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All Journal Berkala Kedokteran Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Devi, Wivina Riza
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Homeostasis: Jurnal Mahasiswa Pendidikan Dokter

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PERBEDAAN KADAR UREUM DAN KREATININ PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Annisa, Haima; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12379

Abstract

Abstract: Preeclampsia is pregnancy disorder (>20 weeks) characterized by hypertension with or without proteinuria. Failure trophoblast invasion in preeclampsia results impaired spiral artery remodeling, hypoxia, placental ischemia, endothelial dysfunction and kidney dysfunction. Kidney dysfunction cause urea and creatinine increase. This research aims determine the difference in urea and creatinine of preeclampsia versus severe preeclampsia at RSUD Ulin Banjarmasin 2020-2022. Analytical observational, retrospective cross-sectional. There were 60 preeclampsia and severe preeclampsia subjects at RSUD Ulin 2020-2022 according inclusion and exclusion criteria, non-probability sampling. Research results for median preeclampsia urea 13.0 mg/dL, minimum value 5.0 mg/dL, maximum value 75.0 mg/dL and median severe preeclampsia 30 mg/dL, minimum value 9.0 mg/dL, maximum value 100 mg/dL. Median preeclampsia creatinine 0.6 mg/dL, minimum value 0.14, maximum value 1.51 mg/dL and mean severe preeclampsia 1.0 mg/dL, standard deviation 0.41 mg/dL. There is significant difference in urea and creatinine in preeclampsia and severe preeclampsia, p=0.000 and p=0.001. Keywords: preeclampsia, severe preeclampsia, ureum, creatinine, RSUD Ulin Banjarmasin. Abstrak: Preeklampsia merupakan kelainan kehamilan (>20 minggu) ditandai hipertensi dengan atau tanpa proteinuria. Gagalnya invasi trofoblas pada preeklampsia mengakibatkan gangguan remodeling arteri spiralis, hipoksia, iskemia plasenta, disfungsi endotel dan berakhir pada disfungsi ginjal. Gangguan ginjal menyebabkan ureum dan kreatinin meningkat. Tujuan penelitian mengetahui perbedaan ureum dan kreatinin preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022. Metode observasional analitik studi cross sectional retrospektif. Terdapat 60 subjek preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022 sesuai kriteria inklusi dan eksklusi, teknik non-probability sampling. Hasil penelitian ureum preeklampsia median 13,0 mg/dL, nilai minimum 5,0 mg/dL, nilai maksimum 75,0 mg/dL dan preeklampsia berat median 30 mg/dL, nilai minimum 9,0 mg/dL, nilai maksimum 100 mg/dL. Kreatinin preeklampsia median 0,6 mg/dL, nilai minimum 0,14, nilai maksimum 1,51 mg/dL dan preeklampsia berat rerata 1,0 mg/dL, simpang baku 0,41 mg/dL. Kesimpulan: Terdapat perbedaan bermakna ureum dan kreatinin pada preeklampsia dan preeklampsia berat, nilai p=0,000 dan p=0,001. Kata-kata kunci: preeklampsia, preeklampsia berat, ureum, kreatinin, RSUD Ulin Banjarmasin
PERBEDAAN AKTIVITAS SGOT, SGPT DAN LDH PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Amelia, Fakhrina; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12376

Abstract

Abstract: Preeclampsia is characterized by hypertension and proteinuria at gestational age >20 weeks. Preeclampsia occurs when endothelial dysfunction triggers organ damage, one of which is the liver. Cellular damage in the liver causes an increase in SGOT, SGPT and LDH. The research aims to determine whether there are differences in SGOT, SGPT and LDH activity in pregnant women with preeclampsia and severe preeclampsia. This type of research is an analytical observational, retrospective cross-sectional study. There were 60 subjects who met the inclusion criteria. Preeclampsia SGOT, SGPT and LDH activity had a median of 22 units/L, 12 units/L and 429 units/L, minimum values of 13 units/L, 3 units/L and 37 units/L, maximum values of 55 units/L, 53 units /L and 989 units/L. SGOT, SGPT and LDH activity in severe preeclampsia had a median of 61 units/L, 40 units/L and 811 units/L, minimum values of 41 units/L, 15 units/L and 402 units/L, maximum values of 1161 units/L, 977 units/L and 1756 units/L. Conclusion: There was a significant difference in SGOT, SGPT and LDH activity in preeclampsia and severe preeclampsia (p=0.000). Keywords: preeklampsia, severe preeklampsia, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Lactate Dehydrogenase Abstrak: Preeklampsia ditandai hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia terjadi disfungsi endotel memicu terjadinya kerusakan organ salah satunya organ hati. Kerusakan seluler di hati menyebabkan peningkatan SGOT, SGPT dan LDH. Penelitian bertujuan mengetahui apakah terdapat perbedaan aktivitas SGOT, SGPT dan LDH pada ibu hamil preeklampsia dan preeklampsia berat. Jenis penelitian observasional analitik, studi cross sectional retrospektif. Didapatkan 60 subjek yang sesuai kriteria inklusi. Aktivitas SGOT, SGPT dan LDH preeklampsia mempunyai median 22 unit/L, 12 unit/L dan 429 unit/L, nilai minimum 13 unit/L, 3 unit/L dan 37 unit/L, nilai maksimum 55 unit/L, 53 unit/L dan 989 unit/L. Aktivitas SGOT, SGPT dan LDH preeklampsia berat mempunyai median 61 unit/L, 40 unit/L dan 811 unit/L, nilai minimum 41 unit/L, 15 unit/L dan 402 unit/L, nilai maksimum 1161 unit/L, 977 unit/L dan 1756 unit/L. Kesimpulan : didapatkan perbedaan bermakna aktivitas SGOT, SGPT dan LDH pada preeklampsia dan preeklampsia berat (p=0,000). Kata-kata kunci: preeklampsia, preeklampsia berat, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Laktat Dehidrogenase
Co-Authors Abimanyu, Bambang Amelia, Fakhrina Annisa, Haima Azma Rosida, Azma Hendriyono, Franciscus Xaverius Hendriyono, Fransiskus Xaverius Taufiq Hidayat Yuseran, Hariadi