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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Al-Kimia JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA
Fifteen Aprila Fajrin
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Social Sciences Other

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KAJIAN TENTANG PENTINGNYA METODE PBL (PROBLEM-BASED LEARNING) DALAM SISTEMPEMBELAJARAN DI PERGURUAN TINGGI Fajrin, Fifteen Aprila
Jurnal Pengembangan Pendidikan Vol 3, No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

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Abstract

Abstrak. PBL (Problem-Based Learning)merupakan salah satu metode pembelajaran dimana mahasiswa berperan sebagai“active learner” bukan sebagai “passive learner”. Dengan adanya PBL diharapkanmahasiswa dapat berperan serta dalam menyelesaikan permasalahan-permasalahanyang terjadi di sekitarnya berdasarkan bidang ilmu yang menjadi kehliannya.Dengan adanya PBL, mahasiswa juga diharapkan dapat memotivasi dirinya untukterus dan selalu belajar, sehingga tujuan dari sistem pendidikan nasional dapattercapai dengan baik. Kata kunci : Sistem pendidikan nasional, belajar, PBL(Problem-Based Learning).
KETERKAITAN CYCLOOXYGENASE (COX)-2 TERHADAP PERKEMBANGAN TERAPI KANKER Fajrin, Fifteen Aprila
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 10, No 1 (2013)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

The growth of tumors is caused by imbalances between the rates at which cells are produced through cell division and the rate at which they die through a natural cell death process known as programmed cell death (also referred to as apoptosis). Problems in apoptosis mechanisms also contribute to therapy resistance, making tumors more difficult to kill with radiation or chemotherapy. It is important therefore to understand why tumors become refractory to apoptosis and to devise strategies for restoring proper function to cell death pathways in tumor cells. Recently it has been discovered that cyclooxygenase-2 (COX-2) have a relationship with apoptosis pathway. Higher levels of COX-2 have been reported in some kinds of cancer. One of the roles of COX-2 in tumor development is its positive effect on the survival of tumor cells. The goal of this project is to provide review insights into the role of COX-2 in cancer. We will explore whether COX-2 inhibitors can shut off survival genes in cancer cells, and we will study how COX-2 affects the programmed cell death machinery of cancer cells. Understanding the mechanisms by which COX-2 contributes to cancer development will reveal to what extent this enzyme is an important target in the chemoprevention and treatment of cancer.
Uji Aktivitas Antidiabetes Ekstrak Air Kelopak Bunga Rosella (Hibiscus sabdariffa L.) pada Tikus dengan Metode Induksi Aloksan Dianasari, Dewi; Fajrin, Fifteen Aprila
Jurnal Farmasi Sains dan Terapan Vol 2, No 1 (2015)
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.649 KB) | DOI: 10.33508/jfst.v2i1.812

Abstract

Salah satu jenis tanaman yang diduga memiliki khasiat sebagai antidiabetes adalah Rosella (Hibiscus sabdariffa L.) yang termasuk dalam famili Malvaceae. Kelopak bunga Rosella (Hibiscus sabdariffa L.) mengandung senyawa flavonoid khususnya antosianin dan vitamin C sebagai antioksidan yang mampu menetralisir radikal bebas yang menjadi salah satu penyebab diabetes dan mengurangi komplikasi penyakit tersebut. Tujuan dari penelitian ini adalah untuk menguji aktivitas antidiabetes dari ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dan untuk mengetahui aktivitas antidiabetes pada ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) pada dosis yang berbeda (250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB). Metode penelitian yang digunakan adalah dengan cara induksi aloksan. Hasil penelitian menunjukkan bahwa kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 500 mg/kgBB dan 750 mg/kgBB memiliki aktivitas antidiabetes yang sebanding dengan kontrol positif yaitu Glibenklamid dengan dosis 0,45 mg/kgBB, sedangkan kelompok uji ekstrak air kelopak bunga Rosella (Hibiscus sabdariffa L.) dosis 250 mg/kgBB tidak menunjukkan aktivitas antidiabetes yang berarti karena tidak ada perbedaan yang bermakna dengan kontrol negatif (aquadest 5 mL/kgBB).
AKTIVITAS EKSTRAK ETANOL KETAN HITAM UNTUK MENURUNKAN KADAR KOLESTEROL Fajrin, Fifteen Aprila
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

