Article Per Year (5 Year)
p-Index From 2019 - 2024
5.72
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Folia Medica Indonesiana Jurnal Kebidanan Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Majalah Kedokteran Andalas YARSI Medical Journal Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Conferences of Medical Sciences Dies Natalis
Subandrate
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 65 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 65 Documents
Search

 1   2   3   4   5 
Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students Safyudin, Safyudin; Subandrate, Subandrate
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.89-95

Abstract

BackgroundSmoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students.MethodsThis study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. ResultsThe results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092).ConclusionsSmoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.
Malondialdehyde levels are higher and glutathione levels are lower in preeclampsia than in normal pregnancies Subandrate, Subandrate; Faisal, Mia Esta Poetri Afdal; Anggraini, Nurul Windi; Sinulingga, Sadakata
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.179-186

Abstract

BackgroundMaternal mortality rate is still a health problem in Indonesia. One major contributor to maternal mortality rate in Indonesia is preeclampsia. One widely accepted theory is that preeclampsia is caused by oxidative stress. Placental hypoxia or ischemia among preeclampsia patients is thought to be the cause of the formation of free radicals such as malondialdehyde (MDA), which decreases endogenous antioxidants such as glutathione (GSH). This study aims to ascertain the difference in plasma malondialdehyde and glutathione levels between healthy and preeclamptic pregnant women.MethodsThis was an observational analytic study of cross sectional design. Research subjects were 30  normal (healthy) pregnant women (NP), and 30 pre-eclamptic pregnant (PE) women. The measurement of plasma MDA and GSH levels was done at the Biochemistry and Molecular Biology laboratories, Faculty of Medicine, Sriwijaya University using Sigma-Aldrich MDA and GSH assay kits. Mann Whitney test was used to analyze the data. ResultsSubjects aged >35 years, with age of gestation >35 weeks and multipara was significantly higher in the PE group compared to the NP group (p=0.016; p=0.01 and p=0.36; respectively). MDA level was significantly higher in the PE group than in the NP group (p=0.002). In contrast, GSH level was significantly lower in the PE group than in the NP group (p=0.003).ConclusionMDA and GSH may reflect vascular complications of PE, and the ensuing increases in lipid peroxidation may play important pathogenic roles.
Hubungan Profil Lipid dengan Kejadian Ulkus Kaki Diabetik pada Pasien Diabetes Melitus Tipe 2 RSUP dr. Mohammad Hoesin Palembang Sinulingga, Sadakata; Kohar, Evlin; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.415 KB)

Abstract

Diabetic foot ulcersare long-term complications of diabetes mellitus that may increase morbidity and mortality, also reduce the quality of life of the patients. One of the causes of diabetic foot ulcers is peripheral arterial disease due to dyslipidemia. This study was conducted to determine the relationships of lipid profile with diabetic foot ulcers in patients with type 2 diabetes mellitus. Analytical observational study with cross-sectional design was conducted in 69 diabetic patients. Data was retrieved secondarily by observing the medical records. Total cholesterol, triglycerides, LDL, HDL, and consumption of lipid-lowering drugs of the patients were all recorded. Documented variables were analyzed using Fisher Exact test if Chi-square test criterias were not fulfilled. There was a significant association between diabetic foot ulcers with total cholesterol (p=0,001) and HDL (p=0,015), while triglycerides (p=0,393) and LDL (p=0,176) did not have a significant association with diabetic foot ulcers.Multivariable logistic regression identified HDL (B=2,221, S.E.=1,131, Wald=3,855, p=0,050, exp(B)=9,220 IK95% 1,004–84,691)as the most influential lipid profile fraction to the incident diabetic foot ulcers. Total cholesterol and HDL had a significant association with diabetic foot ulcers. The most influential lipid profile fraction to the incident diabetic foot ulcers is HDL.
Hubungan Obesitas dengan Kadar Asam Urat Darah pada Mahasiswa Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Sriwijaya Soputra, Ezra Hans; Sinulingga, Sadakata; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.872 KB)

