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All Journal Majalah Kedokteran Bandung Cermin Dunia Kedokteran
Andi Basuki Prima Birawa
Departemen Ilmu Penyakit Saraf Fakultas Kedokteran Universitas Padjadjaran
Health Professions Medicine & Pharmacology Public Health

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KORELASI KADAR 8-HYDROXY-2-DEOXYGUANOSINE (8-OHDG) SERUM DENGAN DERAJAT DEFISIT NEUROLOGIS PADA STROK ISKEMIK Liza, -; Parwati, Ida; Birawa, Andi Basuki Prima; Rachmayati, Sylvia
Majalah Kedokteran Bandung Vol 46, No 3 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.795 KB)

Abstract

Peningkatan stres oksidatif, sekresi radikal bebas pada strok iskemik dapat merusak inti sel neuron di otak. Peningkatan kadar 8-hydroxy-2-deoxyguanosine (8-OHdG) serum pada strok iskemik yang merupakan hasil interaksi radikal bebas dengan gugus C8 basa guanin menandakan kerusakan sel neuron otak yang tercermin pada penilaian defisit neurologis menggunakan skor The National Institutes of Health Stroke Scale (NIHSS). Tujuan penelitian ini untuk mengetahui korelasi kadar 8-OHdG serum dengan derajat defisit neurologis menggunakan skor NIHSS. Bentuk penelitian adalah observasional dengan desain penelitian potong lintang. Penelitian dilakukan di RSUP Dr. Hasan Sadikin Bandung pada bulan Agustus 2013 hingga Januari 2014. Subjek penderita stroke iskemik onset akut berdasarkan CT-scan. Analisis statistik menggunakan Uji Kruskal-Wallis, Uji korelasi rank Spearman?s. Sebanyak 72 subjek penelitian diperoleh median kadar 8-OHdG dalam serum dengan defisit neurologis ringan 3,9 ng/mL (3,3?12,0 ng/mL), sedang 23 ng/mL (8,0?51,0 ng/mL), berat 77,5 ng/mL (54,0-97,0 ng/mL). Korelasi kadar 8-OHdG serum dengan derajat defisit neurologis rs=0,912 (p<0,001). Simpulan, kadar 8-OHdG dalam serum pada stroke iskemik berkorelasi positif sangat kuat, dengan derajat defisit neurologis, hal ini dapat dipertimbangkan untuk digunakan pada keadaan ketidaksesuaian antara gambaran CT-scan dan klinis atau pada fasilitas kesehatan yang tidak mempunyai CT scan.Kata kunci: Defisit neurologis, stroke iskemik, 8-OHdG dalam serum Correlation between Serum 8-Hydroxy-2-Deoxyguanosine (8-OHdG) and Neurological Deficits in Ischemic Stroke Increased oxidative stress and free radicals can cause neuron cell damage. Serum 8-hydroxy-2-deoxyguanosine (8-OHdG) concentration is the result of free radical interactions with cluster C8 guanine bases, which is used to assess the degree of neuron cells damage and the oxidative stress levels. Increased serum 8-OHdG concentration indicating brain cells damage is reflected in neurological deficits based on the The National Institutes of Health Stroke Scale (NIHSS). The aim of this study was to determine the correlation between serum  8-OHdG concentration and the degree of neurological deficit by NIHSS. This was an observational cross-sectional study. Seventy-two patients with acute ischemic stroke who visited Dr. Hasan Sadikin General Hospital Bandung during the period of August 2013 to January 2014 were enrolled. Statistical analysis was performed using Kruskal-Wallis test and rank Spearman?s correlation test. The mild neurological deficit median serum 8-OHdG concentrations was 3.9 ng/mL (3.3?12.0 ng/mL), moderate was 23 ng/mL (8.0?51.0 ng/mL), and severe was 77.5 ng/mL (54.0?97.0 ng/mL). Correlation of serum 8-OHdG concentration with neurological deficits in acute ischemic stroke rs=0.912 (p<0.001). In conclusion, serum 8-OHdG have a strong meaningful positive correlation with neurological deficits. Serum 8-OHdG concentration may be considered to be use in the assessment of discrepancy between CT scan and clinical symptoms and in health facilities with no CT scan facility.Key words: Ischemic stroke, neurological deficits, serum 8-OHdG DOI: 10.15395/mkb.v46n3.313
Stroke pada Usia Muda Birawa, Andi Basuki Prima; Amalia, Lisda
Cermin Dunia Kedokteran Vol 42, No 10 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.878 KB) | DOI: 10.55175/cdk.v42i10.955

Abstract

Hampir 10% stroke terjadi pada usia relatif muda (kurang dari 45 tahun). Angka kejadian stroke pada usia di bawah 45 tahun diperkirakan 7 – 15 kasus/100.000 penduduk/tahun dan lebih jarang pada kelompok anak-anak, yaitu 1 – 8 kasus/100.000/tahun. Faktor risiko terjadinya stroke pada usia muda berbeda-beda, antara lain: (1) Migren, (2) Sickle-cell disease, (3) Penyakit jantung, (4) Abnormalitas pembuluh darah serebral, (5) Focal cerebral arteriopathy of childhood (FCA), (6) Ensefalopati pasca-varisela, (7) Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS), (8) Diseksi arteri, (9) Penyalahgunaan obat, (10) Vaskulitis serebral seperti arteritis temporal, arteritis Takayasu, polyarteritis nodosa (PAN), Wegener’s granulomatosis, (11) Systemic lupus erythematosus (SLE), (12) Cerebral autosomal dominant arteropathy with subcortical infarcts
and leucoencephalopathy (CADASIL), (13) Fabry’s disease, dan (14) Trombofilia. Khusus pada wanita usia muda, beberapa faktor risiko lainnya antara lain: (1) Penggunaan kontrasepsi oral terutama pada wanita perokok, migren dengan aura, dan hipertensi; (2) Kehamilan, terutama jika terdapat preeklampsi, eklampsi, dan sindrom HELLP (hemolysis, elevated liver enzymes, and low platelets). Stroke pada usia muda memiliki karakteristik tersendiri, sehingga membutuhkan pendekatan yang berbeda. Faktor risiko perlu diidentifikasi untuk penatalaksanaan dan pencegahan terjadinya stroke berulang. Penelitian berbasis populasi dengan metodologi yang baik penting untuk lebih mengetahui besaran masalah stroke pada usia muda.Nearly 10 % strokes occur at a relatively young age (less than 45 years old). The incidence of stroke in under 45 year-old is between 7-15 cases/100,000 persons/year and 1-8 cases /100,000/year in children. Disorders or diseases related or suspected as risk factors are: (1) Migraine, (2) Sickle - cell disease, (3) Heart disease, (4) Cerebral blood vessels abnormality,
Co-Authors - Liza Ida Parwati Lisda Amalia Sylvia Rachmayati