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All Journal Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Anesthesiology and Reanimation (IJAR) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology Journal of Global Pharma Technology
Rizka Fathoni Perdana
Department Of Otorhinolaryngology And Head-Neck Surgery, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya
Humanities Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Tropical and Infectious Disease

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NO ASSOCIATION OF RECURRENT RESPIRATORY PAPILLOMATOSIS AGGRESSIVENESS AND HUMAN PAPILLOMAVIRUS TYPE 6 AND 11 Rizka Fathoni Perdana; Sri Herawati; Bakti Suroso; Eduardus Bimo Aksono
Indonesian Journal of Tropical and Infectious Disease Vol. 6 No. 5 (2017)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.917 KB) | DOI: 10.20473/ijtid.v6i5.3705

Abstract

Recurrent Respiratory Papillomatosis (RRP) is the most common benign neoplasm of the larynx among children as a result of HPV infection mainly type 6 and 11. RRP is still considered as serious problem since papilloma in the airway can cause hoarseness and obstruction which later described as aggressive and non aggressive types. Patients underwent multiple surgeries to keep airway patency and in order to communicate vocally. Previous studies reported that HPV-11 was associated with a more aggressive disease course. This study aim is to determine the association of RRP aggressiveness with HPV-6 and 11. Papilloma specimens were taken from patients who underwent surgical treatment of RRP patients and subjected HPV typing. All 17 patients with completed data and epidemiologic questionaires were defined for their staging to disease severity. Informations in the database were analyzed to identity statistically significant relationship with HPV type and knowing the HPV type is to predict the disease course. 17 patients RRP (12 males and 5 females) with age at onset 3,15 + 2,28 years and age at diagnosis 3,81 + 2,51 years. Surgery was performed 2,71 ± 1,16 times per year and 9 patients treated more than 3 surgeries per year. 10 patients had distal papilloma and 11 patients had tracheotomy. Agrressive disease was show found in 14 patients among 17 patients. HPV-11 was detected in 10 patients, HPV-6 was detected in 7 patients. According to the statisitcal analysis (Chi square test), there is no relationship between HPV type and disease aggressiveness. HPV-6 and 11 are not the only cause that affect the aggressiveness of Recurrent Respiratory Papillomatosis.
Co-Authors Alfian nurfaizi Alfian Nurfaizi Annisa Maya Sabrina Bakti Suroso Chriscelia Valery So Chriscelia Valery So Eduardus Bimo Aksono Herupradoto Falerina, Rosa Hendra Kurnia Rakhma Hendra Kurnia Rakhma Mariza Fitriati Maulydia Muhammad Qodri Anantomo Nugroho, Puguh Setyo Nyilo Purnami Puji Utami Raka Ihsanulhaj Reyna Cesariyani Rahmadianti Rusuldi Sahudi Abdul Mujib Sri Herawati Sriati Sriati Sumarman Sumarman Thamrin, Husin Yoga Rahmadiyanto Yoga Rahmadiyanto Yoga Rahmadiyanto