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All Journal Jurnal Ilmiah Farmasi INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA DWIJA CENDEKIA: Jurnal Riset Pedagogik Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Journal of Chemistry JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal PKM Agri Hatantiring Journal of Electrical Engineering, Energy, and Information Technology (ETTLI)
Arief Rahman Hakim
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Social Sciences Other

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Efek Penghambatan Terhadap Pertumbuhan Tumor Paru dan Uji Ketoksikan Akut Ekstrak Kapsul Chang Sheuw Tian Ran Ling Yao Pada Mencit (Mus musculus) dan Tikus (Ratus tanezumi) Fudholi, Ahmad; Meiyanto, Edy; Donatus, Imono Argo; Nurrochmad, Arief; Hakim, Arief Rahman; Murwanti, Retno
JURNAL BIOLOGI INDONESIA Vol 5, No 1 (2008): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.692 KB) | DOI: 10.14203/jbi.v5i1.3202

Abstract

Inhibitory Phases Effect of The Lung Cancer And Acute Toxicity of Chang Sheuw Tian RanLing Yao Capsule Extracts in House mice (Mus musculus) and Rat (Ratus tanezumi). Effortsto find anticancer agents have been developed nowadays, some of them are focused in traditionalherbs. One of the available products in the market that claims effective to cure cancer isthe Chang Sheuw Tian Ran Ling Yao, PT. Daun Teratai extract containing CAPSULE (CSTRLYextract). The aim of this study is to examine of confession of some people which are usingthe useful of medicine CSTRLY extract capsule through inhibitor laboratory effect of theCSTRLY extract in the initiation and post initiation phases of the lung cancer in mice and ratsthat had been induced by eather Benzo[?]pyrene (BP) or Dimetilbenz[?]antrazene (DMBA)and to clarify the potency of acute toxicity and specific toxic manifestations of thephytopharmaca.The results showed that the CSTRLY extract can reduce the cancer incidence caused bycarcinogen, BP and DMBA. Moreover, the extract can also inhibit the cancer growth in themice and rats, especially in the early post-initiation phase. Further, the histopathologicalevaluation showed that up to the highest dose level that technically could be administrated tothe animals (12500 mg/kg bw), no animal death was occurred. Furthermore, the ADG values formale and female rats indicated no significant different (P > 0.05) that relative to the controlgroup. No animals were shows physical symptom as a toxic manifestation. It’s indicated thatthe phytopharmaca no influenced to somatomotor and nervous system. Within the dose rangeadministrations, no detectable morphological toxic effects or histophatological changes of theliver, spleen, heart, and lungs were observed. the acute toxicity value of Chang Sheuw TianRan Ling Yao Capsule was very low (or minimal almost non-toxic with LD50 > 12500 mg/kg bw)and the spectrum of toxic effects of the phytopharmaca were considered negligible.Key words: Ekstract, CSTRLY, mice and rat, BP, DMBA, carsinogenesis, lung cancer
SYNTHESIS AND ANALGETIC ACTIVITY EVALUATION OF 4-[N-(4-HYDROXYPHENYL)CARBOXYMIDOYL]-2-METHOXYPHENOL Pudjono, Pudjono; Anindita, Jessica; Hakim, Arief Rahman; Purnomo, Hari
INDONESIAN JOURNAL OF PHARMACY Vol 27 No 2, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (627.434 KB) | DOI: 10.14499/indonesianjpharm27iss2pp99

