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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 7 Documents

Search results for , issue "Vol 1, No 1 (2013)" : 7 Documents clear

Efek Pemberian Fraksi Ekstral Etanol Daun Sirih (Piper betle L) pada Penurunan Nafsu Makan dan Berat Badan Tikus Wistar Jantan Mude, Serafin Anastasia; Tamayanti, Wahyu Dewi; Liben, Paulus
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Telah dilakukan penelitian mengenai elek pemberian Iraksi air ekstrak etanol pada daun sirih (Piper betle L.) pada penurunan nalsu makan dan berat badan pad a tikus Wistar. Pa~a penelitian ini tikus Wistar (Rattus norvegicus) jantan sebanyak 25 ekor dibagi dalam 5 kelompok, kelompok kontrol negatil K(-); 3 kelompok uji (Fl, F2, F3); dan kelompok kontrol positil (P). K(-) menerima perlakuan PGA 3% tanpa bahan aktil; Fl, F2, F3 masing-masing menerima Iraksi air ekstrak etanol daun sirih dengan dosis 300, 450, dan 600 mglkgBB; dan P menerima orlistat dengan dosis 10,B mglkgBB. Setiap perlakuan diberikan seeara oral selama 7 hari berturut-turut sekali sehari sebelum pengamatan. Jumlah sisa makanan dan berat badan (BB) ditimbang dan dieatat setiap hari. Hasil penelitian menunjukkan bahwa Fl, F2, dan F3 mampu menurunkan nalsu makan dan berat badan t ikus putih dibandingkan terhadap K(-). Selisih rerata penurunan jumlah makanan adalah 3,4 g (Fl); 3,8 g (F2); dan 4,2 g (F3). Penurunan tersebut setara dengan penurunan jumlah makanan kelompok P yaitu 4,2 g. Pada sisi BB, Fl; F2; dan F3 menunjukkan selisih rerata penurunan BB sebesar 14,6 g; 20,8 g dan 26,6 g. Selisih penurunan yang dihasilkan oleh F3 menunjukkan nilai mendekati penurunan berat badan oleh kelompok P yaitu 28,6 g. Penelitian ini mengindikasikan bahwa pemberian Iraksi air ekstrak etanol daun sirih (Piper betie L.) dalam dosis 300; 450; dan 600 mglkgBB seeara ora l mampu menurunkan jumlah makanan dan berat badan pada tikus Wistar jantan . Perhitungan koelisien korelasi menunjukkan tidak ada hubungan linear antara peningkatan dosis dengan peningkatan penurunan jumlah makanan dan berat badan tikus.

Uji Aktivitas Antibakteri dan Antikuorum Sensing Fraksi dari Ekstrak Etanol Daun Salam (Eugenia polyantha Wight.) Ardani, Yonas Bianityo; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Eugenia polyantha is being used as empirical plant for antiseptic, anthelmintic, anesthetic, keratolytic and also has properties protein in bacterial cells. The antibacterial activity of extract of Eugenia polyantha has been proved in previous study, therefore this research was conducted to know the antibacterial and antiquorum sensing from fractions of ethanolic extract of Eugenia polyantha. The extraction was prepared by maceration and fraction was prepared by liquid-liquid fractionation method with n-hexane (non polar), ethyl acetate (semipolar) and water (polar). Bioautography method with thin layer chromatography and chloroform as mobile phase was conducted to determine the active fraction. The diameter of inhibition zone was measured or determined by diffusion method, while concentration of minimum inhibition (MIC) and bactericidal concentration (MBC) were determined using broth and agar dilution methods. Antiquorum sensing activity for P. aeruginosa was carried on, using pigment survey and motility method~ The antibacterial activities showed that ethyl acetate fraction 2596 gave diameter of growth inhibition zone greater than others, 1:1.48 mm against S. aureus and 9.03 mm against P. aeruginosa. The MIC of ethyl acetate fraction gave value of :1.56% against S. aureus and 12.5% against P. Aeruginosa, meanwhile the MBC was 3.1396 against S. aureus and more than 12.5% against P. aeruginosa. The result showed that ethyl acetate fraction has potential antiquorum sensing activity on concentration of 2.5 %. The active fraction of ethanolic extract of Eugenia polyantha which has antibacterial and antiquorum sensing activity was ethyl acetate fraction.

Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dan Escherichia coli Pudjianto, Andreyanus Eko; Ervina, Martha; Caroline, Catherine; Soekardjo, Bambang; Foe, Kuncoro
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methylpiperazin-N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoculated with Micrococcus luteus and Escherichia coli. Based on orientation studies, concentration of 4-methylpiperazin-N-carbonyl ampicillin and ampiCillin were 0.5 ppm against Micrococcus luteus and 500 ppm against Escherichia collin order to get visible zone of inhibition. The results showed that 4-methylpiperazin-Ncarbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coli.

