Article Per Year (5 Year)
p-Index From 2019 - 2024
0.61
P-Index
This Author published in this journals
All Journal Jurnal Saintika Medika Sainteks Herb-Medicine Journal International Journal of Nasopharyngeal Carcinoma Psycho Idea
Oke Kadarullah
Universitas Muhammadiyah Purwokerto
Religion Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

Published : 8 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : International Journal of Nasopharyngeal Carcinoma

 1 
ADVANCED NASOPHARYNGEAL CARCINOMA WITH NASAL POLYP: A MISDIAGNOSED CASE Oke Kadarullah
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 1 No. 03 (2019): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v1i03.2042

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) commonly misdiagnosed in early stage, because of it’s multiple nonspesific sign and symptoms also because of the difficult anatomic site. Especially if there is a comorbid in the area around the nasopharynx, most likely will end up with missdiagnosis. So the mortality rate are still high due to advanced stage incidence. Case report: Reported a 58 years male with history of recurrent nasal bleeding since 6 months ago accompanied by hearing problem and also ear fullnes since 11 months ago. There also a severe headache since 4 months ago and a left neck mass arised within 2 months approximately 6 cm in dimension. In nasopharyngocopy found a gelatinous mass at right nasal cavity and nasopharyngeal mass extend to both nasal cavity. The biopsy results are polip nasi Hellquist Type I and Nonkeratinizing Carcinoma Undifferentiated type. CT showed the nasopharyngeal mass has extend intracranially. Patient’s management were planned to polypectomy and chemoiiradiation. Despite of the tumor was radiosensitive, the prognosis and the survival rate are low because the patient came at stage IV. Conclusion: Educating the society, health workers and hospital staff is a critical step for controlling NPC at early stage
Probability of Anti PDGF/R as Antiangiogenic Nasopharyngeal Carcinoma: A Review Oke Kadarullah
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 04 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i04.4892

Abstract

Introduction: Nasopharyngeal Carcinoma (NPC) is frequently found in Southeast Asia, especially in Indonesia, with a higher incidence rate compared to global numbers. The mortality rate of NPC in Indonesia is also higher than the standardized mortality rate. Radiotherapy and chemotherapy are the first line treatment, but still has 5 – 10% chance of recurrence. NPC is mostly persistence and recurrence, and this itself is a challenge in achieving effective treatment. Patients in Indonesia commonly search for treatment at an advanced stage. Review: Advanced stage NPC requires an additional combination therapy such as chemotherapy and targeted therapy. Targeted therapy in the past 10 years have not shown a significant improvement in recurrent NPC. Cetuximab is the empiric choice for head and neck squamous cell carcinoma. EGFR and VEGFR are target molecules tyrosine kinase, including PDGF/R, which plays a role in angiogenesis and cancer progressivity. PDGF and its receptors shows an important role in certain cancers including head and neck cancer. PDGF/R in NPC has been researched in vitro and in vivo but more clinical data is still needed. Conclusion: The role of PDGF/PDGFR in targeted therapy development is still being used. This is to push the anti angiogenic combination strategy as an option for NPC with radio-chemotherapy resistance, or for stable, progressive and recurrent NPC while considering its unwanted effects.
Co-Authors Abdul Hakim Ani Setiyowati Anis Kusumawati Arumita Puspa Hapsari Fatimah Qonitah Diyanah M Nurrizki Haitamy Nurrizki Haitamy Refni Riyanto Susiyadi Yunia Annisa