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Rachmat Hidayat
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eureka.herba.indonesia@gmail.com
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Dr. Moh Ali street Palembang South Sumatera Indonesia
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INDONESIA
Eureka Herba Indonesia
Published by HM Publisher
ISSN : -     EISSN : 27465152     DOI : https://doi.org/10.37275/ehi.v1i1.1
Core Subject : Health,
Medicine & Pharmacology
Eureka Herba Indonesia (EHI) is peer review scientific journal that focused on reserach in exploration potential Herba of Indonesia for enhancing healthy. EHI focused on : 1. Medicinal Plants. 2. Efficacy of Herba Study. 3. Safety of Herba Study. 4. Animals that potential for developing as healthy products. 5. Minerals that potential for developing as healthy products.
Arjuna Subject : Kedokteran - Kedokteran Komplemen dan Alternatif
Articles 74 Documents
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The Effects of Sambiloto Leaf Extract (Andrographis paniculata) on Blood Sugar Regulation: An In Vivo Study Rachmat Hidayat; Lusia Hayati
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.1

Abstract

Sambiloto (Andrographis paniculata) is one of the most common plants in Indonesia. Sambiloto contains quite varied secondary metabolites, where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aims to assess the effect of Sambiloto (Andrographis paniculata) leaf extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which indicates the potential of the test extract's ability to improve blood glucose intake to cells so that it can maintain blood sugar regulation. The process of extracting sambiloto is carried out by maceration in which 500 grams of simplicia are macerated with 96% ethanol for 72 hours. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group (100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambiloto extract was able to reduce blood sugar levels significantly, were at the ES 100 and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach the target below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extract are believed to be responsible for the effect of blood glucose regulation. In conclusion, Sambiloto extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
Effect of Noni Fruit Extract (Morinda citrifolia) on Glucose Intake to Diabetes Mellitus White Rat Muscle Tissue Patricia Wulandari
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.2

Abstract

Noni fruit (Morinda citrifolia) is one of the most common plants in Indonesia. This plant is often found in various regions in Indonesia, where these plants are often in the form of shrubs or wild plants that grow in yards or plantations. This study aims to assess the effect of noni (Morinda citrifolia) fruit extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which shows the potential of the test extract's ability to improve blood glucose intake in cells so that it can maintain blood sugar regulation. This research was an experimental study that used white rats as research subjects. Induction of diabetes was done by injecting alloxan at a dose of 110 mg/kg BW intraperitoneally; then the white rats were given 10% glucose to drink. Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly. In white rats induced with diabetes mellitus, there was a decrease in GLUT4 levels in muscle tissue. The administration of metformin drugs or noni fruit extracts shows the ability to increase levels of GLUT4 protein. In conclusion, noni fruit extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
Acute Toxicity Ethanol Extract of Bidara Leaves (Ziziphus spina-christi L.) Against Liver and Kidney Function of White Rats Nur Syamsi Dhuha; Haeria; Hardyanti Eka Putri
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.3

Abstract

Bidara plants have the efficacy as antioxidants, anti-inflammatory, antimicrobial, anti- fungal and prevents tumours. Bidara is efficacious to protect human DNA cells caused by damage from actinic radiation. This study aims to explore the acute toxicity test of the ethanol extract of Bidara leaves using white mice as experimental animals. A total of 30 white rats (Rattus norvegicus) Wistar strain obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams. After one week of adaptation, the mice were randomly divided into the following six groups, each containing five animals: Normal control group and Bidara extract group (50mg/kg BW; 150 mg/kg BW; 450 mg/kg BW; 1350 mg/kg BW; and 4050 mg/kg BW). This study shows that the extract of Bidara leaves has a relatively high toxic dose, namely at a dose of 4050 mg/kg BW. Bidara leaf extract at doses below 1500 mg/kg BW, shows no toxic effect on the liver. In conclusion, bidara leaf extract has a toxic dose above 4000 mg/kg BW in Wistar white rats.
Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in Rat Muscle Tissue Induced Aloxan Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.4

Abstract

Diabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. Bay leaves contain entirely various secondary metabolites, and this plant is rich in flavonoids, alkaloids, terpenes, and glycosides. This study aims to assess the effect of bay leaf extract (Syzygium polyanthum) on blood sugar levels and the expression of GLUT4 protein in muscle tissue. A total of 30 white rats (Rattus norvegicus) Wistar strains were obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 – and 250 grams. Bay leaf Simplicia was obtained from the Tawangmangu Herbal Research Center, Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) and diabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a very significant increase in blood sugar levels, where the use of the drug metformin was able to reduce blood sugar levels significantly even though they had not reached the target blood glucose target of less than 200 mg / dL. The treatment with bay leaf extract was able to reduce blood sugar levels significantly. The administration of metformin drugs or bay leaf extract showed the ability to increase the level of GLUT4 protein. In conclusion, bay leaf extract affects reducing blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
The Effect of Soursop Leaves Fraction (Annona squamosa L.) as Anticancer Makbruri Amin; Irsan Saleh
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.5