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Abstract

Cardiovascular disease has become a number one causing of death in Asia Pasific. From Sudarmanto research (2006), frying oil consumption that was used for 27 times can affect to serum total cholesterol levels. Black glutinous rice have chemical compound such as anthocyanin that have hipolipidemic activity. This research was an experimental study, using the post test only group design. The samples are 28 male wistar rats, were divided into 7 groups, 4 rats for each group. The control group, given by CMC-Na 1%. The negative control group, given by frying oil used and CMC-Na 1%. The treatment group, given by frying oil used and ethanol extract dose 150,300,600 and 1200 mg/kgBW. The positive control group, given by frying oil used and simvastatin 0,5 mg/kgBW. The results :show ethanol extract of black glutinous rice dose 1200 mg/kgBW have the greatest anticholesterol effect. ethanol extract of black glutinous rice can decrease cholesterol serum 54,40 mg/dL±3,98 and haven’t significant differences with simvastatin.Conclusion of this research show: ethanol extract of black glutinous rice have an anticholesterol effect on male wistar rats. ABSTRAK Penyakit kardiovaskular merupakan penyebab kematian nomor satu di kawasan Asia Pasifik. Berdasarkan penelitian Sudarmanto (2006) menyatakan bahwa konsumsi minyak goreng bekas pakai 27 kali dapat mempengaruhi kadar kolesterol total. Ketan hitam memiliki kandungan senyawa kimia yaitu antosianin yang diduga mempunyai kemampuan sebagai agen hipolipidemik. Penelitian eksperimental ini berdesain post test only control group, menggunakan 28 tikus Wistar jantan yang dibagi 7 kelompok, masing-masing kelompok 4 tikus. Kelompok kontrol, diberi CMC-Na 1%. Kelompok kontrol negatif diberi diet minyak goreng bekas pakai dan CMC-Na 1%.  Kelompok perlakuan, diberi diet minyak goreng bekas pakai dan ekstrak etanol ketan hitam dosis 150,300,600 dan 1200 mg/kgBB. Kelompok kontrol positif diberi diet minyak goreng bekas pakai dan simvastatin. Perlakuan diberikan selama 14 hari. Hasil penelitian berupa kadar kolesterol serum total diuji dengan menggunakan one way anova (p<0,05).Hasil penelitian menunjukkan ekstrak etanol ketan hitam dengan dosis 1200 mg/kgBB memberikan efek antikolesterol dengan penurunan kadar kolesterol total serum paling besar yaitu sebesar 54,40±3,98 dan tidak berbeda signifikan dengan simvastatin. Kesimpulan dari penelitian ini Pemberian ekstrak etanol ketan hitam menurunkan kadar kolesterol total serum pada tikus putih jantan yang diberi perlakuan minyak goreng bekas pakai.
KAJIAN TENTANG PENTINGNYA METODE PBL (PROBLEM-BASED LEARNING) DALAM SISTEMPEMBELAJARAN DI PERGURUAN TINGGI Fajrin, Fifteen Aprila
Jurnal Pengembangan Pendidikan Vol 3 No 1 (2006)
Publisher : Jurnal Pengembangan Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak. PBL (Problem-Based Learning)merupakan salah satu metode pembelajaran dimana mahasiswa berperan sebagai“active learner” bukan sebagai “passive learner”. Dengan adanya PBL diharapkanmahasiswa dapat berperan serta dalam menyelesaikan permasalahan-permasalahanyang terjadi di sekitarnya berdasarkan bidang ilmu yang menjadi kehliannya.Dengan adanya PBL, mahasiswa juga diharapkan dapat memotivasi dirinya untukterus dan selalu belajar, sehingga tujuan dari sistem pendidikan nasional dapattercapai dengan baik. Kata kunci : Sistem pendidikan nasional, belajar, PBL(Problem-Based Learning).
AKTIVITAS EKSTRAK ETANOL KETAN HITAM UNTUK MENURUNKAN KADAR KOLESTEROL Fajrin, Fifteen Aprila
Jurnal Farmasi Indonesia Vol 5, No 2 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i2.39

