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Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
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Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

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Articles 7 Documents

Search results for , issue "Vol 6, No 2 (2019)" : 7 Documents clear

Uji Efektivitas Ekstrak Daun Binahong (Anredera cordifolia (TEN) Steenis) terhadap Jumlah Fibroblas dan Ketebalan Kolagen pada Luka Infeksi Tikus Wistar Ratu, Maria T H; Syahrial, Iwan; Hermanu, Liliek
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Binahong (Anredera cordifolia) is a medicinal plant that can be used to accelerate the healing process of wound infections. The purpose of this study was to determine the effect of the ethanol extract of binahong leaves (Anredera cordifolia) on the healing process of incision wounds infected by Staphylococcus aureus. The ethanol extract of binahong leaves is made in the form of ointments to facilitate the application and release of the drug into the skin layer. The study used 24 male Wistar rats which were divided into 4 treatment groups namely the group without treatment, the group with fusidic acid ointment, the group with 20% extract of binahong leaf ethanol extract and the group with 40% extract of binahong leaf ethanol. Infected mice were treated and then observed the number of fibroblasts and collagen thickness on day 3 and day 7. Data was analyzed using One Way Anova followed by Duncan Test. The results showed that the ethanol extract of binahong leaves 40% could increase the number of fibroblasts on the 3rd day (43.33 Â± 8.08) and the 7th day (61.67 Â± 7.02), the ethanol extract of the binahong leaf 20% on 3rd day (31.67 Â± 5.50) and 7th day (57.00 Â± 7.55). The ethanol extract of binahong leaves 40% increased the thickness of collagen on the 3rd day (10.37 Â± 2.69) and the 7th day (16.55 Â± 0.32), the ethanol extract of the binahong leaf 20% on the 3rd day ( 8.87 Â± 0.71) and 7th day (12.09 Â± 1.26). Based on the results of the study, it can be concluded that the ethanol extract of binahong leaves 40% can accelerate the healing process of wound infections by increasing the number of fibroblasts and collagen thickness better than the administration of ethanol extracts of binahong leaves 20%.

Standarisasi Spesifik dan Non Spesifik dari Ekstrak Etanol Daun dandang Gendis (Clinacanthus nutans) Wijaya, Sumi; Setiawan, Henry Kurnia; Purnama, Veronica Bella
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Standardization of natural materials is needed as an effort to improve the quality and safety of products that are expected to further increase trust in medicines derived from natural ingredients. Snake grass leaf has several pharmacological activities including antioxidants, anticancer, anti-inflammatory, analgesic, enhancing the immune system, antibacterial, antivenom, even there are also uses in the cosmetics field. In this study macroscopic and microscopic observation of Snake grass leaves and determination of specific and non-specific standardization on ethanol extracts of Snake grass leaves have been done. The parameters tested on Snake grass leaf extract include the identity of the extract, organoleptic, ethanol soluble extract, water soluble extract, phytochemical screening, chromatogram profile using TLC, spectrum profile using UV-Vis spectrophotometer, spectrum profile using IR (infrared)spectrophotometer, determination of secondary metabolite content, total ash content, water soluble ash content, acid insoluble ash content, water content, pH, and specific gravity. The results showed the characteristics of ethanol extract of Snake grass leaf in the form of green-black extract, aromatic distinctive odor; ethanol soluble extract content> 54%; water soluble extract content> 37%; phytochemical screening results showed the presence of alkaloid compounds, flavonoids, polyphenols, saponins, steroids and terpenoids; the results of IR spectrophotometer analysis show spectrum profiles in the range wave of numbers 3325-3351 cm-1, 2924-2919 cm-1, 1622 -1633 cm-1, 1341-1345 cm-1 and 1020-1047 cm-1; total phenol levels> 0.16%; total flavonoid levels> 0.11%; total alkaloid levels> 0.03%; water content

