This research aims to investigate the effect of Trade Openness, Foreign Direct Investment (FDI), and Inflation on the Gross Regional Domestic Product (GRDP) in Riau Province 2003-2022. The analytical method employed is multiple linear regression analysis, specifically the Ordinary Least Squares (OLS) method, using E-Views 12 software. The simultaneous analysis results show that the variables Trade Openness, Foreign Direct Investment (FDI) and Inflation collectively have a significant impact on the GDP in Riau Province 2003-2022. Meanwhile, the partial analysis indicates that the variables Trade Openness, Foreign Direct Investment (FDI) have a positive effect and inflation has a negative effect on the GRDP in Riau Province.