 2 (2015): Edisi Desember 2015 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Background:  repeatedly heated cooking oil is cooking oil that is used many times, had saturated fatty acids containing free radicals. Red rosella petals extract contains antioxidants to minimize the effects of repeatedly heated cooking oil that can raise the levels of SOD. The aim of this study was to analyzed the effect of red rosellaâs petals extract against oxidative stress of Wistar rats were induced by repeatedly heated cooking oil with examine levels of  serum SOD.This research was conducted True Experimental Laboratory with a completely randomized design (CRD) and use the post test. The sample consisted of 24 male rats were divided 4 groups: negative control (fed with standard diet); positive control (fed with standard diet + administered by repeatedly heated cooking oil as much as 2.1 ml / kg bw); treatment group dose I (fed with standard diet + administered by red rosella extract dose 540 mg / kg bw + repeatedly heated cooking oil as much as 2.1 ml / kg bw), and treatment group dose II (fed with standard diet + administered by red rosella extract dose 810 mg / kg bw + repeatedly heated cooking oil as much as 2.1 ml / kg bw). Analysis of data using statistical test One Way ANOVA and Tukey HSD (α = 0.05).Results: There were significant differences (p = 0.000) between groups. Red rosella extract treatment group dose 810 mg / kg bw and 540 mg / kg bw were significantly different from the positive control (p = 0.000). Red rosella extract group dose 540 mg / kg bw was significantly different from the negative control (p = 0.000). Red rosella extract group dosage of 810 mg / kg bw was not differ significantly from the control group (p = 0.171).Conclusion: The red rosellaâs petals extract dose of 810 mg / kg bw and dose of 540 mg / kg bw were able to prevent oxidative stress. Optimal deose of red rosella petals extract dose of 810 mg / kg bw was the most effective, because the higher antioxidant activity (67.33%) at dose 810 mg / kg bw dose than 540 mg / kg bw.]]>
<![CDATA[EFFECT OF FORTIFIED MILK (CALCIUM AND VITAMIN D) AND OSTEOPOROSIS GYMNASTICS TOWARD BONE DENSITY OF PRE ELDERLY WOMEN IN THE WORKING AREA OF HEALTH CENTER BANYUANYAR IN DISTRICT SAMPANG ]]>
<![CDATA[Prasetya, Desy]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 1 (2015): edisi September 2015 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Disorders of bone density becomes a major public health problem, especially in women pre elderly. Besides due to low intake of essential nutrients for bone, also because of declining estrogen due to menopause. Low bone density can lead to osteoporosis and impact on risk of bone fracture. Fortified milk is one of strategy to provide the intake of calcium and vitamin D daily. In addition, osteoporosis gymnastics also plays a role to increase the absorption of calcium in the small intestine. The aim of this study was to analyzed the effect of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density in women pre elderly in the working area of health center Banyuanyar Sampang. Research design used Non equivalent Control Group Design. Samples were 45 pre elderly womens (age 50-59 years) which is composed of 15 people (treatment group I) in the form of gymnastics osteoporosis, 15 (treatment group II) in the form of osteoporosis gymnastics and fortified milk, and 15 people in the control group. Statistical test using paired T-test, Wilcoxon and Kolmogorov Smirnov. There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density (p = 0.037). While in the first treatment group (p = 0.217) and showed no effect on controls groups (p = 0.157). There was the influence of fortified milk (calcium and vitamin D) and osteoporosis gymnastics on bone density. Some respondents have improvement or increase of T-score.]]>
<![CDATA[THE EFFECTS OF CORN FLOUR WITH TEMPEH FLOUR SUPPLEMENTATION FEEDING IN DIABETES MELLITUS WISTAR RATS TOWARD BLOOD GLUCOSE LEVEL ]]>