Perbandingan Sintesis Antara Senyawa 2'-Nitrokhalkon dan 2,4-Dimetoksi-2'-Nitrokhalkon dengan Bantuan Iradiasi Gelombang Mikro Putri, Navyanti Firda; Soewandi, Ami; Budiati, Tutuk
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

The purposes of this research were to find out the influence of a methoxy group to the result percentage reaction and synthesize derivatives of chalcone from derivatives of acetophenone and 2-nitrobenzaldehyde. The purity analysis of the synthesized result was determined by melting point assay and thin layer chromatography, while the identification of the structure was determined by spectrophotometry, infrared pectrophotometry and nuclear magnetic resonance (H-NMR). In the synthesis of compounds formed 3-hydroxy-3- (2-nitrophenyl)-1-fenilpropan-1one and 3-hydroxy-1-(2,4-dimetoksifenil)propan-1-on. The synthesis results obtained an average percentage yield synthesis of 3-hydroxy-3-(2-nitrophenyl)-1-phenylpropan-1-on with the conventional method and with the aid of microwave irradiation amounted to 60.45% and 32.36%. The percentage results of the synthesis for compounds 3-hydroxy-1-(2,4-dimethoxyphenyl)-3-(2-nitrophenyl)propan-1-on with the conventional method and with the aid of microwave irradiation amounted to 11.51% and 5.57%. The influence of methoxy groups can decrease the reactivity of acetophenone.

Studi Penggunaan Sefalosporin Generasi Ketiga pada Pasien Pneumonia di Instalasi Rawat Inap Rumah Sakit Umum Haji Surabaya Worotikan, Natania Imanuella; Hasmono, Didik; Kasih, Elisabeth; Ramdani, Dewi
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Pneumonia is an acute lung tissue infection caused by inflammation of the lung parenchyma and the presence of exudate compaction in lung tissue. Based on epidemiology, pneumonia can be differentiated into communityacquired pneumonia and health care-associated pneumonia. The HCAP category divided pneumonia into hospital acquired pneumonia and ventilator-associated pneumonia. This study aims to analyze the pattern of third generation cephalosporin use in pneumonia patients based on drug route of administration, dosage, frequency, interval and duration of drug usage, and laboratory data. This study was conducted retrospectively with time limited sampling method during the period of August 1, 2016 - August 31, 2017. The study was conducted in 31 patients with diagnosis of pneumonia undergoing hospitalization and received third generation cephalosporin antibiotic therapy at inpatient installation of RSU Haji Surabaya which traced through Medical Record. All samples were recorded on the data collection sheet, and then the data was recapitulated and analyzed. Based on the observation result, it was found that ceftriaxone with frequency and dose 2x1 g (iv) used as much as 41% (11 people), the combination between ceftriaxone 2x1 g (iv) with levofloxacin 1x1 g (iv) used as much as 22% (4 people). The longest use of third generation cephalosporin antibiotics was ceftriaxone (4-6 days) as much as 35% (12 people).

