<![CDATA[Background: Social support is a form of interpersonal relationship where the social environment provides assistance in the form of emotional attention, instrumental assistance, providing information, appreciation or assessment to individual sufferers. Lack of social support will lead to a decline in physical and mental conditions, which can cause a person to be lazy to carry out routine daily self-care activities. As a result, people with HIV/AIDS do not adhere to treatment programs. If a person with HIV/AIDS does not regularly take anti-retroviral (ARV) for a long time, this will greatly affect the quality of life for people with HIV/ AIDS. This study aims to examine the relationship between social support and quality of life in people with HIV / AIDS.Subjects and Method: This was a meta-analysis study conducted by systematically reviewing articles from PubMed, Science Direct, Springer Link, and Google Scholar. The articles used in this research are articles that have been published from 2010-2020. The search for articles was carried out by considering the eligibility criteria using the PICO model, P: people living with HIV/AIDS, I: strong social support, C: weak social support, O: Quality of life. The keywords for finding articles were as follows: "people living with HIV/AIDS "AND" social support "OR" family support "OR" care relationship "AND" quality of life "AND" cross sectional "AND" multivariate ". The inclusion criteria used were full paper, used English, cross-sectional study design and results reported adjusted odds ratio. Articles were collected using PRISMA diagrams, and analyzed using the Review Manager 5.3 application.Results: The meta-analysis was carried out on 8 articles in this study with a sample size of 2,719. The results of a meta-analysis with a cross-sectional study showed that people living with HIV/AIDS with strong social support improved their quality of life (aOR= 2.82; 95% CI= 2.26 to 3.53; p <0.001).Conclusion: Strong social support can improve the quality of life for people with HIV / AIDS.Keywords: Quality of life, social support, people with HIV / AIDS, meta-analysisCorrespondence: Maria Regina Tri Yonita. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah, Indonesia. Email: mreginatry@gmail.comJournal of Epidemiology and Public Health (2020), 05(04): 435-441https://doi.org/10.26911/jepublichealth.2020.05.04.05]]>
