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All Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) CARADDE: Jurnal Pengabdian Kepada Masyarakat INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Medicra (Journal of Medical Laboratory Science/Technology) Prosiding Seminar Nasional Pengabdian Kepada Masyarakat
Adyan Donastin
Department Of Medicine, Faculty Of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Mathematics Nursing Public Health Social Sciences

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POTENSI SENYAWA BIOAKTIF TANAMAN KELOR PENGHAMBAT INTERAKSI ANGIOTENSIN-CONVERTING ENZYME 2 PADA SINDROMA SARS-COV-2 Maharani Pertiwi Koentjoro; Adyan Donastin; Endry Nugroho Prasetyo
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 7 No. 2 (2020): December 2020
Publisher : Balai Bioteknologi, Badan Pengkajian dan Penerapan Teknologi (BPPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (798.499 KB) | DOI: 10.29122/jbbi.v7i2.4156

Abstract

The Potential of Moringa oleifera Bioactive Compounds for Inhibiting Angiotensin-Converting Enzyme 2 Interaction in SARS-Cov-2 Syndrome Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19) is a threat to human health. This infection is determined by the interaction of the spike S1 domain protein with angiotensin-converting enzyme 2 (ACE2) in the epithelial cells of the respiratory tract, especially the lungs. ACE2 inhibition is an important target in controlling COVID-19. Flavonoids of medicinal plants, are known to interfere with ACE (ACE2 homologous). Therefore, this study aims to explore the ability of apiin, epicatechin, and hesperetin from Moringa oleifera in interacting with the ACE2 using MOE 2008.10. The ligand molecules were prepared from PubChem database. The ACE2 protein was retrieved from Protein Data Bank (ID 1R4L) and analyzed for the active sites. Analysis of docking scores and hydrogen bonds of ACE2-ligand complex and active site showed that the affinity of flavonoids can be ranked as hesperetin > epicatechin > apiin > C19H23Cl2N3O4. The results provided computational information that apiin, epicatechin, and hesperetin have the potential to prevent COVID-19 infection. The prediction of activity spectra for substances (PASS) score showed the ligand displays antiviral activity. Infeksi severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pada pandemi coronavirus disease 2019 (COVID-19) menjadi ancaman dunia kesehatan saat ini. Infeksi SARS-CoV-2 ditentukan oleh interaksi protein spike envelope S1 domain dengan reseptor angiotensin-converting enzyme 2 (ACE2) yang diekspresikan pada sel epitel saluran pernafasan terutama paru-paru. Mekanisme penghambatan ACE2 menjadi target penting dalam pengendalian COVID-19. Senyawa bioaktif tanaman obat, seperti flavonoid diketahui mampu mengganggu fungsi banyak makromolekul termasuk ACE (homolog dengan ACE2). Penelitian ini bertujuan mengeksplorasi kemampuan senyawa apiin, epicatechin, dan hesperetin dari Moringa oleifera dalam berinteraksi dengan sisi aktif ACE2 menggunakan metode penambatan molekul. Studi dilakukan dengan preparasi struktur molekul ligan dari PubChem database dan diolah dengan MOE 2008.10. Selanjutnya, data protein ACE2 (Protein Data Bank ID 1R4L) dianalisis sisi aktifnya untuk mengetahui lokasi penambatan ligan senyawa. Analisis skor docking dan ikatan hydrogen komplek ligan dan sisi aktif ACE2 menunjukkan bahwa afinitas flavonoid dapat diperingkatkan sebagai afinitas hesperetin > epicatechin > apiin > C19H23Cl2N3O4. Ketiga ligan senyawa yang terkandung dalam M. oleifera secara in silico mampu mengikat sisi aktif ACE2, sehingga berpotensi mencegah infeksi COVID-19. Skor PASS (prediction of activity spectra for substances) menunjukkan aktivitas biologis ligan yang menyerupai antiviral.
MICROBIAL PATTERN OF DIABETIC FOOT ULCER PATIENT IN JEMURSARI ISLAMIC HOSPITAL SURABAYA PERIOD 2012-2016 Adyan Donastin; Aisyah Aisyah
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 1 No 1 (2019): The Value, Importance, and Oversight of Health Research
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v1i1.914

