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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma
Herni Suprapti, Herni
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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RESPONSE ON THE PHYSICAL FUNCTION AND ANTHROPOMETRY OF LUNG TB PATIENTS BY REGULAR THERAPY AND FOOD INTERVENTION: A PRELIMINARY RESEARCH Setiawan, Budhi; Ernawati, Ernawati; Suprapti, Herni
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 3, No 2 (2014): edisi Oktober 2014
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Patients with active lung tuberculosis (TB) have low body mass index (BMI) because of a wasting. Changes in body weight during the initial period of TB therapy correlated with the death risk, illness severity and relapse as well as decrease of patients physical function. This study aimed to measure the effectiveness of soybean supplementation among TB patients with standard therapy in improving physical function and nutritional status. Fifty nine patients were randomly divided into two groups.Intervention group received one hundred fifty gram nutritional supplementation and control group did not receive anything. Both groups were on the same regular antituberculosis treatment. Assessment of outcomes were done twice, before supplementation and then after 1 month of the treatment. There were significant differences in the changes in proxy physical function parameter in the control and treatment group (3.16 ± 0.83 vs. 4.50 ± 1.47, P < 0.05) and changes in nutritional status variable (0.33 ± 0.15 vs. 0.47 ± 0.16, p < 0.05). However there was no significant difference in the change in mid upper arm circumference (0.83 ± 0.31 vs. 0.93 ± 0.31, p > 0.05). Further research is needed to confirm this result.
Pharmacogenomics Statins: Biomarkers for Clinical Prediction Suprapti, Herni
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

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Statins are the most widely prescribed drug for hyperlipidemic therapy and for the prevention of Cardiovascular disease. But although statins are very effective for the prevention of atherosclerosis, there are still patients with CVD. In this case, it is thought to be the influence of genetic factors. There is a static gene link to statin dose required for therapy, but there are still no relevant pharmacogenomic tests for statin therapy guidelines. This article describes basic pharmacogenomic terminology, genes (CETP, HMGCR, SLCO1B1, ABCB1, and CYP3A4 / 5), and progression of statin pharmacogenomic biomarkers for predicted therapeutic outcomes.
Co-Authors Ernawati Ernawati Yundari, Yundari