Abstract

Anticancer drugs are primarily aimed at inhibiting the growth and proliferation of cancer cells. The soursop plant (Annona squamosa L.) has the potential to be developed as an anticancer drug. This plant contains several active compounds including flavonoids, borneol, camphor, alkaloids, terpenes, saponins, tannins, polyphenols, and polyketide compounds. This study was conducted to assess the efficacy of the polar fraction of soursop leaves on cytotoxic activity based on the IC₅₀ value in T47D cells. This research is experimental in vitro study using cell line T47D. The methanol fraction of soursop leaves was diluted with DMSO and DMEM to obtain a concentration of 500; 250; 125; 62.5; 31.25 µg/ mL cisplatin with a concentration of 50:25:12,5: 6,25:3,125 µg/mL. The methanol fraction of soursop from the highest concentration of 500 µg/ml has average viability of 46.77% and the average percentage of viability will increase in proportion to the decrease in the concentration of the test compound. The IC50 value shows the concentration value that results in the inhibition of cell proliferation by 50% of the population. In conclusion, the methanol fraction of soursop leaves have an anticytotoxic effect on the T47D cell line through the role of flavonoid metabolites.
The Effect of Bay Leaf Extract (Syzygium polianthum) Against Cholesterol Regulation in Hypercholesterolemic Rats Lusia Hayati; Rachmat Hidayat
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.6

Abstract

Cholesterol is an important precursor that plays a role in the production and regulation of various sterol group compounds, especially steroid hormone compounds, androgen hormone compounds, cortisol compounds, and estrogen compounds. This herb is known to have the effect of improving glucose regulation by increasing glucose intake into cells and tissues. Its ability to improve cell and tissue metabolism is mediated by the content of secondary metabolite compounds. This ability is believed to have the potential to improve cholesterol regulation. Bay leaf extract is effective in lowering cholesterol levels through regulation of Acetyl CoA production.
Indonesian Plants with Potential as Anti-diabetes Mellitus Agent Rachmat Hidayat; Lusia Hayati; Nita Parisa
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.7

Abstract

Diabetes Mellitus (DM) is a degenerative disease that continues to increase in number in Indonesia and is a disease that is spread throughout the world due to unbalanced nutritional conditions. Treatment of diabetes mellitus is a chronic and lifelong treatment. Treatment of diabetes mellitus, such as the use of insulin and oral antihyperglycemia drugs, is relatively expensive, is used for a long time and can cause unwanted side effects. There are many plants that have potential as antihyperglycemia drugs. One of the active compounds that act as antihyperglycemia is flavonoids.Flavonoids derived from various types of plants studied are thought to act as antihyperglycemic agents. Flavonoids are known to have the ability to scavenge free radicals or act as natural antioxidants. The antioxidant activity of flavonoids is related to phenolic –OH groups which can capture or neutralize free radicals (such as ROS or RNS). Flavonoids can play a role in pancreatic tissue damage caused by DNA alkylation due to alloxan induction as a result of improving the morphology of the rat pancreas.
Potential of Sambung Nyawa Leaves (Gynura procumbens) as Antidiabetic Mellitus Mustofa
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.8

Abstract

Diabetes mellitus is a metabolic disease characterized by an increase in blood sugar due to defects in insulin secretion, insulin sensitivity, or both. The number of people with diabetes mellitus in Indonesia has increased every year. The number of people with diabetes is 6.9% in 2013 to 10.9% in 2018. Various therapies have been carried out for the treatment of Diabetes Mellitus, one of which is herbal therapy. Gynura procumbens is a plant that is widely used as a treatment for diabetes mellitus, kidney, rash and fever, and hypertension. The flavonoid content in Gynura procumbens replaces the decrease in blood sugar. This review article attempts to explain the role of Gynura procumbens as an antidiabetic therapy in previous studies. The method used in this article is through searching articles through the NCBI database and Google Scholar. The results of an article search found that Gynura Procumben has antidiabetic potential which can reduce blood sugar in patients with Diabetes Mellitus.
The Utilization of Pasak Bumi Plants (Eurycoma longifolia Jack.) as Traditional Medicine and Its Bioactivity Marina Silalahi
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.9

Abstract

Pasak bumi (Eurycoma longifolia Jack.) is a species belonging to Simarobuaceae that has been long used as traditional medicine, which is known very well as an aphrodisiac. The studies have been conducted to reveal the benefits of E. longifolia through ethnobotany, phytochemical, and bio essay approaches, but the review articles on its utilization and bioactivity are limited. This article is based on scientific articles published online or offline, then synthesized so that to be information on the relationship between use and bioactivity. Ethnobotany of E. longifolia has been used as a medicine for fever, malaria, improved stamina, diabetes, cancer, aphrodisiac, and erectile dysfunction. The bioactivity of E. longifolia is antiosteoporotic, antimicrobial, aphrodisiac, anticancer, angiogenesis, and hepatoprotective. Eurycomanone is a secondary metabolite in E, longifolia has activity as an antimalaria, antipyretic, aphrodisiac, and cytotoxic. The quassinoids, coumarin, and glycosides of El have activity increase the production, quality, totality, synthesis, and release of spermatozoa. Eurycoma longifolia is very potential to be developed as an antiosteoporotic and a prosidiac drug, but until now most of it is harvested directly from the forest, so to preserve it, we need to study the cultivation method.
Curcuma zedoaria (Christm.) Roscoe: Benefits and Bioactivity Marina Silalahi
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.10

Abstract

Curcuma zedoaria (Christm.) Roscoe or Temu Putih is a native plant in India and has been long cultivated in Indonesia. By the local communities in Java, it has been used as a component of the Jammu and the traditional medicine. This article is based on literature from offline and online media. Offline literature used the books, whereas online media used Web, Scopus, Pubmed, and scientific journals. Based on a study of ethnobotany Curcuma zedoaria was used as medicine and spices. The main secondary metabolites of Curcuma zedoaria rhizomes are terpenoids, especially sesquiterpenoids and monoterpenoids. Curcuma zedoaria have bioactivities as anticholesterol, anti-tumor/cancer, anti-inflammation, fever, antipyretic, analgesic dan anti-microbial

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