Abstract

Diabetic foot ulcers (DFU) are complications in people with diabetes mellitus (DM) in the form of wounds or tissue damage resulting in vascular insufficiency and or neuropathy that can develop into an infection. Early detection of germs of diabetic foot ulcers may be used as a recommendation of empirical therapy before the definitive treatment based on culture results and appropriate antibiotics treatment, which may reduce hospitalization time and amputation events. According to Riskesdas in 2013, state that the number of antibiotic used without prescriptions in Indonesia about 86.1%. The study aims to retrospectively analyze the bacterial culture and drug susceptibility test results for patients with diabetic foot ulcers (DFU) in Jemursari Islamic Hospital Surabaya during 2012–2016 to help clinicians choose a more appropriate empirical antibiotic treatment for DFU. This study used cross–sectional designed with retrospective approaches, which analyzed descriptively and samples were taken by the total sampling of 11 samples. This research was conducted at Islamic Hospital of Jemursari Surabaya in May–September 2017 by using medical record data which are outpatient and inpatients who treatment at Jemursari Islamic Hospital. The result was found 6 types of bacteria consisting of Staphylococcus aureus (18%), Staphylococcus non–haemolytic (18%), Klebsiella pneumonia (27%), Enterobacter aerogenes (18%), Burkholderia cepacia (9%), Escheria coli (9%). The most sensitive antibiotics in the Gram–positive bacteria in this study are Amikacin, Teicoplanin and Oxacillin and the most resistant to Amoxicillin and Ampicillin whereas the most sensitive antibiotics in the Gram–negative bacteria in this study were Meropenem and the most resistant to Ciprofloxacin and Trimethroprim–sulfamethoxazole.
Workshop Online: Prosedur Analisis Multidrug-Resistance Tuberculosis (MDR-TB) dengan Teknik Sekuensing Bagi Guru SD, SMP dan SMA Maharani Pertiwi Koentjoro; Bagas Dewantara Pratama Putra; Adyan Donastin; Endry Nugroho Prasetyo
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 3 (2021): April
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v3i3.850

Abstract

Teachers and students have difficulties in studying cell molecular in Cell Biology, Genetics, and Microbiology subjects. This difficulty is due to the molecular nature of the cell is something abstract and the learning media does not support the delivery of material. Therefore, in this community service activity, Laboratory Procedure Training in Analyzing Molecular Multidrug-Resistance Tuberculosis (MDR-TB) with Sequencing Techniques for Health Sector Teachers aims to provide teachers with understanding and skills regarding laboratory procedures in analyzing molecular MDR-TB with techniques sequencing. Activities are divided into 3 stages. Stage I is a pre-test to determine the teacher's ability to analyze DNA. Phase II is the online training stage, which is divided into 3 meetings, where the first meeting is the delivery of DNA material, the second meeting is about laboratory procedures in DNA isolation, and the third meeting is bioinformatics techniques in DNA analysis. Stage III is a post-test, to find out whether the material and skills presented are acceptable to the participants or not. Based on the results of the evaluation through a questionnaire distributed to the participants at the end of the event, it can be concluded that around 76.1% of participants were satisfied with the workshop provided, as many as 50% were able to carry out the assignment to make poster teaching media, and 65.2% of participants were satisfied with the workshop method used.
Predictive Analysis of NLR, Absolute Lymphocyte Count, and CT-Value on The Severity of Covid-19 Patients Bastiana; Adyan Donastin; Devi Maya Arista; Prima Ardiansah Surya
Medicra (Journal of Medical Laboratory Science/Technology) Vol 5 No 1 (2022): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v5i1.1625

