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All Journal Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Hasan Mihardja
Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology

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Prospek Akupunktur dalam Pengobatan Kanker Melalui Peningkatan Proliferasi dan Sitotoksisitas Sel Natural Killer Mihardja, Hasan; -, Hety
Indonesian Journal of Cancer Vol 5, No 4 (2011): Oct - Dec 2011
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Kanker adalah penyakit yang ditandai oleh proliferasi yang tidak terkontrol dan penyebaran sel abnormal. Imunitas spesifik dan nonspesifik merupakan sistem yang penting dalam perlawanan terhadap inisiasi pertumbuhan tumor. Salah satu sel yang berperan dalam sistem pertahanan nonspesifik terhadap tumor adalah sel natural killer (NK). Oleh karena itu, sel NK telah menunjukkan prospek dalam imunoterapi kanker. Beberapa penelitian menunjukkan bahwa akupunktur dapat meningkatkan sitokin sehingga merangsang proliferasi dan aktivitas sitotoksik sel NK melalui mekanisme seluler dan molekuler spesifik. Hal itu disebut sebagai acupuncture immune-enhancement hypothesis. Efek akupunktur terhadap sel NK juga berkaitan dengan peningkatan sekresi opioid endogen, nitric oxide, dan perubahan pada tingkat transkripsi. Melalui mekanisme tersebut diharapkan akupunktur dapat dikembangkan sebagai salah satu modalitas imunoterapi kanker.Kata kunci: akupunktur, sel natural killer, opioid endogen, sitokin, nitric oxide
Peranan Akupunktur dalam Bidang Kanker Mihardja, Hasan
Indonesian Journal of Cancer Vol 2, No 1 (2008): Jan - Mar 2008
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

Pedoman pelatihan dasar dan keselamatan di bidang akupunktur yang diterbitkan Badan Kesehatan Dunia (WHO) antara lain mengemukakan peranan akupunktur di bidang kanker.Manfaat akupunktur di bidang kanker adalah mengurangi rasa nyeri dan mual, muntah akibat penyakit kanker ataupun sebagai efek samping pengobatan konvensional kanker. Xerosthalmia paska radiasi dan hot flash yang timbul setelah pengobatan hormon juga menunjukan perbaikan setelah tindakan akupunktur. Kecermatan dalam hal dalamnya serta arah penusukan perlu diperhatikan untuk menghindari tertusuknya organ dalam misalnya pneumotorak, penggunaan elektro akupunktur cenderung merugikan penderita.Kata kunci: akupunktur, kanker, keselamatan.
Peran Terapi Akupunktur pada Nyeri Tulang Metastasis MIHARDJA, HASAN; AGUNG, ZULHAFIZ MUFTI
Indonesian Journal of Cancer Vol 10, No 2 (2016): April - June 2016
Publisher : Indonesian Journal of Cancer

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Abstract

ABSTRACTBone pain caused by cancer is a common complication in bone metastasis. Bone pain has the characteristic triad of pain including continuous pain, spontaneous pain and incident pain. Various mechanisms that allow bone metastasis can cause pain have been reported. These mechanisms include the possibility of local production of growth factors and cytokines. The management of the pain bone metastasis include aspects of pharmacological and non-pharmacological therapies. Acupuncture can play a role in the treatment of bone metastasis pain through modulation of various neurotransmitters and increase the production of endogenous opioids that can cause analgesika effect. This paper describes a male patient aged 62 years old with painful bone metastasis who experience an improvement after acupuncture therapy, with the goal of providing information on the possible use of acupuncture for painful bone metastasis. ABSTRAKNyeri tulang yang disebabkan oleh kanker merupakan suatu komplikasi yang sering terjadi pada metastasis tulang. Nyeri tulang ini memiliki karakteristik trias nyeri, yaitu nyeri terus-menerus, nyeri spontan, dan nyeri insiden. Berbagai mekanisme yang memungkinkan metastasis tulang dapat menyebabkan rasa nyeri telah dilaporkan. Mekanisme ini termasuk kemungkinan adanya produksi lokal faktor pertumbuhan dan sitokin. Tata laksana pada nyeri tulang metastasis meliputi aspek terapi farmakologis dan nonfarmakologis. Akupunktur dapat berperan dalam terapi nyeri tulang metastasis melalui modulasi berbagai neurotransmitter dan meningkatkan pengeluaran endogen opioid sehingga menimbulkan efek analgesik. Makalah ini memaparkan pasien laki-laki berusia 62 tahun dengan nyeri tulang metastasis yang mengalami perbaikan setelah terapi akupunktur, dengan tujuan memberikan informasi kemungkinan penggunaan akupunktur pada nyeri metastasis tulang.
Peran Terapi Akupunktur pada Kondisi Leukopenia Kanker Payudara Pasien Kemoterapi NARESWARI, I; HARYOKO, N.R.; MIHARDJA, HASAN
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : Indonesian Journal of Cancer