Abstract

Paracetamol is an analgesic-antipyretic compound derived from p-aminophenol. Though paracetamol has good efficacy and safety on consumption, parasetamol has hepatotoxic effect as its     adverse drug reaction. 4-[N-(4-hydroxyphenyl)carboxymidoyl]-2-methoxyphenol is one of p-aminophenol derivative that was already been determined in silico using molecular docking PLANTS method, and it was known that 4-[N-(4-hydroxyphenyl) carboxymidoyl]-2-methoxyphenol has analgesic effects more potent and has hepatotoxic adverse effect lower than paracetamol. 4-[N-(4-hydroxyphenyl)carboxymidoyl]-2-methoxy-phenol can be synthesized through reaction of p-aminophenol with vanillin under acid condition. The synthesized products were recrytalized, dried, and the purity was determined with melting point determination and Thin Layer Chromatography. The structure of pure crystals were elucidated using IR, 1H-NMR, C-NMR, and Mass Spectroscopy. The analgesic evaluation was carried in vivo using writhing test method. The synthesized compound were divided into three dosage variations, 0,5; 1; and 2 mol equivalent to 100 mg/kgBB of paracetamol (reference drug). 4-[N-(4-hydroxyphenyl)carboxymidoyl]-2-methoxyphenol with 1 mol dosage has analgesic activity better than paracetamol but the difference was not significant.Keywords: 4-[N-(4-hydroxyphenyl)carboxymidoyl]-2-methoxyphenol, p-aminophenol, analgesic, writhing test
PENGARUH PRAPERLAKUAN BROKOLI (Brassica oleracea L. var. botrytis L.) TERHADAP FARMAKOKINETIKA RIFAMPISIN PADA TIKUS Wahyono, Djoko; Hakim, Arief Rahman
Jurnal Farmasi Indonesia Vol 3, No 1 (2006)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v3i1.69

Abstract

The research was aimed to observe broccoli (Brassica oleracea L. var. botrytis L.) activities to rifampicin pharmacokinetics in rats. The study was conducted using female Sprague Dawley rats which were divided  into 3 groups (6 rats for each group). The groups were given a single oral rifampicin 50,4 mg/kg BW as a control group and were confered multiple doses oral (once daily for seven days) (P-I) and single dose oral oral (P-II) broccoli 23,43 g/kg BW before treatment with rifampicin. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged rifampicin in blood. From the concentration of rifampicin vs time data  was determined rifampicin pharmacokinetics parameters i.e. Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2 elimination, ClT and K. The results have shown that the pharmacokinetics values of rifampicin in the animals prefed with broccoli 23,43 mg/kg bw 1 hours prior to single oral administration of the drug did not change significantly (P>0,10). Prefeeding the animals with broccoli 23,43 g/kg bw once daily for 7 consecutive days has increased the total clearance of rifampicin 46,90% (P<0,10). The increase in the total clearance rifampicin due to the compound has decreased Cmaks 36,54% (P<0,10). ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh pemberian praperlakuan brokoli (Brassica oleracea L. var. botrytis L.) terhadap farmakokinetika rifampisin pada tikus. Penelitian menggunakan tikus putih betina galur Sprague Dawley yang dibagi menjadi 3 kelompok masing-masing terdiri dari 6 ekor hewan. Kelompok I (kontrol) diberikan  rifampisin secara oral dosis 50,4 mg/kg BB,   kelompok II dan III (perlakuan) diberikan brokoli secara oral dosis 23,43 g/kg BB sekali sehari selama 7 hari (P-I) dan 1 jam sebelum (P-II) diberikan rifampisin dengan dosis yang sama seperti kelompok I. Setelah seluruh hewan mendapatkan perlakuan, pada jam-jam ke- 0,25; 0,5; 1; 1,5; 2;  3; 4; 6; 8; 10; 12, dan 24  diambil cuplikan darah (0,2 ml) dari vena lateralis ekor, guna penetapan kadar rifampisin utuh secara HPLC. Kadar rifampisin utuh dalam darah dihitung berdasarkan kurva baku. Harga-harga parameter farmakokinetika rifampisin (Ka, Cmaks, tmaks, AUC0-~, Vdss, t1/2, ClT dan K) dihitung berdasarkan data kadar rifampisin utuh dalam darah terhadap waktu. Hasil penelitian menunjukkan praperlakuan brokoli satu jam sebelum pemberian rifampisin tidak mempengaruhi farmakokinetika rifampisin (P>0,10), namun pemberian brokoli sekali sehari selama 7 hari sebelum pemberian rifampisin mampu meningkatkan ClT rifampisin sebesar 46,90% (P<0,10). Akibat kenaikan ClT rifampisin tersebut, harga Cmaks mengalami penurunan sebesar 36,54% (P<0,10).
VALIDASI METODE PENETAPAN KADAR PENTAGAMAVUNON-1 DALAM DARAH SECARA KROMATOGRAFI CAIR KINERJA TINGGI Ningrum, Anita Dwi Juwita; Astini, Siluh Made Yuni; Hakim, Arief Rahman
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.20

