Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

JFST
Website

Published by Universitas Katolik Widya Mandala Surabaya

ISSN : 23388404 EISSN : 26572311 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) is published twice a year, containing research articles, review, and short communication in pharmacy science field, including medicinal chemistry, analytical chemistry, biologjcal pharmacy, pharmaceutical sciences and clinical pharmacy research and practice of pharmacy in industry, clinic, and community practice, such as pharmacies, distributors, and pharmacy education.

Arjuna Subject : -

Articles 7 Documents

Search results for , issue "Vol 7, No 1 (2020): Februari" : 7 Documents clear

Studi Penggunaan Carboplatin untuk Penderita Kanker Payudara di RUMKITAL Dr. Ramelan Surabaya Alfin Giovani; Didik Hasmono; Siti Surdijati; Joko Semedi
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Cancer is an abnormal growth of new cells that grow beyond normal limits. Cancer can metastasize by attacking parts of the body and spread to other organs. The prevalence of cancer Indonesian’s people in 2013 is estimated at 347,792. Breast cancer is the most common cancer in women with a percentage of 23%. Breast cancer is the second most common cancer with death after cervical cancer. Breast cancer is divided according to histologic subtype to Ductal Carcinoma in Situ (DCIS) and Lobular Carcinoma in Situ (LCIS). Carboplatin is a platinum analog cancer drug that belongs to the class of antineoplastic agents. Carboplatin doses used in AUC 6 (i.v) breast cancer chemotherapy for 1 cycle with 21 days to 6 cycle times. This research was conducted observasional with descriptive research design and retrospective data retrieval. The purpose of this study was to know the profile of carboplatin as an anti-cancer drug that is expected to provide safe treatment. This research was conducted at Dr. RUMKITAL Ramelan Surabaya with the number of inclusion of 30 patients in the period January 1, 2017 - December 31, 2017. From the results of this study obtained the use of single carboplatin as much as 7% and a combination of 93%. Patients with chemotherapy administered without surgery and surgery were 73% and 27%, respectively. Toxicity of nausea and vomiting happen as much as 42% and pain as much as 19%.

Validasi Metode Identifikasi Sildenafil Sitrat, Tadalafil dan Fenilbutazon dalam Jamu Obat Kuat Secara Kromatografi Lapis Tipis – Densitometri Henry Kurnia Setiawan; Neysa Marcella Kahar; Stephanie Stephanie; Emi Sukarti
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Jamu/Herbal Medicine that contain chemical compounds/Pharmaceutical compounds has been banned by The National Agency of Drug and Food Control in Indonesia, but in December 2017, BPOM released a public warning about aphrodisiac herbal medicine that contain chemical compound like sildenafil citrate and phenylbutazone in the market. The aim of this study was to find out the valid method for identification of sildenafil citrate and phenylbutazone in aphrodisiac herbal medicine. In this study, the developed method was applied to 22 brands of aphrodisiac herbal medicine sample. Sample was extracted with methanol, then 5 µl of sample spotted on silica gel plate 60 F 254 and eluated by chloroform : methanol : amonia (70 : 3 : 1.5, v/v/v). The spots were analyzed by TLC scanner at λ 286 nm. Sildenafil citrate was appeared at Rf 0.76; tadalafil at 0.6 and phenylbutazone at Rf 0.12 with resolution (Rs) value of sildenafil and tadalafil was 1.1 meanwhile tadalafil and phenylbutazone was 5.4. Limit of detection of sildenafil citrate was 8.552 µg/ml (2.053 mg/600 mg capsul), tadalafil was 1.629 µg/ml (0.391 mg/600 mg capsul), and phenylbutazone was 7.877 µg/ml (1.890 mg/600 mg capsul). This study found 14 brands that gave a positive result containing sildenafil citrate and no sample contain tadalafil and phenylbutazone.