Abstract

Uric acid is the end product of purine catabolism which is sinthesized especially by the liver and excreted through urinary tract. Increased blood uric acid levels can cause many disease such as gout arthritis, hipertension, and renal disease. Individual with obesity often have lower renal excretion rate and may have increased production of uric acid. This study is conducted to determine the relationship of obesity and blood uric acid levels.This Study with cross-sectional design took a sample of 119 students of Medical Education Program Study at Medical Faculty of the Sriwijaya University by consecutive sampling. Body weight, body height, and uric acid levels then are taken using measurement tools appropriate, categorized, and processed according to research objectivesThe study found that 27,5% female and 10,3% male have hyperuricemia. A total of 39,3% obese students and 16,5% non-obese students have high level of uric acid. The result of bivariate analysis showed that there is a significant relationship between obesity and gender with blood uric acid levels (p=0,022 and 0,035 respectively). After multivariate analysis, factor that has relationship with uric acid level is obesity.Obesity have a significant relationship with uric acid levels.
Mekanisme Antifertilitas Fraksi Biji Pepaya pada Tikus Jantan Nita, Sri; Hayati, Lusiya; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 2 No. 1 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.089 KB)

Abstract

Biji pepaya dapat bersifat sebagai antifertilitas. Penelitian ini dilakukan untuk mengetahui senyawa dan mekanisme antifertilitas fraksi biji pepaya pada tikus jantan dari berat vesikula seminalis dan prostat serta jumlah spermatosit primer dan spermatid. Jenis penelitian eksperimental secara in vivodengan rancangan acak lengkap. Hewan uji adalah tikus jantan (Rattus norvegicusL.) galur Sprague Dawley usia 60 hari dengan berat badan 200-210 g. Dosis pemberian 100mg/kg bb selama 24 hari. Senyawa yang dikandung oleh fraksi didapat melalui uji fitokimia. Hasil penelitian memperlihatkan senyawa yang ditemukan pada fraksi nHeksan adalah steroid, terpenoid, saponin, flavonoid. Fraksi etil asetat terdapat senyawa steroid, terpenoid dan flavonoid. Fraksi etanol air mengandung senyawa terpenoid dan flavonoid. Berat vesikula seminalis dan prostat meningkat dibandingkan kontrol. Rerata jumlah spermatosit primer dan spermatid menurun secara nyata pada semua fraksi namun penurunan terendah pada fraksi nHeksan. Dapat disimpulkan mekanisme antifertilitas fraksi biji papaya adalah melalui penurunan rerata jumlah spermatosit primer dan spermatid.
Hubungan Epidural Hematoma Dengan Fraktur Kranium Pada Pasien Cedera Kepala Untoro, Danang Bagus; Permono, Trijoso; Subandrate, Subandrate
Sriwijaya Journal of Medicine Vol. 2 No. 3 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.732 KB)

Abstract

Penyebab cedera kepala terbanyak adalah jatuh (40,9%), kecelakaan sepeda motor (40,6%), terkena benda tumpul dan tajam (7,3%), kecelakaan alat transportasi darat lain (7,1%), dan kejatuhan benda (2,5%). Cedera kepala merupakan penyebab kematian dari hampir setengah kasus trauma. Fraktur kranium merupakan patahnya satu atau lebih tulang pada tulang tengkorak. Sekitar 1% sampai 5,5% dari total kasus cedera kepala terdapat epidural hematoma. Tingkat mortalitas pada kasus epidural hematoma mencapai 20%. Menurut Daniel P. Prince, epidural hematoma ditemukan dalam 1-2% dari seluruh kejadian trauma kepala. Dalam 90% kasus epidural hematoma berhubungan dengan fraktur kranium. Tujuan dari penelitian ini yaitu menganalisis hubungan antara epidural hematoma dan fraktur kranium pada pasien cedera kepala. Jenis penelitian ini adalah penelitian analitik observasional dengan desain penelitian cross sectional berdasarkan data sekunder, yaitu hasil pengamatan rekam medis pasien cedera kepala yang dirawat di RSUP Dr. Mohammad Hoesin Palembang. Terdapat hubungan yang signifikan (p=0,015) antara kejadian fraktur kranium dengan epidural hematoma pada pasien cedera kepala yang dirawat di RSUP Dr. Mohammad Hoesin, Palembang pada tahun 2017. Pasien cedera kepala dengan fraktur kranium lebih berisiko 4,250 kali lebih besar untuk mengalami epidural hematoma dibandingkan dengan pasien yang tidak memiliki fraktur kranium, dan pasien cedera kepala dengan fraktur kranium berisiko sekurang-kurangnya 1,256 kali mengalami epidural hematoma dan sebesar-besarnya 14,151 kali mengalami epidural hematoma. Kesimpulan penelitian ini yaitu terdapat hubungan yang signifikan antara fraktur kranium dengan epidural hematoma pada pasien cedera kepala.
KADAR SUPEROKSIDA DISMUTASE MAHASISWA PEROKOK DI PROGRAM STUDI PENDIDIKAN DOKTER UNIVERSITAS SRIWIJAYA Albasyam, Subandrate; Safyudin, Safyudin; Arifin, Mutmainah; Oktalisa, Wenni
Jurnal Kedokteran YARSI Vol 23, No 2 (2015): MEI - AGUSTUS 2015
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.646 KB) | DOI: 10.33476/jky.v23i2.113

