Musyarrafah Musyarrafah
Fakultas Kedokteran Universitas Islam Al-Azhar

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Pengaruh Susu Kuda Liar Sumbawa Terhadap Kadar TNF-a pada Tikus Gastritis yang Diinduksi Indometasin Musyarrafah Musyarrafah; Halia Wanadiatri; Putu Demas Ardina Merta; I Gede Angga Adnyana; Rozikin Rozikin; Metha Luktiana
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 4: December 2021
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v6i4.1031

Abstract

Gastritis is an inflammatory, irritating, or erosive condition that affects the mucosa submucosa of the stomach. Uncontrolled use of NSAIDs for a long time can cause excess stomach acid that will lead injury to the gastric lumen which results in the immune system release of pro-inflammatory factors, one of which is TNF-a. This study aims to determine the effect of Sumbawa’s mare milk (SMM) on TNF-a Levels in Wistar Rats with Indomethacin-induced gastritis. This study used 24 male Wistar rats which were divided into 4 treatment groups, namely negative control group (group 1), positive control group (group 2), SMM treatment group + Indomethacin (group 3), and SMM treatment group (group  4). Treatment was given for 14 days analyzed using an ELISA reader. Group 3 showed the highest levels of TNF-a (median=52.36). While group 4 got the lowest TNF-a level (median=24.49). In the control group, TNF-a levels were higher in group 1(median=35.14) than in group 2 (median=30.14). Results showed that SMM had a significant effect on TNF-a levels (p less than 0.05). Effects that can be given vary, either decreasing or increasing TNF-a depending on the conditions in the tissue. SMM has the potential not only as a preventive treatment but also as a curative treatment.Abstrak: Gastritis adalah kondisi inflamasi, iritasi, maupun erosif yang mengenai daerah mukosa dan submukosa lambung. Pemakaian NSAID yang tidak terkontrol dalam waktu lama dapat mengakibatkan asam lambung berlebih sehingga mukosa lambung terkikis. Perlukaan pada lumen lambung akan membuat sistem imun mengeluarkan faktor proinflamasi, salah satunya adalah TNF-a, sehingga terjadi gastritis. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kuda liar Sumbawa terhadap kadar TNF-a pada Tikus Gastritis yang diinduksi Indometasin. Penelitian ini menggunakan 24 ekor tikus jantan galur Wistar yang dibagi menjadi 4 kelompok perlakuan yaitu kelompok kontrol negatif (kelompok 1), kelompok kontrol positif (kelompok 2), kelompok perlakuan SKL (Susu Kuda Liar) Sumbawa + Indometasin (kelompok 3), dan kelompok perlakuan SKL (kelompok 4). Perlakuan diberikan selama 14 hari dan dilakukan analisis menggunakan ELISA-reader. Kelompok 3 menunjukkan kadar TNF-a tertinggi (median=52,36). Sedangkan kelompok 4 mendapatkan kadar TNF-a terendah (median=24,49). Pada kelompok kontrol, kadar TNF-a lebih tinggi pada kelompok 1 (median=35,14) dibandingkan dengan kelompok 2 (median=39,74). Hasil penelitian menunjukkan bahwa susu kuda liar Sumbawa berpengaruh terhadap kadar TNF-a secara signifikan (p kurang dari 0,05). Pengaruh yang dapat diberikan beragam, baik menurunkan maupun meningkatkan kadar TNF-a tergantung dengan kondisi di jaringan tersebut. SKL Sumbawa tidak hanya berpotensi sebagai pengobatan preventif namun juga sebagai pengobatan kuratif.
HUBUNGAN INDEKS MASSA TUBUH DAN RIWAYAT KELUARGA DENGAN KEJADIAN DIABETES MELLITUS TIPE 2 DI DAERAH PESISIR KOTA KENDARI Ti en; Musyarrafah Musyarrafah; Andi Noor Kholidha; Pranita Aritrina; Ikhlasul Amal Abdal; Arimas wati
JURNAL KEDOKTERAN Vol 4 No 2 (2019)
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.195 KB) | DOI: 10.36679/kedokteran.v4i2.100