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Abstract

Breast cancer is a malignant disease that has the highest against women. Management of breast cancer that is currently done is a combination of surgery and chemotherapy, because in addition to effective therapy, but also can extend the recurrence. Chemotherapy given a systemic therapy that has serious side effects, one of which the effects of myelosuppression. Leukopenia is a condition that requires proper treatment and immediately, because it can cause dose reductions and delays in chemotherapy. Medication is given on the condition of chemotherapy-induced leukopenia one of which is the provision of Granulocyte Stimulating Factor (G-CSF), but these drugs have side effects, and requires a high cost. Based on several studies, acupuncture is effective in treating conditions due to the effects of chemotherapy leukopenia, and give excellent results. Acupuncture can stimulate the formation of CSF thereby increasing the number of leukocytes in the blood and improve the function of hematopoiesis in bone marrow.ABSTRAK Kanker payudara merupakan penyakit keganasan yang menyerang wanita dan menduduki peringkat tertinggi. Tatalaksana kanker payudara yang saat ini banyak dilakukan adalah kombinasi pembedahan dan kemoterapi, karena terapi tersebut selain efektif, juga dapat memperpanjang masa kekambuhan. Kemoterapi yang diberikan merupakan terapi sistemik yang mempunyai efek samping cukup serius, salah satunya efek myelosupresi. Leukopenia merupakan kondisi yang memerlukan penanganan tepat dan segera, karena dapat menyebabkan penurunan dosis dan penundaan kemoterapi. Salah satu medikasi yang diberikan pada kondisi leukopeni akibat kemoterapi adalah pemberian Granulocyte Stimulating Factor (G-CSF). Namun, obat ini mempunyai efek samping dan membutuhkan biaya yang tinggi. Berdasarkan beberapa penelitian yang dilakukan, akupunktur efektif dalam mengatasi kondisi leukopenia akibat efek kemoterapi dan memberikan hasil yang sangat baik. Akupunktur dapat merangsang pembentukan CSF sehingga meningkatkan jumlah leukosit dalam darah dan memperbaiki fungsi hematopoiesis di sumsum tulang.
The Effect of Electroacupunture on the Percentage of Lymphocyte Count on the Peripheral Blood Smear of C3H Mice Breast Adenocarcinoma Model Kamalia, Rizki; Mihardja, Hasan; Srilestari, Adiningsih; Barasila, Atikah C; Thamrin Akib, Husniah Rubiana
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.552 KB) | DOI: 10.33371/ijoc.v12i1.551