<![CDATA[Asmarani, Fatifa]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 2 (2015): Edisi Desember 2015 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Background: Diabetes mellitus (DM) is metabolic disorder syndrome characterized by hyperglycemia due to deficiency of insulin secretion. Patients of diabetic patients increases each year, so it needs proper handling. Corn flour is a source of carbohydrates with a low glycemic index to help reduce the rise in blood sugar levels. In addition, supplementation with tempeh flour containing isoflavones act to protect cells from free radical thereby inhibiting damage cells. Fiber in tempeh affect blood glucose levels because it slows the absorption of glucose.Objective: To determine the effect supplementation of corn flour with tempeh flour on blood sugar levels in diabetes mellitus Wistar rats.Methods: The study was true experimental design with Pre-posttest control group design, samples were 20 male Wistar rats aged 2-3 months were then divided into 4 groups (T0, T1, T2, T3.) T0 was injected with alloxan as 30 mg / 150 grams of BB rats are subsequently treated with standard diet; T1 was dministered by standard diet 50% + 50% corn flour; T2 was administered by standard diet 50% + 30% + corn flour tempeh flour 20%; and T3 was administered by standard diet of corn flour 50% + 15% + 35% tempeh flour for 2 weeks. Blood glucose levels were measured with a glucose kit (GOD FS). Research data were analyzed by One Way ANOVA followed by Tukeys Post Hoc test p-value <0.05.Results: There were significant differences on blood sugar levels in all groups (p = 0.000): control group (only dietary standards), T1 (administered by standard diet 50% + corn flour 50%), T2 (administered by a standard diet 50% + cornstarch 30% tempeh flour + 20%) and T3 (administered by standard diet of corn flour 50% + 15% + 35% tempeh flour).Conclusion: corn flour with tempeh flour supplementation effect on decresing of blood sugar levels.]]>
<![CDATA[THE GIVING EFFECTS OF BISCUITS AND TEMPEH-BASED FLOUR CAKES AS SUPPLEMETARY FEEDING TOWARDS IMPROVEMENTS IN BODY WEIGHT AND HEIGHT IN CHILDREN SUFFERING MALNUTRITION 2015 ]]>
<![CDATA[Rizky, Oktovina]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 4, No 1 (2015): edisi September 2015 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Background: Nutritional problem in children is considered as a major issue and one that should receive priority in treatment is concerning to malnutrition. Malnutrition in children occurs due to insufficiency in energy and protein. Energy and protein are required in supporting rapid growth in children.Objective: to learn the giving effects of biscuits and tempeh-based flour cakes as supplementary feeding towards improvements in body weight and height of children under five suffering malnutrition in one of Public Health Center working area, northern region of Kediri Municipality.Methods: This study used a Randomized Control Triall Design, towards groups of children under five by providing tempeh-based flour cakes for supplementary feeding in the treatment group and by providing biscuits for supplementary feeding in control group. Samples were as many as 30 children under five and the data were being analyzed using peason and pre-post differences analysis was done using paired samples T-testResult: There was significant difference between body weight and body height after provision of providing biscuits and tempeh-based flour cakes for supplementary feeding with  p = 0.001 (p <α) for the treatment group and p = 0.001 (p <α) for the control group.Conclution: Providing and tempeh-based flour cakes in the treatment group for 30-days gave influence on increasing body weight and height.]]>
<![CDATA[ Young Khalaal Dates (Phoenix dactylifera) Effect on Blood Glucose in Alloxan-induced Wistar Male Rats ]]>
<![CDATA[Sholikhah, Desty Muzarofatus]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Health Notions Vol 2 No 1 (2018): January, 2018 ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453) ]]>
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<![CDATA[Young Khalaal Dates (Phoenix dactylifera) Effect on Blood Glucose in Alloxan-induced Wistar Male Rats]]>
<![CDATA[ Bee Pollen Effect on Blood Glucose Levels in Alloxan-induced Male Wistar Rats ]]>
<![CDATA[Rahayu, Aprilia Nurcahyaning]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>;
<![CDATA[M., Soenarnatalina]]>;
<![CDATA[Winarni, Dwi]]>;
<![CDATA[Hartiningsih, Sri]]>
<![CDATA[ Health Notions Vol 2 No 1 (2018): January, 2018 ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453) ]]>
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<![CDATA[The Role Of Zinc Sulphate And Omega 3 On The Improvement Of Weight And Speed Conversion Conversion On Tuberculosis Parent Patients At Surabaya Park Hospital, 2015 ]]>
<![CDATA[Durry, Fara Disa]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018 ]]>
Publisher : <![CDATA[Universitas Wijaya Kusuma Surabaya ]]>