Abstract

Merokok merupakan suatu masalah kesehatan pada masyarakat Indonesia dan ancaman besar bagi kesehatan di dunia. Asap rokok mengandung komponen gas dan partikel yang berpotensi untuk menimbulkan radikal bebas, peroksidasi lipid (MDA) dan menurunkan kadar antioksidan endogen (SOD). Penelitian ini bertujuan untuk mengetahui kadar superoksida dismutase mahasiswa perokok di Program Studi Pendidikan Dokter FK Unsri. Penelitian ini adalah penelitian analitik observasional dengan pendekatan potong lintang yang dilakukan dari bulan April sampai Desember 2014. Jumlah sampel yang didapat di dalam penelitian ini adalah 20 mahasiswa perokok dan 10 mahasiswa bukan perokok. Kadar superoksida dismutase darah ditentukan secara biokimia menggunakan kit RanSOD®. Hasil penelitian ini menunjukkan bahwa rata-rata kadar SOD subjek penelitian yang merokok adalah 0,76 u/mL dan yang tidak merokok adalah 0,87 u/mL. Hasil uji statistik kadar SOD menunjukkan nilai signifikansi p=0,860. Kadar SOD mahasiswa perokok Program Pendidikan Dokter FK Unsri lebih rendah daripada kadar SOD mahasiswa nonperokok. Pada mahasiswa Program Pendidikan Dokter FK, merokok tidak berpengaruh signifikan terhadap penurunan kadar SOD.Smoking is a public health problem in the world. Cigarette smoke contains gas and particle which leads to generate free radicals, lipid peroxidation (MDA) and reduced levels of endogenous antioxidants (SOD). This study aimed to determine the levels of superoxide dismutase of smoker student in Medical Education of Sriwijaya University. We used a cross sectional study from April to December 2014.  Subject of this study consisted of 20 smoker students and 10 nonsmoker students. Blood levels of superoxide dismutase was determined biochemically using RanSOD® kit. The results showed that average of SOD level in smokers was 0.76 U/mL and nonsmokers was 0.87 U/mL (p= 0.860). SOD levels of smoker students were lower than nonsmoker students. In Medical Education of Sriwijaya University, smoking had no significant effect on reducing the levels of SOD.
CYTOTOXICITY EFFECTS OF BENALU TEA EXTRACT (SCURRULA OORTINA) ON HELLA CELLS Hariyadi, Kusumo; Fatmawati, Fatmawati; Subandrate, Subandrate; Aninditia, Fahira; Dzakiyah, Dzakiyah
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
CYTOTOXICITY EFFECTS OF BENALU TEA EXTRACT (SCURRULA OORTINA) ON HELLA CELLS Hariyadi, Kusumo; Fatmawati, Fatmawati; Subandrate, Subandrate; Aninditia, Fahira; Dzakiyah, Dzakiyah
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.10281

Abstract

Tea garden waste has been investigated in the form of parasite tea Squrula oortina Species Family: Loranthaceae from the Dempo Pagar Alam tea plantation, Lahat Regency, South Sumatra. Stem and leaf samples are then dried and powdered, then isolated with 70% water-ethanol subfraction. The extract was then dried by vacuum distillation at 70oC until a concentrated extract without ethanol was obtained. The results of the study were tea parasite extract, and the extract was tested for phytochemicals (monounsaturated fatty acids and double, theobromine derivates, quercetin derivates and Epicatekin derivates). Next, it would be taken to the Laboratory of Biological Sciences at Gajah Mada University to be tested for cytotoxic effects on Hella cells, with control positive doxorubicin. The results of the research were tea leaves extract IC50 = 2538 ug/mL and the standard of doxorubicin IC50 = 0.88 ug/mL so that it could be concluded that the parasite of the tea parasite had cytotoxic and proliferative effects.
Hubungan Antara Karakter Klinikopatologik dengan Grup Prognostik WHO pada Pasien Gastrointestinal Stromal Tumor di RSUP Dr. Mohammad Hoesin, Palembang Nur Azizah; Suly Auline Rusminan; Subandrate
Majalah Patologi Indonesia Vol 30 No 1 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.365 KB) | DOI: 10.55816/mpi.v30i1.463