Abstract

Cardiovascular disease has become a number one causing of death in Asia Pasific. From Sudarmanto research (2006), frying oil consumption that was used for 27 times can affect to serum total cholesterol levels. Black glutinous rice have chemical compound such as anthocyanin that have hipolipidemic activity. This research was an experimental study, using the post test only group design. The samples are 28 male wistar rats, were divided into 7 groups, 4 rats for each group. The control group, given by CMC-Na 1%. The negative control group, given by frying oil used and CMC-Na 1%. The treatment group, given by frying oil used and ethanol extract dose 150,300,600 and 1200 mg/kgBW. The positive control group, given by frying oil used and simvastatin 0,5 mg/kgBW. The results :show ethanol extract of black glutinous rice dose 1200 mg/kgBW have the greatest anticholesterol effect. ethanol extract of black glutinous rice can decrease cholesterol serum 54,40 mg/dL±3,98 and havenâ??t significant differences with simvastatin.Conclusion of this research show: ethanol extract of black glutinous rice have an anticholesterol effect on male wistar rats. ABSTRAK Penyakit kardiovaskular merupakan penyebab kematian nomor satu di kawasan Asia Pasifik. Berdasarkan penelitian Sudarmanto (2006) menyatakan bahwa konsumsi minyak goreng bekas pakai 27 kali dapat mempengaruhi kadar kolesterol total. Ketan hitam memiliki kandungan senyawa kimia yaitu antosianin yang diduga mempunyai kemampuan sebagai agen hipolipidemik. Penelitian eksperimental ini berdesain post test only control group, menggunakan 28 tikus Wistar jantan yang dibagi 7 kelompok, masing-masing kelompok 4 tikus. Kelompok kontrol, diberi CMC-Na 1%. Kelompok kontrol negatif diberi diet minyak goreng bekas pakai dan CMC-Na 1%.  Kelompok perlakuan, diberi diet minyak goreng bekas pakai dan ekstrak etanol ketan hitam dosis 150,300,600 dan 1200 mg/kgBB. Kelompok kontrol positif diberi diet minyak goreng bekas pakai dan simvastatin. Perlakuan diberikan selama 14 hari. Hasil penelitian berupa kadar kolesterol serum total diuji dengan menggunakan one way anova (p<0,05).Hasil penelitian menunjukkan ekstrak etanol ketan hitam dengan dosis 1200 mg/kgBB memberikan efek antikolesterol dengan penurunan kadar kolesterol total serum paling besar yaitu sebesar 54,40±3,98 dan tidak berbeda signifikan dengan simvastatin. Kesimpulan dari penelitian ini Pemberian ekstrak etanol ketan hitam menurunkan kadar kolesterol total serum pada tikus putih jantan yang diberi perlakuan minyak goreng bekas pakai.
Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Abstract

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.
Anti inflammatory Activity of the Ethanol Extract of Cinnamon (Cinnamomum burmannii) Bark using Membrane Stabilization Method and Protein Denaturation Annisa Shalihah; Fransiska M. Christianty; Fifteen Aprila Fajrin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36323

Abstract

Inflammation is the body's reaction to infection, irritation, or foreign substances, as an effort to defend the body's defenses. Inflammatory mediators such as bradykinin, prostaglandins, fluid extravasation, and tissue damage are essential to protect our body as an inflammatory response. One of the plants in Indonesia which is the potential to develop is Cinnamomum burmanii. These plants are identified to contain some substances such as flavonoid, tannin, and saponin. This study was aimed to determine the anti-inflammatory effect of the Cinnamomum burmanii extract using in vitro method compared with diclofenac sodium. Cinnamon bark was extracted using 96% of ethanol, and phytochemical screening was determined. Anti-inflammatory test in vitro using two methods, membrane stabilization using red blood cell suspension and protein denaturation inhibition using bovine serum albumin. After an anti-inflammatory test using the membrane stabilization method, the IC50 of the extract was 84.45 ± 3.55 g/mL, while in the protein denaturation method, the IC50 of the extract was 57.412 ± 0.718µg/mL. Even though the IC50 of the extract was lower, it is still higher than diclofenac sodium as drug control. Our result showed that cinnamon has potential as an antiinflammation and needs to develop further
The Influence of Long-term Diabetes Mellitus on Pain Response in Mice: In Vivo Models of Painful Diabetic Neuropathy (PDN) Fifteen Aprila Fajrin; R Susilowati; A Nurrochmad; AE Nugroho
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 3 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.088 KB) | DOI: 10.19106/JMedSci004903201701