Abstract

Pentagamavunon-1 (PGV-1) is curcuminâ??s analogue that reported as analgesic, antioxidant, antiinflamatory, and has antiproliferation activity to breast cancer. The aim of this study is to develop and validate the method for determinating PGV-1â??s concentration in blood by reverse phase HPLC. Analytical method validation include system suitability test, determination of LOD and LOQ, linearity test, accuracy and precisionâ??s determination, stability test of PGV-1 in blood and acetonitrile. Concentration of PGV-1 in blood is measured by HPLC using LiChrosphere® 100 Cartridge RP C18 (125 x 4 mm i.d., 5 μm), mixed mobile phase methanol : buffer acetate 0,05 M pH 3,7 (80:20 v/v), flow rate 0,5 ml/minute, detector Vis-416 nm, and injection volume 80 μl. System suitability tests suggest that separation condition is suitable to analyze PGV-1â??s concentration in blood. The recomended method up to standard selectivity, linearity (corelation coefficient = 0,9999), accuracy, and precision. Value of LOD and LOQ is 4,93 ng/ml and 16,42 ng/ml, respectively. PGV-1 in blood is stable for the first hour. In acetonitrile at room temperature, PGV-1 is stable for 3 hours while storage at 5°C, PGV-1 is stable for 3 days. Therefore, the recomended analytic method is applicable to determine PGV-1â??s concentration in blood. ABSTRAK Pentagamavunon-1 (PGV-1) merupakan analog kurkumin yang telah terbukti berkhasiat sebagai antioksidan, antiinflamasi, dan mempunyai aktivitas antiproliferasi terhadap sel kanker payudara. Penelitian ini bertujuan untuk mengembangkan dan memvalidasi metode penetapan kadar PGV-1 dalam darah secara KCKT fase terbalik. Validasi metode analisis meliputi uji kesesuaian sistem, penentuan LOD dan LOQ, uji linearitas, penentuan akurasi dan presisi, uji stabilitas PGV-1 dalam darah dan asetonitril. Kadar PGV-1 dalam darah ditetapkan menggunakan KCKT dengan kondisi kolom LiChrosphere® 100 Cartridge RP C18 (125 x 4 mm i.d., 5 μm), fase gerak campuran metanol : bufer asetat 0,05 M pH 3,7 (80:20 v/v), kecepatan alir 0,5 ml/menit, detektor Vis-416 nm, dan volume injeksi 80 μl. Uji kesesuaian sistem menunjukkan bahwa kondisi pemisahan sesuai untuk analisis PGV-1 dalam darah. Metode yang diusulkan memenuhi syarat selektivitas, linieritas (rhitung = 0,9999), akurasi dan presisi. Nilai batas deteksi dan kuantitasi yang didapat masing-masing sebesar 4,93 ng/ml dan 16,42 ng/ml. PGV-1 dalam darah stabil hingga jam pertama. Dalam asetonitril pada penyimpanan suhu kamar, PGV-1 stabil selama 3 jam sedangkan pada penyimpanan suhu 5°C, PGV-1 stabil selama 3 hari. Dengan demikian, metode analisis yang diusulkan dapat diaplikasikan untuk menetapkan kadar PGV-1 dalam darah.
EFFECT OF PENTAGAMAVUNON-0 TO THE THEOPHYLLINE PHARMACOKINETICS IN RATS Hakim, Arief Rahman; Hakim, Lukman; Margono, Supardjan A.
Indonesian Journal of Pharmacy Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.087 KB) | DOI: 10.14499/indonesianjpharm0iss0pp244-249