Abstract

BackgroundGastrointestinal stromal tumors are the most common mesenchymal tumors in the gastrointestinal tract. Based on tumor size andmitotic index, WHO classified GIST into three prognostic groups which were benign, uncertain malignant potential, and malignant.Some studies revealed that there was variation in association between age, gender, tumor location, histopathologic type and prognosisof GIST patients. This study aimed to identify and analyze the association between clinicopathologic characteristics and WHOprognostic group in GIST patients at RSUP Dr. Mohammad Hoesin Palembang.MethodsThis study used 30 medical records of GIST patients during 01 January 2014 to 27 December 2018 in the Department of AnatomicPathology RSUP Dr. Mohammad Hoesin. Clinicopathologic characteristics and WHO prognostic group data were collected. Theassociation between clinicopathologic characteristics (age, gender, tumor location, histopathologic type) and WHO prognostic groupwere analyzed by chi-square test.ResultsFrom 30 subjects, 40% of the patients aged 52-58 years.There was no gender predilection. A total of 33.3% of the GISTs were locatedin the small intestine. Majority of histopathologic type was spindle cell type (93.3%). Bivariate analysis showed there were no significantassociation between clinicopathologic characteristics: age (p=0.811), gender (p=0.682), tumor location (p=1.000), histopathologic type(p=0.469) and WHO prognostic group.ConclusionThere was no significant association between clinicopathologic characteristics and WHO prognostic group in GIST patients at RSUPDr. Mohammad Hoesin Palembang. We suggest doing a cohort study about association between clinicopathologic characteristics andsurvival rate in GIST patients.
Co-Authors Adiyatma Putra Mahardika Alexander Theo Yuda Salean Anggraini Tiara Septiyana Gunawan Aninditia, Fahira Aninditia, Fahira Annes C. Adma Aprilia Putri Arifin, Mutmainah Aulia Firdha Tariza Az Zahra, Fatihah Bebbi Arisya Kesumaputri Danang Bagus Untoro Dazakiah Dazakiah Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Dzakiyah, Dzakiyah Dzakiyah, Dzakiyah Eka Febri Zulissetiana Ella Amalia Ella Amalia, Ella Ellla Amalia Erial Bahar Eva Syahriana Evlin Kohar Ezra Hans Soputra Fadel Fikri Suharto Fahira Aninditia Fahira Aninditia Faisal, Mia EPA Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fifa Argentina Galuh Anggraini Hariyadi, Kusumo Hayati, Lusiya Hayati, Lusiya Hermansyah Hestiningsih, Tyas Iche Andriyani Liberty, Iche Andriyani Intan Rahma Dewi Irfannuddin Irfannuddin Irfannudin Irfannudin Irsan Saleh Kohar, Evlin Kohar, Evlin Kusumo Hariyadi Kusumo Hariyadi Kusumo Hariyadi Lathifah Nudhar Liniyanti D. Oswari Lusia Hayati M Fakhri Altiyan M Fitra Romadhon M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Mariana Mariana Masayu Farah Diba Masayu Farah Diba Mediarty Mediarty Mediarty Medina Athiah Medina Athiah Medina Athiah Medina Athiah Melina Indah Sari Mgs Irsan Saleh Mgs. Irsan Saleh Mia EPA Faisal Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Mohamad Sadikin MOHAMAD SADIKIN Muhammad Irsan Saleh Muniaty Sulam Ng Muthmainnah Arifin Mutia Muthmainnah Firdaus Mutiara Budi Azhar Naomi W Tioline Nur Azizah Nurul Windi Anggraini Nurul Windi Anggraini, Nurul Windi Oktalisa, Wenni Oswari, Liniyanti D Permono, Trijoso Putriana Fuji Safitri Raafqi Ranasasmita Rasyid, Riana Sari Puspita Ray Suga Aulia Rini Yana Rini Yana Rini Yana Rizki Andini Nawawi Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safyudin Safyudin Safyudin Safyudin Safyudin Salni Salni Salni Salni Salni Salni Setyorini, Dwi Indira Soputra, Ezra Hans Soputra, Ezra Hans Sri Hartini Harianja Sri Nita Sri Nita Sri Nita, Sri Sri Wahyuni Suly Auline Rusminan Susilawati Susilawati Susilawati Susilawati Tri Suciati Trijoso Permono Trijoso Permono Triwani Triwani Untoro, Danang Bagus Untoro, Danang Bagus Zen Hafy