Abstract

Background: Diabetes Mellitus is a metabolic disease characterized by chronic hiperglikemia and caused by the impairment of insulin secretion or insulin resistance or both. There are some risk factors in the process. They are obesity, lack of activity, nutritional deficiency, family history of diabetes, history of gestational diabetes, old age, and genetic. Research Purpose: This research purpose is to understand the relationship between risk factors including obesity and family history with the incident of type-2 DM in coastal area of Kendari. Research Methods: This research used analytical-observational study with case control approach. The independent variables used in this research are Body Mass Index (BMI) and family history while the the dependent variables are the incident of type-2 DM. The location of this research is working area of Puskesmas Mata, Puskesmas Benu-benua, Puskesmas Kandai, Puskesmas Abeli and Puskesmas Poasia located in the coastal area. There are 75 people choosen to be our samples by include and exclude criteria with cluster sampling method. Data are obtained by using questionnaire and laboratory analysis. The results are processed by applying Chi-Square test with p<0,050 and the Odd Ratio score. Research Result: This research showed that between BMI with the incident of type-2 DM has p=0,000 (OR=7,875), between family history with the incident of type-2 DM has p=0,030 (OR=2,800), between BMI and family history with the incident of type-2 DM has p=0,000 (OR=14,571). Conclusion: The conclusion of this research was that the relationship between BMI with the incident of type-2 DM in the coastal area of Kendari exists. The relationship between family history with the incident of type-2 DM in the coastal area of Kendari exists. The relationship between BMI and family history with the incident of type-2 DM in the coastal area of Kendari exists.
Pengaruh Susu Kuda Liar Sumbawa Terhadap Kadar TNF-a pada Tikus Gastritis yang Diinduksi Indometasin Musyarrafah Musyarrafah; Halia Wanadiatri; Putu Demas Ardina Merta; I Gede Angga Adnyana; Rozikin Rozikin; Metha Luktiana
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 4: December 2021
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v6i4.1031

Abstract

Gastritis is an inflammatory, irritating, or erosive condition that affects the mucosa submucosa of the stomach. Uncontrolled use of NSAIDs for a long time can cause excess stomach acid that will lead injury to the gastric lumen which results in the immune system release of pro-inflammatory factors, one of which is TNF-a. This study aims to determine the effect of Sumbawa’s mare milk (SMM) on TNF-a Levels in Wistar Rats with Indomethacin-induced gastritis. This study used 24 male Wistar rats which were divided into 4 treatment groups, namely negative control group (group 1), positive control group (group 2), SMM treatment group + Indomethacin (group 3), and SMM treatment group (group  4). Treatment was given for 14 days analyzed using an ELISA reader. Group 3 showed the highest levels of TNF-a (median=52.36). While group 4 got the lowest TNF-a level (median=24.49). In the control group, TNF-a levels were higher in group 1(median=35.14) than in group 2 (median=30.14). Results showed that SMM had a significant effect on TNF-a levels (p less than 0.05). Effects that can be given vary, either decreasing or increasing TNF-a depending on the conditions in the tissue. SMM has the potential not only as a preventive treatment but also as a curative treatment.Abstrak: Gastritis adalah kondisi inflamasi, iritasi, maupun erosif yang mengenai daerah mukosa dan submukosa lambung. Pemakaian NSAID yang tidak terkontrol dalam waktu lama dapat mengakibatkan asam lambung berlebih sehingga mukosa lambung terkikis. Perlukaan pada lumen lambung akan membuat sistem imun mengeluarkan faktor proinflamasi, salah satunya adalah TNF-a, sehingga terjadi gastritis. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kuda liar Sumbawa terhadap kadar TNF-a pada Tikus Gastritis yang diinduksi Indometasin. Penelitian ini menggunakan 24 ekor tikus jantan galur Wistar yang dibagi menjadi 4 kelompok perlakuan yaitu kelompok kontrol negatif (kelompok 1), kelompok kontrol positif (kelompok 2), kelompok perlakuan SKL (Susu Kuda Liar) Sumbawa + Indometasin (kelompok 3), dan kelompok perlakuan SKL (kelompok 4). Perlakuan diberikan selama 14 hari dan dilakukan analisis menggunakan ELISA-reader. Kelompok 3 menunjukkan kadar TNF-a tertinggi (median=52,36). Sedangkan kelompok 4 mendapatkan kadar TNF-a terendah (median=24,49). Pada kelompok kontrol, kadar TNF-a lebih tinggi pada kelompok 1 (median=35,14) dibandingkan dengan kelompok 2 (median=39,74). Hasil penelitian menunjukkan bahwa susu kuda liar Sumbawa berpengaruh terhadap kadar TNF-a secara signifikan (p kurang dari 0,05). Pengaruh yang dapat diberikan beragam, baik menurunkan maupun meningkatkan kadar TNF-a tergantung dengan kondisi di jaringan tersebut. SKL Sumbawa tidak hanya berpotensi sebagai pengobatan preventif namun juga sebagai pengobatan kuratif.