Pengaruh Ekstrak Kulit Buah Mangga Harum Manis (Mangifera indica L) terhadap Tekanan Darah pada Tikus Putih Jantan Hipertensi Ifmaily, Ifmaily
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Hypertension is the most common disease in Indonesia. The impact of hypertension can affect other organs such as the kidneys, heart, and eventually cause death. The prevalence of hypertension increases from year to year. One alternative treatment for hypertension is the use of natural ingredients that contain flavonoids. Mango (the leaves, fruit, fruit peel and stems) is one of the plants that can be used for anti-hypertension, because of its flavonoid content. Ethanol extract of leaves, fruit and stem of Mango already proved as an antihypertensive drug, but the peel of the fruit has not been studied, so far it has only been a waste. The purpose of this study was to determine the effect of varying doses of the extract of mango peel varieties Harum Manis (EKBMHM) on white male hypertensive rats. This study was experimental with a pretest-posttest control group design, using male white rats, divided into 6 groups: negative control group, positive control, treatment group 30 mg / kg BW, treatment group 60 mg / kg BW, treatment group 120 mg / kg BW and comparison group (amlodipine 5 mg / kgBW. Prednisone 1.5 mg / kgBW in 2.5% NaCl are used to induce hypertension in animal. The parameters used were blood pressure which measured using a Non-Invasive Blood Pressure. Data analysis was calculated using one-way ANOVA followed by Duncan's test. The results obtained showed a dose of 30 mg / kg BW and a dose of 120 mg / kg BW extract of mango peel cannot reduce blood pressure, while a dose of 60 mg / kg BW can reduce blood pressure in hypertensive rats where the results of blood pressure measurements are not significantly different with comparison group (amlodipine 5 mg / kg BW). The conclusion for this research,the administration of mango peel varieties Harum Manis extract at a dose of 60 mg / kg BW given to hypertensive rats shows potential as an antihypertensive drug (p value = 0.047).

Standarisasi Spesifik dan Non Spesifik Simplisia dan Ekstrak Etanol Bawang Putih Tunggal Terfermentasi (Allium sativum Linn.) Vernanda, Renna Yulia; Puspitasari, Maria Revina; Satya, Hadianto Nur
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Garlic that has undergo a fermentation process (Black garlic) has been shown to have a total content of flavonoids and polyphenols greater than fresh garlic. One of garlic varieties is single bulb Garlic (Allium sativum Linn.) which contains only one small bulb. This study aims to determine specific and non specific standardization of dried fermented single bulb Garlic and ethanol extract of fermented single bulb Garlic (Allium sativum Linn.). Samples were collected from three different regions: Temanggung, Bromo and Banyuwangi. The results of the study showed that dried fermented single bulb garlic have round shape oval, brown color blackish, and aromatic odor; water soluble content >25%, ethanol soluble content >26%, total polyphenols >4.5% b/b, total flavonoids >0.6% b/b; dred fermented single bulb Garlic contain polyphenols, flavonoids, and saponins; total ash content 2% b/b; the ethanol extract contain polyphenols and flavonoids; total ash content

Uji Aktivitas Antibakteri dan Antibiofilm Fraksi Biji Kelengkeng (Euphoria longan Lour. Steud.) terhadap Staphylococcus aureus ATCC 6538 Prasety, Oda Shantina; Soegianto, Lisa; Wijaya, Sumi
Jurnal Farmasi Sains dan Terapan Vol 6, No 2 (2019)
Publisher : Jurnal Farmasi Sains dan Terapan

Longan (Euphoria longan Lour. Steud.) has an antibacterial potential. Longan seed is one part of Longan that has antibacterial activity. This study was conducted to determine the antibacterial and antibiofilm activity of longan seed fraction (Euphoria longan Lour. Steud.) against Staphylococcus aureus ATCC 6538. In this study, the extract was obtained from maceration using 96% ethanol and it was fractionated by liquid-liquid solvent method using nhexane, ethyl acetate, and water. Each fraction prepared at concentration 100000 ppm, and then the antibacterial activity on Staphylococcus aureus was determined by well diffusion method, antibiofilm activity using microdilution method, and phytochemical screening to determine the metabolite compounds that have antibacterial and antibiofilm activity using thin layer chromatography. The results showed that the diameter of growth inhibition in ethyl acetate fraction with a concentration of 100000 ppm was 14.59 mm Â± 0.01, n-hexane fraction at 7.15 mm Â± 0.63 and water fraction of 12.52 mm Â± 0.40. Antibiofilm test results showed that the percentage of growth inhibition of biofilm on the fraction of ethyl acetate with a concentration of 100000 ppm was 99.08%. Phytochemical screening using thin layer chromatography carried out on the fraction of ethyl acetate and showed that the fraction contains tannin/polyphenols, triterpenoid saponins and flavonoids.

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