<![CDATA[Bacterial vaginosis (BV) in pregnancy is associated with the increase of adverse pregnancy outcomes such as premature rupture of membranes and preterm labor. One of the multifactorial causes of BV is thechange in vaginal immunity. Malnutrition, including micronutrient deficiency, increases the vulnerability toinfections. This study aim to investigate the association between folic acid and zinc concentration with theincidence of bacterial vaginosis in the first trimester of pregnancy. This descriptive cross sectional studyinvolved 139 mothers with first trimester pregnancy, aged between 17-39 years old. The study was conductedat dr. Cipto Mangunkusumo Hospital from September 2013 until August 2014. Vaginal secretions was sampledto diagnose BV under nugent criteria. Folic acid and zinc in the serum were measured. From 139 subject,18.7% (n=26) were found to be BV positive (nugent score =7). No deficiency of folic acid (<7 ng/mL) and40.3% (n=56) of zinc deficiency (<60 µg/dL) were found. Bivariate analysis used Kruskal-Wallis test betweenfolic acid and zinc concentration with BV incidence gives p value of 0.668 and 0.478 respectively. Prevalenceof BV in this study was 18.7%. The relation between the maternal statuses of folic acid with BV in the firsttrimester of pregnancy was not found. Keywords: bacterial vaginosis, folic acid, zinc, pregnancy. Hubungan antara Kadar Asam Folat dan Seng terhadap KejadianVaginosis Bakteri pada Trimester Pertama Kehamilan Abstrak Bakterial vaginosis (BV) pada kehamilan dihubungkan dengan meningkatnya luaran maternal yang buruk seperti ketuban pecah dini dan persalinan prematur. Penyebab BV multifaktor salah satunya adalahperubahan imunitas di vagina. Malnutrisi termasuk defisiensi mikronutrien meningkatkan kerentananterhadap infeksi. Studi ini dilakukan untuk mengetahui hubungan antara kadar asam folat dan seng terhadapkejadian vaginosis bakteri pada trimester pertama kehamilan. Penelitian ini merupakan studi deskriptif potonglintang yang mengikutsertakan 139 ibu hamil trimester pertama berusia 17–39 tahun. Penelitian dilakukandi Rumah Sakit Cipto Mangunkusumo pada bulan September 2013–Agustus 2014. Sekret vagina diambiluntuk mendiagnosis BV berdasarkan kriteria nugent. Dilakukan pengukuran kadar asam folat dan seng dalamserum. Dari 139 subjek, didapatkan 18,7% (n=26) positif BV (skor nugent = 7). Tidak terdapat defisiensi asamfolat (<7ng/mL) dan 40,3% (n=56) defisiensi seng (<60 µg/dL). Analisis bivariat menggunakan uji kruskalwallisantara kadar asam folat dan seng dengan BV memberikan nilai p masing-masing 0,668 dan 0,478.Disimpulkan prevalensi BV pada penelitian ini adalah 18,7%. Tidak ditemukan hubungan antara status asamfolat dan seng maternal trimester pertama dengan BV. Kata kunci: bakterial vaginosis, asam folat, seng, kehamilan]]>
