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All Journal Sumatera Medical Journal
Sholat, Alfi Dewi
Talenta Publisher
Immunology & microbiology Medicine & Pharmacology

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Journal : Sumatera Medical Journal

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Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer Sholat, Alfi Dewi; Gatot, Dairion; Handayani, Savina; Mardia, Andri Iskandar; Syafril, Santi
Sumatera Medical Journal Vol. 1 No. 1 (2018): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.068 KB) | DOI: 10.32734/sumej.v1i1.439

Abstract

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.
Co-Authors Dairion Gatot, Dairion Handayani, Savina Mardia, Andri Iskandar Santi Syafril, Santi