Mistakes during medical treatments are a rising concern in patient safety. Nurses are critical in ensuring the safe administration of drugs to patients, influenced by various factors. This literature review aims to identify factors influencing nurses in medication safety. The pieces of literature were sourced from the PubMed, Proquest, Science-Direct, and Willey Library electronic databases, with search terms of “risk factor or related factorâ€, “nurse or nurse role,†“medication errorâ€, “drug safetyâ€, “drug administrationâ€. The review process resulted in twenty-three original articles meeting the inclusion criteria. The review shows five main factors influencing a nurse’s role in medication safety which are; organization & management (training programs, career paths, medication error reporting systems, staffing, information systems), working environment (additional routines, official shifts, number of service days, interruptions during action, workloads), work, learning culture), team (leadership style, oral and written communication), nurse’s personal and work history (age, length of work, experience, education, knowledge and skills/competence, motivation and attitude, nurse awareness) and task (availability & use of protocol). Keywords: Nurse’s Role; Medication Errors; Patient Safety; Medication System