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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

Arjuna Subject : -

Articles 8 Documents

Search results for , issue "Vol 5, No 2 (2018)" : 8 Documents clear

Pola Penggunaan Antihipertensi pada Pasien Diabetes Mellitus Tipe 2 di Poli Penyakit Dalam RS Bhayangkara Surabaya Pramadani, Yana; Hasmono, Didik; Kasih, Elisabeth; Hartono, Ruddy
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia. This disease can be caused due to abnormalities in insulin secretion, insulin action or both. Management of diabetes mellitus in general is to improve the quality of life of people with diabetes, namely to eliminate complaints of diabetes mellitus, improve quality of life, and reduce the risk of acute complications; to achieve this goal their blood pressure must be controlled using antihypertensive therapy. The purpose of this study was to examine the pattern of antihypertensive drug use related to the type, dose, and frequency of administration in reducing blood pressure in patients with type 2 diabetes mellitus in the internal medicine clinic of Bhayangkara Hospital Surabaya. The method of this study was observational because researchers did not provide treatment directly to patients. Data were collected retrospectively between August 1 and September 15, 2015. The results showed 80 patients (48%) used single therapy and 86 patients (52%) used combination therapy. The antihypertensive drug that is often used as a single therapy is valsartan (1x80 mg) given orally in 16 patients (20%) and as a combination is valsartan (1x80 mg) + amlodipine (1x10 mg).

Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya Pambudi, Rien Esti; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.

Formulasi Sediaan Masker Wajah Ekstrak Labu Kuning (Cucurbita moschata) Bentuk Clay Menggunakan Bentonit dan Kaolin Sebagai Clay Mineral Santoso, Cynthia C.; Darsono, Farida L.; Hermanu, Liliek S.
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Free radicals can cause oxidative damage that plays a role in the aging process and cause degenerative diseases that appear on the skin, so that antioxidants are needed to reduce the cumulative effects of oxidative damage in the form of clay mask. One of the natural materials that can be used as a clay mask is pumpkin fruit. Beta carotene in the yellow pumpkin can be used as an antioxidant that has a mechanism of electron transfer process so that free radical can be deactivated, and the saponin content in yellow pumpkin was function as cleanser effect. The aims of this study were to determine the effect of the combination of bentonite and kaolin as clay minerals, and to get the optimum composition of the formula. Clay mask formulation was optimized using factorial design with design expert software ver 10.0. Responses used were the viscosity, spreadability, and drying time. The results showed that bentonite give a significant effect to increase the viscosity, decrease spreadability and drying time. Kaolin gives a significant effect to increase the viscosity, decrease spreadability and drying time. The interaction between kaolin and bentonite give significant effect to increase the viscosity, spreadability, and drying time. The optimum formulation of clay mask was obtained with the combination of bentonite 23.95% and kaolin 18.60%, which estimates viscosity 236222 cps; spreadability 4.20 cm; and drying time 14.65 minute.

Studi pendahuluan: Korelasi Aktivitas Antikolesterol dengan Aktivitas Antioksidan Ekstrak Etanol Daun Salam (Syzygium polyanthum) Wijaya, Sumi; Yonas, Stefani Maureen Kasih; Hartanti, Lanny; Setiawan, Henry K.; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Bay leaf leaves (Syzygium polyanthum) are known to have anti-cholesterol activity, with the mechanism inhibited HMG-CoA Reductase enzyme. The purpose of this study was to determine the correlation between anticholesterol activity of bay leaf ethanol extract obtained by percolation method and its antioxidant activity. The parameter used to measure anticolesterol activity is the IC50 value. Antioxidant activity was evaluated by DPPH and Frap methods. The results showed that the ethanolic extract of bay leaves had an IC50 value of 49.50 Â± 0.70 ppm. Ethanol extract of bay leaf showed antioxidant activity with IC50 value of 888.0835 ppm and equality of values with 1 mM FeSO4 of 295 ppm. Based on the results of the analysis, the anticholesterol activity of Bay leaf ethanol extract in inhibiting the HMG-CoA Reductase enzyme did not have a linear correlation with its antioxidant activity.

Perbandingan Sintesis Antara Senyawa 2-Metoksikhalkon dan 2,4â€™-Dimetoksikhalkon dengan Bantuan Iradiasi Gelombang Mikro Wibawa, Vincentius Tio Putra; Soewandi, Ami; Caroline, Catherine
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Chalcone (1,3-diphenylprop-2-en-1-one) is a precursor compound of flavonoids that have two aromatic rings connected by three Î±, Î²-unsaturated carbons. Chalcone can be synthesized by the base-catalysed crossed aldol condensation (Claisen-Schmidt) that reacts aromatic aldehyde with aryl ketone. In this research, synthesize of 2-methoxychalcone and 2,4'-dimethoxychalcone compounds with microwave irradiation assistance had been done. 2-methoxychalcone was synthesized from 2'-methoxyacetophenone and benzaldehyde, while 2,4'-dimethoxychalcone was synthesized from 2'-methoxyacetophenone and 4-methoxybenzaldehyde. The purity of the synthesis compounds were analyzed from melting point and thin layer chromatography data. Identification of structure was performed using infrared spectral data and proton nuclear magnetic resonance. From the obtained results, 2-methoxychalcone and 2,4'-dimethoxychalcone compounds can be synthesized by microwave irradiation assistance. The yield of 2,4'-dimethoxychalcone was 69,69%, while 2-methoxychalcone was 5,15%. The effect of the methoxy group (-OCH3) on benzaldehyde facilitates the reaction formation of khalkon compounds in terms of the yield of synthesis.