Pemodelan Interaksi Turunan Potensial Asam Benzoilsalisilat dengan Reseptor Enzim Siklooksigenase-2 Natalia, Ongki; Caroline, Catherine; Soekardjo, Bambang
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

The research of synthesize and quantitative structure activity relationship of benzoyl salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that O-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (EDso value was 15.7396 mg/kg) while the EDso value of acetyl salicylic acid was 3296 mg/kg. Therefore further studies were carried out to determine the interaction modelling of potential benzoy/saJicyJic acid derivatives with enzyme cyclooxygenase-2 receptor by using Glide (Schrodinger license). The result showed that the GScore of 0-(2-trifluoromethoxybenzoyl)salicylic acid: -9.97, 0-(2.4-dimethylbenzoyl)salicylic acid: -9.94, O-(2-fluorobenzoyl)saJicylic acid : -9.62 and 0-(2.3-dimethy/chlorobenzoyl)salicylic acid : -9.49 more active than O-(3-chloromethylbenzoyl)saJicylic acid (-9.48), which GScore of each compound less than 0-(3-chloromethylbenzoyl)salicylic acid that had been synthesized. 0-(2-trifluoromethoxybenzoyl)salicylic acid, 0-(2.4-dimethylbenzoyl)salicylic acid, O-(2-fluorobenzoyl) salicylic acid and O-(2.3-dimethylchlorobenzoyl) salicylic acid are compounds that have a good potency as an analgesic. Interaction of potential benzoy/salicy/lc acid derivatives with enzyme cyclooxygenase-2 receptor was on residues Tyrosine 385, Leusine 531, Tyrosine 355 dan Arginine 120.

Optimasi Formula Tablet Floating Metformin Hidroklorida Menggunakan Polimer Guar Gum Elim, Siska; Hadisoewignyo, Lannie; Sukarti, Emi
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Metformln hydrochloride Is an orally administered blguanlde derivative drug and functions as an anti hyperglycemic In patient with type 2 diabetes mellitus with bioavallablllty between 50-6096. Floating system Is the one method to enhance absorption and bioavallablllty of metformln hydrochloride. The purpose of this research was to determine the effect of guar gum concentration and concentration effervescent components and Interactions of both components on physical properties of tablets, floating lag time, floating time, and dissolution rate constant and get the optimum formula with drug release pattern according to zero order kinetics. In this research using factorial design with two factors Is concentrations factor of guar gum at 15-2096 and concentrations factor of effervescent components Is citric acid and sodium bicarbonate (1:1) at 5-1096. The method used Is direct compression method. Concentration of guar gum have a significant effect on floating lag time and dissolution rate constant but do not have a significant effect on tablet hardness. While the concentration of effervescent components not have a significant effect on tablet hardness and dissolution rate constant but a significant effect on floating lag time. Interaction between guar gum concentration and concentration effervescent components not have a significant effect on tablet hardness, floating lag time, and dissolution rate constant Based on Design - Expert program optimization, the optimum formula obtained Is formula with combination 19,596 guar gum concentration and 5,596 concentration effervescent components which resulting 11,43 Kp hardness, floating lag time 8,69 min and K dissolution 0,324 mUmln.

Fraksinasi dan Identifikasi SenyawaAntioksidan pada Eksb-ak Etanol buah Goji beny(Lycium barbarum linn.) secaraKromatografi Kolom Albrian, Diga; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Goji berry fruit (Lycium barbarum), familia Solanac'eae, is a red berry fruit. The chemical compounds contained in this fruit are polysaccharides, zeaxanthin and beta-carotene. Activity of the chemical compounds is still considered as a family of antioxidant compounds, which are used as a medicine to cure the diseases caused by the presence of free radicals such a~ atherosclerosis, cancer, liver cirrhosis, hypertension and diabetes. The research will be carried on fractionation and identification of the ethanol extract of Goji berry fruit to obtain compounds that have antioxidant power using chromatographic column method and DPPH method. The isolated compounds will be identified using methods phytochemica/s screening, TLC, UV-Vis spectrophotometer and infrared spectrophotometer. The result showed that secondary metabolites of Goji berry fruit which are potential as antioxidant compound were flavonoid (flavono/s or flavones). The isolated compound had higher antioxidant activity compare to the ethanol extract of Goji berry fruit Flavonoids are the major compounds that have antioxidant capacity. Whereas, the ethanol fraction of Goji berry fruits has the best antioxidant activity than the ethanol extract Keywords: Antioxidant, Goji berry, DPPH and chromatographic column

Bioaktivitas Produk Fermentasi Monascus Srianta, Ignatius; Widharna, Ratna Megawati; Kardono, Leonardus Broto S.
Jurnal Farmasi Sains dan Terapan Vol 1, No 1 (2013)
Publisher : Jurnal Farmasi Sains dan Terapan

Monascus-fermented product has been used traditionally in Asian countries as food and medicine. Traditionally, Monascus-fermented rice was produced with cultivate Monascus sp. on steamed rice medium. During fermentation, Monascus sp. produce various metabolites. Beside pigments, Monascus sp. also produces monacolin K, monascin, dimerumic acid, etc which possess positive health impacts. Recent studies reported that Monascus sp. could grow on non rice medium i.e. soybean, dioscorea, adlay etc. This paper is a review of bioactivities of Monascus-fermented products including anti-inflammatory, anti hypercholesterolemic, anti hyperlipidemia, anti hypertensive, antioxidant and anti diabetes activities.

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