Abstract

The research was aimed to observe pentagamavunon-0 activities to theophylline pharmacokinetics in rats. The study of interaction pentagamavunon-0 and theophylline was conducted employing a completely randomized design using male Wistar rats which were divided into 5 groups (6 rats for each group). The groups were given a single oral theophylline 25 mg/kg BW as a control group and were administered single oral pentagamavunon-0 2, 5, 10 and 40 mg/kg BW each dose 4 hours before treatment with theophylline. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged theophylline in blood. The concentration of theophylline was determined based on a standard curve. The concentration-time data determines theophylline pharmacokinetics i.e. Ka, Cmaks, tmaks, AUC0-, Vdss, t1/2 elimination, Clt and MRT. The results indicated that pentagamavunon-0 was found to be able to decrease theophylline clearance 40-51% (P<0.05). The decrease in clearance causes the prolonged life of theophylline in the body.Key words : Pentagamavunon-0, Theophylline, Pharmacokinetics
Effect of the curcuma plus® syrup on the pharmacokinetics of rifampicin in rats Wahyono, Djoko; Hakim, Arief Rahman; ., Purwantiningsih
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.119 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-168

Abstract

The research was aimed to observe the effect of Curcuma plus® syrup on rifampicin pharmacokinetics in rats.The study of interaction Curcuma plus® syrup with rifampicin pharmacokinetics was conducted employing a completely randomized design using male Sprague Dawley rats which were divided into 3 groups (5 rats for each group). The groups were given a single oral rifampicin dose of 50 mg/kg BW as a control group and were confered single oral Curcuma plus syrup 2.7 mL/kg BW one hour before rifampicin and daily dose for 7 days, then is given rifampicin after that. Serial blood samples (0,2 mL) were withdrawn at various interval via the vein for HPLC analysis of unchanged rifampicin in blood. The concentration of rifampicin was determined based on a standard curve, and from the concentration to time data was determined rifampicin pharmacokinetic parameters (Cmaks, tmaks, AUC0-∼, Vd/F, t1/2, ClT dan K).The results indicated that Curcuma plus® syrup single dose 2.7 mL/kg BW one hour before rifampicin could increased rifampicin volume of distribution by 225.80% (P<0.05) and caused decreased Cmaks 72.81% and AUC0-inf 63.93% (P<0.05), while daily dose Curcuma plus® syrup for 7 days could rise rifampicin total clearance 225.60% (P<0.05) and caused decrease by 76.94% of AUC0-inf (P<0.05).Key words : pharmacokinetics, Curcuma plus® syrup, rifampicin
A BIOAVAILABILITY STUDY OF INDONESIAN GENERIC TABLET OF CAPTOPRIL IN HEALTHY VOLUNTEERS Nugroho, Agung Endro; Hakim, Arief Rahman; ., Purwantiningsih; Hakim, Lukman
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.336 KB) | DOI: 10.14499/indonesianjpharm23iss3pp183-187