Isolasi dan Karakterisasi Fungi Endofit dari Daun Tanaman Bintaro (Cerbera odollam) yang Berpotensi sebagai Antibakteri Wonowijaya, Suwandi; Soegianto, Lisa
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

The need of antibiotics is increasing, spurred to find compounds that have antimicrobial activity from natural ingredients. One way to obtain antimicrobial compounds is through endophytic fungi. This study aimed to isolate and characterize endophytic fungi obtained from the leaves of the plant Bintaro (Cerbera odollam) that potential as an antibacterial against Staphylococcus aureus and Escherichia coli. Leaf surface was sterilized by soaking in 70% alcohol for 2 minutes, 5.3% sodium hypochlorite for 5 minutes, 70% alcohol for 1 minute, rinsed with sterile distilled water and dried using sterile wipes. Bintaro leaf that have been sterilized was puton Potato Dextrose Agar (PDA) and then incubated at room temperature for 7-14 days. The growing fungi was inoculated in Potato Dextrose Yeast (PDY) for 7-14 days at room temperature based on the macroscopic difference. Endophytic fungi that have been purein macroscopic way was tested antibacterial activity on Staphylococcus aureus and Escherichia coli and continued to macroscopic and microscopic observation. Obtained three types of endophytic fungi were isolated from bintaro leaves (Cerbera odollam) with the code EB 1, EB 2 and EB 3 that suspected from genus Fusarium, Geotrichum and Aspergillus. The antibacterial activity test show that results of three endophytic fungi obtained has no antibacterial activity against Staphylococcus aureus and Escherichia coli.

Standarisasi dari Daun Kirinyuh (Chromolaena odorata) dan Simplisia Kering dari Tiga Daerah yang Berbeda Ance, Paulina Erlianda; Wijaya, Sumi; Setiawan, Henry Kurnia
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Siam wead (Chromolaena odorata) is used traditionally for treatment lesoin, amenorrhea, antidiabetic and antimicrobial. Based on previous research, there is no reference about the standardization Siam Weed leaves dried powder. This study aims to determine macroscopic and microscopic of siam weed leaves fresh plant obtained from, Surabaya, to determine the spesific and non spesific quality profile of dried powder of siam weed leaves dried powder obtained from different areas (Bogor, Malang and Surabaya). The spesific parameter that used were identity, organoleptic, microscopic, determination of soluble extract, phytochemical screening, determination chromatogram profile using Thin Layer Chromatography, determination spectrum profile using spektrophotometer UV-Vis and Infrared, determination of alkaloid, phenol and flavonoid content. Non spesific parameters that used were the determination of total ash value, water soluble ash value, acid insoluble ash value, drying losses and pH. Based on result of the study, it was concluded that siam weed fresh plant leaves have elliptico-oblongus shape, acutus shape for the upper and lower base, green colored for the top and bottom surfaces, adge shape for the wavy , 6.4-11.8 (L), 3.3-5.9 (W), wavely leaf rib, fluffy leaf texture, and the position of facing a single, microscopically have the fragments as same as the dried powder fragments, ethanol soluble concentration â‰¥ 12%, water soluble concentration â‰¥ 20%, solvent can be used for chromatogram profile in TLC is chloroform : ethyl acetate (15:1), spectral profile with spectrophotometer UV-Vis have wavelength 533.5 nm, 500 nm, 534.5 nm, 501.5 nm, 284.5 nm, 289 nm and 292 nm, spectral profile with IR spectrophotometers have wavenumber 3266.28 cm-1-3282.21 cm-1, 1416.01 cm-1, 1514.53 cm-1, 1514.93 cm-1, 1245.35 cm-1, 1249.52 cm-1 dan 1251.27 cm-1, flavonoid content â‰¥ 0.4%, phenol content â‰¥ 1.0% and alkaloid content â‰¥ 1.0%, total ash content â‰¤ 14%, water ash soluble â‰¤ 5%, acid unsoluble ash â‰¤ 10%, drying losses â‰¤ 11% and range pH 5-7.

Uji Antipiretik Patch Ekstrak Etanol Bawang Merah (Allium ascalonicum L.) dengan Matriks Kitosan dan Enhancer SPAN-80 terhadap Temperatur dan Jumlah Makrofag pada Tikus Putih Vivi Kariyaningtias; Iwan Sahrial Hamid; Teguh Widodo
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

Traditional medicine can be used to treat various diseases, one of which is onion (Allium ascalonicum L.) as an antipyretic agent. In this study, the antipyretic potency of ethanol extract of onion (Allium ascalonicum L.) was tested using chitosan and Span-80 as enhancer matrix with temperature and number of intraperitoneal macrophages in white rats as parameters. This study used 20 male white rats Wistar that were induced with DPTHb vaccine intraperitoneally and then divided into four groups namely positive control group (paracetamol), negative control (placebo without extract and without enhancer), formulation 1 (with extract and without enhancer), and formulation 2 (with extracts and enhancers). The results were analyzed using One Way Anova and if the results were significant, then the test continued with Duncan 5%. Correlation calculations were used to determine the relationship between temperature reduction and total intraperitoneal macrophages. The results showed that the temperature reduction did not provide a significant difference between the positive control (paracetamol) and formulation 2 (with extracts and enhancers), whereas in the negative control (without extract and without enhancer) there was no significant difference with formulation 1 (with extract and without enhancers). The total results of intraperitoneal macrophages were significantly different in all groups with a significant> 0.05.

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