Abstract

Laboratory parameters in Covid-19 patients may have a relationship with the clinical severity of the patient on arrival. This study aims to Analyzing the relationship between NLR, ALC, and CT values with the clinical severity of Covid-19 patients on arrival. A total of 101 subjects were collected from medical records of RSI Jemursari Surabaya from April to September 2020. The correlation laboratory parameters (NLR, ALC, and CT-value) with the severity of Covid-19 patients (mild, moderate, severe and critical) were analyzed using One Way Anova and Kruskal Wallis. The relationship of NLR with severity (p-value=0.143), ALC with severity (p-value=0.165), and CT-value with severity (p-value= 0.987). Patients with COVID-19 tend to have a high NLR in all clinical conditions. The mean value of the ALC was within normal limits for all degrees of severity. There is no significant relationship between NLR, ALC, CT-value with the severity of Covid-19 patients.
Edukasi Kesehatan Paru - Paru Bagi Mahasiswa SMAS di Pulau Poteran, Sumenep Adyan Donastin; Maharani Pertiwi Koentjoro; Bunga An Nur Rahmillah Almah; Ayu Slatim Maifanda; Elyk Dwi Mumpuningtias; Endry Nugroho Prasetyo
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT UNIVERSITAS NAHDLATUL ULAMA SURABAYA Vol. 1 No. 1 (2022): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Perguruan Tinggi Meng
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1074.146 KB) | DOI: 10.33086/snpm.v1i1.831

Abstract

Sekolah merupakan lembaga pendidikan formal dimana terjadi proses belajar mengajar yang bertujuan untuk membentuk perilaku dan watak bagi peserta didik. Salah satu pendidikan yang penting diajarkan di sekolah adalah pendidikan kesehatan. Pendidikan ini meliputi pembelajaran terkait perilaku yang meningkatkan taraf kesehatan. Pendidikan kesehatan ini perlu diberikan sedini mungkin agar siswa dapat memiliki perilaku sehat, menerapkan perilaku tersebut di lingkungan rumah dan berperan aktif dalam mewujudlan derajat kesehatan yang optimal di lingkungan sekitarnya. Untuk meningkatkan pengetahuan dan kesadaran menjaga kesehatan paru-paru di masa pandemi ini, maka pencegahan dan penatalaksanaan sesuai dengan panduan kesehatan harus dapat dipahami oleh semua orang. Metode yang digunakan adalah observasi dengan melakukan wawancara dan kegiatan diakhiri dengan pemberian sosialisasi dan diskusi mengenai cara menjaga Kesehatan paru – paru yang bertujuan untuk memberikan pengetahuan mengenaipencegahan dan penatalaksanaan kesehatan paru-paru. Sasaran dari pengabdian masyarakat ini adalah siswa-siswi dan guru pendamping di SMAS Sayyid Yusuf yang merupakan salah satu Sekolah Menengah Atas di Pulau Poteran, Kabupaten Sumenep. Hasil kegiatan ini menunjukkan sebanyak 20 peserta memiliki peningkatan mengenai pemahaman mengenai Kesehatan paru sebesar 50%. Pemahaman ini diukur melalui pre-test dan post-test. Semya peserta memiliki animo yang baik dalam proses pembelajaran danmengikuti kegiatan dari awal sampai akhir. Oleh karena itu, dapat disimpulkan bahwasanya kegiatan ini penting untuk mengedukasi siswa agar dapat membawa ilmu dan pengetahuan ke lingkungan tempat tinggal untuk mengurangi angka kejadian penyakit paru-paru.
Co-Authors Aisyah Aisyah Ayu Slatim Maifanda Bagas Dewantara Pratama Putra Bastiana Bermawi Bunga An Nur Rahmillah Almah Devi Maya Arista Elyk Dwi Mumpuningtias Endry Nugroho Prasetyo Maharani Pertiwi Koentjoro Maharani Pertiwi Koentjoro Maharani Pertiwi Koentjoro Prima Ardiansah Surya Setyo Nugroho