Abstract

Captopril  is  a  selective  inhibitor  of  angiotensin-converting enzyme  (ACE)  and  is  formulated  by  several  pharmaceutical companies in Indonesia. This study was conducted to compare the bioavailability  of  a  captopril  tablet  with  reference  products  in healthy  volunteers.  The  relative  bioavailability  of  captopril  was determined in single dose, randomized, crossover,  and  two-phase studies.  The  relative  bioavailability  of  the  test  product  (a  generic captopril 50 mg tablet) with respect to the reference product was determined. Twelve healthy volunteers in two groups took part in these  studies  and  took  either  the  test  or  reference  tablets  in  the first  phase  and  received  the  other  tablet  in  the  second  phase  of each  study.  The  bioavailability  parameters  include  the  peak concentration  of  captopril  in  serum  (Cmax);  the  time  to  achieve the  peak  concentration  (Tmax);  and  the  area  under  the  curve  of captopril  in  serum  versus  time.  Non-compartmental  analysis  on observed concentration versus time data has resulted in the mean value of Cmax of 545.26 ± 22.90 ng/mL (test product) and 548.91 ± 25.07 ng/mL (reference product) and mean Tmax of 1.13 ± 0.08 hours  (test  product)  and  1.08  ± 0.08  hours  (reference  product), mean  of  AUC0-7  value  of  1820.51  ± 75.31  ng.  hour/mL  (test product)  and  1822.09  ± 99.29  ng.  hour/mL  (reference  product), and  mean  of  AUC0-inf  value  of 1967.83  ±  95.65  ng. hour/mL  (test product)  and  1996.94  ± 124.52  ng.  hour/mL  (reference  product). Based on the data, it can be concluded that there is no significant difference  (p>0.05)  in  bioavailability  between  both  captopril Tablet (test and reference product).Key words: Bioequivalence, Captopril, HPLC, Human serum, Generic 
The effect of pentagamavunon-0 pretreatment to the pharmacokinetic of paracetamol profile on wistar male rats Wahyono, Djoko; Hakim, Arief Rahman
Indonesian Journal of Pharmacy Vol 17 No 4, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.142 KB) | DOI: 10.14499/indonesianjpharm0iss0pp194-198

Abstract

Drug interaction can happen when two or more drugs are given together. This research was aimed to observe the effect of PGV-0 pretreatment to paracetamol pharmacokinetic profile in male rats.The study was conducted employing a one-way randomized completely design, using male Wistar rats weight 150 g (±10%). The animals were divided into three groups (5 rats for each group). Group I (control) was given a single oral paracetamol 150 mg/kg BW. The other groups II dan III were given a single oral PGV-0 20 and 40 mg/kg BW one hour before treatment with paracetamol respectively. After all rats were pretreated, serial blood and urine samples were withdrawn and were analysed using HPLC for unchanged paracetamol. Pharmacokinetic parameters of paracetamol i.e. Cmax, tmax, AUC, K, t1/2, Vdss/F, Cl/F, Aecum, dan %fe were determined based on concentration to time data in the blood and urine. The paracetamol pharmacokinetic parameters were analyzed by one-way analysis of varians (ANOVA) using 95% confidence interval. And the difference between groups were analyzed using Tukey-test method. The results showed that the pharmacokinetic parameters of paracetamol in the animals prefed with PGV-0 20 and 40 mg/kg BW did not change significantly (P > 0.05).Key words : pharmacokinetics, interaction, paracetamol, Pentagamavunon-0
PENGARUH PRAPERLAKUAN JUS PISANG AMBON ( Musa paradisiaca L. ) TERHADAP BIOAVAILABILITAS SULFAMEZATIN PADA TIKUS PUTIH JANTAN Farida Hayati; Arief Rahman Hakim; Rhatna Dewi Riptasari
Jurnal Ilmiah Farmasi Vol. 1 No. 1 (2004)
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The influence of ambon banana’s fruit ( Musa paradisiaca L. ) juice on the bioavailability of sulfamezathin on the rat that aim to know there are interaction result from their consumption together has been studied. The study was using experiment’s animal is white rats Wistar’s spesies that have age around 3-4 months and their weight 200-300 g. This experimental was used completely randomized design with three group’s test, each group’s test is contain seven rats. The first group is pretreatment single dose sulfamezathin (60 mg/kg ww; peroral ), second is sullfamezathin and banana ( 12,6 g/kg ww; peroral ) together and third group is sulfamezathin after one hour dose banana like second group. Respectively blood samples take up from tail vein of rat at 15, 30, 45, 60, 90, 120, 150, 180, 240, 360, 480 and 600 minutes. Consentrations of Sulfamezatin were measured use Bratton Marshall methode with spektrofotometer instrument at 545 mn wavelength. Consentrations of sulfamezathin versus times by software of Stripe used to calculate pharmacokinetics parameters in each group’s test and the value parameters of pharmacokinetics have statistic analysis by ANOVA and if there are difference’s significant ( p < 0,05 ) from calculated value, statistic analysis continued by Tukey test. The results from experimental banana at second and third groups in compare with control at the first group can increased significant ( p < 0,05 ) parameters C maks, t maks, AUC0- .Bioavailability, Sulfamezathin, Ambon banana, Musa paradisiaca L.
Population-Based Approach to Analyze Sparse Sampling Data in Biopharmaceutics and Pharmacokinetics using Monolix and NONMEM Akhmad Kharis Nugroho; Arief Rahman Hakim; Lukman Hakim
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1378.459 KB) | DOI: 10.14499/indonesianjpharm28iss4pp205