Standarisasi Simplisia Daun Ekor Kucing (Acalypha hispida Burm.f.) dari Tiga Daerah Berbeda Wilhelmina Walu Bay; Liliek S. Hermanu; Restry Sinansari
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

The fox tail (Acalypha hispida) is known for its many benefits and has been used in traditional medicine. This aim of this research was determining the profile of specific and non specific standardization of fox tail leaves from three different areas (Batu, Bogor and West Sumba). The specific parameters consist of identity, organoleptic, microscopic, water soluble extract, ethanol soluble extract, phytochemical screening, chromatogram profile determination by thin layer chromatography (TLC), determination of infrared spectrum profile (IR), determination of UV spectrum profile and determination of secondary metabolite content (phenol and flavonoid). Non spesific parameters include shrinkage drying, ash content, acid insoluble ash, water soluble ash, percent foreign material and pH measurement. The result of standardization of dried powder fox tail leaves, have value of soluble ethanol extract ˃ 14%, water soluble extract ˃ 23%, contain flavonoids compounds, polyphenols, tannins, quinones and triterpenoids, total flavonoid levels > 0.2% and phenol > 0.7%, pectrophotometry IR result showed the presence of O-H, C-H, C = C and C-C groups, total ash content < 15.5%, acid insoluble ash < 2.5%, water soluble ash < 5.5%, drying shrinkage level < 10% and pH 4.5-5.

Efektivitas dan Keamanan Furosemid Continuous Infusion Dosis 10 dan 20 mg/jam pada Pasien Penyakit Ginjal Kronik Kondisi Fluid Overload Syndrome disertai Hipoalbumin di RSUD Abdul Wahab Sjahranie Diga Albrian Setiadi; Widyati Widyati; Kuntjoro Yakti
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Furosemide continuous infusion is the first choice drug in overcoming the condition of Fluid overload syndrome with hypoalbuminemia in patients with Chronic Kidney Disease (CKD). However, in these conditions, the dose of furosemide used by clinicians is between 10 and 20 mg/hour. No studies have compared the effectiveness and safety of different doses of furosemide. This study aimed to evaluate the effectiveness and safety of 10 and 20 mg/hour furosemide given in continuous infusion in CKD patients with fluid overload syndrome with hypoalbuminemia. The method is a Single-blind, Randomized Clinical Trial conducted during the period of February-April 2017 in the inpatient ward of Abdul Wahab Sjahranie Hospital. Data processing was carried out by statistical analysis, Two Independent T-Test parametric test for data that normally distributed and those that did not correlate with each other, whereas for data that not normally distributed and those that did not correlate with each other, non-parametric test Mann Whitney and Wilcoxon were used. Outcomes studies were 24-hour urine volume, shortness of breath, duration of oxygen consumption, Ronchi and safety of therapy seen from drug side effects (hypotension, hyperuricemia, hyperglycemia, hyponatremia, hypokalemia). The results of the study, 34 patients with CKD with fluid overload syndrome with hypoalbuminemia (2.5-3.0 g/dL) were registered. On the effectiveness of therapy, there was no significant difference in 24-hour urine volume (P = 0.324; P> 0.05; 95%; CI=714.6-1017.8 ml group 1; CI=818.0-1113.2 ml group 2), shortness of breath (P = 0.781; P> 0.05; 95 % CI=0.68-1.32 group 1; CI=0.72-1.40 group 2), duration of oxygen use (P = 0.363; P> 0.05; 95% CI=1.34-2.66 day group 1; CI=1.72-3.10 day group 2), Ronk (P = 0.692; P> 0.05 ) and the absence of drug adverse events (P = 1.000; P> 0.05) between the two groups. In conclusion, the dose of 10 and 20 mg/hour furosemide has the same

Formulasi Sediaan Antijerawat Ekstrak Daun Pepaya (Carica papaya L.) dalam Bentuk Gel Hamalatul Qur’ani Romelli; Farida L Darsono; Lisa Soegianto
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

