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All Journal Jurnal Insan Farmasi Indonesia Jurnal Komunitas Farmasi Nasional
Inderiyani Inderiyani
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics Public Health

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UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL KULIT BATANG SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe TERHADAP MENCIT PUTIH (Mus musculus) JANTAN DENGAN METODE PROTEKSI DIARE Inderiyani Inderiyani; Sulastri Sulastri
Jurnal Insan Farmasi Indonesia Vol 4 No 2 (2021): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v4i2.825

Abstract

Sengkuang Dracontomelon dao (Blanco) Merr & Rolfe is a plant that has secondary metabolites tannins and flavonoids which are thought to have anti-diarrheal activity. The purpose of this study to determine activity and dose of ethanol extract of the stem bark of Dracontomelon dao (Blanco) Merr & Rolfe which has antidiarrheal effect on male white mice (Mus musculus). The antidiarrheal activity test was using the diarrhea protection method, where mice were induced by 0.75 mL of oleum ricini orally, 1 hour later the test solution was given i.e. 0.5% Na CMC suspension (negative control), loperamid 0.26 mg/kg bw (positive control), dose of sengkuang stem bark ethanol extract 100 mg/kg bw, 200 mg/ kg bw and 300 mg/kg bw. Then observed the onset of diarrhea, frequency of diarrhea, consistency of diarrhea, duration of diarrhea and weight of diarrhea every 30 minutes for 4 hours. The results is the ethanol extract of the stem bark Dracontomelon dao (Blanco) Merr & Rolfe at a dose of 100 mg/kg bw, 200 mg/kg bw and 300 mg/kg bw has antidiarrheal activity as indicated by a significant difference in the test group (control positive and all extracts) against the negative control group (p <0.05).
UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL KULIT BATANG SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe TERHADAP MENCIT PUTIH (Mus musculus) JANTAN GALUR SWISS WEBSTER inderiyani inderiyani; Sulastri Herdaningsih; Ihsanul Arief Arief
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Diabetes mellitus (DM) is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Sengkuang Dracontomelon dao (Blanco) Merr & Rofle has the potential as an alternative treatment for DM because it contains secondary metabolites in the form of alkaloids, tannins and flavonoids which have antihyperglycemic properties. This study aims to determine the antihyperglycemic activity of sengkuang stem bark against male white mice. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test antihyperglycemic activity by measuring initial glucose levels with a glucose test strip and given a test solution in the form of 0.5% Na.CMC suspension; glibenclamide 65 mg/kgbb; ethanol extract of sengkuang stem bark dose of 100 mg/kgbb; 200 mg/kgbb and 400 mg/kgbb. Then the test animals were induced with glucose 75 gram/kgbb and blood glucose levels were measured at 0, 30, 60, 90, 120, 150 and 180 minutes. The results showed that the ethanol extract of sengkuang bark at a dose of 400 mg/kgbb had activity as antihyperglycemic indicated by a significant difference with the negative control group. Keywords : Antihyperglycemia, diabetes mellitus, ethanol extract of sengkuang bark, Dracontomelon dao (Blanco) Merr & Rofle
Co-Authors Ihsanul Arief Arief Sulastri Herdaningsih Sulastri Sulastri