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Acta Biochimica Indonesiana
Published by Perhimpunan Biokimia dan Biologi Molekuler Indonesia
ISSN : 26546108     EISSN : 26543222     DOI : https://doi.org/10.32889
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
Acta Biochimica Indonesiana (ActaBiolna) is a peer-reviewed and open-access journal that disseminates original research articles and review articles covering diverse topics in Biochemistry and Molecular Biology. The journal is published biannually by Indonesian Society for Biochemistry and Molecular Biology.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 68 Documents
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Is heme biosynthesis influenced the mitochondrial function and cell proliferation in cancer? Raisa Nauli; Sri Widia A Jusman
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.65

Abstract

Heme is a compound consisting of an iron (Fe) atom bound to a pyrrole ring forming protoporphyrin IX (PPIX). Protoporphyrin combines with a protein-forming hemoprotein compound that plays an essential role in oxygen-binding and transport as well as in the process of energy production in the mitochondria. Some cancer cells have more heme biosynthesis than normal cells, which is thought to be linked to more cancer cell growth. Inhibition of heme biosynthesis in some cancer cells leads to decreased cell proliferation. This review article discusses the synthesis of heme, the role of heme in energy metabolism, which is needed for cell proliferation, the inhibition of heme synthesis and its effect on cancer cell proliferation, and the possibility of the inhibition of heme biosynthesis as an approach in therapy of cancer in the future.
Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India Niharika Singh; Saba Khan; Mohammad Mustufa Khan; Haseeb Ahsan; Roshan Alam
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.89

Abstract

Background: During pregnancy, the physiological production of reactive oxygen species (ROS) is associated with a variety of maternal, placental, and fetal developmental functions. These functions are disrupted by excessive amounts of ROS, resulting to pregnancy complications. Different stages of pregnancy require a balance between oxidant and antioxidant production. Objective: The aim of this study is to investigate the status of malondialdehyde (MDA) and catalase (CAT) activity in pregnant and age matched non-pregnant women. Methods: In this cross-sectional study, a total of 74 participants were enrolled, including 37 pregnant and 37 age-matched non-pregnant women. The age range of participants was 18 to 40 years. MDA and CAT levels were measured spectrophotometrically. A p-value 0.05 was statistically significant. Results: Compared to non-pregnant women, the mean plasma level of MDA was considerably elevated in pregnant women (p<0.0001). However, the mean level of CAT activity in pregnant women was significantly lower than in non-pregnant women (p<0.0001) In pregnant women, there is a significant strong negative correlation between MDA levels and CAT activity (p<0.01). Conclusion: Pregnant women have high level of oxidative stress, indicating that the pregnant women are more susceptible to oxidative damage and may develop pregnancy-associated complications.
Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats Rauza Sukma Rita; Elmatris Sy; Endrinaldi
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.118

Abstract

Background: Free radicals are atoms or molecules with one or more unpaired electrons. Lead acetate has been reported to increase the presence of free radicals in the body. Objective: This study aims to investigate the effect of oral administration of jamblang (Syzygium cumini) leaf extract on hydrogen peroxide (H2O2) serum levels in rats induced with lead acetate. Methods: A total of 24 male rats were divided into three groups: the negative control, the positive control, and the treatment group. The negative control group received a standard diet, the positive control group received lead acetate at a dose of 40 mg/kg body weight, and the treatment group received lead acetate at the same dose along with jamblang leaf extract at a dose of 150 mg/kg body weight. Lead acetate and jamblang leaf extract administration was carried out for 30 days. Afterward, serum H2O2 levels were examined using the colorimetry method. Results: Results revealed that H2O2 levels in the negative control, positive control, and treatment groups were 3.08±0.24, 4.94±0.75, and 3.44±0.65 nmol/L, respectively. Significant differences were observed between the groups, as well as between the negative control and positive control, and between the positive control and treatment group. Conclusion: The study showed that jamblang leaf extract can reduce hydrogen peroxide levels in Wistar rats treated with lead acetate, indicating its ability to address oxidative stress.
Histopathological analysis of the liver in hypercholesterolemia rats treated with Dillenia serrata fruits Tien; Tri Wistya Utami; Pranita Aritrina; Laode Kardin; Sukurni; Andi Noor Kholidha Syarifin
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.56

Abstract

Background: Dillenia serrata (locally known as singi) is a natural product with the potential to improve liver function in hypercholesterolemia, due to anticholesterol and antioxidant properties. Objective: This study aimed to investigate the effect of D. serrata on the histopathological features of rat livers induced by a high-fat diet. Methods: This study used a quasi-experimental in vivo with a post-test-only control group design. Rats were divided into four groups: normal, high-fat diet, as well as D. serrata, and simvastatin treatment. Hypercholesterolemia was induced by a high-fat diet for two weeks. Rat liver tissues were analyzed histologically using Hematoxylin-Eosin (HE) staining, and were observed under a light microscope at 40x magnification in five wide fields of view. Results: The high-fat diet group had the most adipose cells, while the D. serrata group had the least. Statistical analysis demonstrated a significant difference between the high-fat diet group and the other groups (p < 0.05). Interestingly, no significant difference between the D. serrata group and either the normal or simvastatin group (p > 0.05), suggesting the treatment of fruit may restore liver function comparable to normal and simvastatin group. Conclusion: The D. serrata fruit reduces the number of fat cells in the histopathology of rats induced with the high-fat diet.
The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice Petrus Mantur; Efrisca Meliyuita Br. Damanik; Elisabeth Levina Sari Setianingrum; Prisca Pakan
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabiona.97

