Neck pain is a common musculoskeletal disorder which causes an increase in worker absenteeism and health expenses of companies. This study aimed to determine the relationship of the head position and other risk factors towards the incidence of acute neck pain among taxi drivers. The study was carried out on June to September 2015 using cross-sectional design with a sample of 113 respondents via consecutive sampling. Data were collected by interview, physical examination and photographic methods for measuring the head position while driving. The subject were taxi drivers in Jakarta. Exclusion criteria were driver with preexisting neck pain or neck discomfort at the initial time of the study, analgesic usage in the last 24 hours and the usage of neck pads while driving. Data was analyzed using multivariate logistic regression and cutoff point determination based on ROC curve. 46.7% of respondents were experiencing acute neck pain. The head position associated with acute neck pain was neck-horizontal angle (OR=14.72, 95% CI=5.08-42.6). Respondents with neck-horizontal angle ≤50º had 15 times greater risk of experiencing acute neck pain than neck-horizontal angle >50º. Risk factor of occupation associated with acute neck pain was duration of rest on duty (OR=7.61, 95% CI=2:51 to 23:13). Respondents with the duration of rest on duty ≤3 hours per day had 8 times greater risk of experiencing acute neck pain than respondents with longer rest >3 hours. There were no individual factors associated with acute neck pain.