The purpose of this study was to determine the concentration of papaya (Carica papaya L.) leaf extract which gave antibacterial activity and to determine the effect of increasing concentrations of papaya (Carica papaya L) leaf extract on physical quality, effectiveness of antibacterial inhibition and stability in the gel form. The antibacterial activity was tested using the well method. The evaluations consist of physical quality tests including organoleptic, pH, homogeneity, dispersion and viscosity; effectiveness (antibacterial activity); safety; acceptability and stability (organoleptic, pH and viscosity). The results showed that the higher the concentration of extract of papaya leaf, the higher the antibacterial activity and also influenced its physical quality and the stability. The concentration of papaya leaf extract (Carica papaya L) which have the highest antibacterial activity is 30%. The increasing of the concentration of papaya leaf extract (Carica papaya L.) affected the physical quality (pH, viscosity and dispersion), the effectiveness (antibacterial activity) and stability (pH stability and viscosity stability). The best formula in this study is formula 2 (papaya leaf extract 20%) which fulfill requirements of physical (organoleptic), pH, viscosity, dispersion, homogeneity, have antibacterial activity, safety and stability test

Skrining Senyawa Antibakteri dari Minyak Atsiri Rimpang Temu Kunci (Boesenbergia pandurata) terhadap Staphylococcus aureus dengan Metode Bioautografi Kontak Indah Christiana; Lisa Soegianto
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Fingerroot are generally used as a remedy for rheumatism, gastroenteritis, mucositis, diuretic, malaria, bowel disorders, flatulence, skin diseases, diarrhea, mouth sores, and intestinal worms. Essential oils found in Fingerroot are generally used as antibacterial. The purpose of this study is to determine the antibacterial activity of Fingerroot essential oils against Staphylococcus aureus and to determine the antibacterial compound of Fingerroot essential oils (Boesenbergia pandurata) using contact biautography methods. Fingerroot essential oil was obtained by the Stahl distillation method. Determination of the class of efficacious compounds was carried out by contact bioautography method and anisaldehyde-sulfuric acid and vanillin sulfate were used as spray reagent. The Fingerroot essential oil yields 0.38% and monoterpenes was determined as an antibacterial agent against Staphylococcus aureus.

Studi Penggunaan Kombinasi Obat Fenitoin dan Natrium Valproat terhadap Serum Magnesium dan Jumlah Kejang pada Pasien Epilepsi di RSUD DR. Soetomo Vonneth Glorya Sambono; Paulus Sugianto; Elisabeth Kasih; Evi Octavia
Jurnal Farmasi Sains dan Terapan Vol 7, No 1 (2020): Februari
Publisher : Jurnal Farmasi Sains dan Terapan

Epilepsy is a clinical condition that is recognized by the pattern of seizures ranging from neurological development status according to age, history of seizures, and prognosis. Clinical research in humans and animals shows that magnesium deficiency can cause seizures. Drug therapy in epilepsy patients can be done by monotherapy and polytherapy. The combination of phenytoin and sodium valproate can be used as a polytherapy. The purpose of this study was to describe the serum magnesium levels and the number of seizures in epilepsy patients who received phenytoin and sodium valproate using a descriptive method prospectively. The parameters used are the conditions of the patient while receiving treatment. Ten epilepsy patients which treated with combination therapy of phenytoin and sodium valproate were used for this research.The results showed that the highest dose used in polytherapy was phenytoin 500 mg and sodium valproate 500 mg 2 x 1 po. The highest normal magnesium level was 2.21 mg / dL (10%). The highest number of seizures was 7 times a month (10%) and no adverse drug interactions occured. Phenytoin and sodium valproate therapy can minimize the number of seizures but do not affect the patient's magnesium level.

Page 1 of 1 | Total Record : 7

Filter by Year

2020 2020

Filter By Issues

All Issue Vol 10, No 1 (2023): February Vol 9, No 2 (2022): October Vol 9, No 1 (2022): Februari Vol 8, No 2 (2021): Oktober Vol 8, No 1 (2021): Februari Vol 7, No 2 (2020): Oktober Vol 7, No 1 (2020): Februari Vol 6, No 2 (2019) Vol 6, No 1 (2019) Vol 5, No 2 (2018) Vol 5, No 1 (2018) Vol 4, No 2 (2017) Vol 4, No 1 (2017) Vol 2, No 2 (2015) Vol 2, No 1 (2015) Vol 1, No 1 (2013) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name -

Contact Email -

Phone -

Journal Mail Official -

Editorial Address -

Location Kota surabaya, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
-

Contact Email
-

Phone
-

Journal Mail Official
-

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA