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All Journal Paediatrica Indonesiana Jurnal Ilmu Faal Olahraga Indonesia
Dewi Irawati Soeria Santoso
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Ilmu Faal Olahraga Indonesia

 1 
PERAN LATIHAN FISIK DALAM PENANGANAN OBESITAS: AKSI IRISIN PADA PROSES PENCOKELATAN Dewi Irawati Soeria Santoso; Imelda Rosalyn Sianipar; Neng Tine Kartinah
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 3, No 1 (2020)
Publisher : PAIFORI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (890.616 KB) | DOI: 10.51671/jifo.v3i1.86

Abstract

In recent years, the prevalence of obesity continues to increase, leading to a public health problem. Therefore, the obesity problem needs serious attention and treatment approaches. Exercise is one of the treatment approach to combat obesity because exercise plays a role in beiging/browning process. Beiging is a differentiation process from white adipocyte to beige adipocyte, which has similar characteristics to brown adipocyte and is marked with an increase of UCP-1 expression. Irisin plays a role in increasing UCP-1 expression by activating p38 mitogen-activated protein kinase (MAPK) and extracellular-signal regulated kinase (ERK) signaling. Muscle contraction during exercise can activate PGC-1α, which leads to the synthesis of irisin. Exercise may increase irisin levels in skeletal muscle and consequently, play as a mediator of beiging process in adipose tissue.
Co-Authors Badriul Hegar Evita Karianni Bermanshah Ifran Imelda Rosalyn Sianipar Nadjib Advani Neng Tine Kartinah Almuktabar Rinawati Rohsiswatmo Saleha Sungkar Tetty Yuniarti Wresti Indriatmi Yvan Vandenplas