Abstract

Although it has been developed since 1972, the implementation of a population-based modeling approach in Indonesia, particularly to analyze biopharmaceutics and pharmacokinetics data is still very limited. This study was aimed to evaluate the performance of Monolix and NONMEM, two of the popular software packages in a population-based modeling approach, to analyze the limited data (sparse sampling data) of the time profiles of the simulated plasma drug concentration of a theoretical compound. and NONMEM were used to model the limited data (40 data points) as a results of the random selection from the 180 point data of simulated plasma drug concentration (Cp) on 20 subjects at 0.25; 0.5; 0.75; 1; 1.5; 3; 6; 12 and 18 hours after per-oral administration of a 100mg of a theoretical compound. Population values of the absorption rate constant (Ka), the elimination rate constant (Kel) and volume of distribution (Vd) were compared to the average Ka, Kel and Vd obtained by the conventional method (two stage approach) using PKSolver on the Cp data of all subjects. The calculation system of a nonlinear mixed effect model in Monolix and NONMEM, successfully describes the sparse data, based on the visual evaluation of the goodness of fit. Comparison of parameter estimates of population values in Monolix and NONMEM are in the range of 94 to 108% of the real values of the rich data analysed by PKSolver. A population-based modeling can adequately analyze limited or sparse data, demonstrating its capability as an important tool in clinical studies, involving patients.
Co-Authors ., Purwantiningsih ., Purwantiningsih A.A. Ketut Agung Cahyawan W Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Ahmad Fudholi Akhmad Kharis Nugroho ANDIKA GUTAMA, ANDIKA Anindita, Jessica Arief Nurrochmad Astini, Siluh Made Yuni Cicilia Ika Rahayu Nita Dedy Suryadi Dion Notario Djoko Wahyono Djoko Wahyono Djoko Wahyono Edy Meiyanto Endang Lukitaningsih Eny Masruriati Eny Susilowati Fajar Rakhmatullah Farida Nur Kumala Fathul Jannah Hakim, Lukman Hakim, Lukman HARI PURNOMO Hayati, Farida Imono Argo Donatus, Imono Argo Indah Purwantini Liberti Natalia Hia Lukman Hakim Lukman Hakim Mahmudah, Amirotul M.H Margono, Supardjan A. Marlyn Dian Laksitorini Neilcy Tjahja Mooniarsih Ningrum, Anita Dwi Juwita Nugroho, Agung Endro Pudjono, Pudjono Purwatiningsih Purwatiningsih Retno Murwanti Rhatna Dewi Riptasari Rosmawiah Rosmawiah Sesanti, Nyamik Rahayu Silvia Arianti Sudibyo Martono Sumiatie Sumiatie Wahyono, Djoko Wahyono, Djoko Zullies Ikawati