Abstract

Background: High blood sugar levels that exceed normal limits or commonly refered to as hyperglycemia, is an early symptom of diabetes mellitus. Objectives: This study explored the effect of lemon (Citrus limon) extract on blood sugar levels and pancreatic b cell regeneration in alloxan-induced hyperglycemic mice (Mus musculus). Method: This research is an experimental study using a post-test group. The sampling was carried out using a randomization method. By administering 125 mg/kg BW of alloxan, the sample was conditioned for hyperglycemia. The samples were divided into five groups: normal control, alloxan-induced control, and three treatment groups that received lemon extract with dosages of 100 mg/kg BW, 300 mg/kg BW and 500 mg/kg BW, respectively. Semiquantitative analysis was used to evaluate pancreatic damage. Results: The results showed that lemon extract can decrease blood sugar levels. Histopathological imaging revealed a significant improvement in b cell distribution and decreased vacuolization in the Langerhans islets of mice administered lemon extract. No significant differences were observed among different dosages of lemon extract (p>0.05). Conclusion: Our findings underscore the potential therapeutic benefits of lemon extract in managing blood sugar levels and promoting pancreatic b cell regeneration in alloxan-induced mice.
The correlation between plasma malondialdehyde levels and pain in adolescent females diagnosed with primary dysmenorrhea Ocktariyana Ocktariyana; Dian Lestari; Abdul Kadir; Listrianah Listrianah; Handayani Handayani
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.119

Abstract

Background: Endometrial inflammation factors play a crucial role in the common pathophysiology of primary dysmenorrhea. Malondialdehyde (MDA), a byproduct of inflammatory processes, might be correlated with primary dysmenorrhea in adolescents. Objective: To assess plasma MDA levels in patients with primary dysmenorrhea. Methods: This cross-sectional study involved the collection of blood samples from 23 teenage females with primary dysmenorrhea and 23 age-matched individuals without this condition. Plasma MDA levels were quantified through spectrophotometry. The independent t-test was employed to ascertain the disparity in plasma MDA levels between the two groups, while the Pearson correlation test was utilized to analyze the relationship between pain severity and oxidative stress levels. Results: Plasma MDA levels were significantly higher in females with primary dysmenorrhea than in the control group (0.631 ± 0.105 and 0.395 ± 0.076, respectively). A significant difference in oxidative stress levels was observed between the case and control groups (p<0.001). Furthermore, a robust positive correlation was observed between plasma MDA levels and pain severity in adolescent females with dysmenorrhea (r2 = 0.564, p<0.001). Conclusion: The plasma MDA is increased in adolescent females with primary dysmenorrhea.
Zinc deficiency effect on clinical features of Coronavirus Disease 2019 patients: A scoping review Moch Ikhsan Juliansyah; Lisa Adhia Garina; Mirasari Putri
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.123

Abstract

COVID-19 was declared a pandemic in March 2020. Various therapeutic guidelines have been established for treating COVID-19, such as anti-inflammatory, antiviral therapies, and zinc supplementation. Zinc deficiency is thought to worsen the condition of patients with COVID-19 infection. However, the effect of zinc deficiency on COVID-19 patients has not been widely reported. In this scoping review, we aim to explore the impact of zinc deficiency on the clinical features of COVID-19 patients. A comprehensive search was conducted across the databases, including PubMed, ScienceDirect, Springer Link, ProQuest, and Google Scholar, using the keywords “Zinc” AND “(COVID-19 or SARS-CoV-2)”. A total of 2,458 articles published between 2019 and 2020 were screened following the PRISMA guidelines and subjected to critical appraisal. Three articles were included, focusing on the effect of zinc deficiency on the clinical features of COVID-19 patients. As of 2022, two articles reported worsening symptoms, one described an increased hospitalization duration, and one reported worsening treatment outcomes in the zinc deficiency group. This review concludes that zinc deficiency worsens symptoms, increases the duration of hospitalization, and leads to worse outcomes in COVID-19 patients.
Evaluation of serum amylase and lipase in diagnosed Covid-19 survivors in a North Indian Hospital, Lucknow, India Nabeela Usmani; Mukhtar Ahmad; Saba Khan; Mohammad Mustufa Khan; Haseeb Ahsan; Sadaf Parveen; Roshan Alam
Acta Biochimica Indonesiana Vol. 6 No. 1 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.141

Abstract

Background: Coronavirus disease 2019 (Covid-19) is a novel disease caused by coronavirus-2 that causes severe acute respiratory syndrome (SARS-CoV-2). Although it primarily affects the respiratory system, the virus may also target the pancreas. It was suggested that upregulation of angiotensin-converting enzyme II (ACE-II) cell receptors or inflammatory cytokines play a major role in predisposing pancreatic injury in SARS-CoV-2 patients. Our aim was to conduct a critical evaluation of in order to provide an insight into the possibility of pancreatic injury. Methods: A case control study was conducted in the Department of Biochemistry IIMS&R, Integral University, Lucknow. Two groups of subjects (70 adults consisting of 35 Covid-19 survivors and 35 controls) aged between 35 to 70 years were selected for the study with mild to moderate Covid-19 diagnosed using RT-PCR/rapid antigen test and a control group of healthy individuals without history of Covid-19. The serum amylase was determined by the direct substrate method and serum lipase by the turbidimetric UV method using a semi-autoanalyzer. Results: The study showed that the serum amylase (p=0.023) and lipase (p=0.002) levels were significantly elevated in Covid-19 patients compared to the control subjects. The findings indicated that Covid-19 patients had a substantially higher mean serum amylase and lipase levels than the control subjects. Conclusions: The Covid-19 patients are prone to pancreatic injury.

Page 7 of 7 | Total Record : 68

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