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<![CDATA[Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, can affect almost all organs of the body with the most locations in the lungs. Immunity and high nutrients such as vitamin C, zinc and other antioxidants have shown good effects for infections, including tuberculosis. One effort to help accelerate sputum conversion of people with pulmonary tuberculosis is by supplementation of Zinc Sulphate and Omega 3.Objective: Analyze the role of Zinc Sulphate and Omega 3 on sputum conversion acceleration in patients with pulmonary tuberculosis at Surabaya Paru Hospital 2015.Method: This research use Randomized Pre Post Test Post Control Group Design design. In patients with pulmonary tuberculosis with Zinc Sulphate and Omega 3 in the treatment and placebo group in the control group. A sample of 20 patients consisting of 10 treatment patients and 10 control patients. Statistical test using paired T-Test, Friedman test and Mann whitney.Results: Friedman test showed that in the treatment group showed significant difference in the number of BTA between before and after supplementation (p=0,001), while in the control group significance of 0.141. Mann-Whitney test showed no significant difference in the amount of reduction of BTA between the treatment group and the control group (p = 0.080). This means that statistically does not show any significant difference.Conclusions: Zinc Sulphate and Omega 3 play a role in accelerating sputum smear conversion of respondents. The results of smear test in pulmonary TB patients with Zinc Sulphate and Omega 3 supplementation showed positive results]]>
<![CDATA[ Influence of Cinnamon Extract (Cinnamomum burmanii) Provision on the Reduction of Blood Glucose Level of Hyperglycemic Male Wistar Rats ]]>
<![CDATA[Aulia, Kharina]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Health Notions Vol 2 No 3 (2018): March 2018 ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453) ]]>
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<![CDATA[The number of patients with hyperglycemia in the world and in Indonesia is estimated to increase rapidly in the next 25 years. The content of cinnamaldehyde, flavonoids, polyphenols, and chromium in cinnamon thought to have an influence of hypoglycemia. This study aimed to determine the influence of cinnamon extract to a decrease of blood glucose levels in hyperglycemic rats induced by a single dose of alloxan as much as 125 mg/kg. This study was laboratory experiment by using RAL (Complete Randomize Design) with Pre-Post Test Control Group Design Research. Experimental animals used were male Wistar rats divided into 5 groups. KN was negative control group. KP was hyperglycemic positive control group. P1 was the first treatment group (a dose of 200 mg/kg). P2 was the second treatment group (a dose of 250 mg/kg). P3 was the third treatment group (a dose of 300 mg/kg). Cinnamon therapy was given orally for 14 days. The results of this research was tested statistically by using One Way ANOVA and showed that there were significant differences between the blood glucose levels in the treatment group with the positive and negative control groups. The conclusion was that the provision of cinnamon extract for 14 days could provide an influence of lowering blood glucose levels.
Keywords: Blood glucose, Cinnamon, Hyperglicemia]]>
<![CDATA[ Effects of Purple Sweet Potatoes on Oxidative Stress Biomarkers in Rats Subjected to Exhaustive Exercise ]]>
<![CDATA[Sholikhah, Anindya Maratus`]]>;
<![CDATA[Wirjatmadi, Bambang]]>;
<![CDATA[Adriani, Merryana]]>
<![CDATA[ Health Notions Vol 2 No 2 (2018): February 2018 ]]>
Publisher : <![CDATA[Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453) ]]>
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<![CDATA[Oxidative stress is a condition caused by the imbalance between the production of free radicals or ROS and the antioxidants; the level of free radicals is higher than the antioxidants. Exhaustive exercise is one of the causes of this oxidative stress. However, it can be reduced by antioxidants found in purple sweet potatoes (PSP) (Ipomoea batatas L). This study aims to evaluate the effect of two weeks supplementation of PSP extract on rats inducedoxidative stress. Twenty rats were distibuted into four groups consisted five rats each. Rats in the treatments groups were administered PSP extract for two weeks then were forced to swim until exhausted. Bloods from all samples were drawn to see the changes in the levels of malondialdehyde ans superoxide dismutase after two weeks of treatment. The data was then analyzed using descriptive and inferential statistic. The results showed that mean level of MDA and SOD differ significantly (p<0.05) between groups after the administration of PSP extract as well as after exhaustive exercise. The extracts and exhaustive exercise concurrently showed a significant effect on oxidative stress biomarkers (p<0.05). It concluded that PSP extract can protect cells against free radical produced by exhaustive exercise. ]]>