Abstract

Background: Breast cancer patients often experience decreased the immune system such as a decreased of lymphocytes, which can increase mortality. Acupuncture is expected to be a therapeutic option to increase lymphocyte because current pharmacological therapy is very expensive with the risk of adverse event. This study aims to prove the action of Electroacupuncture (EA) as an immunomodulator for cellular immunity by increasing the percentage of lymphocytes of Peripheral Blood Smear (PBS) in C3H mice of breast adenocarcinoma model. Methods:Laboratory experimental study with post test only controls group design involving twenty PBS preparations taken from 20 C3H mice of breast adenocarcinoma models divided into 4 groups. Group K with no EA treatment, group P1 was given 1 time EA treatment, group P2 was given 2 times EA treatment and P3 was given 3 times EA treatments (with seven days interval). EA stimulation was performed at ST36 Zusanli, BL18 Ganshu, BL20 Pishu with frequency of 2 Hz for 15 minutes. Result:The mean weight of mice was 23.90 ± 3.03 gr in control group, 25.40 ± 1.54 gr in P1 group, 27.00 ± 3.87 gr in P2 group and 25.90 ± 5.83 gr in P3 group, with most of them were female mice. The mean volume tumor in mice of control group was 14.49 ± 2.75 mm3, 16.72 ± 6,40 mm3 in P1 group, 20.18 ± 5.94 mm3 in P2 group and 22.07 ± 6.51 mm3 in P3 group. The mean percentage of lymphocyte was 44.20 ± 15.72 in control group, 43.00 ± 11.70 in P1 group, 49.60 ± 7.02 in P2 group and 43.20 ± 13.10 in P3 group. The correlation between the number of electro­acupuncture treatments on the number of lymphocytes in the treatment group were compared to the control group with p = 0.811. Conclusions: Research acupuncture on cancer management has been done and provided good result. Acupuncture in particular EA has benefits in improving immunity by affecting lymphocyte enhancement. Acupuncture can be considered as adjuvant therapy in cancer patients breast. ABSTRAKLatar Belakang: Pada pasien kanker payudara sering terjadi penurunan sistemimun antara lain menurunnya limfosit, yang dapatm eningkatkan angka kematian. Akupunktur diharapkan dapat menjadi pilihan terapi untuk meningkatkan limfosit karena terapi farmakologi saat ini harganya sangat mahal dengan resiko efek samping. Penelitian ini bertujuan untuk membuktikan bahwa tindakan elektroakupunktur (EA) dapat berefek sebagaii mmunomodulator terhadap imunitas seluler dengan meningkatkan persentase limfosit sediaan apus darah tepi (SADT) pada mencit C3H model adenokarsinoma payudara. Metode: Penelitian eksperimental ini dilakukan dengan post test only control group design terhadap dua puluh sediaan apus darah tepi yang diambil dari 20 mencit C3H model adenokarsinoma payudara. Kelompok studi dibagi menjadi 4 kelompok yaitu Kelompok K tidak diberi perlakuan EA, kelompok P1 dilakukan EA 1 kali, kelompok P2 dilakukan EA 2 kali dan P3 dilakukan EA 3 kali. Tindakan EA dilakukan pada titik ST36 Zusanli, BL18 Ganshu, BL20 Pishu dengan frekuensi 2 Hz selama 15 menit. The
ACUPUNCTURE IN THE MANAGEMENT OF FUNCTIONAL DYSPEPSIA Yoveline, Anastasia; Abdullah, Murdani; Darmawan, Guntur; Mihardja, Hasan; Sungkar, Saleha
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 1, April 2012
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/131201249-55

Abstract

Dyspepsia is an uncomfortable sensation or pain in the upper abdomen which is persisting or recurring. Dyspepsia can be classified into functional and organic dyspepsia. Functional dyspepsia is more commonly found compared to the organic type, approximately 60%. Pharmacologic therapy in the management of functional dyspepsia has not shown optimal results, with the multifactorial etiology of functional dyspepsia as the main challenge. Therefore, the management of functional dyspepsia is widened and involves variety treatment modalities, acupuncture being one of them. Acupuncture is a way of treatment by puncturing needles to particular area on the skin to eliminate pain and treat particular diseases. Acupuncture affects stomach motility and gastric acid secretion in functional dyspepsia patients. Two acupuncture points commonly used in functional dyspepsia are ST 36 and PC 6. Acupuncture can restore gastric motility in patients with functional dyspepsia, who have gastric emptying disturbance. Besides, functional dyspepsia complaints, such as epigastric pain, nausea, vomiting, anorexia, burning sensation, and bloating were found to improve after acupuncture therapy. Side effects of acupuncture are not life threatening with low incidence rate. The effectiveness of acupuncture therapy compared to standard medication shows varies results. Further studies are needed to determine the characteristics of functional dyspepsia patients which could have optimal results through acupuncture therapy. Keywords: epigastric pain, gastric motility, ST 36, PC 6
Co-Authors Adiningsih Srilestari AGUNG, ZULHAFIZ MUFTI Anastasia Yoveline Barasila, Atikah C Guntur Darmawan HARYOKO, N.R. Hety -, Hety Kamalia, Rizki Murdani Abdullah NARESWARI, I Saleha Sungkar Thamrin Akib, Husniah Rubiana