Abstract

ABSTRACTPainful diabetic neuropathy (PDN) is a complication of long-term Diabetes Mellitus (DM) characterized by hyperalgesia and allodynia. In streptozotocin (STZ)-induced diabetic mice, higher dose of STZ and lengthen hiperglycemic condition results in better model of PDN. However, higher dose of STZ tend to induce mortality. Evaluate the doses of STZ that caused PDN with less mortality rate and the timing of pain behavior development in mice model of PDN. Balb/c mice were divided into non-diabetic and STZ-induced diabetic group. The doses of STZ were started from 180 mg/kg i.p. Serum glucose levels were measured 7 days after induction. Mice with glucose levels ≥ 200 mg/dl were considered as diabetic. Pain behaviour was determined by four method i.e. hot plate, tail flick test, von Frey fillament and Randall Selitto,measured on week-0 (baseline), 1, 2, 3, 4 and 5. Data were presented as mean±SEM. The mean differences between weeks were evaluated by One-Way ANOVA and the mean differences between two groups by independent t-test. STZ doses 180 mg/kg, 150 mg/kg and 120 mg/kg caused 100% death and STZ 90 mg/kg failed to induce diabetic condition. STZ 110 mg/kg resulted in 0% mortality while it induced diabetes in 100% mice. Latency time toward thermal stimulus decreased to 5.8 s at 1st week after the mice become diabetes  (p<0.05) and it was continued decrease until 4th week. The same result was also showed in tail flick test and Randal Selitto. The pain sensitivity determined by von Frey filament decreased to 1.37 g at week 1 (p<0.05) and continued decrease until 5th week. Optimum dose of STZ to induce PDN was 110 mg/kg. Pain behaviour of diabetic group was observed at 1st week after diabetic and continued until 4th week.Keywords: PDN, hot plate, tail flick test, von Frey fillament, Randall Selitto
Analisis HKSA dan Docking Aktivitas Inhibisi Turunan HEPT terhadap Enzim Reverse Transcriptase HIV (QSAR and Docking of Inhibition Activity of HEPT Derivatives Against Enzym Reverse Transcriptase HIV) Ani Riani Hasana; Ayik Rosita; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

This study describes the analysis of QSAR and Docking based on the inhibition activity of the enzyme Reverse Transcriptase HIV by 1-[(2-hydroxyethoxy) metil]-6-(phenylthio) timin (HEPT) derivatives. QSAR modeling using 85 compounds HEPT derivatives have calculated the value of biological activity in vitro inhibition of the value of log1/C, then made a linear regression equation against QSAR parameters like as lipophilic, electronic and steric to obtained maximum results correlation r2 by method Multiple Linear Regression (MLR). Docking used to determine the predictive ability of the inhibitor affinity value when HEPT derivatives interacting with the enzyme Reverse Transcriptase HIV. QSAR study results that play a role in the activity is the refractive index parameter (η), molar volume (MV), Parachor (Pc), I2 (parameter which indicates the presence of Sulphur in position R2) and ISP (parameter which indicates the presence of Sulphur in position X). Best equation obtained with compound 75 has a value of R=0.9135, R2adj=0.8064, RMSE=0.5104, and F=69.4881. Docking study results indicate derivatives with the number 80 has the smallest affinity by -11.3 kcal / mol. Keywords: docking, reverse transcriptase enzyme , HEPT, MLR, QSAR.
Co-Authors A Nurrochmad AE Nugroho Ajeng Merdeka Putri Annisa Shalihah Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Holidah Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Hasana, Ani Riani Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Junaidi Khotib Lelyta - Septiandini Lesti Eko Pangestuti M Nuril Huda Nia Kristiningrum Prihwanto Budi Subagio R Susilowati Riza Rastri Wihardiyanti Tsabit Barki Wardhani, Firdha Aprillia Zainah Rajab